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Natural Products Chemistry and Pharmacognosy Commons™
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- Aallium schugnanicum (1)
- Allium afghanicum (1)
- Antimicrobial and anfungal properties (1)
- Antioxidant activity (1)
- Antioxidant antibacterial correlation (1)
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- Antiviral activity; roseofungin; polyene macrolide; Influenza A virus; neuraminidase; viral adsorption; oseltamivir resistance (1)
- Endemic species (1)
- Extracts (1)
- F. gigantea (1)
- F. kuhistanica (1)
- F. violacea (1)
- Ferula (1)
- Growth inhibition (1)
- Hospital strains of bacteria (1)
- Influenza A viruses (H1N1 and H3N2) (1)
- Juzen-taiho-to (1)
- Kampo medicine (1)
- Lipid A (1)
- Lipopolysaccharide (1)
- Medicinal plants (1)
- Plants (1)
- Polyphenol content (1)
- Reference strains of bacteria (1)
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Articles 1 - 5 of 5
Full-Text Articles in Natural Products Chemistry and Pharmacognosy
Antiviral Activity Of The Polyene Macrolide Roseofungin Against Influenza A Virus: In Vitro, In Ovo, And Preliminary In Vivo Evaluation, Ahdrey P. Bogoyavlenskiy, Vladimir Berezin, Pavel Alexyuk, Madina Alexyuk, Irina Zaitseva, Aidar Mukhametkaliyev, Yergali Moldakhanov, Elmira I. Anarkulova, Timur Kerimov, Vyacheslav Dushenkov
Antiviral Activity Of The Polyene Macrolide Roseofungin Against Influenza A Virus: In Vitro, In Ovo, And Preliminary In Vivo Evaluation, Ahdrey P. Bogoyavlenskiy, Vladimir Berezin, Pavel Alexyuk, Madina Alexyuk, Irina Zaitseva, Aidar Mukhametkaliyev, Yergali Moldakhanov, Elmira I. Anarkulova, Timur Kerimov, Vyacheslav Dushenkov
Publications and Research
Roseofungin, a polyene macrolide antibiotic produced by Streptomyces roseoflavus, was evaluated for antiviral activity against Influenza A virus using complementary in vitro, in ovo, and preliminary in vivo toxicity models, supported by molecular docking and molecular dynamics simulations. The compound exhibited antiviral activity against multiple influenza A virus subtypes, including an oseltamivir-resistant H1N1 strain, with EC50 values ranging from 2.0 to 2.5 μg/mL and selectivity indices of 20–25. Functional assays demonstrated that roseofungin interfered with early stages of the viral life cycle by reducing viral adsorption and partially inhibiting neuraminidase activity. In virucidal assays, treatment with roseofungin resulted …
Efficacy Of Ferula L. Species Extracts From Tajikistan Against Influenza Viruses, Saidbeg Satorov, Sulhiy Mavlonazarova, Ahdrey P. Bogoyavlenskiy, Salomuddin D. Yusufi, Vyacheslav Dushenkov
Efficacy Of Ferula L. Species Extracts From Tajikistan Against Influenza Viruses, Saidbeg Satorov, Sulhiy Mavlonazarova, Ahdrey P. Bogoyavlenskiy, Salomuddin D. Yusufi, Vyacheslav Dushenkov
Publications and Research
Efficacy of Ferula L. Species Extracts from Tajikistan Against Influenza Viruses One of the challenges facing both the domestic and international pharmaceutical industries is the limited selection and suboptimal efficacy of available antiviral drugs. The high mutational variability of influenza viruses contributes to rapid acquisition of drug resistance, which diminishes or nullifies the effectiveness of existing therapies, thereby necessitating the exploration for novel therapeutics. This study aimed to assess the antiviral activities of three species of the genus Ferula— indigenous to the Republic of Tajikistan—against influenza strains A/Vladivostok/2/09 (H1N1) and A/Almaty/8/98 (H3N2). The investigation revealed that phytochemical constituents—specifically, root …
Comparative Analysis Of Polyphenol Content, Antioxidant Activity And Antimicrobial Properties In Endemic And Widespread Allium Species Of Tajikistan, Fazila Mirzoeva, Saidbeg Satorov, Salomuddin Usufi, Vyacheslav Dushenkov, Shukhratdzhon Shukhratdzhon
Comparative Analysis Of Polyphenol Content, Antioxidant Activity And Antimicrobial Properties In Endemic And Widespread Allium Species Of Tajikistan, Fazila Mirzoeva, Saidbeg Satorov, Salomuddin Usufi, Vyacheslav Dushenkov, Shukhratdzhon Shukhratdzhon
Publications and Research
In Tajikistan, the Allium genus is notably prolific, with over 80 species documented, and new species continually being identified in the mountainous regions. The Gorno- Badakhshan Autonomous Region (GBAO) of Tajikistan, within the Pamir Mountains, is significant for its 31 distinct Allium species, including endemics like A. afghanicum Wendelbo and A. schugnanicum Vved. The distribution of these species is often geographically restricted, and their biological activities, especially their antimicrobial properties, remain largely unexplored, presenting significant opportunities for future phytochemical and pharmacological research. This scholarly inquiry is aimed at contributing substantially to the academic discourse on the therapeutic capacities of Allium …
Comparative Characteristics Of Antibacterial Activity Of Plants Growing In The Central Part Of The Republic Of Tajikistan., Saidbeg Satorov, F. Mirzoeva, Sh. Satorov, M. Vakhidova, Vyacheslav Dushenkov
Comparative Characteristics Of Antibacterial Activity Of Plants Growing In The Central Part Of The Republic Of Tajikistan., Saidbeg Satorov, F. Mirzoeva, Sh. Satorov, M. Vakhidova, Vyacheslav Dushenkov
Publications and Research
Objective: To evaluate the spectrum of antibacterial activity of plants growing in the central part of the Republic of Tajikistan.
Methods: The antibacterial properties of 18 plant species from the 14 families were studied. The extract samples on dry filter discs were prepared according to the method developed at Rutgers University. Screens-to-Nature (STN) and disc diffusion (DD) methods were used to assess antimicrobial properties of the extracts. The antimicrobial activity of plant extracts was determined against four types of pathogenic standard museum strains of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, as well as …
Bacterial Lps At The Immune Modulating Component In Juzen-Taiho-To, Diego Montenegro
Bacterial Lps At The Immune Modulating Component In Juzen-Taiho-To, Diego Montenegro
Dissertations, Theses, and Capstone Projects
Juzen-taiho-to (JTT) is an immune-boosting herbal formulation with an ideal balance of safety and efficacy. For example, JTT is clinically used in Japan to stimulate the immunological functions of cancer patients undergoing chemotherapy and radiation. Although the clinical effects of JTT are recognized, the active compounds and mechanism of action are unknown. The studies conducted previously in our laboratory associated several phytosterols and plant glycolipids with the potent immunostimulatory activity of JTT: namely, β-sitosteryl β-D-glucoside (BSSG), glucocerebroside (GluCer), digalactosyldiacylglycerol (DGDG) and monogalactosyldiacylglycerol (MGDG). However, these compounds, when further purified, exhibited little or no immunostimulatory activity. This suggested that the immunostimulatory …