Public Health Commons^™

Immunologic Assessment In Patients With Prostatic Carcinoma, Richard C. Klugo

Henry Ford Hospital Medical Journal

The role of immune mechanisms in the development and control of prostatic carcinoma appears to be complicated by the endocrine response of some tumors. The progression of endocrine-independent tumors is more directly related to host-immune response. Evaluation of the role of chemotherapeutic agents must include their effect on the host-immune response. The use of BCC in patients with metastatic prostatic carcinoma produces no alteration in cell-mediated immunity but produces local tumor necrosis. The use of nonspecific antigens to enhance host-immune response may be more effective when used as adjuvant therapy in earlier stages of prostatic adenocarcinoma.

Hormonal And Chemotherapeutic Management Of Disseminated Carcinoma Of The Prostate, Robert W. Brownlee

Henry Ford Hospital Medical Journal

The management of disseminated prostatic carcinoma with hormonal and chemotherapeutic agents is discussed. Hormonal manipulation consists of ablative as well as additive modalities. A new agent, Adriamycin, has shown some effectiveness In selected cases. Significant difficulties are encountered in assessing the objective state of remission of patients undergoing therapy. Further advances through co-operative, randomized clinical trials must be sought. The development of additional chemotherapeutic agents will hopefully expand our horizons.

Changes In Serum Testosterone After Bilateral Orchiectomy In Patients With Metastatic Carcinoma Of The Prostate, Richard Senn, Riad Farah, Julius Ohorodnik, Joseph C. Cerny

Henry Ford Hospital Medical Journal

From a study of 38 patients, it may be concluded that, first, changes in serum testosterone levels of patients undergoing orchiectomy for metastatic carcinoma of the prostate are unrelated to the clinical course of the patient; second, no clear correlation exists between quantitative Leydig cell counts and levels of plasma testosterone; and, third, exacerbation of metastatic disease is observed while plasma testosterone remains in the castrate range. These observations question the exact function of the Leydig cell and its role in androgen production, and indicate that prostatic neoplasms have varying degrees of response to reduced androgen levels and/or androgen-Iike substances …

Atomic Models For The Polypeptide Backbones Of Myohemerythrin And Hemerythrin, W A Hendrickson, K B Ward

Faculty, Staff and Students Publications

Background: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly after its identification in December 2019 to cause a global pandemic. The respiratory tract is the primary site of infection, and there is a large range in the severity of respiratory illnesses caused by the virus. Defining molecular and cellular factors for protection from severe disease and death has been a goal to better understand and to predict and mitigate the effects of SARS-CoV-2 and future coronaviruses.

Objective: Despite well-known susceptibilities to respiratory viral infections, respiratory allergy and allergic asthma have not been identified as risk factors …

The Effects Of Immobility On Long Bone Remodelling In The Rhesus Monkey, Charles C. Schock, Frank R. Noyes, Michael M. Crouch, Catharina H. E. Mathews

Henry Ford Hospital Medical Journal

Using Frost's method for undecalcified bone sections, long bones of the lower extremities of ten rhesus monkeys were examined following two months' immobilization and compared with thirteen controls. A decrease in appositional rate and in the surface extent of the ossification process were noted in the immobilized animals. No typical change in resorption was noted. The immobilized animals showed a decreased cortical-total area ratio. These findings suggest that a decrease in activity affects bone by depressing functions mediated by the osteoblast without necessarily evoking an Increased remodelling response.

Sjogren's Syndrome: Relationship Between Ocular Findings And Parotid Sialograms, A. O. Carbone, C. F. Petrozzi, J. Delcarpio, J. A. Zegarra

Henry Ford Hospital Medical Journal

This study evaluates the incidence and severity of the ocular findings and its correlation with the parotid gland changes, as demonstrated by sialography, in 82 patients with Sjogren's syndrome. It is shown that the ocular component of the syndrome manifests rather autonomously with respect to the accompanying collagen disease and that there seems to be only a tentative trend towards a positive correlation between the ocular and parotid findings. Sjogren's syndrome immunologically is closer to the collagen diseases than to the so-called organ-specific autoimmune diseases.

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Supportive Care Of The Leukemic Patient, Ellis J. Van Slyck

Henry Ford Hospital Medical Journal

The outlook for the patient with leukemia or lymphoma has been improved by the exponential expansion of basic scientific knowledge in physical chemistry and microbiology, added to much new clinical information based on large cooperative group studies. Most of this progress derives, not from a specific treatment for the disease, but from better understanding and use of multiple support measures. These include the availability of blood components, such as red blood cell, platelet and granulocyte concentrates, better protective isolation measures, and greater expertise in the recognition and treatment of bacterial, fungal, and viral infections in immunosuppressed patients. In addition, the …

Spontaneous Asymptomatic Pneumoperitoneum, Fernando Canavati, Thomas A. Fox Jr.

Henry Ford Hospital Medical Journal

A 65-year-old man developed a spontaneous asymptomatic pneumoperitoneum which was managed conservatively without exploratory laparotomy. However, the authors caution that repeated and careful examinations of the abdomen, observation of vital signs, and leucocyte counts must be made. Also, complete radiological examination of the gastrointestinal and respiratory tracts is necessary to eliminate a possible unrecognized lesion that might explain the origin of the spontaneous pneumoperitoneum.

Bacterial Endocarditis And Incarceration Of A Transvenous Pacemaker: Removal Under Cardiopulmonary By-Pass After Prolonged Traction Proved Ineffective, Remigio Garcia, Mehdi Hakimi-Naini

Henry Ford Hospital Medical Journal

Transvenous electrode endocardial pacing of the right ventricle is the most simple and common modality of permanent pacing at present. The incidence of endocarditis is rare. Only two patients were found in our hospital series of over 200 who had permanent transvenous pacemakers implanted. A 40-year-old housewife developed staphylococcus aureus endocarditis secondary to local wound infection in the power pack pocket, requiring removal of the infected electrode under cardiopulmonary by-pass. Prolonged traction of the retained electrode proved ineffective. The mechanism of electrode entrapment is discussed.

Congestive Cardiomyopathy As An End Stage Of Toxoplasma Myocarditis, Mohsin Alam, Wolf F. C. Duvernoy, Edward L. Quinn, Evelyn J. Fisher

Henry Ford Hospital Medical Journal

Congestive cardiomyopathy is a clinical entity which may be due to many different etiologies in addition to the primary type. The case presented defines the etiology in a 30-year-old patient as previous acute toxoplasma myocarditis. This diagnosis was corroborated by diagnostic rise of fluorescent antibody and Sabin-Feldman dye test titers and response to specific therapy. Toxoplasmosis has to be considered among the causes of congestive cardiomyopathy.

Amikacin: Clinical And Laboratory Studies, Erwin J. Haas, T. Madhavan, Evelyn J. Fisher, Frank Cox, Keith Burch, Edward L. Quinn, Richard D. Nichols

Henry Ford Hospital Medical Journal

Amikacin was evaluated in vitro against S aureus and a variety of gram negative bacilli. In concentrations of 12.5 μg/ml or less, it suppressed the growth of all organisms except 15% of Proteus mirabilis. Peak serum levels in patients, following a 7.5 mg/kg IM dose, averaged 21 μg/ml at one hour. Most of the drug appeared in the urine during the first six hours after administration. Of six patients receiving an adequate course of treatment, all but one were cured. Treatment in that patient also failed with a subsequent course of gentamicin and carbenicillin and he was cured only by …

The Bacteriology Of The Biliary Tract: A Preliminary Report., J. A. Sapala, J. L. Ponka, T. R. Neblett

Henry Ford Hospital Medical Journal

The bacterial flora of acute biliary tract disease has not been completely elucidated. The organisms identified most often were coliforms. Anaerobic culture technics were not precise enough to provide proper identification. In a 12-month study of 250 patients operated upon for inflammatory gallbladder disease, culture specimens were collected in a most strict and rigorous fashion. It was hoped that a more exact understanding of the relationship between bacteria and inflammatory biliary tract disease might be appreciated. Important technics were developed for gathering specimens, delivery to the laboratory and culturing. More meaningful results are to be expected In the future.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Depth Doses In The Region Of Overlap Of The Supraclavicular And Internal Mammary Portals In Postoperative Radiation Therapy Of Carcinoma Of The Breast, Joel E. White, Michael Reidy, Murray Boles

Henry Ford Hospital Medical Journal

Computer-generated depth-dose data was obtained for the region of overlap of the internal mammary and supraclavicular portals utilized in post-operative radiation therapy for carcinoma of the breast. A phantom arrangement was created and measurements were obtained and compared with computer-generated depth doses for this arrangement. The actual measured and computer-generated values agreed to within 3%. On the patients measured at the center of the overlap region, the dose was found to vary from 3323 rets to 2571 rets over a depth range of 2-6 cm. It is occasionally the practice to ignore small areas of overlap. The dose at the …

Pseudo-Atrioventricular Block Due To Premature Systoles With Concealed Conduction, Boguslaw Godlewski, Wolf F. C. Duvernoy, Remigio Garcia

Henry Ford Hospital Medical Journal

Two patients are presented with EKC findings suggesting pseudo AV block Mobitz type II. Pseudo AV block was related to the presence of premature junctional or ventricular beats with concealed conduction. Response to therapy confirmed the initial diagnosis of pseudo AV block. Awareness of clinical conditions simulating type II second degree AV block is important because of the therapeutic implications and prognosis.

Utilization Of Mental Health Services For Children Relative To Social Class. A Pilot Study, H. K. Von Brauchitsch

Henry Ford Hospital Medical Journal

Two groups of children were selected from those evaluated and treated over a two-year period. The study attempted to contrast the mental health care needs and the health care delivery system of children from the uppermost classes against those of the lowest classes. Very few diagnostic discriminators were found. Prevalence of intellectual dysfunctions In the lower classes and neuroses in the upper classes did not correlate with behavior pattern of "acting out" or "acting in." Autistic psychoses were found almost exclusively among the upper classes; suicidality almost exclusively In the lower classes. Upper class children were more frequently referred by …

A Rapid Flexible Method For Determining Bile Lipids, William T. Beher, Grace J. Lin, Sofia Stradnieks

Henry Ford Hospital Medical Journal

A rapid flexible method has been developed for the quantitative determination of bile lipids In gallbladder and hepatic bile and duodenal aspirates. Quantification of bile salts involves separation of bile salt conjugates from one another and other bile lipids by thin layer chromatography. The separated salts are determined using 3-hydroxysteroid dehydrogenase and gas liquid chromatography. Cholesterol is determined in petroleum ether extracts of saponified bile by application of the Lieberman-Burchard reaction. Phospholipid phosphorus is determined in purified bile lipid extracts by oxidation followed by application of Bartlett's modification of the Fiske- SubbaRow method.

Isolation Of Cell Wall Deficient Mycobacterium Tuberculosis From A Case Of Chronic Arthritis, W. D. Lebar, L. H. Mattman, L. Ross

Henry Ford Hospital Medical Journal

Synovial fluid from a case of pyarthrosis was cultured for fungi, mycobacteria, aerobes and anaerobes with negative results. A Cell Wall Deficient (CWD) form was isolated in numerous cultures which showed the physico-chemical reactions characteristic of wall deficient M. tuberculosis.

Fiberoptic Colonoscopic Polypectomies, Thomas A. Fox Jr., Bernard Schuman, Hubert M. Allen, E. Escobar

Henry Ford Hospital Medical Journal

The development of fiberoptic instruments which permit direct visualization of the entire colonic lumen has made possible the safe removal of polyps from any part of the colon. The avoidance of transabdominal colotomy and polypectomy significantly decreases the mortality and morbidity as well as the duration of hospital stay. We wish to present our experience in performing the endoscopic removal of 128 colonic polyps larger than 0.5 cm in size in 103 patients, located from the cecum to the sigmoid colon and beyond the reach of the rigid sigmoidoscope. The polypectomy procedures via the colonoscope were done without mortality and …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Penicillin-Resistant Viridans Streptococcus Endocarditis Related To The Administration Of Penicillin G Or Carbenicillin And Alterations In Mouth Flora, Keith Burch, Edward L. Quinn, Donald Romig, Frank Cox, Evelyn Fisher, T. Madhavan

Henry Ford Hospital Medical Journal

Of 135 patients with streptococcal (non-group D) endocarditis seen at the Henry Ford Hospital (1957-1973), 133 had isolates which were penicillin- sensitive (inhibited by ≤ 0.2 μg/ml of penicillin C). The remaining two causative organisms were inhibited by 0.8 μg/ml of penicillin G and both of the infected patients received antibiotics just prior to the onset of endocarditis. The first patient received oral penicillin C for rheumatic fever prophylaxis and the second high dose parenteral carbenicillin. Using high dose parenteral therapy with ampicillin and streptomycin, the first patient was cured while the other patient relapsed. The second patient responded to …

A Modified Lateral Approach To The Hip Joint For Total Hip Replacement, Kent K. Wu

Henry Ford Hospital Medical Journal

A modified lateral approach to the hip provides good exposure to the hip joint. It is safe, simple, direct and remote from the contaminated perineal area.

Kidney Cortex Lysosomal Acid Proteinase Activity During Induction Of A Protein-Losing Nephropathy With The Aminonucleoside Of Puromycin, Paul D. Bartlett, Laura Katona

Henry Ford Hospital Medical Journal

Effects have been studied of induction of aminonucleoside-nephrosis in the rat on kidney cortex lysosomal acid proteinase activity (pH 3.2) and on such activity in the cytosol from which the lysosomes were isolated. In parallel with the onset of the massive proteinuria of the disease process but not preceding this effect, activity in the cytosol fraction was significantly increased. Significantly increased activity in the lysosomal fraction, on the other hand, was not observed until the proteinuria was well-established. Comparative study of the release of acid proteinase activity, from intact lysosomes isolated from normal and from aminonucleoslde-nephrotic rat kidneys, suggest-in the …

In Vivo Quantitation Of Adipose Tissue By Differential Absorptiometry Using Penetrating Isotopic Radiation, Luther E. Preuss, Frank B. Bolin, Claudius K. Bugenis

Henry Ford Hospital Medical Journal

The physical principles for determining tissue lipid content In vivo by selective radiation attenuation have been studied and are compared to other methods of body composition analysis. Two penetrating photon beams, each monoenergetic but of differing energies, are simultaneously passed through the low Z components of tissue and the relative beam absorption measured. A mathematical function incorporating the unabsorbed and absorbed photon beam intensities is applied to determine experimentally the relative proportion of fat and lean in the tissue. '"Cd is used as the radioactive source of both xrays and gamma radiation. Results of experiments on low 2 phantom material …

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

Namru-3 Translations Of Parasite Literature From Russian, French, Japanese, Etc. Into English (1856-1975) T901-T1000, United States Naval Medical Research Unit Number Three, Cairo, Medical Zoology Department

United States Naval Medical Research Unit 3: Publications

T901. TRANSLATION FROM RUSSIAN. STARKOV, O. A. (1975). Anomalohimalaya lama Hoogstraal, Kaiser and Mitchell, a new ixodid tick genus and species for the fauna of USSR. Zool. Zh., 54(2):304-305.

T902. TRANSLATION FROM RUSSIAN. MOTEYUMAS, L. E. and EZERSKENE, E. P. (1974). Small mammals of human disease natural foci in Lithuanian SSR. Zool. Zh., 53(1):1580-1583.

T903. TRANSLATION FROM RUSSIAN. BELYAEVA, A. P. (1965). Omsk hemorrhagic fever virus culture in chick embryos. In: Endemic viral infections (hemorrhagic fever with renal syndrome, Crimean hemorrhagic fever, Omsk hemorrhagic fever, and Astrakhan virus from Hyalomma pl. plumbeum tick), ed. Chumakov, M. P. Trudy Inst. Polio. …

Namru-3 Translations Of Parasite Literature From Russian, French, Japanese, Etc. Into English (1948-1975) T1001-T1100, United States Naval Medical Research Unit Number Three, Cairo, Medical Zoology Department

United States Naval Medical Research Unit 3: Publications

T1001. TRANSLATION FROM RUSSIAN. KOROLEV, M. B., DONETS. M. A. and CHUMAKOV, M. P. (1975). Electron microscopic study of Crimean hemorrhagic fever virus in the brain of infected mice and pig kidney cell cultures. Tezisy Konf. Vop. Med. Virus. (Moscow, October 1975), pp. 202-303.

T1002. TRANSLATION FROM RUSSIAN. KUIMA, A. U. (1975). Some characteristics of distribution and numbers of Crimean hemorrhagic fever vectors in southern Tadzhikistan. Tezisy Konf. Vop. Med. Virus. (Moscow, October 1975), pp. 310-311.

T1003. TRANSLATION FROM RUSSIAN. LEONOVA, G. N., SAFRONOV, A. V., ISACHKOVA, L. M. and BARANOV, N. I. (1975). Study of biological properties of Powassan …

Sclerosing Cholangitis: Surgical Significance, C. Grodsinsky, M. A. Block, B. E. Brush

Henry Ford Hospital Medical Journal

The authors' experience with the rare entity of sclerosing cholangitis suggests that several anatomical patterns of involvement of the extrahepatic biliary tract may occur. The involvement may include the intraluminal ducts segmentally or diffusely, or the process may primarily be external to the ducts as pericholedochitis. It may or may not represent one component of a systemic disease, particulady autoimmune disease. Although involvement may be diffuse, progression may be slow and compatible with many years of life. Long time followup is essential before any value can be assigned to a given modality of treatment. Carcinoma of the ductal system may …