Open Access. Powered by Scholars. Published by Universities.®
Medicinal and Pharmaceutical Chemistry Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicinal and Pharmaceutical Chemistry
Role Of Sphingosine Kinase 1 And Sphingosine-1-Phosphate Axis In Hepatocellular Carcinoma, Michael Maceyka, Timothy Rohrbach, Sheldon Milstein, Sarah Spiegel
Role Of Sphingosine Kinase 1 And Sphingosine-1-Phosphate Axis In Hepatocellular Carcinoma, Michael Maceyka, Timothy Rohrbach, Sheldon Milstein, Sarah Spiegel
Richard Bland Faculty Works
Hepatocellular carcinoma (HCC) is primarily diagnosed in the latter stages of disease progression and is the third leading cause of cancer deaths worldwide. Thus, there is a need to find biomarkers of early HCC as well as the development of more effective treatments for the disease. Sphingosine-1-phosphate (S1P) is a pleiotropic lipid signaling molecule produced by two isoforms of sphingosine kinase (SphK1 and SphK2) that is involved in regulation of many aspects of mammalian physiology and pathophysiology, including inflammation, epithelial and endothelial barrier function, cancer, and metastasis, among many others. Abundant evidence indicates that SphK1 and S1P promote cancer progression …
Sphingosine Kinase And Sphingosine-1-Phosphate In Liver Pathobiology, Timothy Rohrbach, Michael Maceyka, Sarah Spiegel
Sphingosine Kinase And Sphingosine-1-Phosphate In Liver Pathobiology, Timothy Rohrbach, Michael Maceyka, Sarah Spiegel
Richard Bland Faculty Works
Over 20 years ago, sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule. Subsequent studies later identified two related kinases, sphingosine kinase 1 and 2, which are responsible for the phosphorylation of sphingosine to S1P. Many stimuli increase sphingosine kinase activity and S1P production and secretion. Outside the cell, S1P can bind to and activate five S1P-specific G protein-coupled receptors (S1PR1–5) to regulate many important cellular and physiological processes in an autocrine or paracrine manner. S1P is found in high concentrations in the blood where it functions to control vascular integrity and trafficking of lymphocytes. Obesity increases blood S1P …