Pharmacy and Pharmaceutical Sciences Commons^™

Annual Evaluation Of The Student's Perception Of The Value Of Writing Goals, Renee Kuess

ONU Student Research Colloquium

Focus: This study focused on pharmacy students’ perception of the value of writing goals and how this perception changes as students progress in the program.

Methods: Annually, all students in the pharmacy program are required to reflect on the previous year’s goals and develop new goals. Following this assignment, a survey was sent out to a random sample (n=162) of students. Based on the feedback, the response was classified as indicating “value” or “no value”.

Results: Of the 162 surveys sent out, there were 78 completed responses. 56.25% of responses indicated the student found “value” in the assignment. The data …

Gauging Interest In An Elective Course To Further Careers In Healthcare Academia, Karielle Shaffery

ONU Student Research Colloquium

There has been continuous growth in the number of pharmacy schools, which has led to an expanded need for pharmacy faculty members. Although there is a recognized and unmet need for such faculty, the topic of pharmacy academia is sparsely addressed in pharmacy programs. Integrating students in an elective teaching course during their didactic education, prior to determination of their career path, could inspire more students to take on the role of an educator. Ideally, allowing students to have first-hand experience in academia focused activities and exposing them to the responsibilities of an academician could peak interest in this area. …

“Put Me In Coach!”: How Pharmacists Can Contribute To Elite Sports, Mel Sturgill

BU Well

Professional and amateur athletes alike often have teams of healthcare professionals that oversee the care of injuries. Among these healthcare professionals, pharmacists have not been included as a member of the care team. Pharmacists are medication experts that can help mitigate medication mistakes and adverse reactions. Additionally, the pharmacist can provide medication information and doping awareness to help athletes reach and maintain their top performance levels in a healthy and safe manner.

Stress: The Silent Sickness, Neethu George

BU Well

From cramming for a test to arguing with a friend, individuals experience stress every day. While stress can be beneficial in certain situations, letting stress get out of control can lead to a variety of mental and physical health issues. This article examines the different types of stress, ways to cope with stress, and the overall effect of stress on human health.

Pharmacist-Driven Culture And Sexually Transmitted Infection Testing Follow-Up Program In The Emergency Department, Stephanie C. Shealy, Christine Alexander, Tina Grof Hardison, Joseph Magagnoli, Julie Ann Justo, Caroline Derrick, Joseph Kohn, Hana Rac Winders, Troy Privette, Majdi N. Al-Hasan, P. Brandon Bookstaver

Faculty Publications

Expanding pharmacist-driven antimicrobial stewardship efforts in the emergency department (ED) can improve antibiotic management for both admitted and discharged patients. We piloted a pharmacist-driven culture and rapid diagnostic technology (RDT) follow-up program in patients discharged from the ED. This was a single-center, pre- and post-implementation, cohort study examining the impact of a pharmacist-driven culture/RDT follow-up program in the ED. Adult patients discharged from the ED with subsequent positive cultures and/or RDT during the pre- (21 August 2018–18 November 2018) and post-implementation (19 November 2018–15 February 2019) periods were screened for inclusion. The primary endpoints were time from ED discharge to …

The Urban/Rural Divide In Access To Medication-Assisted Treatment For Opioid Use Disorder In Utah, Debasree Dasgupta, Erin Fanning Madden, Sandra H. Sulzer, Timothy Light, Michelle Chapoose, Suzanne Prevedel

All Current Publications

Death by drug poisoning is the leading cause of death due to injury in the state of Utah (UDOH, 2014). From 2013-2015, Utah ranked seventh in the nation for drug overdose deaths, the majority of which were opioid-related (CDC, 2018a). In 2017, the age-adjusted mortality rate from drug overdose in Utah was 15.5 per 100,000, putting the state above the national average of 14.9 per 100,000 (CDC, 2018b). Opioid overdose death rates in most of rural Utah far exceeds rates across the urban counties of the state. The higher rates of deaths in rural Utah is indeed concerning. Evidence indicates …

Vaccines In Current Culture: The Hpv Vaccine Controversy, Alyssa Johnston

Senior Honors Theses

The use of vaccinations has drastically decreased mortality and morbidity rates related to infectious disease and has become an intrinsic part of modern health care. However, the fear of risks related to vaccines has been partially responsible for the decisions of many parents to delay or avoid vaccinating their children. The human papilloma virus (HPV) vaccine specifically is one of the most controversial vaccines in current culture due to reports of new onset or exacerbation of autoimmune diseases, infertility, and even death following its administration. This review synthesizes information regarding the relevance and safety of the HPV vaccine, as well …

The Pediatric Anti-Viral Immune Response Impairs Neural Stem/Progenitor Cell Activity, Yashika Kamte, Manisha N. Chandwani, Lauren A. O'Donnell

Graduate Student Research Symposium

The neuropathological outcomes of a viral infection in the brain are often age-dependent. Infection of the immature CNS can lead to impairment of neural/stem progenitor cell (NSPCs) activity. NSPCs are multi-potent progenitor cells of the CNS and are responsible for populating the brain with neurons, astrocytes, and oligodendrocytes during development. Viral infections may alter NSPC activity via two mechanisms; directly by infection of the NSPC or indirectly due to the anti-viral immune response. Here, we examined the impact of a neurotropic infection on NSPC activity in pediatric mice (postnatal day 10), where brain and immune system development is ongoing. In …

Maternal Exposure To Δ9-Tetrahydrocannabinol Impairs Female Offspring Glucose Homeostasis And Endocrine Pancreatic Development In The Rat., Ryan Gillies, Kendrick Lee, Sebastian Vanin, Steven R Laviolette, Alison C Holloway, Edith Arany, Daniel B Hardy

Physiology and Pharmacology Publications

Recent reports indicate that 7% of pregnant mothers in North America use cannabis. This is concerning given that in utero exposure to Δ9-tetrahydrocannabinol (Δ9-THC), the main psychoactive component in cannabis, causes fetal growth restriction and may alter replication and survival of pancreatic β-cells in the offspring. Accordingly, we hypothesized that maternal exposure to Δ9-THC during pregnancy would impair postnatal glucometabolic health of offspring. To test this hypothesis, pregnant Wistar rats were treated with daily intraperitoneal injections of either 3 mg/kg Δ9-THC or vehicle from gestational day 6 to birth. Offspring were subsequently challenged with glucose and insulin at 5 months …

Prevalence Of Syphilis Disease Throughout Some Expatriate Workers In Iraq, Israa Mamdooh Subhi, Abdul-Raheem Yahya Mahdi

Al-Esraa University College Journal for Medical Sciences

Syphilis is a sexually transmitted infection caused by the spirochete Treponema pallidum. Syphilis has been a major infection in man throughout recorded history and has challenged clinicians with its many clinical manifestations. It can also spread to other people by kissing or close body contact. The disease begins with sores and then could spread to other parts of the body through its stages (primary, secondary, tertiary and latent stages) and can also reach the heart and nervous system, and it may be fatal. The data on this disease in Iraq is limited and literature is scanty. A total of 70 …

Nefopam Versus Ketorolac For Post-Operative Pain Control In Cesarean Section, Shireen Kh Almuradi, Ali H. Mosleh, Ghison Ik Al-Adal

Al-Esraa University College Journal for Medical Sciences

More than 230 million people undergo surgery each year worldwide, and the number is increasing annually. Surgery commonly causes postoperative pain that should be alleviated as soon and as effectively as possible to reduce suffering, promote the healing process and rehabilitation, and prevent complications. However, clinical pain management after surgery remains far from successful despite the dramatically increased scientific evidence in this area. Many patients suffer from severe pain after surgery. Aim: The aim of this study is to compare between ketorolac and nefopam when administered intravenously as post-operative analgesia in cesarean section. Patients and methods: 60 patients, who were …

Weaving Charlotte's Web: An In-Depth Guide To Cannabidiol, Lauren Pitts

Honors Theses

Cannabidiol, also known as CBD, first gathered national spotlight after Charlotte Figi and her mother Paige were able to find two physicians willing to prescribe CBD to treat Charlotte’s seizures. Charlotte suffered from Dravet Syndrome, but was able to find relief from CBD, which decreased the number and severity of her seizures. This sparked national interest and was the catalyst that lead to research and changes surrounding CBD uses and legality. Cannabidiol is a single cannabinoid that is found within the Cannabis sativa plant family—the same family that includes marijuana. This cannabinoid differs from tetrahydrocannabinol (THC) and does not provide …

Research News. Grants, 2020. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during January - March 2020

Exposed Root Coverage After Soft Tissue Tumor Removal Using Two-Step Surgery Technique (Case Report), Nafhat Almisk Amer Saleh, Yousif Laith Mahmood

Al-Esraa University College Journal for Medical Sciences

When intra-oral lesions in soft tissue reach the gingival margin, they can produce aesthetic problems during their presence and after their removal. Periodontal plastic surgery can be used in the correction of the gingival contour using many different techniques. This is a case report of a peripheral ossifying fibroma removal in the interproximal area between the maxillary left central and lateral incisors. The procedure also included the coverage of the exposed root in the affected area using two surgical stages: the first stage involved keratinized gingival tissue augmentation surgery with a free gingival graft concurrent with the removal of the …

Detection Of Van B Gene In Staphylococcus Spp. Isolated From Food In Baghdad/Iraq, Zina A.S Hadi, Mohamed F. Al-Marjani

Al-Esraa University College Journal for Medical Sciences

Seventy-three Staphylococcus spp. isolates were recovered from bacterial samples including poultry, foods, sewage, and soil. Antibiotic susceptibility tests were conducted on all environmental isolates for Methicillin and Vancomycin. The results showed that 39 Staphylococcus spp. isolates (53.42%) were resistant to Methicillin, while 26 isolates (35.61%) were resistant to Vancomycin. The minimum inhibitory concentration (MIC) range of Vancomycin was found to be between 2-512 µg/mL. Plasmid DNA extraction from Methicillin and Vancomycin-resistant isolates revealed that some isolates had one plasmid band. Detection of Vancomycin resistance genes (vanA and vanB) showed the presence of the vanB gene in isolate No. ESf44 with …

Betamethasone Gel Compared With Lidocaine Gel To Reduce Tracheal Tube Related Post-Operative Airway Symptoms, Mustafa Bs Atatfah, Ali H. Mosleh, Ghisan Ik Al-Adal

Al-Esraa University College Journal for Medical Sciences

Background: The commonest method to secure the airway in general anesthesia is the use of cuffed Endotracheal Tube (ETT). However, the recovery is often complicated by ETT-induced airway and circulatory reflexes, which can lead to potentially dangerous complications. Many studies and researches have been focused on the prevention of these emergence phenomena (EP); nevertheless, the problem is still far from a final solution. Aim: To compare the efficacy of Lidocaine gel vs. Betamethasone gel in attenuating the ETT-induced EP. Patients and methods: 51 patients chosen for elective intermediate average duration operations and classified in class 1 & 2 of the …

Impact Of Reappraisal Of Fluoroquinolone Minimum Inhibitory Concentration Susceptibility Breakpoints In Gram-Negative Bloodstream Isolates, Stephanie C. Shealy, Matthew M. Brigmon, Julie Ann Justo, P Brandon Bookstaver, Joseph Kohn, Majdi N. Al-Hasan

Faculty Publications

The Clinical Laboratory Standards Institute lowered the fluoroquinolone minimum inhibitory concentration (MIC) susceptibility breakpoints for and glucose non-fermenting Gram-negative bacilli in January 2019. This retrospective cohort study describes the impact of this reappraisal on ciprofloxacin susceptibility overall and in patients with risk factors for antimicrobial resistance. Gram-negative bloodstream isolates collected from hospitalized adults at Prisma Health-Midlands hospitals in South Carolina, USA, from January 2010 to December 2014 were included. Matched pairs mean difference (MD) with 95% confidence intervals (CI) were calculated to examine the change in ciprofloxacin susceptibility after MIC breakpoint reappraisal. Susceptibility of to ciprofloxacin declined by 5.2% (95% …

April 2020, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy.

Chronic Morphine Regulates Trpm8 Channels Via Mor-Pkcβ Signaling, Mircea Iftinca, Lilian Basso, Robyn Flynn, Charlie Kwok, Corinne Roland, Ahmed Hassan, Manon Defaye, Rithwik Ramachandran, Tuan Trang, Christophe Altier

Physiology and Pharmacology Publications

© 2020 The Author(s). Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root ganglion (DRG) nociceptors. Deletion or inhibition of the TRPM8 channel was found to prevent the cold hyperalgesia induced by chronic administration of morphine. Here, we examined the mechanisms by which morphine was able to promote cold hypersensitivity in DRG neurons and transfected HEK cells. Mice daily injected with morphine for 5 days developed cold hyperalgesia. Treatment with morphine did not alter the expressions of cold sensitive …

Novel Paclitaxel Nanoparticles For Enhanced Therapeutic Effects In Breast Cancer, Pallabita Chowdhury

Theses and Dissertations (ETD)

Drug delivery to triple negative breast cancer (TNBC) remains a formidable challenge. Given the lack of expressions of estrogen (ER), progesterone (PR) and human epidermal growth factor receptor (HER2), there is no specific prognostic marker for targeting this aggressive cancer. In spite of rapid advancement in breast cancer with agents such as Trastuzumab in HER2 positive, chemotherapy with cytotoxic agents remains the mainstay treatment for TNBC. Although these cytotoxic agents are potent in managing the tumor progression, yet they pose adverse effects on healthy tissues. Paclitaxel (PTX) has been used as a gold standard chemotherapeutic agent for breast, ovarian, pancreatic …

Association Of Long-Term Consumption Of Repeatedly Heated Mix Vegetable Oils In Different Doses And Hepatic Toxicity Through Fat Accumulation, Gul Ambreen, Afshan Siddiq, Kashif Hussain

Department of Biological & Biomedical Sciences

Background: Hepatic diseases are one of the chief reasons for worldwide morbidity and mortality. The increased incidence in Asian countries is driving researchers to explore preventive ways from nature. It is more practical to go with healthy routine edibles like vegetable oils to avoid environmental and chemical hepatic injuries. With the use of thermally oxidized oils overproduction of reactive oxygen species (ROS) with overwhelmed cellular antioxidants defense system results in oxidative stress, the known cause of cardiovascular diseases (CVDs), cancers and neurodegenerative disorders. Little is investigated about the effect of daily used oxidized cooking oils on hepatic function changes with …

School Of Pharmacy Intellectual Property Report Fy20, Third Quarter Report, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

School of Pharmacy Intellectual Property Report FY20, Third Quarter Report (as of 3/31/2020)

First-In-Human Studies Of Mw01-6-189wh, A Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, And Pharmacodynamic Studies In Healthy Adult Volunteers, Linda J. Van Eldik, Lumy Sawaki, Karen Bowen, Daniel T. Laskowitz, Robert J. Noveck, Byron Hauser, Lynn Jordan, Tracy G. Spears, Huali Wu, Kevin Watt, Shruti Raja, Saktimayee M. Roy, D. Martin Watterson, Jeffrey T. Guptill

Sanders-Brown Center on Aging Faculty Publications

MW01-6-189WH (MW189) is a novel central nervous system-penetrant small-molecule drug candidate that selectively attenuates stressor-induced proinflammatory cytokine overproduction and is efficacious in intracerebral hemorrhage and traumatic brain injury animal models. We report first-in-human, randomized, double-blind, placebo-controlled phase 1 studies to evaluate the safety, tolerability, and pharmacokinetics (PK) of single and multiple ascending intravenous doses of MW189 in healthy adult volunteers. MW189 was safe and well tolerated in single and multiple doses up to 0.25 mg/kg, with no clinically significant concerns. The most common drug-related treatment-emergent adverse event was infusion-site reactions, likely related to drug solution acidity. No clinically concerning changes …

Imatinib-Induced Interstitial Pneumonitis – A Literature Review And Case Report, Olga Hilda Orasan, Andreea Maria Stefan, Iulia Minciuna, Adela Sitar-Taut, George Ciulei, Simina Tarmure, Ioana Para, Flaviu Muresan, Ovidiu Fabian, Sorina Cezara Coste, Vasile Negrean, Angela Cozma, Laura Urian

Journal of Mind and Medical Sciences

Imatinib is generally well tolerated, with mild common side effects such as nausea and vomiting, diarrhea, muscle cramps, fatigue, skin rash and edema; however, pulmonary complications are uncommon. A 73-year-old woman undergoing one month treatment with Imatinib for chronic myeloid neoplasm associated with eosinophilia was admitted for sudden alteration of her performance status, dyspnea at rest and productive cough. On clinical examination, the patient was hypoxic (oxygen saturation on room air was 87%), and auscultation of her lungs revealed diffuse bilateral fine crackles. Computed tomography showed bilateral pulmonary interstitial syndrome. Imatinib was discontinued and the patient received systemic corticosteroid therapy …

Risk Factors, Predictive Markers And Prevention Strategies For Intrauterine Fetal Death. An Integrative Review, Roxana Bohiltea, Natalia Turcan, Christina M. Cavinder, Ionită Ducu, Ioana Paunica, Liliana Florina Andronache, Monica Mihaela Cirstoiu

Journal of Mind and Medical Sciences

According to World Health Organization (WHO), fetal death is defined as the death of the fetus prior to its complete expulsion, independent of the duration of pregnancy, thus only ascribing the term stillbirth to fetal deaths in the case of pregnancies after 28 weeks of gestation. The great progress of perinatology care is reflected in a significant reduction in the rate of stillbirths, especially in well-developed countries, with approximately 98% of stillbirth cases now occurring in poor and developing countries. Stillbirth powerfully impacts both the patient and the practitioner. Because nearly half of stillbirth cases result from apparently uncomplicated pregnancies, …

Muc13 Modulated Nanomechanical And Biophysical Responses In Pancreatic Cancer Cells, Andrew E. Massey

Theses and Dissertations (ETD)

Pancreatic adenocarcinoma is one of the deadliest forms of cancer. Even with recent advances in diagnostic tools, chemotherapeutic regimens, and biomarkers for earlier detection, it still has dismal survival rates. Part of the reason for this is the inherent difficulty in detecting and treating this disease. Recent findings suggest that the altered expression of mucins, including MUC13, may be useful molecular signatures for early disease diagnosis, chemotherapy response and predicting patient survival. MUC13, a recently identified transmembrane glycoprotein, is normally associated with forming a protective barrier on epithelial tissues. However, its overexpression/aberrant subcellular localization has been associated with cancer, disease …

Coronavirus Disease 2019 (Covid-19), Matthew Dunbar

Pharmacy Student Scholarship

No abstract provided.

Identification Of Factors Affecting Clinical Management And The Outcomes In Patients With Guillain Barre Syndrome, Vijaynarayana Kunhikatta Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Introduction: Guillain Barre syndrome (GBS) is a rare autoimmune neurological disorder in which the body’s immune system attacks part of its peripheral nervous system resulting in limb and cranial nerve weakness often with respiratory compromise and limitation on physical function. The worldwide incidence of GBS ranges from 0.81 to 1.89 cases per 100000 person-years. Various factors such as age, symptoms and disease form that influence the outcome of GBS have been previously studied. This study seeks the additional fundamental knowledge of the factors affecting clinical management and the outcome in patients with GBS. Objective: To identify factors affecting clinical management …

Cancer Stem Cell Chemotherapeutics Assay For Prospective Treatment Of Recurrent Glioblastoma And Progressive Anaplastic Glioma: A Single-Institution Case Series, Tulika Ranjan, Candace M. Howard, Alexander Yu, Linda Xu, Khaled Aziz, David Jho, Jodi Leonardo, Muhammad A. Hameed, Stephen M. Karlovits, Rodney E. Wegner, Russell Fuhrer, Seth T. Lirette, Krista L. Denning, Jagan Valluri, Pier Paolo Claudio

Faculty and Student Publications

© 2020 BACKGROUND: Chemotherapy-resistant cancer stem cells (CSC) may lead to tumor recurrence in glioblastoma (GBM). The poor prognosis of this disease emphasizes the critical need for developing a treatment stratification system to improve outcomes through personalized medicine. METHODS: We present a case series of 12 GBM and 2 progressive anaplastic glioma cases from a single Institution prospectively treated utilizing a CSC chemotherapeutics assay (ChemoID) guided report. All patients were eligible to receive a stereotactic biopsy and thus undergo ChemoID testing. We selected one of the most effective treatments based on the ChemoID assay report from a panel of FDA …

Concordance Between Electronic Health Record Data And Medicare Part D Claims Data For Oral Anticancer Drug Use, Manvi Sharma, Michael L. Johnson, Hui Zhao, Sharon H. Giordano, Holly M. Holmes

Faculty and Student Publications

No abstract provided.