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Medicinal and Pharmaceutical Chemistry Commons™
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Full-Text Articles in Medicinal and Pharmaceutical Chemistry
A Comparison Of The Effect Of Intermittent And Continuous Infusion Of Meropenem On The Prevalence Of Nausea In Pediatric Cystic Fibrosis Patients, Marissa Cushing, Juanita A. Draime, Bao-Ngoc Ho, Jordan Nicholls, Bethany Sibbitt, Rebecca Widder, Rebecca J. Gryka, Denise S. Simpson
A Comparison Of The Effect Of Intermittent And Continuous Infusion Of Meropenem On The Prevalence Of Nausea In Pediatric Cystic Fibrosis Patients, Marissa Cushing, Juanita A. Draime, Bao-Ngoc Ho, Jordan Nicholls, Bethany Sibbitt, Rebecca Widder, Rebecca J. Gryka, Denise S. Simpson
Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session
Cystic Fibrosis (CF) is a genetic disease, leading to changes of membrane secretions causing obstruction of smaller airways. CF patients often develop pulmonary infections and require antibiotic treatment. Meropenem is a broad spectrum beta lactam that acts by lysing microbes through interfering with bacterial cell wall synthesis. Although a safe and effective treatment, data on pediatric patients is limited.
A Potent And Selective Inhibitor Of Cdc42 Gtpase, Zurab Surviladze, Anna Waller, J. Jacob Strouse, Cristian G. Bologa, Oleg Ursu, Virginia M. Salas, Genevieve K. Phillips, John F. Parkinson, Elsa Romero, Angela Wandinger-Ness, Larry A. Sklar, Chad E. Schroeder, Denise S. Simpson, Julica Nöth, Jenna Wang, Jennifer E. Golden, Jeffrey Aubé
A Potent And Selective Inhibitor Of Cdc42 Gtpase, Zurab Surviladze, Anna Waller, J. Jacob Strouse, Cristian G. Bologa, Oleg Ursu, Virginia M. Salas, Genevieve K. Phillips, John F. Parkinson, Elsa Romero, Angela Wandinger-Ness, Larry A. Sklar, Chad E. Schroeder, Denise S. Simpson, Julica Nöth, Jenna Wang, Jennifer E. Golden, Jeffrey Aubé
Pharmacy Faculty Publications
Cdc42, a member of the Rho family of GTPases, has been shown to play a role in cell adhesion, cytoskeletal arrangement, phagocytosis and cell motility and migration, in addition to a host of other diverse biological processes. The function of Rho-family GTPases in disease pathogenesis has been well established and identification of small, cell permeable molecules that selectively and reversibly regulate Rho GTPases is of high scientific and potentially therapeutic interest. There has been limited success in identifying inhibitors that specifically interact with small Rho family GTPases. The identified probe, ML141 (CID-2950007), is demonstrated to be a potent, selective and …