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Amphiphilic Cyclic Cell-Penetrating Peptides Containing Tryptophan And Arginine As Anticancer Agents And Drug Delivery System, Khalid Zoghebi
Amphiphilic Cyclic Cell-Penetrating Peptides Containing Tryptophan And Arginine As Anticancer Agents And Drug Delivery System, Khalid Zoghebi
Pharmaceutical Sciences (PhD) Dissertations
Amphiphilic cyclic cell-penetrating peptides composed of an increasing number of alternative tryptophan (W) and arginine (R) were synthesized and evaluated as a molecular transporter and for their ability to deliver doxorubicin (Dox) and large molecular weight molecules, such as siRNA and proteins. We prepared a cyclic peptide containing alternative tryptophan (W) and arginine (R) residues and a lysine containing a free side chain amino group. Cyclic peptide [(WR)8WK βA] was conjugated through the free side chain amino group of β-alanine with Dox via a glutarate linker to afford [(WR)8WK]bA-Dox conjugate. The conjugate inhibited the cell viability of ovarian adenocarcinoma (SK-OV-3) …