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Full-Text Articles in Public Health

Mountains Of Injustice : Social And Environmental Justice In Appalachia, Michele Morrone, Geoffrey L. Buckley Nov 2011

Mountains Of Injustice : Social And Environmental Justice In Appalachia, Michele Morrone, Geoffrey L. Buckley

Ohio University Press Open Access Books

Research in environmental justice reveals that low-income and minority neighborhoods in our nation’s cities are often the preferred sites for landfills, power plants, and polluting factories. Those who live in these sacrifice zones are forced to shoulder the burden of harmful environmental effects so that others can prosper. Mountains of Injustice broadens the discussion from the city to the country by focusing on the legacy of disproportionate environmental health impacts on communities in the Appalachian region, where the costs of cheap energy and cheap goods are actually quite high.

Through compelling stories and interviews with people who are fighting for …


Pre- And Post-Bronchodilator Lung Function As Predictors Of Mortality In The Lung Health Study, David M. Mannino, Enrique Diaz-Guzman, Sonia Buist Oct 2011

Pre- And Post-Bronchodilator Lung Function As Predictors Of Mortality In The Lung Health Study, David M. Mannino, Enrique Diaz-Guzman, Sonia Buist

Preventive Medicine and Environmental Health Faculty Publications

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is supposed to be classified on the basis of post-bronchodilator lung function. Most longitudinal studies of COPD, though, do not have post-bronchodilator lung function available. We used pre-and post bronchodilator lung function data from the Lung Health Study to determine whether these measures differ in their ability to predict mortality.

METHODS: We limited our analysis to subjects who were of black or white race, on whom we had complete data, and who participated at either the 1 year or the 5 year follow-up visit. We classified subjects based on their baseline lung function, according …


Thirdhand Tobacco Smoke: Emerging Evidence And Arguments For A Multidisciplinary Research Agenda, Georg E. Matt, Penelope J. Quintana, Hugo Destaillats, Lara A. Gundel, Mohamad Sleiman, Brett C. Singer, Peyton Jacob, Jonathan P. Winickoff, Prue Talbot, Suzaynn Schick, Yinsheng Wang, Bo Hang, Manuela Martins-Green, James F. Pankow, Melbourne F. Hovell, Neal L. Benowitz, Virender K. Rehan, Jonathan M. Samet Sep 2011

Thirdhand Tobacco Smoke: Emerging Evidence And Arguments For A Multidisciplinary Research Agenda, Georg E. Matt, Penelope J. Quintana, Hugo Destaillats, Lara A. Gundel, Mohamad Sleiman, Brett C. Singer, Peyton Jacob, Jonathan P. Winickoff, Prue Talbot, Suzaynn Schick, Yinsheng Wang, Bo Hang, Manuela Martins-Green, James F. Pankow, Melbourne F. Hovell, Neal L. Benowitz, Virender K. Rehan, Jonathan M. Samet

Civil and Environmental Engineering Faculty Publications and Presentations

There is broad consensus regarding the health impact of tobacco use and secondhand smoke exposure, yet considerable ambiguity exists about the nature and consequences of thirdhand smoke (THS). We introduce definitions of THS and THS exposure and review recent findings about constituents, indoor sorption-desorption dynamics, and transformations of THS; distribution and persistence of THS in residential settings; implications for pathways of exposure; potential clinical significance and health effects; and behavioral and policy issues that affect and are affected by THS. Physical and chemical transformations of tobacco smoke pollutants take place over time scales ranging from seconds to months and include …


Hubungan Kadar Timbel Dalam Darah Dengan Kadar Hemoglobin Dan Hematokrit Pada Petugas Pintu Tol Jagorawi, Tan Malaka, Meiri Iryani Aug 2011

Hubungan Kadar Timbel Dalam Darah Dengan Kadar Hemoglobin Dan Hematokrit Pada Petugas Pintu Tol Jagorawi, Tan Malaka, Meiri Iryani

Kesmas

Penelitian tentang hubungan antara kadar timbel dalam darah dengan anemia yang tercermin dalam kadar hemoglobin dan hematokrit pada petugas pintu tol Jagorawi Jakarta. Landasan teori penelitian ini adalah hasil pemantauan kualitas udara Daerah Khusus Ibu Kota (DKI) Jakarta dimana kadar timbel di udara ambien melebihi Baku Mutu Lingkungan (BML) dan adanya petunjuk literatur bahwa timbel memiliki pengaruh negatif terhadap sistem hemopoitik pada manusia. Seratus orang pekerja terpilih untuk penelitian ini. Sebanyak 12% dari pekerja yang merupakan subjek pada penelitian ini tergolong anemia berdasarkan kadar hemoglobin darah dan 10% anemia berdasarkan nilai hematokrit. Kadar timbel darah yang didapatkan pada penelitian ini …


Kesiapsiagaan Masyarakat Menghadapi Bencana Gunung Merapi: Studi Kasus Di Desa Umbulharjo, Sleman, Happy Ade Permanasari, Sunarto Sunarto Aug 2011

Kesiapsiagaan Masyarakat Menghadapi Bencana Gunung Merapi: Studi Kasus Di Desa Umbulharjo, Sleman, Happy Ade Permanasari, Sunarto Sunarto

Kesmas

Daerah Istimewa Yogyakarta adalah provinsi yang rawan bencana terutama Gunung Merapi. Untuk meminimalkan korban bencana dikembangkan program kesiapsiagaan masyarakat menghadapi bencana gunung merapi melalui desa siaga. Tujuan penelitian ini mengetahui pelaksanaan kegiatan dan penerapan program kesiapsiagaan masyarakat menghadapi bencana gunung merapi di Desa Siaga Umbulharjo. Penelitian ini menggunakan rancangan penelitian studi kasus dengan analisis kualitatif. Subjek yang diteliti adalah pelaku pelaksanaan kegiatan pada pelaksanaan desa siaga, sedangkan objek penelitian adalah situasi sosial dalam pelaksanaan kegiatan. Pengumpulan data dilakukan dengan metode observasi nonpartisipatif, wawancara mendalam, dokumentasi, member check, dan triangulasi. Pelaksanaan kegiatan sudah baik, pembiayaan sudah cukup, pelatihan-pelatihan sudah baik, sosialisasi, …


Madison County, Kentucky Hazardous Materials Commodity Flow Analysis, Dr. Vijay Golla, Dr. Ritchie D. Taylor, Aditya Stanam, Prachi Chavan, Connie Ellis, Bryan Makinen, Carl Richards, Michael Bryant Aug 2011

Madison County, Kentucky Hazardous Materials Commodity Flow Analysis, Dr. Vijay Golla, Dr. Ritchie D. Taylor, Aditya Stanam, Prachi Chavan, Connie Ellis, Bryan Makinen, Carl Richards, Michael Bryant

Public Health Faculty Publications

This report presents the results of a Commodity Flow Analysis of Hazardous Materials for Interstate-75 (I-75) (North and South Bound lanes) conducted by Western Kentucky University in partnership with the Madison County (Kentucky) Local Emergency Planning Committee (LEPC). The only Kentucky County within the study area is Madison County as shown in Figure 1.1. The purpose of report is to give information on patterns of hazardous materials being transported along I-75 as observed from July 25th 2011 to August 5th 2011. A secondary purpose is to summarize incidents involving hazardous materials over the previous 6 years (January 2006 – June …


Comparison Of Workplace Protection Factors For Different Biological Contaminants, Kyungmin Jacob Cho, Tiina Reponen, Roy Mckay, Alok Dwivedi, Atin Adhikari, Umesh Singh, Rakesh Shukla, M. Susan Jones, Gordon Jones, Sergey A. Grinshpun Jun 2011

Comparison Of Workplace Protection Factors For Different Biological Contaminants, Kyungmin Jacob Cho, Tiina Reponen, Roy Mckay, Alok Dwivedi, Atin Adhikari, Umesh Singh, Rakesh Shukla, M. Susan Jones, Gordon Jones, Sergey A. Grinshpun

Nursing Faculty Publications

This study compared workplace protection factors (WPFs) for five different contaminants (endotoxin, fungal spores, (1→3)-β-D-glucan, total particle mass, and total particle number) provided by an N95 elastomeric respirator (ER) and an N95 filtering facepiece respirator (FFR). We previously reported size-selective WPFs for total particle numbers for the ER and FFR, whereas the current article is focused on WPFs for bioaerosols and total particle mass. Farm workers (n = 25) wore the ER and FFR while performing activities at eight locations representing horse farms, pig barns, and grain handling facilities. For the determination of WPFs, particles were collected on filters simultaneously …


Oral Ingestion Of Hexavalent Chromium Through Drinking Water And Cancer Mortality In An Industrial Area Of Greece - An Ecological Study, Athena Linos, Athanassios Petralias, Costas A. Christophi, Eleni Christoforidou, Paraskevi Kouroutou, Melina Stoltidis, Afroditi Veloudaki, Evangelia Tzala, Konstantinos C. Makris, Margaret R. Karagas May 2011

Oral Ingestion Of Hexavalent Chromium Through Drinking Water And Cancer Mortality In An Industrial Area Of Greece - An Ecological Study, Athena Linos, Athanassios Petralias, Costas A. Christophi, Eleni Christoforidou, Paraskevi Kouroutou, Melina Stoltidis, Afroditi Veloudaki, Evangelia Tzala, Konstantinos C. Makris, Margaret R. Karagas

Dartmouth Scholarship

Background: Hexavalent chromium is a known carcinogen when inhaled, but its carcinogenic potential when orally ingested remains controversial. Water contaminated with hexavalent chromium is a worldwide problem, making this a question of significant public health importance.

Methods: We conducted an ecological mortality study within the Oinofita region of Greece, where water has been contaminated with hexavalent chromium. We calculated gender, age, and period standardized mortality ratios (SMRs) for all deaths, cancer deaths, and specific cancer types of Oinofita residents over an 11-year period (1999 - 2009), using the greater prefecture of Voiotia as the standard population.

Results: A total of …


Residents' Perceptions Of Social Interaction And Social Activity In An Affordable Assisted Living Facility, Elena Garcia May 2011

Residents' Perceptions Of Social Interaction And Social Activity In An Affordable Assisted Living Facility, Elena Garcia

Honors Scholar Theses

This study is a qualitative study looking at the social interactions and social activities in an assisted living facility, based on the residents’ perceptions. In this study I interviewed 20 residents of an affordable assisted living facility. The participants were male and female, 65 or older, and any ethnicity. Inclusion criteria include: (1) Residing in the assisted living facility at least 6 months and no more than 2 years; and (2) being mentally competent to give informed consent. I recruited the participants based on a list of who was eligible from the facilities administration and then asked the eligible participants …


Opening The Industry Playbook: Myths And Truths In The Debate Over Bpa Regulation, Thomas Mcgarity, Rena I. Steinzor, Matthew Shudtz, Lena Pons May 2011

Opening The Industry Playbook: Myths And Truths In The Debate Over Bpa Regulation, Thomas Mcgarity, Rena I. Steinzor, Matthew Shudtz, Lena Pons

Faculty Scholarship

For the last two decades, scientists have amassed evidence that bisphenol A (BPA) poses a threat to human health.  Although scientists have targeted BPA as a public health concern, plastics industry lobbyists have attempted to thwart the efforts of federal, state, and local authorities to reduce exposure to BPA.  This paper reviews the major arguments advanced by the plastics industry and debunks them as “myths” that public health officials must reject.  The five topics covered include:  the myth of scientific consensus on safety; the myth that only studies complying with “Good Laboratory Practices” guidelines are adequate for making regulatory decisions; …


The Effects Of Climate Change On Public Health And The Healthcare Provider's Role In Addressing Climate Change, Allyson J. Pfeiffer May 2011

The Effects Of Climate Change On Public Health And The Healthcare Provider's Role In Addressing Climate Change, Allyson J. Pfeiffer

Senior Honors Projects

“Climate change is a term that refers to major changes in temperature, rainfall, snow, or wind patterns lasting for decades or longer.  Both human-made and natural factors contribute to climate change” (EPA, p. 1, 2011).  Some examples of human-made causes of global warming include burning fossil fuels (e.g., petroleum, coal, diesel), cutting down forests, and developing land for farms, cities, and roads, because these activities all release green house gases into the atmosphere.  Green house gases are gases that trap heat in the atmosphere.  There are some greenhouse gases such as carbon dioxide that occur naturally and are emitted into …


Identifying And Reducing Lead Exposure Associated With The Use Of Cultural Practices In Southern Nevada Hispanic Communities, Maria Castillo-Couch May 2011

Identifying And Reducing Lead Exposure Associated With The Use Of Cultural Practices In Southern Nevada Hispanic Communities, Maria Castillo-Couch

UNLV Theses, Dissertations, Professional Papers, and Capstones

Despite large amounts of national data on lead and childhood lead poisoning, the status of childhood lead exposure in Nevada as a result of the use of cultural practices in the Hispanic population is unknown. The influx of immigrant Hispanic populations to Nevada, their low education level, the high number of them who are living in poverty present an increased risk for children to be exposed to lead through the use of imported consumables, home remedies and alternative medicine (i.e., healers/ sobadores).

A 61-question survey collected data from Hispanics over 18 years of age who have or take care …


Effectiveness Of Earthtec ® On Killing Invasive Quagga Mussels (Dreissena Rostriformis Bugenis) And Preventing Their Colonization In The Western U.S., Ashlie Watters May 2011

Effectiveness Of Earthtec ® On Killing Invasive Quagga Mussels (Dreissena Rostriformis Bugenis) And Preventing Their Colonization In The Western U.S., Ashlie Watters

UNLV Theses, Dissertations, Professional Papers, and Capstones

Dreissena rostriformis bugensis, an invasive species, also known as the quagga mussel, was discovered in Lake Mead, NV in January of 2007. In the four years since detection, quagga mussels have created tremendous economical, ecological, and human health impacts. The mussels clog pipes, ruin boat motors, and damage recreational equipment, and once established in the lake, routine maintenance is necessary to avoid further damage. Because of quagga mussels' high fecundity, planktonic veliger stage, and ability to attach to substrates with byssal threads, they have easily and swiftly spread to other lakes and reservoirs in the Lower Colorado River Basin. …


Examining Activity Levels And Motor Proficiency: A Comparison Of Children Who Are Overweight And At A Healthy Weight To Their Parents And Peers, Aaron Copeland, Maresa Madsen, Riley Phelps, Brandon Richards May 2011

Examining Activity Levels And Motor Proficiency: A Comparison Of Children Who Are Overweight And At A Healthy Weight To Their Parents And Peers, Aaron Copeland, Maresa Madsen, Riley Phelps, Brandon Richards

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objective: The purpose of this study was to examine relationships and differences between motor proficiency, activity level, and parental activity level in children who are at a healthy weight and children who are overweight or obese.

Methods: Forty-four children (26 children at a healthy weight and 18 children who were overweight or obese) between the ages of 8-16 (BMI: 14.3-43.6 kg/m2) and 36 parents (BMI: 18.1-44.7) participated in this study. Children and parents wore StepWatch activity monitors (SAM) to measure activity levels over a 72 hour period. Tests reflecting several determinants of motor performance were also administered to …


Lingkungan Fisik Dan Angka Kuman Udara Ruangan Di Rumah Sakit Umum Haji Makassar, Sulawesi Selatan, M. Tahir Abdullah, Buraerah Abdul Hakim Apr 2011

Lingkungan Fisik Dan Angka Kuman Udara Ruangan Di Rumah Sakit Umum Haji Makassar, Sulawesi Selatan, M. Tahir Abdullah, Buraerah Abdul Hakim

Kesmas

Udara merupakan salah satu media lingkungan tempat bakteri, virus, dan fungi hidup dan berkembang. Oleh karena mikroorganisme tersebut memerlukan berbagai persyaratan untuk tumbuh dan berkembang, faktor-faktor lingkungan fisik udara tertentu dapat berhubungan dengan angka kuman. Untuk menentukan hubungan ini, telah dilakukan studi potong lintang di ruang rawat inap pasien Rumah Sakit Umum Haji Makasar. Kualitas faktor-faktor lingkungan fisik (pencahayaan, suhu, kelembaban relatif, dan kepadatan ruangan) dan angka kepadatan kuman dalam 5 ruang rawat inap (pavilion, kelas 1, kelas 2, kelas 3, dan recovery room) diukur 3 kali (pagi, siang, dan sebelum matahari terbenam) pada 3 titik pengukuran berbeda setiap ruang. …


An Evaluation Of Presence And Source Of Fecal Contamination At Golden Gardens Park, Jamie Minick, Nicola K. Beck, J. Scott Meschke Apr 2011

An Evaluation Of Presence And Source Of Fecal Contamination At Golden Gardens Park, Jamie Minick, Nicola K. Beck, J. Scott Meschke

College of Health Sciences Poster Presentations

Golden Gardens is an 87.8 acre Park in Seattle, WA that has come under recent scrutiny over concerns about water quality in the streams and at the beach. Located just north of Shillshole marina in Seattle it has a swimming beach which is 1439 m in length, as well as a forested region directly east of the beach on a relatively steep hill with several drainages flowing into the sound. The purpose of this study was to assess the levels of indicator bacteria in beach water and in the fresh water drainages and to determine if the bacterial contamination is …


Dhhs' And Epa's Proposal To Lower Fluoride Levels In Drinking Water, Shannon Wirz Apr 2011

Dhhs' And Epa's Proposal To Lower Fluoride Levels In Drinking Water, Shannon Wirz

College of Health Sciences Poster Presentations

On January 7th, 2011 the U.S. DHHS recommended setting the level of fluoride in drinking water to the lowest end of the current optimal range (0.7 to 1.2 ppm). EPA is initiating a review of the maximum amount of fluoride allowed in drinking water based on scientific assessments of health effects from too much fluoride. MCL (Maximum Contaminant Level) is the legal threshold limit on the amount of a substance allowed in public water systems. EPA sets the MCL to address adverse health effects. Current MCL for fluoride is 4 mg/L. The EPA is unsure if they will revise the …


Can Water Professionals Transform Pharmaceutical Disposal Practices Of Hospice Nurses?, Jennifer L. Mccoy, Kimberly P. Holland Apr 2011

Can Water Professionals Transform Pharmaceutical Disposal Practices Of Hospice Nurses?, Jennifer L. Mccoy, Kimberly P. Holland

Dissertations, Theses and Capstone Projects

This project is an explanatory case study that illustrates the problems associated with pharmaceutical disposal in regard to water quality. The purpose of the study is to investigate the current pharmaceutical disposal practices of hospice nurses, the attitudes of hospice nurses regarding current pharmaceutical disposal practices, and explore ways to educate the hospice community about the concerns associated with flushing pharmaceuticals. The study consisted of reviewing secondary research, completing a survey, forming a focus group, implementing a pilot study, and developing an education plan and outreach materials.

The researchers partnered with two local nonprofit organizations, Georgia Association of Water Professionals …


Second-Hand Smoke In A University Campus: Attitudes And Perceptions Of Faculty, Staff And Students, Cecilia M. Watkins, Sandeep Mishra, Herpreet Kaur Thind, Srinivasa B. Gokarakonda, Grace Lartey, Monia Chahal Mar 2011

Second-Hand Smoke In A University Campus: Attitudes And Perceptions Of Faculty, Staff And Students, Cecilia M. Watkins, Sandeep Mishra, Herpreet Kaur Thind, Srinivasa B. Gokarakonda, Grace Lartey, Monia Chahal

Public Health Faculty Publications

Purpose: To examine the attitudes and perceptions of faculty, staff and students concerning tobacco policies at a university campus in a tobacco producing state. Methods: A questionnaire was administered to faculty, staff and students to assess knowledge, attitudes and beliefs related to smoking and exposure to second-hand smoke on campus. A 3-wave e-mailing was used to send the questionnaire. Results: A total of 2,914 individuals responded to the questionnaire. Majority (60%) of the participants believed a smoke free policy would be a positive move and could possibly improve the quality of life for the campus community, while not negatively affecting …


The Impact Of Bisphenol A And Triclosan On Immune Parameters In The U.S. Population, Nhanes 2003–2006, Erin M. Rees Clayton, Megan Todd, Jennifer B. Dowd, Allison E. Aiello Mar 2011

The Impact Of Bisphenol A And Triclosan On Immune Parameters In The U.S. Population, Nhanes 2003–2006, Erin M. Rees Clayton, Megan Todd, Jennifer B. Dowd, Allison E. Aiello

Publications and Research

Background: Exposure to environmental toxicants is associated with numerous disease outcomes, many of which involve underlying immune and inflammatory dysfunction.

Objectives: To address the gap between environmental exposures and immune dysfunction, we investigated the association of two endocrine-disrupting compounds (EDCs) with markers of immune function.

Methods: Using data from the 2003–2006 National Health and Nutrition Examination Survey, we compared urinary bisphenol A (BPA) and triclosan levels with serum cytomegalovirus (CMV) antibody levels and diagnosis of allergies or hay fever in U.S. adults and children ≥ 6 years of age. We used multivariate ordinary least squares linear regression models to examine …


Repellency Test Of Wet Tissue Containing Deet (N,N-Diethyl- 3-Metatoluamide) And Citronella Oil (Cymbopogon Citratus) Againts Aedes Aegypti Mosquitoes, Tri Baskoro T. Satoto, Budi Mulyaningsih, M.M. Sintorini, A.F. Sugiarto, B. A Kesuma Feb 2011

Repellency Test Of Wet Tissue Containing Deet (N,N-Diethyl- 3-Metatoluamide) And Citronella Oil (Cymbopogon Citratus) Againts Aedes Aegypti Mosquitoes, Tri Baskoro T. Satoto, Budi Mulyaningsih, M.M. Sintorini, A.F. Sugiarto, B. A Kesuma

Kesmas

Demam berdarah merupakan salah satu masalah utama kesehatan di Indonesia. Karena penyakit ini disebarkan oleh nyamuk Aedes aegypti, berbagai cara telah dilakukan untuk memutus rantai pejamu, agen, dan lingkungan, termasuk mencegah kontak manusia dengan vektor dengan menggunakan bermacam-macam pengusir serangga. Uji ini membandingkan waktu proteksi N,N-diethyl-3-metatoluamide (DEET) dengan waktu proteksi minyak sitronella yang terkandungkan dalam tisu basah terhadap Aedes aegypti. Untuk uji ini, dibuat larutan 12,5% DEET dalam etanol dan larutan 20% minyak sitronella. Sejumlah tisu kering dicelupkan ke dalam masing-masing larutan ini, ditiriskan dalam udara terbuka, kemudian dibungkus dengan lembaran aluminium dan disimpan selama satu hari dan satu minggu. …


Subjects With Discordant Airways Obstruction: Lost Between Spirometric Definitions Of Copd, Bernd Lamprecht, Lea Schirnhofer, Bernhard Kaiser, Sonia A. Buist, David Mannino, Michael Studnicka Feb 2011

Subjects With Discordant Airways Obstruction: Lost Between Spirometric Definitions Of Copd, Bernd Lamprecht, Lea Schirnhofer, Bernhard Kaiser, Sonia A. Buist, David Mannino, Michael Studnicka

Preventive Medicine and Environmental Health Faculty Publications

Background. Since the FEV1/FVC ratio declines with age, using the fixed ratio of 0.70 leads to overdiagnosis of COPD in older populations and underdiagnosis among young adults. Objective. To evaluate whether discordant obstructive cases (FEV1/FVC < 0.70 but ≥LLN) are a healthy population or have clinical features that would place them at increased risk. Methods. We used post-bronchodilator spirometry data from the population-based Austrian Burden of Obstructive Lung Disease (BOLD) study. Those with post-bronchodilator FEV1/FVC ratio


Prevalence Of Head Lice And Hygiene Practices Among Women Over Twelve Years Of Age In Sindh, Balochistan, And North West Frontier Province: National Health Survey Of Pakistan, 1990-1994., Sadia Mahmud, Gregory Pappas, Wilbur C Hadden Feb 2011

Prevalence Of Head Lice And Hygiene Practices Among Women Over Twelve Years Of Age In Sindh, Balochistan, And North West Frontier Province: National Health Survey Of Pakistan, 1990-1994., Sadia Mahmud, Gregory Pappas, Wilbur C Hadden

Community Health Sciences

Background: Head lice infestation is an infection of the scalp and skin which causes blood loss, discomfort, and social and psychological distress with the possibility of secondary bacterial infections occurring at scratch sites. In Pakistan, although some small scale studies have been conducted to investigate prevalence of head lice in school children and the general population, no population based estimates have been reported. The National Health Survey of Pakistan (NHSP 1990 - 94) was a nationally representative health examination survey of the Pakistani population. The NHSP is the first population based household survey to collect data on the prevalence of …


Cytogenetic Analysis Of An Exposed-Referent Study: Perchloroethylene-Exposed Dry Cleaners Compared To Unexposed Laundry Workers, James D. Tucker, Karen J. Sorensen, Avima M. Ruder, Lauralynn Mckernan, Christy L. Forrester, Mary Butler Jan 2011

Cytogenetic Analysis Of An Exposed-Referent Study: Perchloroethylene-Exposed Dry Cleaners Compared To Unexposed Laundry Workers, James D. Tucker, Karen J. Sorensen, Avima M. Ruder, Lauralynn Mckernan, Christy L. Forrester, Mary Butler

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Significant numbers of people are exposed to tetrachloroethylene (perchloroethylene, PCE) every year, including workers in the dry cleaning industry. Adverse health effects have been associated with PCE exposure. However, investigations of possible cumulative cytogenetic damage resulting from PCE exposure are lacking.

Methods

Eighteen dry cleaning workers and 18 laundry workers (unexposed controls) provided a peripheral blood sample for cytogenetic analysis by whole chromosome painting. Pre-shift exhaled air on these same participants was collected and analyzed for PCE levels. The laundry workers were matched to the dry cleaners on race, age, and smoking status. The relationships between levels of …


Evaluation Of Toxicological Effects Of Intra Tracheal Instilled Ceo2 Nanoparticles On The Heart Of Male Sprague-Dawley Rats, Radhakrishna Para Jan 2011

Evaluation Of Toxicological Effects Of Intra Tracheal Instilled Ceo2 Nanoparticles On The Heart Of Male Sprague-Dawley Rats, Radhakrishna Para

Theses, Dissertations and Capstones

The growing application of cerium oxide nanoparticles (CeO2 NP) in several industrial products is likely to be associated with increased risk of inhalation and exposure. How the inhalation of CeO2 NP may affect cardiac structure and function has to our knowledge, not been examined. To examine whether inhalation of CeO2 NP affects cardiac structure and function, male Sprague Dawley rats underwent a single intra tracheal instillation of nanoparticles (7 mg/kg body weight). Animals were sacrificed 1, 3, 14, and 28 days after instillation and protein isolates from the hearts were examined for the presence of oxidative stress, autophagy and apoptosis. …


Δ-Aminolevulinic Acid Dehydratase Single Nucleotide Polymorphism 2 And Peptide Transporter 2*2 Haplotype May Differentially Mediate Lead Exposure In Male Children, Christina Sobin, Natali Parisi, Tanner Schaub, Marisela Gutierrez, Alma Ortega Jan 2011

Δ-Aminolevulinic Acid Dehydratase Single Nucleotide Polymorphism 2 And Peptide Transporter 2*2 Haplotype May Differentially Mediate Lead Exposure In Male Children, Christina Sobin, Natali Parisi, Tanner Schaub, Marisela Gutierrez, Alma Ortega

Selected Works Temporary Series

Child low-level lead (Pb) exposure is an unresolved public health problem and an unaddressed child health disparity. Particularly in cases of low-level exposure, source removal can be impossible to accomplish, and the only practical strategy for reducing risk may be primary prevention. Genetic biomarkers of increased neurotoxic risk could help to identify small subgroups of children for early intervention. Previous studies have suggested that, by way of a distinct mechanism, d-aminolevulinic acid dehydratase single nucleotide polymorphism 2 (ALAD2) and/or peptide transporter 2*2 haplotype (hPEPT2*2) increase Pb blood burden in children. Studies have not yet examined whether sex mediates the effects …


Kriged And Modeled Ambient Air Levels Of Benzene In An Urban Environment: An Exposure Assessment Study, Kristina W. Whitworth, Elaine Symanski, Dejian Lai, Ann L. Coker Jan 2011

Kriged And Modeled Ambient Air Levels Of Benzene In An Urban Environment: An Exposure Assessment Study, Kristina W. Whitworth, Elaine Symanski, Dejian Lai, Ann L. Coker

CRVAW Faculty Journal Articles

Background. There is increasing concern regarding the potential adverse health effects of air pollution, particularly hazardous air pollutants (HAPs). However, quantifying exposure to these pollutants is problematic. Objective. Our goal was to explore the utility of kriging, a spatial interpolation method, for exposure assessment in epidemiologic studies of HAPs. We used benzene as an example and compared census tract-level kriged predictions to estimates obtained from the 1999 U.S. EPA National Air Toxics Assessment (NATA), Assessment System for Population Exposure Nationwide (ASPEN) model. Methods. Kriged predictions were generated for 649 census tracts in Harris County, Texas using estimates of annual benzene …


Comparison Of Road Safety Behaviour Of Rented Dublin Bike Users With That Of Owner Cyclists, Eileen Deegan Jan 2011

Comparison Of Road Safety Behaviour Of Rented Dublin Bike Users With That Of Owner Cyclists, Eileen Deegan

Students Learning with Communities

Cycling is a unique way of travelling and exercising. The Irish Heart Foundation recommends thirty minutes of exercise most days in the week to maintain a healthy heart (IHF, 2008). The introduction of the Dublin-bike scheme by Dublin city Council in connection with JCDecaux on the 13th of September 2009 has encouraged and allowed more people to cycle around the city of Dublin. Since their introduction, Dublin-bikes have grown rapidly in popularity. By the 31st of December 2009 24,016 people had subscribed to the scheme (Dublin City Council, 2009). On the 16th of August 2010, The Irish Times published that …


Tanning Predicts Bone Mass But Not Structure In Adolescent Females Living In Hawaii, Daniel L. Osborne, Connie M. Weaver, Linda D. Mccabe, George P. Mccabe, Rachel Novotny, Carol Boushey, Dennis A. Savaiano Jan 2011

Tanning Predicts Bone Mass But Not Structure In Adolescent Females Living In Hawaii, Daniel L. Osborne, Connie M. Weaver, Linda D. Mccabe, George P. Mccabe, Rachel Novotny, Carol Boushey, Dennis A. Savaiano

Department of Anthropology: Faculty Publications

Objectives: To evaluate the relationship between facultative skin pigmentation, which predicts circulating levels of plasma 25-hydroxymitamin D, and several measures of bone mass and structure in a cross sectional sample of adolescent females living in Hawaii.

Methods: Our sample was composed of adolescent females (n = 94) living in Hawaii where seasonal sun exposure is minimal, and who self-identified as either white (n = 16) or Asian (n = 78). Bone mineral content (BMC) of the total body, the lumbar spine and the hip, and cross sectional area (CSA) and section modulus (Z) at the …


Cloudaligner: A Fast And Full-Featured Mapreduce Based Tool For Sequence Mapping, Tung Nguyen, Weisong Shi, Douglas Ruden Jan 2011

Cloudaligner: A Fast And Full-Featured Mapreduce Based Tool For Sequence Mapping, Tung Nguyen, Weisong Shi, Douglas Ruden

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Research in genetics has developed rapidly recently due to the aid of next generation sequencing (NGS). However, massively-parallel NGS produces enormous amounts of data, which leads to storage, compatibility, scalability, and performance issues. The Cloud Computing and MapReduce framework, which utilizes hundreds or thousands of shared computers to map sequencing reads quickly and efficiently to reference genome sequences, appears to be a very promising solution for these issues. Consequently, it has been adopted by many organizations recently, and the initial results are very promising. However, since these are only initial steps toward this trend, the developed software does …