Pharmacy and Pharmaceutical Sciences Commons^™

Design And Mechanistic Investigation Of Novel Metallodrugs: From Structure-Activity Relationships To Selective Cancer Cell Targeting, Samad Khaksar, Nosrat Behzadi, Hasan Zakeri Zakeri, Peyman Salahshour, Sara Abdolmaleki

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The relentless pursuit of alternatives to conventional platinum-based chemotherapeutics, hampered by severe side effects and drug resistance, defines a critical frontier in oncology drug discovery. This review consolidates and highlights the significance of our recent advances in designing novel metallodrugs based on pyridine-2,6-dicarboxylate derivatives coordinated with various metal ions (Ga(III), Ce(IV), Zn(II), Cu(II), Ni(II), Sr(II)). Through systematic synthesis and evaluation, we establish how strategic structural modifications dictate cytotoxicity, cellular uptake, and mechanistic pathways. Our comprehensive in vitro profiling across a panel of human cancer cell lines (including A431, SW480, BEL-7404) revealed potent anticancer activity, with IC50 values as low as …

Sphenocentrum Jollyanum: Pharmacological Insights Into A Neglected African Medicinal Plant, Albashir Tahir

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Sphenocentrum jollyanum Pierre (Menispermaceae) is a West African medicinal plant used traditionally for various ailments, including malaria, diabetes, and reproductive disorders. Despite its ethnobotanical significance, comprehensive scientific validation of its pharmacological properties remains limited. This review aims to provide a comprehensive overview of the plant’s ethnobotany, phytochemistry, and pharmacological activities, integrating traditional knowledge with modern scientific insights to guide future research. A comprehensive literature search was conducted in PubMed, ScienceDirect, Scopus, Google Scholar, and Web of Science, covering publications up to April 2025. Search terms included "Sphenocentrum jollyanum", "ethnobotanical use", "pharmacological effects", and related keywords. Relevant articles were screened, and …

Green Pharmaceutical Systems: Alpha-Tocopherol Encapsulation In Nanostructured Lipid Carriers Via Microwaves-Based Technique As Advanced Topical Drug Delivery Systems, Hayder Kadhim Drais, Mohammed A Albarki, Hayder Ridha-Salman, Ahmed Abbas Hussein, Ashraf Abbas Drais

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Alpha tocopherol (Vitamin E) is practically insoluble in water. It is important for skin health due to its many therapeutic actions, such as antioxidant, anti-inflammatory, and photoprotection. Therefore, the purpose of this study is to develop, prepare, and evaluate nanostructured lipid carriers (NLCs)-based hydrogels as a topical dosage form to improve stability and therapeutic activity of vitamin E. The microwave-based method prepared five lavender oil-based NLCs (LN1–LN5) formulations that were assessed thermodynamically and entered into characterization processes. Hydrogels formulations based on NLCs (LNG1–LNG5) were prepared and evaluated. All of the lavender oil-based NLC formulations (LN1–LN5) had suitable surface charge, a …

History And Prevention Of Foot-And-Mouth Disease Virus In Iraq: A Review, Ashwaq M. S. Al-Jbouri, Baraa Hamid Hadi, Saad Mardi Muhammad, Raoof J. A. Maaroof, Nada Khazal K. Hindi, Karrar Kamoona, Zainab Ayad, Rusul Ahmed Mohammed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Foot-and-mouth disease Virus (FMDV) is an extremely transmittable viral illness that affects cloven-hoofed faunae, such as cattle, goats, sheep, and pigs. This study aimed to demonstrate the history and prevention of foot-and-mouth disease (FMD) in Iraq. This virus poses a significant threat to the economy, necessitating strict measures to control and prevent its spread, particularly due to its high morbidity and mortality rates, especially in young faunae. It is one of the most contagious diseases as it is transmitted directly or indirectly from a diseased fauna to a healthy one through contact with resources contaminated with the virus, such as …

Development Of Self-Assembled Polymeric Polyplexes For Microrna Delivery: Toward Treatment Of Alcohol-Associated Liver Disease, Marjina Akter Kalpana

Theses & Dissertations

Self-assembled polymeric polyplexes have the potential to serve as an RNA interference (RNAi) delivery platform for the combined inhibition of CXCR4 and miR-155 in the treatment of alcohol-associated liver disease (AALD). A central challenge in RNA delivery is balancing the extracellular stability of polyplexes, cellular uptake, and intracellular release of RNA cargo. We developed polymeric polyplexes using the CXCR4-antagonist polymer PAMD, designed to target CXCR4 on activated hepatic stellate cells (HSCs) and deliver therapeutic miRNA to activated Kupffer cells (KCs) in fibrotic liver. We improved the polyplexes by cholesterol modification of PAMD and by PEGylation of PAMD-Ch. The cholesterol modification …

Development And Characterization Of Non-Viral Delivery Systems For Pulmonary Delivery Of Nucleic Acid Therapeutics, Kasturi Siddhanta

Theses & Dissertations

The development of non-viral delivery systems for pulmonary delivery of nucleic acid therapeutics is driven by the need for safer and more accessible approaches to treat lung diseases, while avoiding the systemic side effects and immune responses associated with viral vectors. Such systems encompass both non-invasive inhalation-based platforms, and systemically administered platforms designed to achieve localized lung delivery. These strategies aim to enable high drug concentrations at the site of action, rapid onset of therapeutic effect, and greater therapeutic efficacy than existing treatments. Designing effective pulmonary delivery systems requires precise optimization of particle properties—including size, morphology, surface characteristics, cell-specific targeting, …

Public Perception About Covid-19 Vaccine Hesitancy In South Central Nebraska, Rita Nnenne Oparaocha

Biology Theses, Dissertations, and Student Creative Activity

The COVID-19 pandemic created a shift in the trajectory of vaccination hesitancy, altering risk perceptions and vaccination attitudes among individuals in rural communities. The 5C framework highlights confidence, complacency, constraints, calculation, and collective responsibility as influencing factors of vaccine hesitancy. This study assessed the proportion of adults who refused COVID-19 vaccination and identified the individual reasons for hesitancy among those who refused the COVID -19 vaccines in South Central Nebraska. Data was analyzed from a local cross-sectional public health survey administered to 2,034 adult participants over a six-month period (March-August 2024), including 91 respondents who were from outside the seven-county …

Assessment Of Polymeric Chloroquine Formulations For Targeted Therapy Of Ulcerative Colitis And Metastatic Colorectal Cancer, Neha Kumari

Theses & Dissertations

Effective targeted drug delivery is a critical unmet need in the management of both ulcerative colitis and metastatic colorectal cancer, where conventional systemic therapies may be hindered by suboptimal efficacy and significant side effects. This thesis explores the development and preclinical assessment of polymeric chloroquine (PCQ)-based nanotherapeutics, leveraging stimuli-responsive designs for disease-specific delivery and action.

For ulcerative colitis, a reactive oxygen species (ROS)-responsive nanogel system was engineered to release PCQ, a macromolecular derivative of hydroxychloroquine, specifically in the inflamed areas within the colon. Nanogels with well-defined size and positive surface charge were synthesized via reversible fragmentation chain transfer (RAFT) polymerization …

Abc Pharmaceutical Company Change Model: Implementing J.P. Kotter's 8-Step And Adkar Change Models For Ethical Alignment, Shelbi B. Chandler, Amalfi Gayosso, Alison Lawton, Ali Holness-Roland

The Scholarship Without Borders Journal

In this paper, we use the pseudonym ABC Pharmaceuticals (ABC) to refer to the company under examination, GlaxoSmithKline (GSK). ABC Pharmaceutical (ABC) must assess, adapt, and change to ensure regulatory compliance, maintain and attract employees, and remain competitive. ABC has a history of erroneous practices and is at risk internally with employees, and externally with regulators and the public sectors. The authors applied J.P. Kotter’s (1996) 8-step and the ADKAR (Hiatt, 2006) models for change management. J.P. Kotter’s top-down model addresses leadership’s role in creating a compelling vision aligned with its actions, and the ADKAR bottom-up model assesses employees’ readiness …

Exploring Therapeutic Frontiers: The Beep Regimen In Breast And Brain Metastases, Destiny Carroll

Student Scholar Symposium

No abstract provided.

Examining The Influence Of Mapped Bloom's Taxonomy Items On The Student Pharmacist Experience, Annaston Young

Student Scholar Symposium

Objective: To evaluate the impact of transparent Bloom’s Taxonomy (BT) item mapping on the student experience.

Methods: First-year student pharmacists were oriented to BT twice during their first semester. Using a quasi-experimental research design, a point-of-care testing (POCT) active learning exercise and related low-stakes assessment were identified for the intervention. Following the active learning, a five-question “exit ticket” on Google Forms was randomly distributed based on QR codes: Group 1 (n=20) had no BT item mapping and Group 2 (n=20) had BT labels for each item. Performance, confidence, and experience evaluation were captured on each exit ticket. Descriptive statistics were …

Quantum Rings Simulations Of Cisplatin, Clinton Hutchins, Laci Walmer

Student Scholar Symposium

Cisplatin is a major chemotherapy drug that relies on a platinum-based core to deliver the properties necessary to combat cancer. This platinum-based core creates an undesired toxicity that poses challenges during treatment. The aim of this research is to employ quantum simulations to explore the stability of biochemicals such as cisplatin and predict their binding affinities for targets of interest. Variational Quantum Eigensolver (VQE) simulations are used to explore if the substitution of a core like Au or Pd are possible to retain anticancer efficacy but reduce its toxicity. With the use of these quantum simulations, we can run different …

Spilling The Tea: Effects Of Uv Disinfection On Bioactive Compounds In South African Rooibos Tea, Sora Ghanem, Leah Ankiah, Yusra Ahmed

Student Scholar Symposium

This study investigated the effects of ultraviolet (UV) light disinfection on key bioactive flavonoid compounds in rooibos tea (Aspalathus linearis). There is an interest in non-thermal food preservation technologies, and UV treatment offers potential advantages for beverage processing. However, concerns exist regarding possible degradation of health-promoting compounds during treatment. Rooibos tea samples were subjected to five UV exposure intensities (0, 25, 50, 75, and 100 mJ/cm²), and concentrations of four major flavonoids (aspalathin, orientin, vitexin, and rutin) were measured using high performance liquid chromatography (HPLC). Surprisingly, most flavonoids showed stability or slight concentration increases at higher UV doses. Aspalathin concentrations …

Developing Nlp-Based Open-Source Tools To Improve Titratable Infusion Order Interpretation In Ehr Systems, Benjamin Brewer, Jay Dorris

Student Scholar Symposium

This study evaluates the feasibility of using natural language processing (NLP) tools to identify errors in titratable infusion orders for Joint Commission readiness. Titratable infusions are adjusted at the bedside by nurses based on predefined parameters, such as monitoring goals, titration rate, conditions for adjustment, and maximum dose. These parameters are often documented as free text within order sets but can be inadvertently removed during the verification process. Some electronic health records (EHRs) may not prominently display this critical information, leading to potential Joint Commission violations. A synthetic dataset was generated using artificial intelligence to simulate one year’s worth of …

Investigation Of Aldehyde Oxidase Inhibition By Clopidogrel And Its Thiol Metabolite, Rachel Crouch, Merna Kamal, Hilina Woldeamanuel

Student Scholar Symposium

Aldehyde oxidase (AO) is an enzyme that metabolizes drugs containing aromatic azaheterocycles. Small thiol-containing molecules have been reported to inactivate AO. Clopidogrel is an antiplatelet agent used to treat cardiovascular diseases. Clopidogrel is a prodrug that is bioactivated in vivo by cytochrome P450 enzymes CYP3A4 and CYP2C19 into a thiol metabolite. Our research aims to explore whether the clopidogrel thiol metabolite can inhibit AO, leading to potential drug-drug interactions when co-administered with other drugs that are metabolized by AO. In order to determine whether the prodrug clopidogrel and/or its thiol metabolite inhibit AO, O6-benzylguanine (AO substrate) was incubated with human …

Have You Had Your Vitamins Today? An Lc-Ms/Ms Method To Simultaneously Measure B Vitamins In Plasma From Study Participants In A “Greens” Nutritional Supplement Clinical Trial., Katelyn Covington, Joanna Cravens, Matthew Vergne, Scott Akers

Student Scholar Symposium

Objectives: This study assessed the absorption of key vitamins and other nutrients from amulti- ingredient “greens” nutritional supplement using a newly developed LC-MS/MS method capable of analyzing B vitamins in a single run.

Methods: We conducted a randomized, double-blind, placebo-controlled crossover trial with a number of healthy participants to measure plasma nutrient appearance over 8 hours after supplement consumption. Participants consumed either the nutritional supplement (13g) or placebo after a 10-hour fast, with treatments separated by a one-week. Serial blood samples were collected pre-consumption and at specified intervals post-ingestion. Our novel LC-MS/MS method simultaneously quantified biotin, nicotinamide, pyridoxine, riboflavin, and …

Impact Of An Educational Intervention On Pharmacy Students’ Knowledge, Attitudes, And Confidence Regarding Alcohol And Substance Use Disorders, Lina Itenberg

Student Scholar Symposium

This study examines the impact of an educational intervention on student pharmacists’ knowledge, attitudes, and confidence regarding alcohol and substance use disorders (AUD/SUD) at Lipscomb University College of Pharmacy. Current literature denotes that student pharmacists often feel unprepared to address substance use disorder in practice. This study evaluates whether a targeted educational intervention can enhance student understanding of first-line pharmacological treatments, increase confidence in handling opioid-related emergencies, and improve their ability to educate patients on harm reduction strategies, including naloxone use and opioid overdose risks. Pre- and post-intervention surveys will assess changes in students’ preparedness and identify ongoing concerns about …

Assessment Of The Melt Quality Of A 30% Scrap Adc12 Aluminium Alloy Using The Inclusion And Fluidity Measurement Instrument (Ifmi) With Mullite Ceramic Filters, Gusti Ruri Ruri Lestari, Sandya Ananda Riswan, Muhammad Anis, Ahmad Ashari, Paramita Vidya Ayuningtyas, Bambang Suharno Prof, Donanta Dhaneswara

Journal of Materials Exploration and Findings

The increasing demand for sustainable practices in the metal casting industry has driven the use of recycled aluminum alloys such as ADC12. However, the addition of aluminum scrap tends to increase oxide inclusions, which reduce melt fluidity and compromise casting quality. This study utilizes the Inclusion and Fluidity Measurement Instrument (IFMI), equipped with mullite ceramic filters, to assess the melt quality of ADC12 aluminum alloy containing 30% scrap. Fluidity and inclusion characteristics were evaluated at five pouring temperatures (660°C, 680°C, 700°C, 720°C, and 740°C). The results show that fluidity increased with temperature, reaching a peak of 84.6 g·s⁻¹ at 740°C, …

Equipment Criticality Analysis To Determine Asset Integrity Management System Scheme In Supporting Production Optimization Scenarios In The Aeging Field, Donny Andryanto, Donanta Dhaneswara

Journal of Materials Exploration and Findings

This research investigates the production decline and cost increase in the X&Y oil and gas fields from 2022 to 2023. Production fell by 34%, while production costs per barrel rose by 79%. To address these issues, a series of optimization processes are proposed. These aim to restructure and enhance the production facilities to reduce current production costs. The optimizations include reducing pressure at the PPP Platform in 2024. Additional steps include shutting down CPP-ORF 14” pipelines and most processes at CPP 2 Platform by 2027 to convert it into an accommodation platform. Further, the plan involves optimizing the release of …

Morphological Test Of Areca Nut Fiber Ceramic Membrane Using Scanning Electron Microscopy Energy Dispersive X-Ray Mapping Spectroscopy, Amelia Marzain, Siti Umi Kalsum, Marhadi Marhadi, Ahmad Nabil Shahab

Journal of Materials Exploration and Findings

This study investigates the potential of ceramic membranes derived from areca nut fiber as a cost-effective and environmentally sustainable material for the removal of iron (Fe) and manganese (Mn) from groundwater. Two types of membranes were fabricated: one without activation and one chemically activated using 10% sodium hydroxide (NaOH). The morphological and elemental characteristics of both membranes were analyzed using Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray (EDX) mapping. The concentrations of Fe and Mn before and after treatment were measured using Atomic Absorption Spectroscopy (AAS). The NaOH-activated membrane exhibited a more porous surface structure and higher oxygen content, …

Cv: Maria Josefina Natividad (Medical Assistant, Pharmacy Technician), Maria Josefina Natividad

Rehabilitation and Health Sciences Department Faculty Curricula Vitae

No abstract provided.

Cv: Maria Josefina Natividad (Medical Assistant, Pharmacy Technican), Maria Josefina Natividad

Health Sciences Department Curricula Vitae

No abstract provided.

Analysis Of Leakage In Nearshore Pipelines Using Fitness For Service Method To Ensure Mechanical Integrity Based On Api-579 Level 3, Elriandri Elriandri, Dedi Priadi

Journal of Materials Exploration and Findings

The Fitness for Service (FFS) analysis is performed as a quantitative assessment to evaluate the integrity condition of a pipeline. Essentially, FFS assessment helps determine whether equipment components can operate safely despite existing deficiencies. This evaluation is carried out using the Finite Element Method (FEM). In the case of an underwater pipeline that experiences leak due to anchor pull at the flange connection, it undergoes plastic deformation and is lifted approximately 1 meter. As a mitigation step, inspection and repairs have been carried out by the company. Subsequently, modeling is performed to reconstruct the deformation process of the pipeline. Then, …

Exploring The Prevalence And Determinants Of Self-Medication During Pregnancy Among Women From South Punjab, Pakistan, Madiha Madiha, Sehar Jabbar, Imran Masood

Makara Journal of Health Research

Background: For developing countries with high neonatal and maternal mortality rates, any practice that may threaten the maternal-fetal health must be gauged. This study evaluated the prevalence and contributing factors of self-medication during pregnancy among women opting for antenatal or postnatal care in South Punjab, Pakistan.

Methods: A cross-sectional study design was used. Data was collected from 424 women, selected through multi-stage sampling, who visited health care facilities located in six randomly selected cities of South Punjab. Outcomes reported by descriptive and inferential statistics (p < 0.05). Binary logistic regression analysis was performed to determine the association of self-medication with different factors.

Results: Most of the women were involved in self-medication practice (38.9%) …

Oral Ketamine For Treatment Resistant Depression: A Literature Review, Maeve Buni, Alanna Eisenbeiser

Physician Assistant Capstones, 2020-current

Objective: Assess the efficacy and safety of oral ketamine as alternative therapy for those with treatment resistant depression (TRD). Design: Literature review. Methods: On November 14, 2024, a search was done in Pubmed and James Madison University’s EBSCO Psychology and Behavioral Sciences Collection for the terms “ketamine” and “treatment resistant depression,” excluding parenteral routes of administration and including only randomized controlled trials in adults published in 2018-2024. Results: Three randomized controlled trials that utilized evidence-based surveys to assess antidepressant effects were analyzed. Conclusion: The antidepressant effects of oral ketamine found in these RCTs were somewhat mixed. Oral ketamine did appear …

From Incomplete To Impactful—Finalizing Unfinished Nursing Projects In Nart And Polypharmacy For Lasting Improvement, Paula Thanh Nhat Pham, Armine Lianna Chamichyan, Anastasia Yerofeyeva, Stelene Alexis Tragus

Master's Projects and Capstones

This quality improvement project addressed the problem of incomplete or unsustained clinical initiatives at a long-term care facility by introducing Kotter’s Change Model, an evidence-based framework designed to support and sustain lasting improvements in clinical practice. Within the context of a religious-based residential community for older adults with complex chronic needs, the objective was to strengthen the facility’s capacity to implement and sustain change more effectively. By using two previously unfinished initiatives, the NaRT triage tool and Polypharmacy management process, the project applied Kotter’s model to evaluate how structured change strategies can improve staff engagement, leadership alignment, and long-term project …

In-Silico Test Of Myricetin, Phyllanthin, Luteolin Compounds Against Sars-Cov-2 Proteins, Vidia Noviyanti, Nuha Haifa Arifin, Hayu Ikfini, Rifki Febriansah

Pharmaceutical Sciences and Research

Coronavirus disease 2019 (COVID-19), which emerged in late 2019 and was first detected in Indonesia in March 2020, has significantly reshaped the country’s public health landscape. Aside from the viral outbreak itself, a decline in immunity among the population due to excessive concern about the pandemic has also become a significant issue. This study aimed to evaluate the potential of myricetin, phyllanthin, and luteolin compounds as inhibitors of the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) virus by targeting the main protease and spike glycoprotein receptor-binding domain proteins through in silico molecular docking. Remdesivir and favipiravir were used as comparison …

Disrupting Cell Death: Ferroptosis And Pyroptosis Inhibition In Hepatic Ischemia-Reperfusion Injury Via Modulation Of Gpx4 And Cgas Pathways By Deferoxamine And Octreotide,, Rasha A. Tawfiq, Yasmeen Attia, Hameis M. Sleem, Mai Ghoneim Dr.

Pharmacy

Hepatic ischemia-reperfusion injury (HIRI) is a significant complication of liver transplantation, often precipitating postoperative liver dysfunction/failure. Given the rising global prevalence of end-stage liver disease, which necessitates liver transplantation, protecting against HIRI is crucial. Here, we investigated the effects of octreotide (OCT), a pyroptosis inhibitor, and deferoxamine (DEF), a ferroptosis suppressor, individually and combined in the HIRI model. Their impact on cyclic GMP-AMP synthase/stimulator-of-interferon (cGAS/STING) genes and glutathione peroxidase 4 (GPX4) activity was explored. Male rats (n = 4–5) were subjected to 30 min ischemia followed by 3 h reperfusion and treated with OCT (75 μg/kg; 30 μg/kg, i.p. & …

Effect Of Various Lactobacillus Probiotic Strains On Oral Antihypertensive Drug Response: A Systematic Review, Khoirunnisa Ramadhani, Keri Lestari

Pharmacology and Clinical Pharmacy Research

Hypertension is a major risk factor for cardiovascular disease, and the effectiveness of antihypertensive therapy can be influenced by metabolic and systemic inflammatory factors associated with gut microbiota conditions. Probiotic strains from the genus Lactobacillus have been reported to modulate antihypertensive effects through complex biological mechanisms. This article evaluates experimental evidence from seven in vivo studies on the influence of Lactobacillus strains on the response to antihypertensive drugs, including pharmacodynamic mechanisms and drug–probiotic interactions. The combination of Lactiplantibacillus plantarum with amlodipine enhanced nitric oxide production, increased eNOS expression, reduced IL-6 levels, and improved drug bioavailability, leading to greater blood pressure …

Optimization Of Guava Leaf Extract Cream Formulation Through Variations Of Xanthan Gum And Stearic Acid For Wound Cure In Rats, Ayudia Cipta Khairani, Mia Ariasti

Pharmacology and Clinical Pharmacy Research

Cuts are among the most common skin injuries caused by sharp objects and can lead to infection if not properly treated. Natural ingredients such as guava leaves have been widely investigated for their wound-healing potential. Guava leaves contain bioactive compounds including flavonoids, saponins, alkaloids, and tannins, which contribute to anti-inflammatory, antibacterial, and tissue regeneration processes. This study aimed to formulate and evaluate the physical properties and wound-healing effectiveness of guava leaf ethanol extract cream with varying concentrations of xanthan gum and stearic acid as emulsifiers. The extract was obtained by maceration using 70% ethanol and formulated into four cream formulas …