Pharmacy and Pharmaceutical Sciences Commons^™

Sharksrx Newsletter Fall 2025, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Emergency Medicine Pharmacist Prescriptive Authority For Resolution Of Outpatient Prescription Issues, Kevin Burnham, Christina Tran, Leandra Garcia, Julian Mccreary, Christo Philip, Osama A. Shoair

Pharmacy Faculty Publications and Presentations

Objectives: To describe the implementation and impact of a collaborative practice agreement (CPA) for emergency medicine pharmacists (EMPs) that grants them broad prescriptive authority to resolve outpatient discharge prescription issues independently. Methods: We conducted a retrospective chart review of all prescriptions written by EMPs under a CPA to resolve discharge prescription issues at a 70-bed emergency department (ED) within a large health system in South Dallas, Texas. This review covered the period from November 1, 2021, to June 30, 2023. EMPs were authorized to independently address prescription problems without a provider’s direct involvement. We collected data on patient demographics, the …

Pacific Rxtracts - October 2025, Pacific Rxtracts

Pacific RxTracts

Articles:

• The Resurgence of Cardiac Glycosides in Heart Failure
• Wayrilz: New Breakthrough for Persistent or Chronic Immune Thrombocytopenia
• Atrasentan: An Emerging Therapy in IgA Nephropathy
• The Second FDA-Approved MASH Treatment
• New Pharmacist-Driven Calcitonin Protocol Delivers Cost Savings in Hypercalcemia of Malignancy Care
• Baxdrostat Offers Hope for Patients with Resistant Hypertension
• Challenging the Norm: Anticoagulant Discontinuation is Safe Postablation
• Olezarsen: Redefining Triglyceride Control Through APOC3 Inhibition
• Semaglutide and Tirzepatide Linked to Increased Risk of Vision Disorders
• At Last, a Step Forward in Gastric and GEJ
• Tarlatamab: A Breakthrough in Relapsed Small Cell Lung
• Expanded FDA Approval for Darolutamide
• Linvoseltamab: Redefining Multiple …

Adipose Tissue Estrogen Receptor-Alpha Overexpression Ameliorates High-Fat Diet–Induced Adipose Tissue Inflammation, Marion C. Hope, Christian A. Unger, M Chase Kettering, Cassidy E. Socia, Ahmed K. Aladhami, Barton C. Rice, Darya S. Niamira, Ben P. Wiznitzer, Diego Altomare Ph.D., William E. Cotham, Reilly T. Enos

Faculty Publications

Context

We created an innovative mouse model that enables inducible overexpression of estrogen receptor-alpha (ERα), specifically in adipose tissue (Adipo-ERα↑). Objective

We aimed to investigate how elevated Adipo-ERα↑ influences the development of high-fat diet (HFD)-induced obesity in both male and female mice. Methods

Male and female Adipo-ERα↑ mice and littermate controls were fed a low-fat diet (LFD) or HFD for 13 weeks. Adipo-ERα↑ was induced at the initiation of dietary treatment. Body morphology and composition, hepatic lipid accumulation, glucose tolerance, fasting insulin concentrations, and adipose tissue mRNA profiling were assessed. Liquid chromatography–mass spectrometry was used to determine circulating and adipose …

October 2025, Swosu Rural Health Center

RURAL ROCKS

• SWOSU Doctor in Community Health (DCH)

• Hospitals with highest price markups for elective surgeries have worse outcomes, researchers find

• HHS Final Rule Expands Real-Time Prescription Access, Eases Prior Authorization Burdens

• Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository Evidence Base

• Retail pharmacy is adapting to meet local needs

• IZ Express Sept 24, 2025

Development Of A Strategy To Neutralize Ccl8 Activity And Ablate Ccl8 Cellular Targets, Bernardo Chavez

Theses and Dissertations

The chemokine CCL8 (monocyte chemoattractant protein-2) is a versatile signaling molecule involved in tumor progression, immune cell recruitment, and therapeutic resistance. Through activation of receptors including CCR1, CCR2B, and CCR5, CCL8 promotes leukocyte trafficking, epithelial–mesenchymal transition, and the establishment of immunosuppressive tumor microenvironments. In breast cancer and inflammatory diseases, elevated CCL8 levels correlate with poor clinical outcomes, making it a promising therapeutic target.

A strategy was developed to block CCL8 activity and selectively ablate CCL8 receptor expressing cells. A neutralizing monoclonal antibody, 1G3E5, was identified from a panel of murine candidates based on high affinity CCL8 binding. Sequencing revealed two …

Predictive Gene Expression Signatures For Alzheimer's Disease Using Post-Mortem Brain Tissue, Ashley Duche, Oliver Tan, Andrius Baskys, Rachita K. Sumbria, Moom R. Roosan

Pharmacy Faculty Articles and Research

Background: Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques and tau protein aggregates in the brain. These pathological features manifest in specific regions, but mechanisms rendering some areas more susceptible to early AD-related changes remain poorly understood. To address this, we developed predictive gene expression signatures to explore molecular mechanisms underlying regional vulnerability to AD pathology.

Methods: Post-mortem brain tissues from participants of the Religious Orders Study and Memory and Aging Project (ROSMAP), Mayo Clinic, and Mount Sinai Brain Bank (MSBB) were used to derive gene expression signatures from six brain regions affected at varying …

Ready For Takeoff? Exploring United States Health Care Providers’ Pretravel Consultation Priorities, Gaps, Barriers, And Opportunities, Katherine A. Reifler, Swati S. Sharma, Nicholas A. Bergren, Elizabeth D. Barnett, Lin H. Chen, Jeffery A. Goad, William B. Macleod, Laura Kogelman, Davidson H. Hamer

Pharmacy Faculty Articles and Research

Pretravel consultation by healthcare providers (HCPs) with travel medicine expertise can mitigate travel-related health risks. This analysis aimed to understand US-based HCPs' pretravel consultation educational gaps, priorities, barriers, and opportunities. An electronic survey was conducted May–June 2024, using a convenience sample of HCPs identified through the Med Learning Group and travel specialists from the International Society of Travel Medicine and American Society of Tropical Medicine and Hygiene. In total, 205 HCPs completed the survey, including physicians (50 %), nurse practitioners (19 %), nurses (12 %), pharmacists (11 %), physician associates (7 %). Most (66 %) provided pretravel consultations and only …

Swollen Lymph Node Metastasis In Gastric Cancer: A Forgotten Prognostic Signal In Need Of Clinical Action, Keykavous Parang, Amir Nasrolahi Shirazi

Pharmacy Faculty Articles and Research

Gastric cancer (GC) remains a leading cause of cancer mortality. While the extent of nodal involvement is a well-known prognostic factor, the specific entity of swollen lymph node metastasis (SLNM), bulky nodal tumor deposits detectable radiologically or pathologically, has received little attention in staging. Recent data from a study by Cui et al demonstrated that SLNM is an independent predictor of very poor survival in GC. Through robust data and rigorous propensity-matched analyses, SLNM emerged not merely as an anatomical finding but as an independent predictor of poor prognosis, even among patients undergoing curative resection. As precision oncology advances, the …

Inflammation And Detection: Rethinking The Biomarker Landscape In Gastric Cancer, Keykavous Parang, Koosha Paydary

Pharmacy Faculty Articles and Research

Gastric carcinoma is a leading cause of cancer-related mortality worldwide, yet reliable noninvasive biomarkers for its early detection remain limited. As research continues to elucidate the inflammatory underpinnings of tumor initiation and progression, it has become increasingly clear that pro-inflammatory cytokines may hold promise as diagnostic adjuncts. Serum cytokines such as interleukin (IL)-1β, IL-6, IL-8, and interferon-gamma have been frequently reported as elevated in gastric cancer patients compared to healthy individuals. These molecules, known for their roles in modulating tumor-promoting inflammation, angiogenesis, and immune evasion, may serve as accessible indicators of disease presence or progression. Several studies have shown that …

Enflonsia (Clesrovimab-Cfor): A New Era In Rsv Protection For Infants, Katherine Ghattas Pharmd, Rileigh Smith Pharmd, Amanda Rawa Pharmd

Transformative Medicine

Respiratory Syncytial Virus (RSV) is a leading cause of serious lung infections in infants and young children, especially during the winter months. For decades, preventative options were limited, costly, or only available to babies at high-risk. The FDA approved Enflonsia (clesrovimab-cfor) in June 2025, given as a single injection to protect infants thorough their first RSV season. Since it is designed for broader infant use and can be distributed through programs such as Vaccines for Children, Enflonsia may help close long-standing gaps in RSV prevention.

Confronting The Mental Health Crisis: Structural Inequities, Market Pressures, And The Role Of Pharmacy Solutions, Kasi Gorli, Thomas L. Pile, Craig Kimble, Alberto Coustasse

Management Faculty Research

The mental health crisis in the US is severe, with depression and anxiety leading causes of disability among young adults. The mental health services market is growing, but access to care remains inconsistent, particularly in rural and underserved areas. Pharmacists are playing a crucial role in mental health care, improving medication adherence and patient outcomes through collaborative practice agreements. Systemic reform is needed to address barriers such as affordability and social determinants, with pharmacists integral to closing care gaps.

Implementing A Specific And Standardized Grading Scale For Therapeutic Injection Site Reactions To Improve Adverse Event Reporting, Priya Kale, Kavita Sarin

Research Colloquium

Up to 15.5% of patients taking biologic medication experience injection site reactions (ISRs) leading to morbidity, early discontinuation, and reduced treatment compliance. As biologic medications are increasingly used to treat chronic inflammatory conditions, including psoriasis and atopic dermatitis, there needs to be an improved understanding of ISRs. However, current methods of grading ISRs are nonspecific and unstandardized leading to a lack of understanding of medication-specific ISRs and ambiguity in perceptions of treatment tolerability. Here we aim to develop a standardized ISR grading scale for use in clinical trials. A scoping review was performed to evaluate current ISR grading scales and …

Antiplatelet Effects Of Angelica Dahurica Root Extract Without Gastric Lesion Formation In Rats, Pitiphat Srisom, Kasem Rattanapinyopituk, Uthai Sotanaphun, Rataya Luechapudiporn

The Thai Journal of Pharmaceutical Sciences

Background: Platelet aggregation plays a crucial role in hemostasis; however, excessive platelet activation can lead to thrombus formation, contributing to cardiovascular diseases. While aspirin (acetylsalicylic acid [ASA]) is commonly used as an antiplatelet agent, its longterm use is associated with gastrointestinal side effects. Angelica dahurica (AD), a traditional herbal remedy, has shown in vitro antiplatelet activity and cyclooxygenase enzyme inhibition. However, its in vivo effects on platelet aggregation and gastric safety remain unclear.

Objectives: This study aimed to investigate whether Angelica dahurica root extract (ADE) could inhibit platelet aggregation and prevent aspirin-induced gastric lesions.

Materials and Methods: AD was extracted …

Quality By Design Approach To Method Development And Validation For Quantitative Estimation Of Dapagliflozin And Linagliptin In Pharmaceutical Tablet Dosage Forms, Prechha Shrestha, Ashwinee Kumar Shrestha, Rajan Shrestha, Barsha Thapa

The Thai Journal of Pharmaceutical Sciences

Objectives: The present study utilizes a quality by design approach to develop a simple, robust, and stability-indicating high-performance liquid chromatography method for quantifying dapagliflozin (DAPA) and linagliptin (LINA) in a fixed-dose combination and validate it according to the ICH-Q2 (R1) guidelines.

Materials and Methods: The effect of critical method parameters (CMPs), namely percentage of acetonitrile (ACN), pH of the buffer, and flow rate, on critical quality attributes (CQAs) such as retention time, area, tailing factor, and theoretical plates was studied using Box–Behnken design (BBD). Response optimizer was utilized to optimize the experimental conditions. The mobile phase (MP) consisted of ACN …

Continuous Glucose Monitoring Versus Self-Monitoring For Patients With Type 1 Diabetes: A Systematic Review And Meta-Analysis, Prayuth Poowaruttanawiwit, Kwanchai Rattanamanee, Nonnachanok Chaiyot, Saranpreeya Srisinroongruang

The Thai Journal of Pharmaceutical Sciences

Background: Patients with type 1 diabetes mellitus (T1DM) require intensive glucose monitoring to achieve optimal glycemic control and prevent complications. While self-monitoring of blood glucose (SMBG) has long been the standard approach, continuous glucose monitoring (CGM) offers real-time data and trend analysis that may enhance clinical decision-making.

Objective: This study aimed to evaluate whether CGM provides superior glycemic outcomes compared with SMBG in individuals with T1DM.

Materials and Methods: A systematic review and meta-analysis were conducted following preferred reporting items for systematic reviews and meta-analyses guidelines. Four randomized controlled trials involving T1DM patients using either CGM or SMBG were included. …

Screening And Evaluation Of Thai Herbal Plants As Multifunctional Agents For Targeting Amyloid Β Pathogenesis In Alzheimer's Disease, Ruedeemars Yubolphan, Suchinda Malaivijitnond, Sukanya Jaroenporn

The Thai Journal of Pharmaceutical Sciences

Background: Alzheimer's disease (AD) is a neurodegenerative disorder driven by complex pathophysiological processes. Current therapeutic strategies emphasize the development of multifunctional agents, particularly those derived from natural sources, to target multiple stages of the amyloid β (Aβ) cascade, a central contributor to AD pathology.

Objectives: This study aimed to investigate the anti-Aβ activity of nine Thai herbs and evaluate their potential as multifunctional agents for AD treatment.

Methods: Nine Thai herbs—Caesalpinia sappan (CS), Thunbergia laurifolia (TL), Rhinacanthus nasutus (RN), Tabernaemontana divaricata (TD), Cyperus rotundus (CR), Terminalia chebula (TC), Azadirachta indica (AI), Piper retrofractum (PR), and Asparagus racemosus (AR)—were screened …

Intelligent Pharmacy: Leveraging Ai And Automation To Enhance Patient Care And Pharmacist Roles, Craig Kimble, Alberto Coustasse, Kasi Gorli, Thomas L. Pile

Management Faculty Research

AI and automation in pharmacies enhance clinical care, operational efficiency, and workforce optimization, with widespread adoption in hospitals and retail chains. Key benefits include reduced medication errors, improved patient satisfaction, and increased pharmacist productivity, allowing focus on higher-value clinical roles. Challenges include high initial costs, cybersecurity concerns, and resistance to change, necessitating thoughtful planning and stakeholder engagement. Preparing pharmacy students for technology-driven environments is essential for successful AI integration and ethical oversight in pharmacy practice.

Editorial: Molecular Mechanisms Of Ion Channel Activation And Modulation, Meng Cui, Miao Zhang

Pharmacy Faculty Articles and Research

"Ion channels are integral membrane proteins that regulate the passage of ions across cell membranes, thereby shaping processes as diverse as neuronal signaling, muscle contraction, and hormone secretion. Channel activation is typically initiated by a stimulus such as voltage, ligand binding, or mechanical stress that induces conformational changes and opens the channel pore. Beyond activation, channels are subject to fine-tuned modulation by a wide range of endogenous and exogenous agents, from lipids and neurotransmitters to pharmacological drugs. Modulators can stabilize the open, closed, or inactivated states, shift ligand affinities, or alter gating kinetics. Dissecting the structural and dynamic basis of …

Clinical Pharmacokinetics, Pharmacodynamics, And Drug Interactions Of Remimazolam, Derek E. Murrell, Sam Harirforoosh

Pharmacy Faculty Articles and Research

Remimazolam, an ultrashort-acting benzodiazepine, has emerged as a promising sedative agent for procedural sedation and general anesthesia. It combines the favorable properties of traditional benzodiazepines with a rapid onset and offset of action, largely due to its unique metabolism via hepatic carboxylesterases rather than cytochrome P450 enzymes. This metabolism allows for predictable pharmacokinetics, reducing the risk of prolonged sedation and drug accumulation, particularly in patients with hepatic or renal impairment. Clinically, remimazolam demonstrates non-inferiority to midazolam and propofol, with advantages including a lower incidence of hypotension and respiratory depression. Multiple randomized controlled trials have shown its efficacy in various procedural …

Smart Dressings Accelerating Wound Healing With Tranexamic Acid-Infused Aligned Electrospun Nanofibers: In Vitro And In Vivo Assessments, Samar A. Salim, Abdullah Elbadry, Eman Gomaa, Mennatullah Faisal, Elbadawy A. Kamoun

Nanotechnology Research Centre

The development of advanced wound dressings capable of accelerating healing and achieving effective hemostasis remains a critical challenge in managing traumatic and surgical wounds. This study reports the fabrication and comprehensive evaluation of a novel multilayered, sandwich-structured nanofiber scaffold composed of Tranexamic acid (TXA), chitosan (CS), polyvinyl alcohol (PVA), L-arginine, and polylactic acid (PLA) for biodegradable wound dressing applications. Using sequential electrospinning, a four-layered scaffold was developed as a smart wound dressing, comprising an immediate-release TXA-CS-PVA layer for rapid clotting, a hydrophobic PLA barrier layer for protection, a sustained-release L-arginine-PVA layer to promote tissue regeneration, and a final PLA protective …

[Pdf] From Usf.Edu Nanoparticles And Nanogel Drug Compositions For Treatment Of Age-Related Macular Degeneration, Vijaykumar Bhadabhai Sutariya, Priyanka Bhatt, Vipul B. Amin, Srinivas M. Tipparaju

Pharmacy Faculty/Staff Publications

Disclosed are nanoparticles and nanogel drug compositions and the use thereof for treating age-related macular degeneration.

Air Pollution And Diseases: Signaling, G Protein-Coupled And Toll Like Receptors, Isabella Cattani-Cavalieri, Katrina F. Ostrom, Jordyn Margolis, Rennolds S. Ostrom, Martina Schmidt

Pharmacy Faculty Articles and Research

Air pollution is a significant public health issue that impacts lung health, particularly in vulnerable populations such as children, the elderly, and individuals with pre-existing respiratory conditions. Both natural and anthropogenic sources of air pollution give rise to a variety of toxic compounds, including particulate matter (PM), ozone (O₃), sulfur dioxide (SO₂), nitrogen dioxide (NO₂), carbon monoxide (CO), and polycyclic aromatic hydrocarbons (PAHs). Exposure to these pollutants is strongly associated with the development and exacerbation of respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), lung cancer, and idiopathic pulmonary fibrosis (IPF). Notably, early life exposure to pollutants such as …

Pharmacy Newsletter : September 2025, Pharmacy Department

Department of Pharmacy Archives

• Pharmacy Newsletter provides information regarding the decisions of P&TC, current concepts in drug therapy, warnings and cautions issued by various regulatory agencies, drug interactions, ADRs, and matters related to drug usage.
• AKUH Clinical Pharmacy Accolades
• Beyond Weight Loss: GLP-1 Receptor Agonists as a Cardiometabolic Paradigm Shift in Type 2 Diabetes
• Key Insights | Drug & Poison Information Center
• Carbamazepine Intoxication Management
• TOX TOK: General Treatment Approach To Unknown Poisoning - Coma Cocktail
• Pharmacy & Therapeutics Committee: Ensuring Safe & Effective Medication Use! Progress & Reports
• Dexamethasone Induced Psychosis: Exploring Steroid Impact on Mental Health
• ASHP Residency Program: Leading Pharmacy Training …

September 2025, Swosu Rural Health Center

RURAL ROCKS

• The 5 biggest challenges facing retail pharmacy
• FDA Launches Green List to Protect Americans from Illegal Imported GLP-1 Drug Ingredients
• From Dispensing to Decision-Making: How Pharmacists Are Redefining Leadership in Oncology Care
• Check out our virtual tour video of the Hodge Center

Recent Updates On Orally Disintegrating Films Regarding Design, Characterization, And Assessment, Asmaa Abdelaziz Mohamed, Firas Aziz Rahi

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Orally disintegrating films (ODFs) are a pharmaceutical dosage form that liquefies or disintegrates rapidly in the mouth without water, creating an attractive option for patients with difficulty swallowing. ODFs offer several advantages, including convenience, a faster onset of action, and enhanced patient compliance.The formulation of ODFs involves selecting suitable film-forming polymers, plasticizers, active pharmaceutical ingredients (APIs), and other excipients. Factors such as taste-masking, stability, and disintegration time are critical considerations in formulating ODFs. Characterization of Orally Disintegrating Films Characterization techniques such as thickness measurement, tensile strength testing, disintegration time determination, and surface morphology analysis are essential for assessing the physical …

Gc-Ms Analysis Of Bioactive Constituents From The Leaves Of Portulaca Afra Jacq. And Portulaca Grandiflora Hook, Sadeq S.K.Al-Taie, Noor F.M. Al-Kenane, Zaidon T. Al-Aqbi

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Portulaca afra and Portulaca grandiflora are traditional medicinal that grow as ornamental plants in Iraq. The present study was conducted for GC-MS analysis of the leaves of these plants to identify possible bioactive compounds. Seventy-nine compounds were recorded in the methanolic extract in Portulaca afra and ninety-two in Portulaca grandiflora. A literature survey revealed that some compounds 4-Vinylphenol, gamma-Sitosterol, Neophytadiene, n-Hexadecanoic acid, Octadecanoic acid, Phytol, Stigmasterol and Tetradecanoic acid possess a variety of biological qualities, including antioxidant, anti-inflammatory, anti-fungal, and anti-cancer effects.

Can Coffee Combat Fatty Liver? A Review Of Emerging Evidence, Mohamed E. Abd El-Hack, Muhammad Arif, Vincenzo Tufarelli, Ayman A. Swelum

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

NAFLD (Non-alcoholic fatty liver disease) is an increasingly spread metabolic status characterized by increasing fat accumulation in the liver, obesity closely associated with it, sedentary habits and insulin resistance. Since there is currently no recognized pharmaceutical treatment, lifestyle changes continue to be the mainstay of treatment. Coffee, a globally consumed beverage rich in bioactive and useful compounds like caffeine, cafestol, kahweol, and chlorogenic acids, has emerged as a potential hepatoprotective agent. Evidence from epidemiological experiments, animal studies, and human trials suggests that regular coffee drinking may help decrease hepatic fat levels, improve antioxidant defenses, prevent inflammatory pathways, and prevent or …

In Silico Evaluation Of Nigella Sativa Phytocompounds As Potential Modulators Of Estrogen Receptor Alpha: A Molecular Docking And Admet Study, Murtala Muhammad Jibril, Samuel Otokpa Ede, Ekwere O. Ekwere

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background: Reproductive dysfunction among women remains a pressing global health issue, often linked to hormonal imbalances involving estrogen receptor alpha (ERα). Nigella sativa has garnered scientific interest due to its diverse phytochemical composition and potential reproductive health benefits. Objective: This study aimed to evaluate selected bioactive compounds from Nigella sativa oil as potential modulators of ERα using advanced computational methods. Methods: A structure-based drug discovery approach was employed. Ten phytocompounds were identified through literature mining and subjected to molecular docking against ERα. Clomiphene citrate, a known selective estrogen receptor modulator (SERM), served as the reference ligand. Binding affinities were analyzed, …

Quality Of Life Among Type Ii Diabetes Mellitus Patients, Duaa Dhia Hameed Al-Baghdadi, Rajha Abdul Hassan Hamza

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background: Type 2 diabetes mellitus (T2DM) is a significant public health concern Approximately 90% of people with diabetes worldwide have diabetes mellitus type 2. Methods: A cross-sectional study was conducted from October 23, 2023, to March 2, 2025, in Al-Najaf Al-Ashraf City to assess the quality of life among individuals with T2DM. A non-probability sampling technique (purposive sampling) was used to select 167 T2DM patients. Data were collected through a questionnaire, which consisted of three parts: Part I covered sociodemographic information, Part II focused on clinical data, and Part III addressed the quality of life among T2DM patients by using …