Pharmacy and Pharmaceutical Sciences Commons^™

Effectiveness Of Empiric Carbapenem Versus Non-Carbapenem Therapy For Extended-Spectrum Β-Lactamase Producing Enterobacterales Infections In Non-Intensive Care Unit Patients: A Real-World Investigation In A Hospital With High-Prevalence Of Extended-Spectrum Β-Lactamase Producing Enterobacterales, Amy Y. Kang, Mary Elkomos, Danny Pham, Michelle Guerrero, Deborah Kupferwasser, Loren G. Miller

Pharmacy Faculty Articles and Research

Objective:

To investigate whether empiric carbapenem therapy, compared to empiric non-carbapenem therapy, was associated with improved clinical outcomes among hospitalized, non-intensive care unit (ICU) patients with extended-spectrum β-lactamase (ESBL)-producing Enterobacterales infections.

Methods:

We performed a retrospective cohort study of adult, non-ICU patients admitted with ESBL-producing Enterobacterales infections. Primary outcome was time to clinical stability from the first empiric antibiotic dose. Secondary outcomes were early clinical response and 30-day all-cause hospital readmission. We used multivariate regression methods to examine time to clinical stability.

Results:

Of the 142 patients, 59 (42%) received empiric carbapenems and 83 (58%) received empiric …

Kratom Safety And Toxicology In The Public Health Context: Research Needs To Better Inform Regulation, Jack E. Henningfield, Oliver Grundmann, Marilyn A. Huestis, Kirsten E. Smith

Institute of Emerging Health Professions Faculty Papers

Although kratom use has been part of life for centuries in Southeast Asia, the availability and use of kratom in the United States (US) increased substantially since the early 2000s when there was little information on kratom pharmacology, use patterns, and effects, all critical to guiding regulation and policy. Here we provide a synthesis of research with several hundred English-language papers published in the past 5 years drawing from basic research, epidemiological and surveillance data, and recent clinical research. This review of available literature aims to provide an integrated update regarding our current understanding of kratom's benefits, risks, pharmacology, and …

Evaluation Of Sphingolipid Biosynthetic Inhibitor L-Cycloserine To Prevent Retinal Degeneration, Faiza Tahia

Alternative Theses and Dissertations (AETDs)

Retinal degenerative diseases, affecting millions worldwide, are caused by irreversible photoreceptor cell death. These conditions lead to irreversible vision loss or blindness, presenting significant economic challenges. Retinal degenerative diseases result from a complex interplay of genetic and environmental factors, such as light exposure and oxidative stress. Effective treatments are currently limited, which underscores the urgent need for comprehensive solutions. Ceramide, a bioactive sphingolipid, has emerged as a pivotal mediator in the apoptotic cascade associated with retinal degeneration, presenting a promising target for therapeutic intervention. This research explores the therapeutic potential of L-Cycloserine, a small molecule inhibitor of de novo ceramide …

Targeting Trpc3: A Promising Therapeutic Strategy For Alzheimer's Disease, Jiaxing Wang

Alternative Theses and Dissertations (AETDs)

Alzheimer's disease (AD) is a progressive neurological disorder characterized by extracellular β-amyloid (Aβ) plaques and intracellular tau tangles. The calcium (Ca2+) hypothesis of AD proposes that disrupted intracellular Ca2+ regulation underlies AD pathology, contributing to inflammation, oxidative stress, impaired autophagy, neurodegeneration, and cognitive dysfunction. Store-operated Ca2+ entry (SOCE) maintains ER Ca2+ stores, involving transient receptor potential canonical (TRPC) and Orai channels. Specifically, we speculated that dysregulated functions of TRPC3 contribute to the pathogenesis of AD. We believe that targeting TRPC3 with a pharmacologically feasible agent could prove beneficial in halting cognitive decline. We previously reported compound JW-65, a novel, metabolically …

Age-Dependent Dynamics Of Breast Cancer Driven By Mutant P53: Insight From A Mouse Model, Jyotsna Devi Godavarthi

Dissertations (2016-Present)

Breast cancer (BC) incidence increases with age, and a substantial proportion of aggressive forms of BC are observed in older women. The mechanisms underlying BC's age dependence remain unclear. Genetic alterations in BC most frequently occur in the tumor suppressor gene p53, with most mutations occurring somatically at arginine (R) 248 to tryptophan (W) or glutamine (Q) (R248W/Q in humans, corresponding to R245W/Q in mice) mutation. Previously, a conditional mouse p53wmR245W allele was generated. It allowed inducing p53R245W mutant in the mammary epithelium of the p53wmR245W/+ mice by delivering adenovirus expressing Cre (Ad-Cre) into the mammary ducts, …

April / May / June 2024, Randy Curry, Cindy Brooks

RURAL ROCKS

This is the April, May, and June issue of Rural Rocks from the SWOSU College of Pharmacy.

Evaluation Of Aluminum Exposure In Neonates Receiving Parenteral Nutrition, Emma Sedarski

2024 Swedish Learning and Celebration Day

No abstract provided.

Naloxone: From Legislation To Distribution, Kailyn Elliot, Emily Stewart, John Delfeld

2024 Swedish Learning and Celebration Day

No abstract provided.

Safety And Efficacy Of Empiric De-Escalation Of Antibiotics For Pneumonia In The Intensive Care Unit, Brandon Carron

2024 Swedish Learning and Celebration Day

No abstract provided.

Safety Of Ketamine Use For Rapid Control Of Agitation In The Emergency Department, Rosa Hong Trieu

2024 Swedish Learning and Celebration Day

No abstract provided.

Iv Vs Po: The Acetaminophen Showdown At Swedish, Diem Pham, Adam Corson, Renee Rassilyer-Bomers

2024 Swedish Learning and Celebration Day

No abstract provided.

Pharmacokinetic Analysis Of A Phenobarbital Overdose Treated With Urinary Alkalinization Alone, Justin Seltzer, Jeremy Hardin, Henrik Galust, Nathan Friedman, Bryan Corbett, Richard F Clark

Faculty, Staff and Student Publications

Phenobarbital is a long-acting barbiturate used to treat alcohol withdrawal and epilepsy. Acute overdoses present with varying levels of central nervous system depression and large overdoses can be life threatening. Phenobarbital is an attractive candidate for enhanced elimination using urinary alkalinization given it is a weak acid with a long half-life and extensive urinary elimination. Limited human data exist regarding use of urine alkalinization for the treatment of phenobarbital overdose. We present a fourteen-year-old female who was treated with urinary alkalinization alone following an intentional ingestion of 3800 mg (84.4 mg/kg) of phenobarbital tablets. Urine drugs of abuse screening was …

Optimizing Recombinant Cas9 Expression: Insights From E. Coli Bl21(De3) Strains For Enhanced Protein Purification And Genome Editing, Shilpi Agrawal, Made Harumi Padmaswari, Abbey L. Stokes, Daniel Maxenberger, Morgan Reese, Adila Khalil, Christopher E. Nelson

Biomedical Engineering Faculty Publications and Presentations

The CRISPR-Cas9 system is a revolutionary tool in genetic engineering, offering unprecedented precision and efficiency in genome editing. Cas9, an enzyme derived from bacteria, is guided by RNA to edit DNA sequences within cells precisely. However, while CRISPR-Cas9 presents notable benefits and encouraging outcomes as a molecular tool and a potential therapeutic agent, the process of producing and purifying recombinant Cas9 protein remains a formidable hurdle. In this study, we systematically investigated the expression of recombinant SpCas9-His in four distinct Escherichia coli (E. coli) strains (Rosetta2, BL21(DE3), BL21(DE3)-pLysS, and BL21(DE3)-Star). Through optimization of culture conditions, including temperature and …

Navigating Copay Adjustment Programs In Specialty Pharmacy, Farah Barada, Sarah Fillman, Angelica Berni, Samuel Casey Yokum

All Publications

Many patients rely on copay cards from manufacturers to help pay for prescriptions, especially for specialty and brand name medications which often result in higher out of pocket expenses. Historically, copay card savings were applied to the patient’s out of pocket expense and/or deductible to help the patient save money on their prescription and benefit plan responsibilities. In some cases, this added up to thousands of dollars in savings. However, in 2018, many Pharmacy Benefit Managers (PBMs) and insurance plans began utilizing copay adjustment programs known as “copay accumulators” and “copay maximizers” as forms of utilization management. These programs are …

A Cost-Effectiveness Analysis Of Telehealth Vs. Office-Based Delivery Of Buprenorphine At The Addiction And Substance Abuse Program (Asap) Clinic - University Of New Mexico Hospital: A Societal Perspective, Rana Alkhafaji

Pharmaceutical Sciences ETDs

This study evaluates the cost-effectiveness of office-based versus telehealth delivery of buprenorphine treatment for opioid use disorder (OUD). A retrospective chart review of 135 patients at the University of New Mexico Hospital's Addiction and Substance Abuse Program compared retention rates and costs between the two settings. Retention was defined as continuous treatment for at least six months. No statistically significant difference in retention rates was found, with 51% for office-based and 42% for telehealth. However, office-based treatment had higher total costs, with an incremental cost-effectiveness ratio of $3,750 per 1% increase in retention. The findings suggest telehealth is a cost-effective …

Targeted Drug Delivery: Investigating Protein Corona Behavior, Atharva Markale

Theses

Due to high specificity and less toxicity, nanoparticles have become promising for targeted drug delivery against cancer, although they face challenges when they enter the bloodstream, making their behavior unpredictable. The deposition of proteins on nanoparticles, the protein corona, changes their biosignature, affecting their circulation, drug release potency, targeting ability, and immunogenicity. The continuous exchange of protein layers on a nanoscale is complex to analyze.

Nanoparticle tracking analysis (NTA) is a method to characterize nanoparticles in blood plasma by combining principles of light scattering microscopy and Brownian motion. In this work, time-dependent experiments with plasma were conducted to analyze the …

Combination Treatment Of Biochanin A And Atorvastatin Alters Mitochondrial Bioenergetics, Modulating Cell Metabolism And Inducing Cell Cycle Arrest In Pancreatic Cancer Cells, Vilas Desai, Satya Murthy Tadinada, Hoora Shaghaghi, Ross Summer, James C.K. Lai, Alok Bhushan

College of Pharmacy Faculty Papers

Background/Aim: Pancreatic cancer is an aggressive type of cancer, with a dismally low survival rate of <5%. FDA-approved drugs like gemcitabine have shown little therapeutic success, prolonging survival by a mere six months. Isoflavones, such as biochanin A and daidzein, are known to exhibit anti-cancer activity, whereas statins reportedly have anti-proliferative effects. This study investigated the effects of combination treatment of biochanin A and atorvastatin on pancreatic cancer cells.

Materials and Methods: Pancreatic cancer cells AsPC-1, PANC-1, and MIA PaCa-2 were procured from ATCC. The cell viability studies were carried out using MTT & cell count assays. Flow cytometry was used to study cell apoptosis whereas cell metabolism studies were carried out using the Seahorse Mito stress test and XF-PMP assay. The effects of treatment on cell signaling pathways & cell cycle associated proteins were investigated using western blot whereas invasiveness of cancer cells was evaluated using gelatin zymography.

Results: The combination treatment …

Update On The Efficacy Of Aerosol Therapy Delivered To Obstructive Lung Disease Patients, Mohammed A. Amin, Hasanain Kamil Hasan, Hebatullah K. Taha, Raghda R.S. Hussein, Mohamed E.A. Abdelrahim

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The distribution of many medications to the body via the respiratory tract system is crucial. This route has emerged as one of the most crucial techniques for the delivery of locally acting medications that can be used to treat a variety of respiratory conditions, including asthma and chronic obstructive pulmonary disease (COPD). The advantages of this focused drug delivery to the lungs over systemic administration methods include an improved therapeutic effect, a faster onset of action, and fewer systemic side effects.

Many formulations as suspension and solutions, such as bronchodilators, corticosteroids, and antibiotics have been recommended in a wide area …

A Study Of Serum Levels Of Ferritin, Hepatic And Renal Functions In Beta-Thalassemia Major (Btm) Patients Treated With Deferasirox (Dfx) Tablets, Desferioxamine (Dfo) Vial, Or Combination Of Both (Dfx + Dfo) In Thalassemia Center/Karbala, Shereen M. Mekkey, Maysam Ali Ameen, Najwa Kahtan Hadi

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

A category of inherited blood illnesses known as beta-thalassemias are defined by abnormalities in the synthesis of hemoglobin beta chains, which can result in a wide range of phenotypes, from severe anemia to people who show no symptoms at all. People who have thalassemia major typically experience severe anemia during the first two years of life, necessitating frequent red blood cell (RBC) transfusions.

Management of individuals with β-thalassemia is centered on appropriate, safe blood transfusions (free of transfusion-transmitted illnesses) and prevention of iron excess. Complications from iron overload are brought on by routine transfusion therapy.

This study is a retrospective …

Greenness Assessment And Development Of An Innovative Hplc Method For The Determination Of Rifaximin And Sodium Benzoate In Oral Suspension, Hani M. Hafez, Naser F. Al-Tannak, Mohamed A. Rabeh

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The pharmaceutical industry has brought advancement and opportunities. However, it has also presented challenges and complexity that must be addressed. The pharmaceutical industry aims to protect public health by providing economical, effective, safe, and appropriate treatments. The analytical method monitors medication concentrations to ensure efficacy and safety. Chemical preservations protect drugs from microbes until administration. In Refax suspensions, the concentration of rifaximin (Antibacterial, API) and sodium benzoate (chemical preservative) must be determined to ensure the suspension's effectiveness, stability, and safety with regulatory standards.

An innovative HPLC method was created to monitor the concentrations of rifaximin (Antibacterial, API) and sodium benzoate …

Assessing Pharmacy Students' Knowledge And Awareness Regarding The Rational Utilization Of Antibiotics And The Issue Of Antimicrobial Resistance In Iraq, Hasanain Kamil Hasan, Mohamed Mahmoud Abdelrahman, Ali A. R. Aldallal, Hayder Ridha Salman, Montadher Mohammad Majeed, Mohammad Jabbar Hassan, Alaa Shukry Mtasher, Ahmed Majid Ibrahim

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Introduction: The Non rational use and overall volume of antibiotic consumption in the community is one of the foremost causes of antimicrobial resistance. In developing countries like Iraq, pharmacists often dispense ‘prescription-only’ drugs, like antibiotics, to patients who do not have a prescription. The objectives of this study are to estimate the prevalence of irrational use of antibiotics bought from pharmacies and other medication outlets in some areas in Iraq, as well as to investigate the factors related with such usage.

Method: The cross-sectional face to face survey was conducted in AL Mustaqbal University, were 267 students at College of …

Development Of A Multi-Target Pharmacophore-Based Virtual Screening Agent Against Covid-19, Nashwa A. Ibrahim, Ahmed M. Gouda, Hany A. M. El-Sherief

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The worldwide outbreak of the COVID-19 pandemic compelled scientists to develop new, highly effective therapeutic approaches to fight it. Multitarget drugs have been proven to be effective in managing complex disorders. But designing multitarget drugs is a great challenge. In this study, to prevent a lack of efficacy due to viral mutation escape, a multi-target agent against the COVID-19 virus was discovered. As crucial targets, RNA-dependent RNA polymerase (RdRp), COVID-19 main protease (Mpro), and SARS-CoV-2 Nsp15 were selected. A pharmacophore model was developed using the native ligands of the chosen targets. This model was used to screen the ZINC Drug …

A Cross – Sectional Observational Study On Pharmacoeconomics Burden Of Covid -19 In Ashmoun Fever Hospital Delta Egypt, Marwa Helmi Desouki, Marwa G. Elhennawy, Samar F. Farid

Bulletin of Faculty of Pharmacy Cairo University

Background: A wide range of respiratory illnesses like common colds, Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS) are caused by coronaviruses.

In 2019 scientists in Wuhan, China discovered a new coronavirus (COVID-19). Unknown new coronavirus that infected people for the first time and causes losses for humans. It has caused a large number of deaths around the world and a greater number of injuries, and the countries of the world began to take measures and closures to confront the spread of this virus, and the economy was greatly affected.

Aim of Study: This study provides …

Perceptions Of Metabolic Syndrome Management Utilization In Relation To Patient Experience And Health-Related Quality Of Life, Olajide Adekunle, Jon C. Schommer, Yun Wang, Ismaeel Yunusa, Marc L. Fleming, Enrique Seoane-Vazquez, Lawrence M. Brown

Pharmacy Faculty Articles and Research

Background

One factor for the poor health outcomes among adult people with metabolic syndrome (MetS) is poor utilization of disease management resources, which may be attributable to prior experience with pharmacists (PEwP) and perceptions of disease management resource utilization (PMU). Therefore, understanding patients' experience could be critical to improving their perceptions and promoting health outcomes.

Objectives

The study explored the influence of PEwP and PMU on the health-related quality of life (HRQoL) of people with MetS.

Methods

Data on perceptions of healthcare, medication, and pharmacy services utilization, PEwP, and HRQoL were collected using validated tools via an electronic survey. Chi-square …

Functionalized Gold Nanoparticles And Halogen Bonding Interactions Involving Fentanyl And Fentanyl Derivatives, Molly M. Sherard, Jamie S. Kaplan, Jeffrey H. Simpson, Kevin W. Kittredge, Michael C. Leopold

Chemistry Faculty Publications

Fentanyl (FTN) and synthetic analogs of FTN continue to ravage populations across the globe, including in the United States where opioids are increasingly being used and abused and are causing a staggering and growing number of overdose deaths each year. This growing pandemic is worsened by the ease with which FTN can be derivatized into numerous derivatives. Understanding the chemical properties/behaviors of the FTN class of compounds is critical for developing effective chemical detection schemes using nanoparticles (NPs) to optimize important chemical interactions. Halogen bonding (XB) is an intermolecular interaction between a polarized halogen atom on a molecule and e−-rich …

Efficacy Of Ferula L. Species Extracts From Tajikistan Against Influenza Viruses, Saidbeg Satorov, Sulhiy Mavlonazarova, Ahdrey P. Bogoyavlenskiy, Salomuddin D. Yusufi, Vyacheslav Dushenkov

Publications and Research

Efficacy of Ferula L. Species Extracts from Tajikistan Against Influenza Viruses One of the challenges facing both the domestic and international pharmaceutical industries is the limited selection and suboptimal efficacy of available antiviral drugs. The high mutational variability of influenza viruses contributes to rapid acquisition of drug resistance, which diminishes or nullifies the effectiveness of existing therapies, thereby necessitating the exploration for novel therapeutics. This study aimed to assess the antiviral activities of three species of the genus Ferula— indigenous to the Republic of Tajikistan—against influenza strains A/Vladivostok/2/09 (H1N1) and A/Almaty/8/98 (H3N2). The investigation revealed that phytochemical constituents—specifically, root …

Comparative Analysis Of Polyphenol Content, Antioxidant Activity And Antimicrobial Properties In Endemic And Widespread Allium Species Of Tajikistan, Fazila Mirzoeva, Saidbeg Satorov, Salomuddin Usufi, Vyacheslav Dushenkov, Shukhratdzhon Shukhratdzhon

Publications and Research

In Tajikistan, the Allium genus is notably prolific, with over 80 species documented, and new species continually being identified in the mountainous regions. The Gorno- Badakhshan Autonomous Region (GBAO) of Tajikistan, within the Pamir Mountains, is significant for its 31 distinct Allium species, including endemics like A. afghanicum Wendelbo and A. schugnanicum Vved. The distribution of these species is often geographically restricted, and their biological activities, especially their antimicrobial properties, remain largely unexplored, presenting significant opportunities for future phytochemical and pharmacological research. This scholarly inquiry is aimed at contributing substantially to the academic discourse on the therapeutic capacities of Allium …

Assessing Health Needs In A Dominican Republic Community During An Interprofessional Service-Learning Trip, Gabriela Andonie, Hanna Rotundo, Ashanti Jones, Logan Dugas, Shylon Francis

Journal of Interprofessional Practice and Collaboration

Purpose: International medical missions may increase access to medicines and care, but international teams must understand local needs to implement appropriate services. In 2023, a multidisciplinary team from our institution partnered with a nonprofit organization in the barrio of Cienfuegos, Dominican Republic with the goal of strengthening local health services. The primary objective of this study was to identify health-related needs in Cienfuegos from the perspective of community members and local health care workers.

Methods: A qualitative study was conducted as part of a service-learning initiative. After obtaining informed consent, the investigators conducted individual semi-structured interviews facilitated by multi-lingual interpreters. …

Concept Analysis: Undergraduate Nursing Student Clinical Performance Anxiety, Maria Gros

Journal of Interprofessional Practice and Collaboration

Concept Analysis: Undergraduate Nursing Student Clinical Performance Anxiety

Maria Gros, MSN, RN, CEN

Department of Nursing, Nicholls State University

Correspondence to: Maria Gros, MSN, RN, CEN. Department of Nursing, Nicholls State University, 906 East 1^st Street, Thibodaux, Louisiana, 70301. Phone: 985-448-4730. Email: [email protected]

Article type: Original article written in a doctoral course in the Doctorate in Nursing Education at University of West Georgia

Word count: 3023 words

Abstract

Purpose: This paper defines and clarifies clinical performance anxiety (CPA) as it pertains to undergraduate nursing students in the clinical setting. This research also identifies how CPA can be detrimental to …

Phytochemical Assay And In – Vitro Cytotoxicity Assessment Of Cassava Peel (Manihot Esculenta) From Ethanol And Ethyl Acetate Extract Against Cervical Cancer Cells (Hela), Alice Hari Soejono, Surya Dwira, Puji Sari

Indonesian Journal of Medical Chemistry and Bioinformatics

Introduction: Cervical cancer is a type of cancer that develops in a woman’s cervix. It is a result of HPV (Human Papilloma Virus) and is one of the deadliest types of cancer. Some cervical cancer management including chemotherapy, which until recently continues to develop to cure the condition, is relatively expensive and comes with multiple different side effects.

Method: Manihot esculenta undergoes multilevel maceration with the solvent of ethanol and ethyl acetate. This leads to the formation of ethanol extract and ethyl acetate extract of Manihot esculenta that is analyzed through phytochemical assay and thin layer chromatography (TLC) to determine …