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Articles 361 - 390 of 2166
Full-Text Articles in Public Health
Pregnancy Following Sequential Bromocriptine Therapy In A Hyperprolactinemic Subject, Malachi J. Mckenna, M. Saeed-Uz-Zafar, Raymond C. Mellinger
Pregnancy Following Sequential Bromocriptine Therapy In A Hyperprolactinemic Subject, Malachi J. Mckenna, M. Saeed-Uz-Zafar, Raymond C. Mellinger
Henry Ford Hospital Medical Journal
Regular menses were maintained in a 26-year-old woman with a prolactinoma by sequential bromocriptine therapy given for either five or 14 days of the menstrual cycle. She conceived promptly when desired.
Comparison Of Four High-Sensitivity Immunoradiometric Assays For Thyrotropin And Results Of Preliminary Clinical Studies, Malachi J. Mckenna, Earl Goad, Mohini Pimputkar, Carolyn S. Feldkamp
Comparison Of Four High-Sensitivity Immunoradiometric Assays For Thyrotropin And Results Of Preliminary Clinical Studies, Malachi J. Mckenna, Earl Goad, Mohini Pimputkar, Carolyn S. Feldkamp
Henry Ford Hospital Medical Journal
New immunoradiometric assays (IRMAs) that detect low concentrations of thyroid-stimulating hormone (TSH) have recently become available for routine diagnostic use. These new assays have the putative advantage over conventional radioimmunoassay in that they can distinguish hyperthyroidism from euthyroidism by the finding of a serum TSH below the normal limit. In the present study we sought to evaluate four of these kits according to analytical performance characteristics and clinical utility. All IRM As could detect TSH at a concentration substantially below the lower limit of normal and thus effectively identify hyperthyroid samples. Although differences in the performance characteristics were found, all …
Neurobehavioral Symptoms In Mild Primary Hyperparathyroidism: Related To Hypercalcemia But Not Improved By Parathyroidectomy, Gregory G. Brown, Richard C. Preisman, Michael Kleerekoper
Neurobehavioral Symptoms In Mild Primary Hyperparathyroidism: Related To Hypercalcemia But Not Improved By Parathyroidectomy, Gregory G. Brown, Richard C. Preisman, Michael Kleerekoper
Henry Ford Hospital Medical Journal
The neurobehavioral symptomatology of severe primary hyperparathyroidism (PHPT) has been thoroughly described. Less is known about more mild cases. We evaluated 34 patients with mild PHPT and followed 19 for an average of six months. Of those cases followed, ten had parathyroidectomy (PTX). Patients with no neurobehavioral abnormalities had the lowest serum calcium levels (10.9 ± 0.88 mg/dL), patients with signs of affective disorder had intermediate levels (11.25 ± 0.66 mg/dL), and patients with signs of cerebral dysfunction had the highest levels (12.17 ± 1.17 mg/dL). Serum calcium significantly correlated with motor speed, psychomotor speed, fluid intelligence, and short term …
Prolonged Remission Of Cushing's Disease Following Bromocriptine Therapy, Malachi J. Mckenna, Marc Linares, Raymond C. Mellinger
Prolonged Remission Of Cushing's Disease Following Bromocriptine Therapy, Malachi J. Mckenna, Marc Linares, Raymond C. Mellinger
Henry Ford Hospital Medical Journal
A 33-year-old woman developed hypercorticism of fulminant onset following delivery of a full-term, normal child. An ectopic hormone-producing neoplasm was excluded by extensive studies. Pituitary dependent hypercorticism of intermediate lobe origin was suggested on the basis of onset following pregnancy, failure of Cortisol suppression by high-dose dexamethasone, hyperresponsiveness of prolactin to thyrotropin-releasing hormone stimulation, and reduction in adrenocorticotropin titers following oral administration of bromocriptine. Initial remission of disease achieved with bromocriptine was followed by recurrence on discontinuation of the agent. However, complete remission which occurred following a prolonged course of bromocriptine has persisted for a total of 22 months.
Hypothalamic Hypogonadotropic Hypogonadism In An Adolescent Male: A Rare Manifestation Of Aqueductal Stenosis, Robert J. Wilson, Max Wisgerhof
Hypothalamic Hypogonadotropic Hypogonadism In An Adolescent Male: A Rare Manifestation Of Aqueductal Stenosis, Robert J. Wilson, Max Wisgerhof
Henry Ford Hospital Medical Journal
No abstract provided.
Naltrexone Does Not Affect Adrenal Steroidogenesis In Women With Hirsutism/Oligomenorrhea, Jeffrey A. Jackson, Thomas J. Wincek, Jose F. Pliego
Naltrexone Does Not Affect Adrenal Steroidogenesis In Women With Hirsutism/Oligomenorrhea, Jeffrey A. Jackson, Thomas J. Wincek, Jose F. Pliego
Henry Ford Hospital Medical Journal
We studied the effects of the oral opiate receptor antagonist naltrexone on basal and ACTH-stimulated adrenal steroid levels in six women with hirsutism/oligomenorrhea and preexisting elevation of serum dehydroepiandrosterone sulfate. One of the six patients met the criteria for partial 3-β-hydroxysteroid dehydrogenase deficiency. No statistical differences were detected in steroid levels or ratios before and after 14 days of 50 mg/day of naltrexone. Thus, we find no support for the hypothesis that opioid peptides acting through opiate receptors (predominantly μ subtype) modulate the abnormal adrenal androgen secretion seen in these women with hirsutism/oligomenorrhea.
Hyperthyroidism Due To A Thyrotropin-Secreting Pituitary Microadenoma, Jeffrey A. Jackson, Mitchell Smigiel, John F. Green Jr.
Hyperthyroidism Due To A Thyrotropin-Secreting Pituitary Microadenoma, Jeffrey A. Jackson, Mitchell Smigiel, John F. Green Jr.
Henry Ford Hospital Medical Journal
A 52-year-old man presented with elevated thyroid hormone levels and an inappropriately normal serum thyrotropin (TSH) (4.0 μU/mL: normal 0.5 to 6.0 μU/mL). Computed tomography suggested an intrasellar mass without radiographic sellar enlargement. Serum alpha-subunit was elevated with flat responses of both alpha-subunit and TSH to thyrotropin-releasing hormone. Transsphenoidal adenomectomy resulted in clinical and biochemical cure with subsequent development of hypothyroidism with otherwise preserved anterior pituitary function. Pathologic studies demonstrated an 8 mm typical thyrotroph cell adenoma. Early diagnosis of such tumors requires a high index of clinical suspicion and may be facilitated in the future by utilization of highly …
Primary Hyperparathyroidism And Associated Neoplasms, Angelos A. Kambouris, Mohammed R. Ansari, Gary B. Talpos
Primary Hyperparathyroidism And Associated Neoplasms, Angelos A. Kambouris, Mohammed R. Ansari, Gary B. Talpos
Henry Ford Hospital Medical Journal
No abstract provided.
Effects Of Weight Reduction, Exercise, And Diet Modification On Lipids And Apolipoproteins A-L And B In Severely Obese Persons, J. David Fachnie, Craig C. Foreback
Effects Of Weight Reduction, Exercise, And Diet Modification On Lipids And Apolipoproteins A-L And B In Severely Obese Persons, J. David Fachnie, Craig C. Foreback
Henry Ford Hospital Medical Journal
We assessed the lipid and apolipoprotein effects of hypocaloric dieting, increased physical activity, and dietary modification in severely overweight adults (body mass index [BMI] 43.05 kg/m-). The 34 women and four men enrolled in the ambulatory weight control program donated blood before, during, and after hypocaloric dieting (420 kcal/day). Mean values before dieting included cholesterol of 223 mg/dL, high-density lipoprotein (HDL) cholesterol of 43 mg/dL, and cholesterol/HDL cholesterol of 5.90. This placed our subjects at high risk for coronary artery disease. Other values included triglycerides of 138 mg/dL, apolipoprotein A-l of 152 mg/dL. and apolipoprotein B/apolipoprotein A-l of 0.64. Significant …
Renal Involvement In Type 2 Diabetes Mellitus: A Clinicopathologic Study Of The Henry Ford Hospital Experience, Francis Dumler, Vijay Kumar, Raymond N. Romanski, Pedro Cortes, Nathan W. Levin
Renal Involvement In Type 2 Diabetes Mellitus: A Clinicopathologic Study Of The Henry Ford Hospital Experience, Francis Dumler, Vijay Kumar, Raymond N. Romanski, Pedro Cortes, Nathan W. Levin
Henry Ford Hospital Medical Journal
To better understand renal dysfunction in type 2 diabetes mellitus, we studied the clinical and autopsy findings in comparable cohorts of 108 diabetic and 77 nondiabetic patients. In the diabetic group, no differences were noted between black and white patients in blood glucose concentrations, mean blood pressure, or the prevalence of diabetic glomerulosclerosis. However, the prevalence of renal insufficiency was significantly greater (P = 0.002) in black diabetics (58%) than in white diabetics (35%). black controls (28%), and white controls (20%). Logistic regression analysis demonstrated a significant association of renal insufficiency with diabetes (P = 0.006) and race (P = …
Primary Aldosteronism At Henry Ford Hospital In The 1980s, Max Wisgerhof
Primary Aldosteronism At Henry Ford Hospital In The 1980s, Max Wisgerhof
Henry Ford Hospital Medical Journal
This report describes the experience with the diagnosis and treatment of primary aldosteronism at Henry Ford Hospital since 1980. Of the 28 patients who received the diagnosis. 13 had unilateral primary aldosteronism and 15 had idiopathic hyperaldosteronism. Individual cases are used to demonstrate clinical points. The clue to the presence of primary aldosteronism in a hypertensive patient is hypokalemia. The diagnosis is established by showing 1) high plasma aldosterone after intravenous saline or high urinary aldosterone after treatment with sodium chloride orally, and 2) low stimulated plasma renin activity. Treatment with potassium supplement should be given during the testing. Unilateral …
Management Of Extramedullary Plasmacytomas, James A. Bonner, Jadranka Dragovic, Michael P. Abrash
Management Of Extramedullary Plasmacytomas, James A. Bonner, Jadranka Dragovic, Michael P. Abrash
Henry Ford Hospital Medical Journal
From 1965 through 1982. 12 patients with solitary, biopsy-proven extramedullary plasmacytomas (EMPs) were treated at our institution with surgery alone or biopsy followed by radiation therapy. The median age of the patients was 67 years, and the median-follow-up was 58 months. Of the seven patients who were treated by primary surgery, three developed recurrent or distant disease. Five patients underwent biopsy followed by radiation therapy, and none of their tumors progressed. Our series and a review of the literature show that occasionally EMPs will incompletely regress even after high doses of radiation (greater than 65 Gy); however, we recommend that …
Unusual Lymphomas Developing In Chronic Lymphocytic Leukemia, Sundara B. K. Raman, Sheikh M. Saeed, Joseph P. Abraham
Unusual Lymphomas Developing In Chronic Lymphocytic Leukemia, Sundara B. K. Raman, Sheikh M. Saeed, Joseph P. Abraham
Henry Ford Hospital Medical Journal
We report three patients with chronic lymphocytic leukemia (CLL) who developed malignant lymphomas of unusual character and modes of presentation. Two of the patients had received low doses of chlorambucil for several years before they developed malignant lymphoma, diffuse, large cell type (LCL). In one of these patients LCL manifested as a grossly evident osteolytic lesion. In the second patient LCL developed initially as a localized lesion in the iliac bone. Both patients died within a few weeks after LCL was diagnosed. The third patient, who was found to have CLL during a routine examination, did not receive any therapy …
T-Cell Lymphoma In Renal Transplant Recipient, Koichi Maeda, Leslie Bricker, Chan K. Ma, Michael J. Deegan
T-Cell Lymphoma In Renal Transplant Recipient, Koichi Maeda, Leslie Bricker, Chan K. Ma, Michael J. Deegan
Henry Ford Hospital Medical Journal
A 35-year-old woman, who had a renal transplant flve years ago, developed malignant lymphoma of the mediastinum. The lymphoma was of lymphoblastic type and had T-cell immunophenotype. Most transplant-related lymphomas are of B-cell type. T-cell lymphoma in this setting is extremely rare, and the mechanism of development may be different from that of B-cell lymphomas.
Obstructing Giant Pseudopolyposis Of The Colon In Ulcerative Colitis, Roberta E. Sonnino, Farouck N. Obeid
Obstructing Giant Pseudopolyposis Of The Colon In Ulcerative Colitis, Roberta E. Sonnino, Farouck N. Obeid
Henry Ford Hospital Medical Journal
Pseudopolyposis of the colon is a well-recognized local complication of ulcerative colitis. Giant pseudopolyposis is uncommon, and its presentation as a complete obstruction of the colon is a rare occurrence. We report such a case, where retrograde flow of barium on double-contrast barium enema was completely obstructed at midtransverse colon. After resection by total abdominal colectomy, pathology examination ofthe specimen confirmed massive pseudopolyposis without malignancy. A brief review of the pathology and current literature is presented.
Ocular Irrigating Solutions: A Comparison Between Balanced Salt Solution And L-410 (Po-Eis), Philip C. Hessburg, Paul M. Johnston
Ocular Irrigating Solutions: A Comparison Between Balanced Salt Solution And L-410 (Po-Eis), Philip C. Hessburg, Paul M. Johnston
Henry Ford Hospital Medical Journal
The ability of two ocular irrigating solutions to reduce postoperative corneal edema after intracapsular cataract extraction was compared using ultrasonic pachymetry. All patients had anterior chamber intraocular lenses implanted. The solutions were balanced salt solution and solution L-410 (PO-EIS), an eye irrigation solution containing dextran 40 and bicarbonate. Corneas irrigated with either solution showed no significant difference in postoperative edema. The use of L-410 (as an alternative to balanced salt solution) may not be necessary in intracapsular cataract extraction.
Melvin A. Block, Md, Gary B. Talpos
Melvin A. Block, Md, Gary B. Talpos
Henry Ford Hospital Medical Journal
No abstract provided.
Book Review: Guides To Clinical Aspiration Biopsy: Thyroid, John E. Brunner
Book Review: Guides To Clinical Aspiration Biopsy: Thyroid, John E. Brunner
Henry Ford Hospital Medical Journal
No abstract provided.
Thyroid C-Cell Hyperplasia And Micronodules In Close Relatives Of Men-2 A Patients: Pitfalls In Early Diagnosis And Reevaluation Of Criteria For Surgery, Cees J. M. Lips, John R. Leo, Marianne J. H. Berends, Werner H. Minder, A. P. Roeland Blok, Rolf A. Geerdink, Wil H. L. Hackeng, Jan M. M. Roelofs, Hans F. A. Vasen, Jan K. Vette
Thyroid C-Cell Hyperplasia And Micronodules In Close Relatives Of Men-2 A Patients: Pitfalls In Early Diagnosis And Reevaluation Of Criteria For Surgery, Cees J. M. Lips, John R. Leo, Marianne J. H. Berends, Werner H. Minder, A. P. Roeland Blok, Rolf A. Geerdink, Wil H. L. Hackeng, Jan M. M. Roelofs, Hans F. A. Vasen, Jan K. Vette
Henry Ford Hospital Medical Journal
In a large family with multiple endocrine neoplasia rype 2 A (MEN-2 A), 20 patients were identified by the diagnosis of medullary thyroid carcinoma (MTC) and/or pheochromocytomas. Another five subjects had neck surgery on the basis of slightly increased results of a C-cell provocative test. Retrospectively, however, although the immunohistochemical diagnosis of C-cell hyperplasia was confirmed, the diagnosis of MEN-2 was doubtful in these five subjects, and the C-cell hyperplasia observed was probably within the limits of normal variation. The occurrence of C-cell hyperplasia in a normal population was investigated by a C-cell provocative test, as well as in random …
Plasma And Tumor Levels Of Somatostatin (Srif) And Somatostatin Immunochemistry In Medullary Thyroid Carcinoma: Apparently Discrepant Preliminary Results, B. Franc, J. A. Chayvialle, E. Modigliani, C. Calmettes, B. Caillou, N. Dutrieux-Berger, C. Houdent, M. Kujas
Plasma And Tumor Levels Of Somatostatin (Srif) And Somatostatin Immunochemistry In Medullary Thyroid Carcinoma: Apparently Discrepant Preliminary Results, B. Franc, J. A. Chayvialle, E. Modigliani, C. Calmettes, B. Caillou, N. Dutrieux-Berger, C. Houdent, M. Kujas
Henry Ford Hospital Medical Journal
Eighteen cases of medullary thyroid carcinoma (MTC) (11 hereditary) had parallel measurements of basal plasma levels of somatostatin (SRIF), levels of SRIF extracted from fresh tumor tissue (radioimmunoassay), and immunohistochemistry (peroxidase-antiperoxidase method) using an anti-SRIF antibody on paraffin sections. Immunohistochemistry disclosed some cell positivity in nine cases (50%). Plasma levels of SRIF were above normal (> 50 pg/mL expressed in terms of the 14 amino acid SRIF peptide) in only two of 12 patients. Extraction of fresh tumor tissue detected SRIF in 60% of our cases: two patients > l.200pg/mg (equivalents 14). with the other positive values ranging between 13 and …
Impact Of Prospective Screening For Multiple Endocrine Neoplasia Type 2, Robert F. Gagel, Armen H. Tashjian Jr., Tim Cummings, Nick Papathanasopoulos, Seymour Reichlin
Impact Of Prospective Screening For Multiple Endocrine Neoplasia Type 2, Robert F. Gagel, Armen H. Tashjian Jr., Tim Cummings, Nick Papathanasopoulos, Seymour Reichlin
Henry Ford Hospital Medical Journal
Prospective annual screening for hereditary medullary thyroid carcinoma (MTC) in the J-kindred, currently a 117-member family with multiple endocrine neoplasia type 2A, began in 1969. During the initial screening, 12 patients were found to have MTC. Subsequent screening has detected C-cell abnormalities (C-cell hyperplasia or microscopic MTC) in 22 of 23 addilional family members thyroidectomized for abnormal calcium- or pentagastrin-provocative calcitonin (CT) test results. Seven of the initial 12 patients thyroidectomized in 1970 to 1971 and 19 of 23 individuals thyroidectomized since 1971 remain disease-free by all criteria; three patients thyroidectomized since 1971 have had clearly abnormal serum CT measurements …
Subtotal Adrenalectomy In Multiple Endocrine Neoplasia Type 2, Bertil Hamberger, Margareta Telenius-Berg, Bjorn Cedermark, Staffan Grondal, Bengt-Goran Hansson, Sigbritt Werner
Subtotal Adrenalectomy In Multiple Endocrine Neoplasia Type 2, Bertil Hamberger, Margareta Telenius-Berg, Bjorn Cedermark, Staffan Grondal, Bengt-Goran Hansson, Sigbritt Werner
Henry Ford Hospital Medical Journal
We report two patients in whom pheochromocytoma was treated by subtotal adrenalectomy leaving a rim of vascularized cortical tissue in situ. Both patients are doing well without cortisol supplementation although they have subnormal cortisol responses to ACTH stimulation.
Application Of Minisatellite Dna Probes To Linkage In Men-2, Bruce A. J. Ponder, Alec J. Jeffreys, Nicola E. Hartley, Clare Carter, Douglas F. Easton, Hakan Telenius, Margareta Telenius-Berg
Application Of Minisatellite Dna Probes To Linkage In Men-2, Bruce A. J. Ponder, Alec J. Jeffreys, Nicola E. Hartley, Clare Carter, Douglas F. Easton, Hakan Telenius, Margareta Telenius-Berg
Henry Ford Hospital Medical Journal
We describe the potential benefits and the limitations of the use of highly polymorphic minisatellite DNA probes for genetic linkage analysis of multiple endocrine neoplasia type 2A (MEN-2 A). The advantage of these probes is that up to 34 loci can be examined in a single experiment, and since the loci are highly polymorphic, almost every individual in every family is informative. The disadvantage is that the DNA fragment lengths of the alleles at any given locus differ from one family to another, so that families cannot be combined, and large single sibships are needed to obtain significant linkage data. …
One Large Kindred Excludes A Locus For Multiple Endocrine Neoplasia Type 2a From About 25% Of The Human Autosomal Genetic Map, Andrew J. Pakstis, Judith R. Kidd, Carmela M. Castiglione, Beth A. Pletcher, Patricia D. Murphy, Lindsay A. Farrer, Myron Genel, Kenneth K. Kidd
One Large Kindred Excludes A Locus For Multiple Endocrine Neoplasia Type 2a From About 25% Of The Human Autosomal Genetic Map, Andrew J. Pakstis, Judith R. Kidd, Carmela M. Castiglione, Beth A. Pletcher, Patricia D. Murphy, Lindsay A. Farrer, Myron Genel, Kenneth K. Kidd
Henry Ford Hospital Medical Journal
This report presents pairwise linkage results from our search for the locus of the gene (MEN2A) for the multiple endocrine neoplasia type 2A (MEN-2A) syndrome in one large kindred (the N kindred), clearly segregating for an autosomal dominant form. About 25% of the autosomal genome is excluded when these new results are combined with those we have published previously. The genetic markers employed are distributed across at least 19 of the 22 autosomes. Seven genetic markers whose chromosomal locations are not yet established have also been studied.
Immunohistochemistry In Medullary Thyroid Carcinoma: Prognosis And Distinction Between Hereditary And Sporadic Tumors, B. Franc, B. Caillou, A. M. Carrier, N. Dutrieux-Berger, J. Floquet, M. Houcke, E. Justrabo, F. Lange, A. Pages, C. Rigaud, A. Schwartz, M. Viennet, M. F. Lebodic
Immunohistochemistry In Medullary Thyroid Carcinoma: Prognosis And Distinction Between Hereditary And Sporadic Tumors, B. Franc, B. Caillou, A. M. Carrier, N. Dutrieux-Berger, J. Floquet, M. Houcke, E. Justrabo, F. Lange, A. Pages, C. Rigaud, A. Schwartz, M. Viennet, M. F. Lebodic
Henry Ford Hospital Medical Journal
In this retrospective study of 68 cases of medullary thyroid carcinoma (MTC), morphological features were studied, which could be helpful in prognosis and in the distinction between hereditary and sporadic forms of the disease. Necrosis within the tumors seemed to carry a poor prognosis. Bilateral MTC. unquestionable C-cell hyperplasia, glandular or follicular pattern, and thyroglobulin-positive cells seemed to be more prevalent in hereditary forms of the disease. A smaller proportion of calcitonin-immunoreactive cells were encountered in hereditary tumors than in sporadic tumors.
Different Mechanisms Of Calcitonin, Calcitonin Gene-Related Peptide, And Somatostatin Regulation By Glucocorticoids In A Cell Culture Of Human Medullary Thyroid Carcinoma, Gilbert J. Cote, Robert F. Gagel
Different Mechanisms Of Calcitonin, Calcitonin Gene-Related Peptide, And Somatostatin Regulation By Glucocorticoids In A Cell Culture Of Human Medullary Thyroid Carcinoma, Gilbert J. Cote, Robert F. Gagel
Henry Ford Hospital Medical Journal
We have employed the TT cell line, a model for the human medullary thyroid carcinoma cell, lo study the regulation of peptide hormone production by glucocorticoids. Complementary DNA probes were used to measure the calcitonin (CT), CT gene-related peptide (CGRP), and somatostatin (SRIF) mRNA levels. Dose-response experiments in serum-free medium showed that dexamethasone (six-day treatment) lowered somatostatin (to 1% of basal) and CGRP mRNA (to 50% of basal) and stimulated CT mRNA (threefold to thirteenfold) with a half-maximal effective concentration of 10−8 M. Time course studies for cells continuously exposed to 10−6 M dexamethasone showed a rapid (within …
The Second International Workshop On Multiple Endocrine Neoplasia Type 2 Syndromes, Bruce A. J. Ponder, Charles E. Jackson
The Second International Workshop On Multiple Endocrine Neoplasia Type 2 Syndromes, Bruce A. J. Ponder, Charles E. Jackson
Henry Ford Hospital Medical Journal
No abstract provided.