Pharmacy and Pharmaceutical Sciences Commons^™

Assessment Of Community Pharmacists’ Involvement In Public Health Promotion Services In Beirut, Lebanon, Mira Medawar, Maha Aboul Ela, Souraya Domiati

BAU Journal - Health and Wellbeing

Background: The role of pharmacists is growing globally; the shift from the traditional role of preparing and dispensing medications, to a role in medication therapy management and public health services is started to be acceptable worldwide.

Objective: The aim of the study was to assess the participation level of community pharmacists’ in certain public health services promotion as well as the barriers that hindered such provision.

Method: A questionnaire based study has been carried targeting Lebanese community pharmacists working in Beirut, Lebanon. Socio-demographic information, types of public health consultations offered in the pharmacy, and the barriers confronted by the community …

Quantitative Assay Of Binary And Ternary Cardiovascular Mixtures Using Absorption Subtraction Spectrophotometric Method, Marwa Khaled El Jamal

BAU Journal - Health and Wellbeing

Objective: Development and validation of specific spectrophotometric analytical method for the simultaneous determination of co-administered cardiovascular mixtures consisting of Aspirine (ASP) and Prasugrel (PRA) binary mixture and Ticagrelor (TICA), Irbesartan (IRB) and Hydrochlorothazide (HCT) ternary mixture.

Methods: The proposed spectrophotometric method was based on Absorbance Subtraction, where, when a mixture of two drugs X and Y having overlapped spectra, intersecting at isoabsorptive point and Y spectrum is extended more than X, while X doesn’t show any absorbance (A₂) at another wavelength (λ₂), X and Y could be determined in the mixture by simple mathematical manipulation

Results: …

The Inclusion Of Health Data Standards In The Implementation Of Pharmacogenomics Systems: A Scoping Review, Don Roosan, Angela Hwang, Anandi V. Law, Jay Chok, Moom Roosan

Pharmacy Faculty Articles and Research

Background: Despite potential benefits, the practice of incorporating pharmacogenomics (PGx) results in clinical decisions has yet to diffusewidely. In this study,we conducted a review of recent discussions on data standards and interoperability with a focus on sharing PGx test results among health systems. Materials & methods:We conducted a literature search for PGx clinical decision support systems between 1 January 2012 and 31 January 2020. Thirty-two out of 727 articles were included for the final review. Results: Nine of the 32 articles mentioned data standards and only four of the 32 articles provided solutions for the lack of …

Risk Factors For Delayed Viral Suppression On First-Line Antiretroviral Therapy Among Persons Living With Hiv In Haiti, 2013-2017, Shannan N. Rich, Robert L. Cook, Lusine Yaghjyan, Kesner Francois, Nancy Puttkammer, Ermane Robin, Jungjun Bae, Nadjy Joseph, Luisa Pessoa-Brandão, Chris Delcher

Institute for Pharmaceutical Outcomes and Policy Faculty Publications

Studies of viral suppression on first-line antiretroviral therapy (ART) in persons living with human immunodeficiency virus (PLHIV) in Haiti are limited, particularly among PLHIV outside of the Ouest department, where the capital Port-au-Prince is located. This study described the prevalence and risk factors for delayed viral suppression among PLHIV in all geographic departments of Haiti between 2013 and 2017. Individuals who received viral load testing 3 to 12 months after ART initiation were included. Data on demographics and clinical care were obtained from the Haitian Active Longitudinal Tracking of HIV database. Multivariable logistic regression was performed to predict delayed viral …

Analysis Of Glutathione Supplementation Effects On Female Metabolic Syndrome Condition Using Classification Techniques, Nur Rasyidah Hasan Basri

Student Works (2020-2029)

Lesser known to the public that main antioxidants in our body, Glutathione are also said to influence the metabolic syndrome (MS) condition. Oral supplementation consisting of glutathione precursors and vitamin C introduced in the study was to improve glutathione (GSH) status of the consumer and the main objective of this study is to investigate GSH effects on selected MS condition. Several known studies had proven that oral supplementation improved GSH level of consumer. However, there is no definite proof on how it’s affecting MS parameters. Also, there is less study carried out on the relationship between glutathione levels and metabolic …

Purdue College Of Pharmacy Experience With Blood Pressure Screenings At The Indiana State Fair, Samuel L. Stukey, Emily B. Vahary, Allison M. Kenneally, Casey J. Bernier, Bruce C. Carlstedt, Jane E. Krause

Purdue Journal of Service-Learning and International Engagement

The objective of this community outreach initiative is to develop and implement a student-led blood pressure screening at the Indiana State Fair in conjunction with the Purdue College of Pharmacy and the Hook’s Drug Store Museum. Under the mentorship of two pharmacy faculty members, third- and fourth-year professional PharmD students and pharmacy fellows hold a nine-hour blood pressure screening at the Indiana State Fair each year. The screening is held at the Hook’s Drug Store Museum and the students and fellows sign-up in teams of 3-4 to host the event. Fair-goers visiting the screening have their blood pressure taken using …

Student Pharmacists Bridging The Gap With Community Partnerships: Purdue University College Of Psychiatric And Neurologic Pharmacists Chapter, Fatima A. Khan, Elise M. Mann

Purdue Journal of Service-Learning and International Engagement

The CPNP Purdue chapter is a student organization that strives to advance mental health awareness and education, reduce stigma, and volunteer in the local community. CPNP Purdue is strengthened by collaboration with partner organizations, including the National Alliance on Mental Illness (NAMI) and Home with Hope, a Lafayette-based recovery housing center. NAMI advocates for effective treatment and education for families affected by mental illness in the surrounding community. Home with Hope provides a continuum of care and environment conducive to recovery following treatment for substance use disorders. These nonprofit partnerships rely heavily upon volunteers, donations, and advocates to provide services …

Research News. Publications, 2020. Volume 3, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period July 1 through September 30, 2020

Research News. Grants, 2020. Volume 3, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during July - September 2020

D01. Bms Department Poster, University Of Mississippi. Department Of Biomolecular Sciences

Annual Poster Session 2020

Corresponding author (BioMolecular Sciences): Candace Lowstuter, [email protected]

R17. Solid Crystal Suspensions Of Carbamazepine Using Hot-Melt Extrusion: A Solubility Enhancement Approach, Sagar Narala, Neeraja Komanduri, Dinesh Nyavanandi, Suresh Bandari, Michael A. Repka

Annual Poster Session 2020

Corresponding author (Pharmaceutics and Drug delivery): Sagar Narala, [email protected]

D04. Department Of Pharmaceutics And Drug Delivery, Michael A. Repka, Walt G. Chambliss, Soumyajit Majumdar, S. N. Murthy, Seong Bong Jo, Chalet Tan, Mahavir Chougule, Eman Ashour

Annual Poster Session 2020

Corresponding author (Pharmaceutics and Drug Delivery): Eman Ashour, [email protected]

R07. Identification Of Antifungal Bisphosphocholines From Medicinal Gentiana Species, Xing-Cong Li, Siyu Ren, Kejun Deng, Shi Qiu, Mei Wang, Bharathi Avula, Siddharth K. Tripathi, Melissa R. Jacob, Limin Gong, Wei Wang, Ikhlas A. Khan

Annual Poster Session 2020

Corresponding author (NCNPR): Xing-Cong Li, [email protected]

R13. Formulation Development Of Loratadine Immediate-Release Tablets Using Hot-Melt Extrusion Coupled With 3d-Printing Technology, Sundus Hussain Omari, Eman A. Ashour, Mashan Amutairi, Rasha Elkanayati, Michael A. Repka

Annual Poster Session 2020

Corresponding author (Pharmaceutics and Drug delivery): Sundus Hussain Omari, [email protected]

R11. Challenges And Future Directions Of Potential Natural Products Leads Against 2019-Ncov Outbreak, Meirambek Ospanov, Francisco León, Janar Jenis, Ikhlas A. Khan, Mohamed A. Ibrahim

Annual Poster Session 2020

Corresponding author (NCNPR): Mohamed A. Ibrahim, [email protected]

R08. Characterization Of Key Metabolites In Serum Of Fuzheng Huayu Phase Ii Clinical Trial, Yan-Hong Wang, Zachara Catchings, Bharathi Avula, Mei Wang, Huashi Bian, Ikhlas A. Khan

Annual Poster Session 2020

Corresponding author (NCNPR): Yan-Hong Wang, [email protected]

R03. Hiv Tat Protein Activates Plasma Kallikrein-Kinin System In The Doxycycline-Inducible Astrocyte Specific Hiv-1 Tat Transgenic Mice, Logan Sneed, Fakhri Mahdi, Salahoddin Mohamed, Jason J. Paris, Zia Shariat-Madar

Annual Poster Session 2020

Corresponding author (BioMolecular Sciences): Logan Sneed, [email protected]

R18. Preparation And Characterization Of Pegylated Nanostructured Lipid Carrier Systems For The Ocular Delivery Of Antineoplastic Agent, Sushrut Marathe, Narender Dudhipala, Soumyajit Majumdar

Annual Poster Session 2020

Corresponding author (Pharmaceutics and Drug delivery): Sushrut Marathe, [email protected]

D02. Ncnpr Activities At Coy Waller Complex, Mahmoud A. Elsohly, Suman Chandra, Mohamed M. Radwan, Hemant Lata, Amira Wanas, Chandrani G. Majumdar

Annual Poster Session 2020

Corresponding author (NCNPR, School of Pharmacy): Mohamed M. Radwan, [email protected]

R06. Identification Of The Cellular Pathways Targeted By Two Antifungal Natural Products Using Rna-Seq Analysis, Ameeta K. Agarwal, Siddharth K. Tripathi, Qin Feng, Ranga Rao Ravu, Xing-Cong Li, Alice M. Clark

Annual Poster Session 2020

Corresponding author (NCNPR): Ameeta Agarwal, [email protected]

R09. New Atractylon Derivatives Generated In Processed Rhizomes Of Atractylodes Macrocephala Koidz, Chunmei Zhai, Jianping Zhao, Amar G. Chittiboyina, Yonghai Meng, Mei Wang, Ikhlas A. Khan

Annual Poster Session 2020

Corresponding author (NCNPR): Jianping Zhao, [email protected]

R15. Development And Characterization Of Hot-Melt Extruded Ocular Inserts Of Moxifloxacin For Bacterial Keratitis, Ruchi Thakkar, Nagireddy Dumpa, Narendar Dudhipala, Michael A. Repka, Soumyajit Majumdar

Annual Poster Session 2020

Corresponding author (Pharmaceutics and Drug delivery): Ruchi Thakkar, [email protected]

R21. Preparation, Characterization And Stability Evaluation Of Ligand Anchored Primaquine Loaded Nanostructured Lipid Carrier Systems For Liver Targeting, Tabish Mehraj, Samir Senapati, Sushrut Marathe, Narendar Dudhipala, Babulal Tekwani, Soumyajit Majumdar

Annual Poster Session 2020

Corresponding author (Pharmaceutics and Drug delivery): Tabish Mehraj, [email protected]

R10. First In Class (S,E)-11-[2-(Arylmethylene)Hydrazono]-Pbd Analogs As Selective Cb2 Modulators Targeting Neurodegenerative Disorders, Meirambek Ospanov, David Mingle, Mohamed O. Radwan, Nicole M. Ashpole, Masami Otsuka, Samir A. Ross, Larry A. Walker, Abbas G. Shilabin, Mohamed A. Ibrahim

Annual Poster Session 2020

Corresponding author (NCNPR): Mohamed A. Ibrahim, [email protected]

R23. Demographics And Outcomes Of Patients Hospitalized For Covid-19, Jonathan T. Newbaker, Scott S. Malinowski

Annual Poster Session 2020

Corresponding author (University of Mississippi Medical Center): Jonathan T. Newbaker, [email protected]

Synthesis, In Vitro, And In Vivo Evaluation Of Novel N-Phenylindazolyl Diarylureas As Potential Anti-Cancer Agents., Lucas N Solano, Grady L Nelson, Conor T Ronayne, Shirisha Jonnalagadda, Sravan K Jonnalagadda, Kaija Kottke, Robert Chitren, Joseph L Johnson, Manoj K Pandey, Subash C. Jonnalagadda, Venkatram R Mereddy

College of Science & Mathematics Departmental Research

Novel N-phenylindazole based diarylureas have been designed, synthesized and evaluated as potential anticancer agents. In vitro cell viability studies of these derivatives illustrate good potency with IC50 values in the range of 0.4–50 μM in several cancer cell lines including murine metastatic breast cancer 4T1, murine glioblastoma GL261, human triple negative breast cancer MDA-MB-231, human pancreatic cancer MIAPaCa-2, and human colorectal cancer cell line WiDr. The ester group in the lead compound 8i was modified to incorporate amino-amides to increase solubility and stability while retaining biological activity. Further in vitro studies reveal that lead candidates inhibit tube length in HUVEC …

Analysis Of Kshv B Lymphocyte Lineage Tropism In Human Tonsil Reveals Efficient Infection Of Cd138+ Plasma Cells, Farizeh Aalam, Ramina Nabiee, Jesus Ramirez Castano, Jennifer Totonchy

Pharmacy Faculty Articles and Research

Despite 25 years of research, the basic virology of Kaposi Sarcoma Herpesviruses (KSHV) in B lymphocytes remains poorly understood. This study seeks to fill critical gaps in our understanding by characterizing the B lymphocyte lineage-specific tropism of KSHV. Here, we use lymphocytes derived from 40 human tonsil specimens to determine the B lymphocyte lineages targeted by KSHV early during de novo infection in our ex vivo model system. We characterize the immunological diversity of our tonsil specimens and determine that overall susceptibility of tonsil lymphocytes to KSHV infection varies substantially between donors. We demonstrate that a variety of B lymphocyte …

Cyclosporine Shows Benefit As Compared To Methotrexate For Treatment Of Pediatric Atopic Dermatitis Refractory To Topical Medications When Rapidity Of Clinical Response Is Of Key Importance To The Patient, Connor R. Buechler, Steven Daveluy Md

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report appraising El-Khalawany MA, Hassan H, Shaaban D, Ghonaim N, Eassa B. Methotrexate versus cyclosporine in the treatment of severe atopic dermatitis in children: a multicenter experience from Egypt. European Journal of Pediatrics. 2012;172(3):351-356. https://doi.org10.1007/s00431-012-1893-3 for a pediatric patient with severe atopic dermatitis.

What’S The Big Deal About Statins?, Albert Bach, Jelena Lewis, Susie Yoo

Pharmacy Faculty Articles and Research

"Statins are a group of cholesterol-lowering medications that have been shown evidence to be beneficial for tens of millions of Americans. Some examples of statin medications you may have heard of include: atorvastatin (Lipitor), rosuvastatin (Crestor), simvastatin (Zocor), pravastatin (Pravachol) and lovastatin (Mevacor). Statins are one of the most commonly prescribed medications in the United States. One in four adults over the age of 45 years old are currently taking a statin for its many benefits. See below for more information about its use."

Lc–Ms/Ms-Based In Vitro And In Vivo Investigation Of Blood–Brain Barrier Integrity By Simultaneous Quantitation Of Mannitol And Sucrose, Behnam Noorani, Ekram Ahmed Chowdhury, Faleh Alqahtani, Yeseul Ahn, Dhavalkumar Patel, Abraham Al-Ahmad, Reza Mehvar, Ulrich Bickel

Pharmacy Faculty Articles and Research

Background

Understanding the pathophysiology of the blood brain–barrier (BBB) plays a critical role in diagnosis and treatment of disease conditions. Applying a sensitive and specific LC–MS/MS technique for the measurement of BBB integrity with high precision, we have recently introduced non-radioactive [¹³C₁₂]sucrose as a superior marker substance. Comparison of permeability markers with different molecular weight, but otherwise similar physicochemical properties, can provide insights into the uptake mechanism at the BBB. Mannitol is a small hydrophilic, uncharged molecule that is half the size of sucrose. Previously only radioactive [³H]mannitol or [¹⁴C]mannitol has been …