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Articles 31 - 31 of 31
Full-Text Articles in Natural Products Chemistry and Pharmacognosy
Delineating The Biosynthesis Of Capuramycin-Type Antibiotics, Ashley L. Biecker
Delineating The Biosynthesis Of Capuramycin-Type Antibiotics, Ashley L. Biecker
Theses and Dissertations--Pharmacy
New antibiotic scaffolds with novel drug targets are needed to combat the rise of drug-resistant, infectious microorganisms. The bacterial translocase I is a ubiquitous enzyme in the peptidoglycan biosynthetic pathway that has yet to be targeted by clinically used antibiotics. It catalyzes the transfer of N-acetylmuramoyl-pentapeptide to undecaprenylphosphate in order to generate lipid I during cell wall biosynthesis. A screening of bacterial translocase I inhibitors led to the discovery of the novel compound capuramycin and its analogues: A-500359s, A-503083s, and A-102395, produced by various species of actinomycetes. The capuramycins show potent activity against the bacterial translocase I with IC50s …