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University of Malaya

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Full-Text Articles in Natural Products Chemistry and Pharmacognosy

Studies Of Antioxidant And Angiotensin Converting Enzyme Inhibitory Activity Of Orthosiphon Stamineus (Misai Kucing)., Che Wan Imanina Che Wan Takwa Jan 2010

Studies Of Antioxidant And Angiotensin Converting Enzyme Inhibitory Activity Of Orthosiphon Stamineus (Misai Kucing)., Che Wan Imanina Che Wan Takwa

Student Works (2010-2019)

Abstract NA

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Marine Algae As A Source Of Photosensitisers For Photodynamic Therapy Of Cancer., Tang Yee Voon Jan 2010

Marine Algae As A Source Of Photosensitisers For Photodynamic Therapy Of Cancer., Tang Yee Voon

Student Works (2010-2019)

Photodynamic therapy (PDT) involves the intravenous administration of a photosensitiser that preferentially localises in cancerous tissues more than the surrounding normal tissues. Subsequent illumination of photosensitiser generates reactive oxygen species that cause irreversible photo-damage to the cancer cells. To date, most photosensitisers that have been approved for clinical use or are currently in clinical trials are cyclic tetrapyrroles which are derived or inspired by naturally occurring chlorophyll and its degradation products. Some non-tetrapyrrolic photosensitisers have also been found in nature suggesting that there are potential photosensitisers with interesting structures in nature. To this end, this thesis outlines the collection of …

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Bioactivity And Chemical Investigations Of Pereskia Bleo And Pereskia Grandifollia., Sim Kae Shin Jan 2010

Bioactivity And Chemical Investigations Of Pereskia Bleo And Pereskia Grandifollia., Sim Kae Shin

Student Works (2010-2019)

Ethnopharmacological data has been one of the common useful criteria in drug discovery. Pereskia bleo and Pereskia grandifolia (Cactaceae), commonly known as ‘Jarum Tujuh Bilah’ in Malay and ‘Cak Sing Cam’ in Chinese have long been used as natural remedies in Malaysia. The experimental approach in the present study was based on bioassay-guided fractionation. The crude methanol and fractionated extracts of both Pereskia spp. were initially investigated for their biological activities such as antioxidant, antimicrobial and cytotoxic effect against five human cancer cell lines, namely nasopharyngeal epidermoid carcinoma cell line (KB), cervical carcinoma cell line (CasKi), colon carcinoma cell line …

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Chemical Constituents Of Cryptocarya Densiflora., Nurul Nazneem Wan Othman Jan 2010

Chemical Constituents Of Cryptocarya Densiflora., Nurul Nazneem Wan Othman

Student Works (2010-2019)

The extraction of alkaloids from the Malaysian Cryptocarya densiflora has been carried out in this study. The alkaloids were extracted from the bark and leaves of this species using acid base extraction and the crude alkaloids obtained were subjected to extensive chromatographic techniques such as thin layer and column chromatography. The structural elucidation of the purified alkaloids were performed with the aid of spectroscopic methods i.e. 1H NMR, 13C NMR, 2D NMR, IR, UV and LCMS. Investigation of the alkaloidal content from the bark of Cryptocarya densiflora afforded six alkaloids and their structures were elucidated as laurotetanine 63, isocaryachine 64, …

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Chemical Constituents Of Desmos Dumosus, Roxb., Mazdida Sulaiman Jan 2001

Chemical Constituents Of Desmos Dumosus, Roxb., Mazdida Sulaiman

Student Works (2000-2009)

The chemical content of the 'leaves and bark of Des mos dumosus has been carried out in this study. The leaves yielded nine isoquinoline type of alkaloids and two flavones. The isoquinoline alkaloids isolated were pronuciferine 37, stepharine 39, nomuciferine 40, (-) - 3 - hydroxynomuciferine 41, norlirioferine 42, asimilobine 43, liriodenine 44, lysicamine 45 and O - methylmoschatoline 46. The flavones were 5 - hydroxy - 6,7 - dimethoxyflavone 47 and 5 - hydroxy - 7,8 - dimethoxyflavone 48. The same flavones, 47 and 48 and the alkaloids 45 and 46 were also present in the bark of this …

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Sistem Maklumat Perubatan Tradisional Melayu, Omar Rosfazila Jan 2000

Sistem Maklumat Perubatan Tradisional Melayu, Omar Rosfazila

Student Works (2000-2009)

Sistem Maklumat Perubatan Tradisional Melayu adalah merupakan satu sistem makumat berkomputer yang dibangunkan di halaman web. Ia bertujuan untuk membantu pengguna mencapai maklumat mengenai (ubatan tradisional serta tumbuhan berubat yang) diamalkan oleh orang Melayu. Sistem ini akan menceritakan serba sedikit tentang sejarah penggunaan perubatan tradisional. Pengguna sistem juga dijangka dapat mengemukan pertanyaan dan memberi sebarang komen yang berkaitan dengan sistem. Bantuan kepada pengguna sistem tentang cara menggunakan sistem turut dipaparkan dalam pembangunan system ini nanti. Sistem ini juga membolehkan pihak pentadbir membuat pengemaskinian maklumat mengikut kesesuaian semasa dan pembaharuan. Ia adalah sejajar dengan matlamat untuk memastikan penyimpanan maklwnat yang lebih …

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Investigations Of The Absorption And Metabolismof Antioxidant Flavonols, Abdul Aziz Azlina Jan 2000

Investigations Of The Absorption And Metabolismof Antioxidant Flavonols, Abdul Aziz Azlina

Student Works (2000-2009)

Flavonols are polyphenols, secondary plant metabolites commonly found in plants and foods of plant origin. They have widespread biological properties in the human body. The recent discovery of their potential antioxidant activities has prompted extensive research. Flavonols particularly quercetin are potent antioxidants with higher antioxidant properties than the well known antioxidant vitamins C and E. Several epidemiology studies have demonstrated a strong inverse association between flavonoid intake and risk of coronary heart disease. The association with cancer is less defined with only some studies showing an inverse association and others not. In view of their potential to act as antioxidants …

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