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Articles 931 - 960 of 1571

Full-Text Articles in Behavior and Behavior Mechanisms

The Influence Of Parental Control And Parent-Child Relational Qualities On Adolescent Internet Addiction: A 3-Year Longitudinal Study In Hong Kong, Daniel T. L. Shek, Xiaoqin Zhu, Cecilia M. S. Ma May 2018

The Influence Of Parental Control And Parent-Child Relational Qualities On Adolescent Internet Addiction: A 3-Year Longitudinal Study In Hong Kong, Daniel T. L. Shek, Xiaoqin Zhu, Cecilia M. S. Ma

Pediatrics Faculty Publications

This study investigated how parental behavioral control, parental psychological control, and parent-child relational qualities predicted the initial level and rate of change in adolescent internet addiction (IA) across the junior high school years. The study also investigated the concurrent and longitudinal effects of different parenting factors on adolescent IA. Starting from the 2009/2010 academic year, 3,328 Grade 7 students (Mage = 12.59 ± 0.74 years) from 28 randomly selected secondary schools in Hong Kong responded on a yearly basis to a questionnaire measuring multiple constructs including socio-demographic characteristics, perceived parenting characteristics, and IA. Individual growth curve (IGC) analyses …


A Laboratory-Based Experimental Test Of Reasons For Living: Effects On Behavioral Approach Toward A Suicide-Related Stimulus, Sasha Micaella Rojas May 2018

A Laboratory-Based Experimental Test Of Reasons For Living: Effects On Behavioral Approach Toward A Suicide-Related Stimulus, Sasha Micaella Rojas

Graduate Theses and Dissertations

There are few laboratory-based experiments that examine the effects of suicide-related risk or protective factors on suicide-related outcomes. Consistent with extant evidence-based theoretical models and treatments for suicidal behavior, it appears that increasing awareness of reasons for living may reduce risk for suicidal behavior. Thus, the current study represents an initial effort to experimentally examine the impact of bringing awareness to one’s most important reason for living on behavioral approach towards a suicide-related stimulus. Random assignment was used to assign an unselected undergraduate sample of 78 participants to complete either a script-driven imagery procedure specific to the most important reason …


Feeding Behaviors And The Child With Posterior Tongue-Tie : Comparison To Norms., Mckenzie Sexton May 2018

Feeding Behaviors And The Child With Posterior Tongue-Tie : Comparison To Norms., Mckenzie Sexton

Electronic Theses and Dissertations

The tongue is an important muscle used in speech, mastication, swallowing, and breastfeeding. It plays an important role in facial development, dentition, and periodontal status. Posterior ankyloglossia, also known as posterior tongue-tie (PTT), is characterized by a tether beneath the lingual mucosa. Upon visual inspection, the frenulum is non-prominent but with the use of a grooved director it may appear abnormally prominent, short, thick, or cord-like. Palpation of the frenulum may reveal tightness. There is a lack of empirical data about PTT and the impact on feeding beyond early infancy. PTT is not well recognized and can be missed resulting …


Yoga And Its Influence On Children's Behavior, Paige Sellen May 2018

Yoga And Its Influence On Children's Behavior, Paige Sellen

The Eleanor Mann School of Nursing Undergraduate Honors Theses

This study looked at the impact ten minutes of daily yoga had on the behavior of elementary school children. Yoga was led by classroom teachers once daily for ten minutes over a sixteen-week period. At weeks one, eight, and sixteen, classroom teachers evaluated student behavior in six categories: personal awareness, attention, rapport with friends, rapport with teacher, following rules and transition between activities. The teachers rated the behaviors on a never, sometimes, mostly or always scale. The data was then analyzed and interpreted. Results revealed a significant difference in the attention, ability to follow rules, transition between activities, and personal …


Effects Of Norharmane And Nicotine On The Conditioned Place Preference Of Mice, Lindsey Galbo May 2018

Effects Of Norharmane And Nicotine On The Conditioned Place Preference Of Mice, Lindsey Galbo

All NMU Master's Theses

Tobacco smoking in the United States is used by approximately 25% of adults. Many studies using animal models have suggested that nicotine has rewarding properties. Contrastingly, several studies have also found it to be a weakly reinforcing substance at low and high dose levels. Due to this, other tobacco constituents, such as the monoamine oxidase inhibitor norharmane which is found in tobacco leaf and smoke, may be responsible for tobacco addiction by potentiating the rewarding properties of nicotine. Several studies have attempted to observe this phenomenon, however, monoamine oxidase inhibitors that are not found in tobacco leaf or smoke have …


Fear Of Missing Out, Social Media Abuse, And Parenting Styles, Kylie Richter May 2018

Fear Of Missing Out, Social Media Abuse, And Parenting Styles, Kylie Richter

Electronic Theses and Dissertations

With the increasing rise in technology use, particularly engagement in social media, it is important for researchers to gain a better understanding of the usage patterns along with the antecedents and consequences of heavy social media usage. In addition to the rise in social media usage, a new anxiety driven phenomenon is storming the research world, FoMO (Fear of Missing Out). To date, there has been little empirical research on the relationship between social media usage and psychological adjustment. This study aimed to investigate the relationships between FoMO, social media abuse, and parenting styles. It is theorized that because FoMO …


An Exploration Of Barriers To Health Care Access Among Uninsured Patients: Using The Moderating Effect Of Patients’ Enablement, Enedelia L. Jessup May 2018

An Exploration Of Barriers To Health Care Access Among Uninsured Patients: Using The Moderating Effect Of Patients’ Enablement, Enedelia L. Jessup

Electronic Theses and Dissertations

ABSTRACT On March 23, 2010, Congress passed the Patient Protection and Affordable Care Act (ACA) to increase value of care, improve clinical outcomes, decrease health care costs, and increase affordability in health care access. The purpose of the study attempts to examine the moderating effects of patient enablement impacting barriers, low socio economic status, and unmet basic needs, toward health care access in uninsured populations post ACA. Only certain aspects of patient enablement in self-management of an individual’s health care goals have been conducted with uninsured populations with barriers toward health care access. The research design was a quantitative, exploratory, …


Post-Traumatic Stress Disorder: Review Of Dsm Criteria And Functional Neuroanatomy, Cornelius W. Thomas Apr 2018

Post-Traumatic Stress Disorder: Review Of Dsm Criteria And Functional Neuroanatomy, Cornelius W. Thomas

Marshall Journal of Medicine

The Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for post-traumatic stress disorder (PTSD) consist of over twenty possible symptoms that can be divided into six broad categories. These categories correlate with specific brain networks that regulate emotions, behaviors, and autonomic function. Normal functioning of these networks depends on two key regions; the prefrontal cortex and the amygdala. The prefrontal cortex provides top-down executive control over amygdala, whereas the amygdala is critical for threat detection and activation of the ‘fight or flight’ response. Events that trigger extreme and/or prolonged fear can cause persisting dysregulation within the prefrontal-amygdala circuit; resulting …


Performance Anxiety And The Benefits Of Proper Breathing For Singing, Kate Zecher Apr 2018

Performance Anxiety And The Benefits Of Proper Breathing For Singing, Kate Zecher

Undergraduate Theses

The intent of this thesis is to help those with Music Performance Anxiety, or anxiety in general, better understand their anxiety and its causes. They can then use this knowledge to reduce or control their symptoms in order to improve their performance, whether on a stage or in a classroom. One of the main symptoms of Music Performance Anxiety is constriction of the chest. It is one of the most debilitating symptoms to singers as it causes shortness of breath. Therefore, focusing on anxiety in relation to breathing will most benefit those with Music Performance Anxiety. In addition, learning about …


'No Pink Ribbons': How Women's Lived Experiences With Breast Atypia Inform Decisions Involving Risk-Reducing Medications, Sarah L. Goff, Reva Kleppel, Grace Makari-Judson Apr 2018

'No Pink Ribbons': How Women's Lived Experiences With Breast Atypia Inform Decisions Involving Risk-Reducing Medications, Sarah L. Goff, Reva Kleppel, Grace Makari-Judson

Journal of Patient-Centered Research and Reviews

Purpose: Atypical hyperplasia (AH) is associated with a nearly 4-fold elevation of lifetime risk for breast cancer, and lobular carcinoma in situ (LCIS) is associated with a 7- to 8-fold risk. Women with AH/LCIS make numerous decisions in the course of treatment, including whether to take a risk-reducing medication, an option relatively few women pursue. We explored women’s decision-making processes through patient narratives in an effort to inform decision supports for AH/LCIS.

Methods: We conducted in-depth interviews with 20 English-speaking women with AH/LCIS and no subsequent diagnosis of invasive breast cancer who had enrolled in the Rays of Hope Center …


Uncertainty And Competing Priorities In Shared Clinical Decision-Making, Dennis J. Baumgardner Apr 2018

Uncertainty And Competing Priorities In Shared Clinical Decision-Making, Dennis J. Baumgardner

Journal of Patient-Centered Research and Reviews

In this issue introduction, the editor-in-chief of Journal of Patient-Centered Research and Reviews observes that a connecting thread among the articles published therein is an element of uncertainty among patients and clinicians. Competing priorities for the patient also may be present. Several approaches to overcoming these prevalent conflicts to delivery of better health care have been proposed, the most important of which may be clinicians embracing a will to practice shared decision-making.


The Relation Of Seasonal Patterns To Mood Changes And Gender Differences In College-Aged Students, Mariah Meza Apr 2018

The Relation Of Seasonal Patterns To Mood Changes And Gender Differences In College-Aged Students, Mariah Meza

Student Research Posters

This study examined college students’ moods during different seasons patterns throughout the year. Previous research has indicated that many individuals feel more lethargic, lonely and moody during the winter months (Rohan & Sigmon, 2000). These mood and behavior patterns clearly depend on specific seasons of the year. However, many studies have produced inconsistent findings and current data on how weather impacts college aged students moods in California (Lucht & Kasper, 1999). There are many inconsistent studies in the United States that indicate whether there is a higher fluctuation in women’s moods during seasonal change than there is with men(Chotai, Smedh, …


The Predictors Of Juvenile Recidivism: Testimonies Of Adult Students 18 Years And Older Exiting From Alternative Education, La Toshia Palmer Apr 2018

The Predictors Of Juvenile Recidivism: Testimonies Of Adult Students 18 Years And Older Exiting From Alternative Education, La Toshia Palmer

Dissertations

Purpose: The purpose of this descriptive, qualitative study was to identify and describe the importance of the predictors of juvenile recidivism and the effectiveness of efforts to prevent/avoid juvenile recidivism as perceived by previously detained, arrested, convicted, and/or incarcerated adult students 18 years of age and older exiting from alternative education in Northern California. A second purpose was to explore the types of support provided by alternative schools and the perceived importance of the support to avoid recidivism according to adult students 18 years of age and older exiting from alternative education.

Methodology: This qualitative, descriptive research design identified …


Network Specialization During Adolescence: Hippocampal Effective Connectivity In Boys And Girls, Jeffrey D. Riley, E. Elinor Chen, Jessica Winsell, Elyssia Poggi Davis, Laura M. Glynn, Tallie Z. Baram, Curt A. Sandman, Steven L. Small, Ana Solodkin Apr 2018

Network Specialization During Adolescence: Hippocampal Effective Connectivity In Boys And Girls, Jeffrey D. Riley, E. Elinor Chen, Jessica Winsell, Elyssia Poggi Davis, Laura M. Glynn, Tallie Z. Baram, Curt A. Sandman, Steven L. Small, Ana Solodkin

Psychology Faculty Articles and Research

Adolescence is a complex period of concurrent mental and physical development that facilitates adult functioning at multiple levels. Despite the growing number of neuroimaging studies of cognitive development in adolescence focusing on regional activation patterns, there remains a paucity of information about the functional interactions across these participating regions that are critical for cognitive functioning, including memory. The current study used structural equation modeling (SEM) to determine how interactions among brain regions critical for memory change over the course of adolescence. We obtained functional MRI in 77 individuals aged 8–16 years old, divided into younger (ages 8–10) and older (ages …


Behavioral Correlates For Quitting Opioids Among Opioid-Dependent Pregnant And Non-Pregnant Women Of Childbearing Age In Rural Appalachia, Sindura Kompella, Sylvester Olubolu Orimaye, Nigel Dsouza, Karl Goodkin, Steven Kendell, Susan Wallace, Tracy Willson Apr 2018

Behavioral Correlates For Quitting Opioids Among Opioid-Dependent Pregnant And Non-Pregnant Women Of Childbearing Age In Rural Appalachia, Sindura Kompella, Sylvester Olubolu Orimaye, Nigel Dsouza, Karl Goodkin, Steven Kendell, Susan Wallace, Tracy Willson

Appalachian Student Research Forum

Background: The opioid epidemic is particularly worrisome in the pregnant population, wherein concerns are raised about the health of a mother and her child, resulting in an alarming incidence and prevalence of Neonatal Abstinence Syndrome (NAS). The 2016 National Survey on Drug Use and Health (NSDUH) show the rate of illicit psychoactive substance use among the females aged 12 or older was 15.5% in the past year. Among pregnant women aged 15 to 44, 6.3% were illicit psychoactive substance users. In Tennessee, the number of hospital discharged NAS cases from 2002 to 2013 increased from 1.50 to 16.6 cases per …


Cognitive Effects Of Short Duration Short Wavelength Visible Light, Sarah J. Bolton Mar 2018

Cognitive Effects Of Short Duration Short Wavelength Visible Light, Sarah J. Bolton

Theses and Dissertations

This thesis research looks at the effects of short duration, high intensity, short wavelength light with the goal of determining if converting typically white colored lights in breakrooms and bathrooms to blue will cause workers who normally work in a low light environment to be more alert and productive. Sixteen participants were outfitted with Electroencephalography (and Electrooculography (EOG) equipment before being exposed to 200 lux of either 460 nm blue light or D6500 white light for 30 minutes. Afterwards, the light levels were changed to 3.5 lux of D6500 light and the participants were asked to perform six cognitive tests …


The Role Of Stress In The Pathogenesis And Maintenance Of Obsessive-Compulsive Disorder, Thomas G. Adams, Benjamin Kelmendi, C. Alex Brake, Patricia Gruner, Christal L. Badour, Christopher Pittenger Mar 2018

The Role Of Stress In The Pathogenesis And Maintenance Of Obsessive-Compulsive Disorder, Thomas G. Adams, Benjamin Kelmendi, C. Alex Brake, Patricia Gruner, Christal L. Badour, Christopher Pittenger

Psychology Faculty Publications

Individuals with obsessive-compulsive disorder often identify psychosocial stress as a factor that exacerbates their symptoms, and many trace the onset of symptoms to a stressful period of life or a discrete traumatic incident. However, the pathophysiological relationship between stress and obsessive-compulsive disorder remains poorly characterized: it is unclear whether trauma or stress is an independent cause of obsessive-compulsive disorder symptoms, a triggering factor that interacts with a preexisting diathesis, or simply a nonspecific factor that can exacerbate obsessive-compulsive disorder along with other aspects of psychiatric symptomatology. Nonetheless, preclinical research has demonstrated that stress has conspicuous effects on corticostriatal and limbic …


Concussion Competencies: A Framework For School-Based Concussion Management (Flyer), Arthur C. Maerlender, Jonathan Lichtenstein, Jennifer Parent-Nichols Feb 2018

Concussion Competencies: A Framework For School-Based Concussion Management (Flyer), Arthur C. Maerlender, Jonathan Lichtenstein, Jennifer Parent-Nichols

Center for Brain, Biology, and Behavior: Faculty Publications

This volume grew out of many years of clinical practice, research, and program projects. It is the culmination of more than 50 years of work with kids, brains, and schools. While there is research behind the Competencies and the underlying content, the intent was to create a user-friendly manual that cut across levels of responsibility and care. Concussion Competencies was not intended to be a textbook in the traditional manner; however, the Competencies have been shown to be a useful approach to teaching this material.

This volume is organized around a set of Competencies that have been shown to be …


Development Of Body Emotion Perception In Infancy: From Discrimination To Recognition, Alison Heck, Alyson Chroust, Hannah B. White, Rachel Lynn Jubran, Ramesh S. Bhatt Feb 2018

Development Of Body Emotion Perception In Infancy: From Discrimination To Recognition, Alison Heck, Alyson Chroust, Hannah B. White, Rachel Lynn Jubran, Ramesh S. Bhatt

Psychology Faculty Publications

Research suggests that infants progress from discrimination to recognition of emotions in faces during the first half year of life. It is unknown whether the perception of emotions from bodies develops in a similar manner. In the current study, when presented with happy and angry body videos and voices, 5-month-olds looked longer at the matching video when they were presented upright but not when they were inverted. In contrast, 3.5-month-olds failed to match even with upright videos. Thus, 5-month-olds but not 3.5-month-olds exhibited evidence of recognition of emotions from bodies by demonstrating intermodal matching. In a subsequent experiment, younger infants …


Similar Neural Responses Predict Friendship, Carolyn Parkinson, Adam M. Kleinbaum, Thalia Wheatley Jan 2018

Similar Neural Responses Predict Friendship, Carolyn Parkinson, Adam M. Kleinbaum, Thalia Wheatley

Dartmouth Scholarship

Human social networks are overwhelmingly homophilous: individuals tend to befriend others who are similar to them in terms of a range of physical attributes (e.g., age, gender). Do similarities among friends reflect deeper similarities in how we perceive, interpret, and respond to the world? To test whether friendship, and more generally, social network proximity, is associated with increased similarity of real-time mental responding, we used functional magnetic resonance imaging to scan subjects’ brains during free viewing of naturalistic movies. Here we show evidence for neural homophily: neural responses when viewing audiovisual movies are exceptionally similar among friends, and that similarity …


A Multi-Functional View Of Moral Disengagement: Exploring The Effects Of Learning The Consequences, C. Justice Tillman, Katerina Gonzalez, Marilyn V. Whitman, Wayne S. Crawford, Anthony C. Hood Jan 2018

A Multi-Functional View Of Moral Disengagement: Exploring The Effects Of Learning The Consequences, C. Justice Tillman, Katerina Gonzalez, Marilyn V. Whitman, Wayne S. Crawford, Anthony C. Hood

Publications and Research

This paper takes us beyond the unethical act and explores the use of moral disengagement as a multi-stage, multi-functional regulatory, and coping mechanism that not only allows individuals to engage in unethical behavior, but also manage the negative emotions (i.e., guilt and shame) from learning the consequences of such behavior. A resource-based lens is applied to the moral disengagement process, suggesting that individuals not only morally disengage prior to committing an unethical act in order to conserve their own resources, but also morally disengage as a coping mechanism to reduce emotional duress upon learning of the consequences of their actions, …


Specific Relationship Between The Shape Of The Readiness Potential, Subjective Decision Time, And Waiting Time Predicted By An Accumulator Model With Temporally Autocorrelated Input Noise, Aaron Schurger Jan 2018

Specific Relationship Between The Shape Of The Readiness Potential, Subjective Decision Time, And Waiting Time Predicted By An Accumulator Model With Temporally Autocorrelated Input Noise, Aaron Schurger

Psychology Faculty Articles and Research

Self-initiated movements are reliably preceded by a gradual buildup of neuronal activity known as the readiness potential (RP). Recent evidence suggests that the RP may reflect subthreshold stochastic fluctuations in neural activity that can be modeled as a process of accumulation to bound. One element of accumulator models that has been largely overlooked in the literature is the stochastic term, which is traditionally modeled as Gaussian white noise. While there may be practical reasons for this choice, we have long known that noise in neural systems is not white – it is long-term correlated with spectral density of the form …


An Examination Of The Relationships Between Attributional Style, Reappraisal, And Depression Risk In Arab Americans, Khadeja Najjar Jan 2018

An Examination Of The Relationships Between Attributional Style, Reappraisal, And Depression Risk In Arab Americans, Khadeja Najjar

ETD Archive

While depression is a cross-cultural phenomenon, much of the literature that examines risk factors and mechanisms for its occurrence is examined from a Western perspective. As cultural background and level of acculturation to the host culture is known to shape the expression of depressive disorders, as well as their risk factors, this study examined whether cultural factors influence the relationship between two cognitive emotion regulation processes and depression symptoms. Specifically, this study examined whether the relationship between internal, stable, and global causal attributions for negative events (negative attributional style) and depression is mediated by one’s tendency to reframe the meaning …


Studying Facial Expression Recognition And Imitation Ability Of Children With Autism Spectrum Disorder In Interaction With A Social Robot, Farzaneh Askari Jan 2018

Studying Facial Expression Recognition And Imitation Ability Of Children With Autism Spectrum Disorder In Interaction With A Social Robot, Farzaneh Askari

Electronic Theses and Dissertations

Children with Autism Spectrum Disorder (ASD) experience limited abilities in recognizing non-verbal elements of social interactions such as facial expressions [1]. They also show deficiencies in imitating facial expressions in social situations. In this Master thesis, we focus on studying the ability of children with ASD in recognizing facial expressions and imitating the expressions using a rear-projected expressive humanoid robot, called Ryan. Recent studies show that social robots such as Ryan have great potential for autism therapy. We designed and developed three studies, first to evaluate the ability of children with ASD in recognizing facial expressions that are presented to …


Relationships Among Apathy, Health-Related Quality Of Life, And Function In Huntington's Disease., Nora E Fritz, Nicholas R Boileau, Julie C Stout, Rebecca Ready, Joel S Perlmutter, Jane S Paulsen, Kimberly Quaid, Stacey Barton, Michael K Mccormack, Susan L Perlman, Noelle E Carlozzi Jan 2018

Relationships Among Apathy, Health-Related Quality Of Life, And Function In Huntington's Disease., Nora E Fritz, Nicholas R Boileau, Julie C Stout, Rebecca Ready, Joel S Perlmutter, Jane S Paulsen, Kimberly Quaid, Stacey Barton, Michael K Mccormack, Susan L Perlman, Noelle E Carlozzi

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Up to 90% of individuals with Huntington's disease (HD)-a progressive, inherited neurodegenerative disorder-experience apathy. Apathy is particularly debilitating because it is marked by a reduction in goal-directed behaviors, including self-care, social interactions, and mobility. The objective of this study was to examine relationships between variables of apathy, functional status, physical function, cognitive function, behavioral status/emotional function, and health-related quality of life. Clinician-rated measures of physical, cognitive, and behavioral function, including one clinician-rated item on apathy, and self-reported measures of physical function, health-related quality of life, and emotional, cognitive, and social function were collected in a single session from 487 persons …


The Signature Of Undetected Change: An Exploratory Electrotomographic Investigation Of Gradual Change Blindness, John E. Kiat, Michael D. Dodd, Robert F. Belli, Jacob E. Cheadle Jan 2018

The Signature Of Undetected Change: An Exploratory Electrotomographic Investigation Of Gradual Change Blindness, John E. Kiat, Michael D. Dodd, Robert F. Belli, Jacob E. Cheadle

Department of Psychology: Faculty Publications

Neuroimaging-based investigations of change blindness, a phenomenon in which seemingly obvious changes in visual scenes fail to be detected, have significantly advanced our understanding of visual awareness. The vast majority of prior investigations, however, utilize paradigms involving visual disruptions (e.g., intervening blank screens, saccadic movements, “mudsplashes”), making it difficult to isolate neural responses toward visual changes cleanly. To address this issue in this present study, high-density EEG data (256 channel) were collected from 25 participants using a paradigm in which visual changes were progressively introduced into detailed real-world scenes without the use of visual disruption. Oscillatory activity associated with undetected …


Factor Structure And Gender Invariance Testing For The Sport Anxiety Scale-2 (Sas-2), Leilani Madrigal, Vincenzo Roma, Todd Caze, Arthur C. Maerlender, Debra Hope Jan 2018

Factor Structure And Gender Invariance Testing For The Sport Anxiety Scale-2 (Sas-2), Leilani Madrigal, Vincenzo Roma, Todd Caze, Arthur C. Maerlender, Debra Hope

Center for Brain, Biology, and Behavior: Faculty Publications

This study aimed to provide further psychometric validation of the Sport Anxiety Scale-2 (SAS-2) by assessing the factor structure, invariance across gender, and convergent and divergent validity of the SAS-2 by correlating both related (i.e., anxiety sensitivity, brief fear of negative evaluation, intolerance of uncertainty, and negative affect) and unrelated constructs (i.e., positive affect, self-confidence). A total of 542 current and former competitive athletes completed a questionnaire through Amazon’s Mechanical Turk system. All data were collected via online survey. Participants were randomly assigned to an exploratory factor analysis (n = 271) and confirmatory factor analysis group (n = 271). Results …


Accumulating Data To Optimally Predict Obesity Treatment (Adopt): Recommendations From The Biological Domain, Michael Rosenbaum, Tanya Agurs-Collins, Molly S. Bray, Kevin D. Hall, Mark Hopkins, Maren Laughlin, Paul S. Maclean, Padma Maruvada, Cary R. Savage, Dana M. Small, Luke Stoeckel Jan 2018

Accumulating Data To Optimally Predict Obesity Treatment (Adopt): Recommendations From The Biological Domain, Michael Rosenbaum, Tanya Agurs-Collins, Molly S. Bray, Kevin D. Hall, Mark Hopkins, Maren Laughlin, Paul S. Maclean, Padma Maruvada, Cary R. Savage, Dana M. Small, Luke Stoeckel

Center for Brain, Biology, and Behavior: Faculty Publications

Background: The responses to behavioral, pharmacological, or surgical obesity treatments are highly individualized. The Accumulating Data to Optimally Predict obesity Treatment (ADOPT) project provides a framework for how obesity researchers, working collectively, can generate the evidence base needed to guide the development of tailored, and potentially more effective, strategies for obesity treatment. Objectives: The objective of the ADOPT biological domain subgroup is to create a list of high-priority biological measures for weight-loss studies that will advance the understanding of individual variability in response to adult obesity treatments. This list includes measures of body composition, energy homeostasis (energy intake and output), …


Left Lateralized Cerebral Glucose Metabolism Declines In Amyloid-Β Positive Persons With Mild Cognitive Impairment, Christopher M. Weise, Kewei Chen, Yinghua Chen, Xiaoying Kuang, Cary R. Savage, Eric M. Reiman Jan 2018

Left Lateralized Cerebral Glucose Metabolism Declines In Amyloid-Β Positive Persons With Mild Cognitive Impairment, Christopher M. Weise, Kewei Chen, Yinghua Chen, Xiaoying Kuang, Cary R. Savage, Eric M. Reiman

Center for Brain, Biology, and Behavior: Faculty Publications

Background: Previous publications indicate that Alzheimer's Disease (AD) related cortical atrophy may develop in asymmetric patterns, with accentuation of the left hemisphere. Since fluorodeoxyglucose positron emission tomography (FDG PET) measurements of the regional cerebral metabolic rate of glucose (rCMRgl) provide a sensitive and specific marker of neurodegenerative disease progression, we sought to investigate the longitudinal pattern of rCMRgl in amyloid-positive persons with mild cognitive impairment (MCI) and dementia, hypothesizing asymmetric declines of cerebral glucose metabolism. Methods: Using florbetapir PET and cerebrospinal fluid (CSF) measures to define amyloid-β (Aβ) positivity, 40 Aβ negative (Aβ-) cognitively unimpaired controls (CU; 76 ± 5y), …


Novel Biomarkers Of Physical Activity Maintenance In Midlife Women: Preliminary Investigation, Kelly A. Bosak, Vlad B. Papa, Morgan G. Brucks, Cary R. Savage, Joseph E. Donnelly, Laura E. Martin Jan 2018

Novel Biomarkers Of Physical Activity Maintenance In Midlife Women: Preliminary Investigation, Kelly A. Bosak, Vlad B. Papa, Morgan G. Brucks, Cary R. Savage, Joseph E. Donnelly, Laura E. Martin

Center for Brain, Biology, and Behavior: Faculty Publications

The precision health initiative is leading the discovery of novel biomarkers as important indicators of biological processes or responses to behavior, such as physical activity. Neural biomarkers identified by magnetic resonance imaging (MRI) hold promise to inform future research, and ultimately, for transfer to the clinical setting to optimize health outcomes. This study investigated resting-state and functional brain biomarkers between midlife women who were maintaining physical activity in accordance with the current national guidelines and previously acquired age-matched sedentary controls. Approval was obtained from the Human Subjects Committee. Participants included nondiabetic, healthy weight to overweight (body mass index 19–29.9 kg/m …