Medicinal and Pharmaceutical Chemistry Commons^™

Measuring The Decrement Times Of Volatile Anesthetics In Drosophila Melanogaster Using Gas Chromatography-Mass Spectrometry, Jason Tolley

Honors Program Projects

Background

Model organisms are widely used in research, especially in the context of complex situations. One model organism that has been widely used is the common fruit fly, Drosophila melanogaster (D. mel). D. mel are most commonly used in the context of genetics, but they have also been widely used in research focusing on general anesthetics. One value that has not been measured in D. mel, however, as it relates to general anesthetics, is the decrement times. This is what was the present research set out to determine.

Methods

The anesthetics studied in this research were isoflurane …

Synthesis, Including Microwave Promotion, Of Selected Cyclopropyl Derivatives As Stereochemically Rigid Probes Of Certain Pharmalogical Receptors, Grace Hohn

Honors Program Projects

Pharmacologic intervention with stereochemical probes allows for the treatment of medical conditions by affecting receptors in the body and causing receptors to respond to the presence of the probe. Novel cyclopropyl derivatives were synthesized could serve as a stereochemically rigid probes of certain pharmacological receptors and could have potential use as a drug. A probe is a molecule or ligand that can bind to and interact with a receptor in the human body. This interaction triggers a desirable response by increasing or decreasing the presence of a compound (e.g. dopamine for depression) in order to repair a chemical imbalance in …

Countercurrent Chromatography Fractions Of Plant Extracts With Anti-Tuberculosis Activity, Douglas Armstrong, Nathan C. Krause, Drew Frey, J. Brent Friesen, Baojie Wan, Jordan Gunn, Scott Franzblau

Faculty Scholarship – Chemistry

Samples of numerous plant species were received from the southwestern part of the USA, from Richard Spjut, and plant samples were collected here in Illinois. All were extracted with typical solvents, giving crude residues, some of which were subjected to chromatographic methods. Some of the crude residues and some of the fractions were tested for anti-tuberculosis activity and/or antibacterial activity.

In a general way, bioactive natural products are dealt with very well by Liang & Fang. More specifically, the southwestern part of the United States has a large variety of indigenous plants many of which have not been investigated for …

Synthesis And Polarographic Analysis Of A2e, Elise Rivett

Honors Program Projects

As humans age, fluorescent retinoid pigments accumulate in the retinal pigment epithelial (RPE) cells responsible for photoreceptor support. These fluorophores are of interest because they seem to contribute to diseases of the retina, particularly age-related macular degeneration, which is a leading cause of blindness in older adults in the United States and currently has no cure. One well-characterized fluorophore, A2E, can be oxidized by visible light and then generate harmful oxidative species capable of inducing programmed cell death in RPE cells. Further characterization of the redox behavior of A2E could ultimately aid the development of macular degeneration treatments designed to …