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Pharmaceutics and Drug Design Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- Benzonitriles (1)
- Carbon–carbon (C–C) bond activation (1)
- Catalysis (1)
- C–CN bond activation (1)
- Density Functional Theory (1)
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- Drug synthesis (1)
- Energetics (1)
- Homogeneous transition-metal catalysts (1)
- Mesityl and phenyl groups (1)
- Metal complexes (1)
- Pharmaceutical industry (1)
- Pharmaceutical synthesis (1)
- Phosphaalkynes (1)
- Polar solvent (tetrahydrofuran) (1)
- Pt(0) and Ni(0) (1)
- Pt(0)-mediated C–CP bond activation (1)
- Reaction intermediates (1)
- Reaction pathways (1)
- Reductive elimination pathway (1)
- Therapeutic agents (1)
- Transition state energies (1)
- Transition-metal-catalyzed reactions (1)
Articles 1 - 4 of 4
Full-Text Articles in Pharmaceutics and Drug Design
Mechanistic Investigation Of C—C Bond Activation Of Phosphaalkynes With Pt(0) Complexes, Roberto M. Escobar, Abdurrahman C. Ateşin, Christian Müller, William D. Jones, Tülay Ateşin
Mechanistic Investigation Of C—C Bond Activation Of Phosphaalkynes With Pt(0) Complexes, Roberto M. Escobar, Abdurrahman C. Ateşin, Christian Müller, William D. Jones, Tülay Ateşin
Research Symposium
Carbon–carbon (C–C) bond activation has gained increased attention as a direct method for the synthesis of pharmaceuticals. Due to the thermodynamic stability and kinetic inaccessibility of the C–C bonds, however, activation of C–C bonds by homogeneous transition-metal catalysts under mild homogeneous conditions is still a challenge. Most of the systems in which the activation occurs either have aromatization or relief of ring strain as the primary driving force. The activation of unstrained C–C bonds of phosphaalkynes does not have this advantage. This study employs Density Functional Theory (DFT) calculations to elucidate Pt(0)-mediated C–CP bond activation mechanisms in phosphaalkynes. Investigating the …
Evaluation Of Novel Therapeutic Agents For The Treatment Of Chronic Dry Eyes, Lilian Huynh, Evonie Villarete, Surajit Dey
Evaluation Of Novel Therapeutic Agents For The Treatment Of Chronic Dry Eyes, Lilian Huynh, Evonie Villarete, Surajit Dey
Annual Research Symposium
Dry eye disease (DED) is a multifactorial ocular condition, where disrupted tear film stability and ocular surface inflammation affected between 5% to 34% of the worldwide population in 2015 and posed a challenge to conventional ophthalmic treatments. Recent advances have led to potential novel therapeutics aiming to alleviate symptoms and improve patient outcomes.
Designing And Synthesizing A Warhead-Fragment Inhibitory Ligand For Ivyp1 Through Fragment-Based Drug Discovery, Samuel Moore
Designing And Synthesizing A Warhead-Fragment Inhibitory Ligand For Ivyp1 Through Fragment-Based Drug Discovery, Samuel Moore
Symposium of Student Scholars
Fragment-based drug discovery (FBDD) is a powerful tool for developing anticancer and antimicrobial agents. Within this, magnetic resonance spectroscopy (NMR) provides a comprehensive qualitative and quantitative approach to screening and validating weak and robust binders with targeted proteins, making NMR among the most attractive strategies in FBDD. Inhibitor of vertebrate lysozyme (Ivyp1) of P. aeruginosa serves as an excellent target because of its active cellular location and implications in clinical prognosis for cystic fibrosis and immunocompromised patients. This study uses current NMR and biophysical techniques to develop a covalent, fragment-linked warhead inhibitor for Ivyp1 through synthetic methods, warhead linking, and …
Exploration Of Putative Mitochondrial Gene Expression In Crithidia Fasciculata As A Model For Pathogenic Trypanosomes Causing Human Disease, Baylye Boxall, Nadjean Sagesse
Exploration Of Putative Mitochondrial Gene Expression In Crithidia Fasciculata As A Model For Pathogenic Trypanosomes Causing Human Disease, Baylye Boxall, Nadjean Sagesse
Georgia State Undergraduate Research Conference
No abstract provided.