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2005

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Articles 31 - 57 of 57

Full-Text Articles in Pharmacy and Pharmaceutical Sciences

Aluminium Content Of Some Foods And Food Products In The Usa, With Aluminium Food Additives, Salim M. Saiyed, Robert A. Yokel Mar 2005

Aluminium Content Of Some Foods And Food Products In The Usa, With Aluminium Food Additives, Salim M. Saiyed, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

The primary objective was to determine the aluminium (Al) content of selected foods and food products in the USA which contain Al as an approved food additive. Intake of Al from the labeled serving size of each food product was calculated. The samples were acid or base digested and analysed for Al using electrothermal atomic absorption spectrometry. Quality control (QC) samples, with matrices matching the samples, were generated and used to verify the Al determinations. Food product Al content ranged from < 1–27,000 mg kg−1. Cheese in a serving of frozen pizzas had up to 14 mg of Al, from basic sodium …

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Drug Abuse Urine Tests: False-Positive Results, Joseph A. Woelfel Mar 2005

Drug Abuse Urine Tests: False-Positive Results, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

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Sudafed Pe Nasal Decongestant, Joseph A. Woelfel Mar 2005

Sudafed Pe Nasal Decongestant, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

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Constipation Myths, Joseph A. Woelfel Mar 2005

Constipation Myths, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

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Common Inhaled Asthma Medications – Dose Comparison And Tips For Use, Joseph A. Woelfel Mar 2005

Common Inhaled Asthma Medications – Dose Comparison And Tips For Use, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

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Palladone (Hydromorphone Extended-Release Capsules), Joseph A. Woelfel Mar 2005

Palladone (Hydromorphone Extended-Release Capsules), Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

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Research News: 2005, No. 1, University Of Mississippi. School Of Pharmacy Feb 2005

Research News: 2005, No. 1, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants, publications, technology transfer, special announcements

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Nanoscintillation Systems For Aqueous-Based Liquid Scintillation Counting, Russell J. Mumper, Michael Jay Feb 2005

Nanoscintillation Systems For Aqueous-Based Liquid Scintillation Counting, Russell J. Mumper, Michael Jay

Pharmaceutical Sciences Faculty Patents

The present invention relates to the use of nanoscintillation systems, or nanoparticles containing fluor molecules, that can be used to detect an electron-emitting or alpha-particle-emitting radioisotope in the absence of organic-solvents commonly used in organic-based liquid scintillation cocktails. The invention also relates to compositions and use of three oil-in-water microemulsion precursors that can be engineered rapidly, reproducibly, and cost-effectively to produce useful nanoparticles less than 100 nanometers.

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Pharmacy Care Otc Status Supported But Otc Status Of Statins Denied, Joseph A. Woelfel Feb 2005

Pharmacy Care Otc Status Supported But Otc Status Of Statins Denied, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

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C-Reactive Protein And Statin Benefits, Joseph A. Woelfel Feb 2005

C-Reactive Protein And Statin Benefits, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

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Fda Warning For Aluminum-Containing Antiperspirants, Joseph A. Woelfel Feb 2005

Fda Warning For Aluminum-Containing Antiperspirants, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

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Assessment Of Autoimmune Responses Associated With Asbestos Exposure In Libby, Montana, Usa, Jean C. Pfau, J. J. Sentissi, G. Weller, Elizabeth Putnam Jan 2005

Assessment Of Autoimmune Responses Associated With Asbestos Exposure In Libby, Montana, Usa, Jean C. Pfau, J. J. Sentissi, G. Weller, Elizabeth Putnam

Biomedical and Pharmaceutical Sciences Faculty Publications

Systemic autoimmune responses are associated with certain environmental exposures, including crystalline particles such as silica. Positive antinuclear antibody (ANA) tests have been reported in small cohorts exposed to asbestos, but many questions remain regarding the prevalence, pattern, and significance of autoantibodies associated with asbestos exposures. The population in Libby, Montana, provides a unique opportunity for such a study because of both occupational and environmental exposures that have occurred as a result of the mining of asbestos-contaminated vermiculite near the community. As part of a multifaceted assessment of the impact of asbestos exposures on this population, this study explored the possibility …

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Non-Human Primates In Medical Research And Drug Development: A Critical Review, Jarrod Bailey Jan 2005

Non-Human Primates In Medical Research And Drug Development: A Critical Review, Jarrod Bailey

Laboratory Experiments Collection

There is much current debate surrounding the use of non-human primates (NHPs) in medical research and drug development. This review, stimulated by calls for evidence from UK-based inquiries into NHP research, takes a critical view in order to provide some important balance against papers supporting NHP research and calling for it to be expanded. We show that there is a paucity of evidence to demonstrate the positive contribution or successful translation of NHP research to human medicine, that there is a great deal of often overlooked data showing NHP research to be irrelevant, unnecessary, even hazardous to human health and …

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Does The Quantity Of Enteral Nutrition Affect Outcomes In Critically Ill Trauma Patients?, Jennifer L. Ash, Jane M. Gervasio, Gary P. Zaloga, George H. Rodman Jr. Jan 2005

Does The Quantity Of Enteral Nutrition Affect Outcomes In Critically Ill Trauma Patients?, Jennifer L. Ash, Jane M. Gervasio, Gary P. Zaloga, George H. Rodman Jr.

Scholarship and Professional Work – COPHS

Abstract from Clinical Nutrition Week, Orlando, FL, January 29-February 2, 2005.

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Chronic Outpatient Sildenafil Therapy For Pulmonary Hypertension In A Child After Cardiac Surgery, Chad A. Knoderer, E. S. Ebenroth, J. W. Brown Jan 2005

Chronic Outpatient Sildenafil Therapy For Pulmonary Hypertension In A Child After Cardiac Surgery, Chad A. Knoderer, E. S. Ebenroth, J. W. Brown

Scholarship and Professional Work – COPHS

We report the case of a 14-month-old male with d-transposition of the great arteries, ventricular septal defect, and pulmonary hypertension successfully treated with long-term sildenafil following cardiac surgery. To our knowledge, this is the first published report of long-term sildenafil treatment in a child after corrective cardiac surgery.

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Chemical And Biochemical Modification Of Surfaces For Control Of Wettability, Adsorption, And Drug Delivery, Susan C. D'Andrea Jan 2005

Chemical And Biochemical Modification Of Surfaces For Control Of Wettability, Adsorption, And Drug Delivery, Susan C. D'Andrea

Seton Hall University Dissertations and Theses (ETDs)

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Mouse Cytomegalovirus M33 Is Necessary And Sufficient In Virus-Induced Vascular Smooth Muscle Cell Migration, Ryan Melnychuk, Patsy Smith, Craig N. Kreklywich, Franziska Ruchti, Jennifer Totonchy, Laurel Hall, Lambert Loh, Jay A. Nelson, Susan L. Orloff, Daniel N. Streblow Jan 2005

Mouse Cytomegalovirus M33 Is Necessary And Sufficient In Virus-Induced Vascular Smooth Muscle Cell Migration, Ryan Melnychuk, Patsy Smith, Craig N. Kreklywich, Franziska Ruchti, Jennifer Totonchy, Laurel Hall, Lambert Loh, Jay A. Nelson, Susan L. Orloff, Daniel N. Streblow

Pharmacy Faculty Articles and Research

Mouse cytomegalovirus (MCMV) encodes two potential seven-transmembrane-spanning proteins with homologies to cellular chemokine receptors, M33 and M78. While these virus-encoded chemokine receptors are necessary for the in vivo pathogenesis of MCMV, the function of these proteins is unknown. Since vascular smooth muscle cell (SMC) migration is of critical importance for the development of atherosclerosis and other vascular diseases, the ability of M33 to promote SMC motility was assessed. Similar to human CMV, MCMV induced the migration of mouse aortic SMCs but not mouse fibroblasts. To demonstrate whether M33 was required for MCMV-induced SMC migration, we employed interfering-RNA technology to specifically …

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A Comparison Of Esomeprazole And Lansoprazole For Control Of Intragastric Ph In Patients With Symptoms Of Gastro-Oesophageal Reflux Disease, D. A. Johnson, T. Stacy, M. Ryan, T. Wootton, J. Willia, K. Hornbuckle, W. Brooks, M. Doviak Jan 2005

A Comparison Of Esomeprazole And Lansoprazole For Control Of Intragastric Ph In Patients With Symptoms Of Gastro-Oesophageal Reflux Disease, D. A. Johnson, T. Stacy, M. Ryan, T. Wootton, J. Willia, K. Hornbuckle, W. Brooks, M. Doviak

Mathematics & Statistics Faculty Publications

Background: Intragastric acid suppression is the most direct measure of the pharmacodynamic efficacy of proton pump inhibitors, which are the most effective drugs for acid-related diseases.

Aim: To compare the effectiveness of once and twice daily dosing of lansoprazole and esomeprazole in controlling intragastric acidity ( target gastric pH > 4.0) over a 24-hour period.

Methods: In an open-label, two-way crossover study, 45 Helicobacter pylori-negative patients with gastro-oesophageal reflux disease were randomized to receive one of two regimens: 30 mg lansoprazole or esomeprazole 40 mg once daily. Intragastric pH was assessed by 24-hour pH monitoring on day 5 of each regimen. …

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Clinical Pharmacology Of Ms-275, A Histone Deacetylase Inhibitor, Milin R. Acharya Jan 2005

Clinical Pharmacology Of Ms-275, A Histone Deacetylase Inhibitor, Milin R. Acharya

Theses and Dissertations

The goal of this escalating single-dose phase I research study was to determine the safety, tolerability, pharmacokinetics, pharmacodynamics as well as in vitro metabolism and plasma protein binding of MS-275, a novel histone deacetylase inhibitor, in patients with solid tumors and lymphomas. A validated LC/MS assay was developed to quantitate MS-275 in plasma, human liver microsomes and urine. The pharmacokinetic (PK) evaluation was done using a non-compartmental approach. In-vitro plasma protein binding profile of MS-275 was characterized by a validated micro-equilibrium dialysis method. In vitro phase I and phase II hepatic metabolism of MS-275 were evaluated using human liver microsomes. …

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The Influence Of Direct-To-Consumer Advertising: Who Will Talk To Their Doctor As A Result Of Prescription Drug Advertisement?, Hai Dubo Chen Jan 2005

The Influence Of Direct-To-Consumer Advertising: Who Will Talk To Their Doctor As A Result Of Prescription Drug Advertisement?, Hai Dubo Chen

Theses and Dissertations

OBJECTIVES: To identify the types of patients who talk with their physicians as a result of Direct-to-Consumer (DTC) advertising. METHODS: Data were taken from a national survey, "Public Health Impact of Direct-to-Consumer Advertising of Prescription Drugs, July 2001- January 2002", conducted by researchers from Harvard Medical School. Participants (n = 3000) were interviewed by telephone. We constructed a conceptual framework consisting of outcomes (3 types of physician visits), intervention (DTC experience) and five groups of explanatory factors (health beliefs, demographics, health status, socioeconomic status and market factors). Data were analyzed with three multivariate stepwise logistic regressions. The three dependent variables …

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Evaluation Of The Pharmacokinetic-Pharmacodynamic Relationship, Metabolism And Plasma Protein Binding Of The Novel Antitumor Agent, 2-Methoxyestradiol (2me2), Following Oral Administration In Patients With Solid Tumors., Nehal Jagdish Lakhani Jan 2005

Evaluation Of The Pharmacokinetic-Pharmacodynamic Relationship, Metabolism And Plasma Protein Binding Of The Novel Antitumor Agent, 2-Methoxyestradiol (2me2), Following Oral Administration In Patients With Solid Tumors., Nehal Jagdish Lakhani

Theses and Dissertations

The goal of this study was to determine safety, tolerability and pharmacokinetics of 2ME2 in patients with solid tumors and determine maximum tolerated dose (MTD). The following hypotheses were tested: 1) 2ME2 will be well tolerated in clinic when given orally and will have quantifiable effects on the ex vivo markers of angiogenesis and apoptosis; 2) 2ME2 will exhibit linear pharmacokinetics; 3) Plasma protein binding will be extensive and linear; 4) Sulfation will be the major metabolic pathway for 2ME2.This was a phase I dose escalation study. Twenty patients with refractory solid tumors were enrolled. 2ME2 was administered orally starting …

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Dangerous Medications – Preventing Serious Side Effects, Joseph A. Woelfel, N. B. O'Mara Jan 2005

Dangerous Medications – Preventing Serious Side Effects, Joseph A. Woelfel, N. B. O'Mara

School of Pharmacy Faculty Articles

No abstract provided.

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Seasonal Affective Disorder (Sad) Light Therapy, Joseph A. Woelfel Jan 2005

Seasonal Affective Disorder (Sad) Light Therapy, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

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Isosorbide Dinitrate Plus Hydralazine In Blacks With Heart Failure, Joseph A. Woelfel Jan 2005

Isosorbide Dinitrate Plus Hydralazine In Blacks With Heart Failure, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

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Dangerous Medications – Preventing Serious Side Effects, Joseph A. Woelfel Jan 2005

Dangerous Medications – Preventing Serious Side Effects, Joseph A. Woelfel

School of Pharmacy Faculty Articles

No abstract provided.

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A Nomogram For Valproic Acid And The Effect Of Missed Doses, Alaa M. Ahmad Jan 2005

A Nomogram For Valproic Acid And The Effect Of Missed Doses, Alaa M. Ahmad

Theses and Dissertations

Background. Clinicians are divided on dosing recommendations when a dose is delayed or missed. For a neuropsychiatric agent like valproic acid (VPA), rational dosing recommendations are of particular importance. VPA is subject to therapeutic monitoring using total concentrations. Due to non-linear binding of VPA to plasma proteins, current dose titration schemes for VPA are empirical. The objectives of this research were to 1- study the effect of missed/delayed doses on steady state concentrations of VPA and 2-design a nomogram that can be used for dose titration based on total VPA concentrations. Methods. 1- A simulation study was conducted to test …

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Symptoms Of Gastro-Oesophageal Reflux Disease And The Severity Of Obstructive Sleep Apnoea Syndrome Are Not Related In Sleep Disorders Center Patients, H.-N. Kim, R. D. Vorona, M. P. Winn, M. Doviak, D. A. Johnson, J. Catesby Ware Jan 2005

Symptoms Of Gastro-Oesophageal Reflux Disease And The Severity Of Obstructive Sleep Apnoea Syndrome Are Not Related In Sleep Disorders Center Patients, H.-N. Kim, R. D. Vorona, M. P. Winn, M. Doviak, D. A. Johnson, J. Catesby Ware

Mathematics & Statistics Faculty Publications

Background: Studies suggest obstructive sleep apnea syndrome (OSAS) frequently manifests in patients with gastroesophageal reflux disease (GERD) and that there may be a causal relationship.

Aim: To determine the relationship between OSAS and symptoms of GERD.

Methods: Consecutive patients referred to the Sleep Disorders Center (SDC) 18 years and older with polysomnographically defined OSAS were evaluated prospectively for GERD using a validated symptoms questionnaire. The GERD and OSAS relationship was assessed by 1) determining frequency of GERD in patients with and without OSAS; 2) ascertaining the relationship between OSAS severity categories and presence of GERD; 3) examining GERD score in …

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