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Loma Linda University Electronic Theses, Dissertations & Projects
Osteoporosis; Bone Mass; Cldn-18; Cldn-1; Osteoblast Proliferation
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The Role Of Claudins In Bone Metabolism, Fatima Zakariya Alshbool
The Role Of Claudins In Bone Metabolism, Fatima Zakariya Alshbool
Loma Linda University Electronic Theses, Dissertations & Projects
Osteoporosis, a major public health problem in the U.S., is characterized by low bone mass and structural deterioration of bone tissue. Since the imbalance between bone formation and bone resorption during bone remodeling has been documented to be a major factor in the pathogenesis of osteoporosis, it is crucial to identify novel genes and/or novel functions of known genes that regulate the formation and activity of bone forming osteoblasts and bone resorbing osteoclasts. To this end, recent evidence suggests a significant role for caudins (Cldns), which comprise a major group of tight junction proteins, in bone biology and development. This …