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Articles 31 - 60 of 178
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Genetic Variations In A Cytochrome P450 Enzyme And The Effects On Clopidogrel Bioactivation And Metabolism, Maryanne Ventura, Lauren Desko, Kimberly Gathers, Ashley Overy, David Kisor
Genetic Variations In A Cytochrome P450 Enzyme And The Effects On Clopidogrel Bioactivation And Metabolism, Maryanne Ventura, Lauren Desko, Kimberly Gathers, Ashley Overy, David Kisor
Pharmacy and Wellness Review
Clopidogrel, the top prescribed antiplatelet medication for individuals who have experienced a myocardial infarction or cerebral vascular accident or who have peripheral arterial disease, is administered orally as a prodrug. It relies on hepatic metabolism through cytochrome P450 enzymes for conversion to its active form. Current research shows that allelic variation m the gene coding for CYP2C19 is the main factor contributing to the variability of response associated with clopidogrel treatment. Through the promotion of genetic testing for variability in the CYP2C19 gene and competently interpreting test results, pharmacists have the opportunity to use these findings to significantly impact clopidogrel …
Recent Advances Spark Significant Guideline Change: Antiretroviral Therapy (Art) At High Cd4+ Counts In The Treatment Naïve Patient, Joshua Ilenin, Kelly Fargo, Lisa Berni, Kristen Thatcher, Caitlin Swann, Andrew Roecker
Recent Advances Spark Significant Guideline Change: Antiretroviral Therapy (Art) At High Cd4+ Counts In The Treatment Naïve Patient, Joshua Ilenin, Kelly Fargo, Lisa Berni, Kristen Thatcher, Caitlin Swann, Andrew Roecker
Pharmacy and Wellness Review
Human immunodeficiency virus (HIV) targets CD4+ lymphocytes, a critical component to proper functioning of the human immune system. HIV is a significant public health concern, having resulted in over 27 million deaths since its discovery. Currently, several different treatment options exist, with combination antiretroviral therapy (ART) at the forefront. Despite the success of ART therapy, there are number of problems, including poor patient compliance. Due to this, the appropriate time to initiate therapy in the treatment naïve patient is under continuous scrutiny. Recently, several trials have demonstrated evidence suggesting that initiating ART at high CD4+ counts in the treatment naïve …
The Haunting Of Medical Literature, Brieann Miller, Tana Peterman
The Haunting Of Medical Literature, Brieann Miller, Tana Peterman
Pharmacy and Wellness Review
Ghostwriting, or using the names of academic researchers to validate studies commissioned by pharmaceutical companies, has become a growing concern within medical literature. Omission from authorship of the names of individuals making considerable contributions to a paper is one of the most significant aspects of ghostwriting. Policy prohibiting medical ghostwriting is lacking, and it is nearly impossible to prevent the practice without strict and thorough guidelines. More strict guidelines banning ghostwriting, denying government funds to organizations without such policies, and development of databases to track offending authors and organizations could decrease the impact of ghostwriting in medical literature.
The Hiv Vaccine: Learning From Failure And Building On Success, Lindsey Mcclish, Kimberly Gathers, Katie Salay, Lisa Vranekovic, Kristin Seaman, Kelly M. Shields
The Hiv Vaccine: Learning From Failure And Building On Success, Lindsey Mcclish, Kimberly Gathers, Katie Salay, Lisa Vranekovic, Kristin Seaman, Kelly M. Shields
Pharmacy and Wellness Review
An effective vaccine for acquired immune deficiency syndrome (AIDS) has eluded researchers since the identification of the HIV virus. There are many challenges in developing an effective HIV vaccine, including the lack of knowledge regarding the immune response to the virus and its diverse nature. Ethical concerns further complicate research. A recent phase III trial was performed in Thailand and showed that a significant reduction in HIV infection is possible. Pharmacists need to stay informed of these important breakthroughs in AIDS research in order to provide quality health information to patients in their community. This paper aims to evaluate the …
The Use Of Propranolol In The Treatment Of Posttraumatic Stress Disorder, Tana M. Peterman, Alison L. Huet, Sarah E. Drake, Jamie L. Drees, Robert D. Raiff, B. Shane Martin
The Use Of Propranolol In The Treatment Of Posttraumatic Stress Disorder, Tana M. Peterman, Alison L. Huet, Sarah E. Drake, Jamie L. Drees, Robert D. Raiff, B. Shane Martin
Pharmacy and Wellness Review
This article examines the rising issue of post-traumatic stress disorder (PTSD) and possible treatment options. PTSD is a behavioral disorder resulting from memory formation and association with a traumatic event. A search of the published literature reveals several positive studies and case reports suggesting that propranolol, a beta adrenergic receptor antagonist, may be useful for both treatment and prevention of PTSD. Additionally, current studies are being completed in different population groups to determine the overall effectiveness and mechanism by which propranolol is able to provide relief from certain symptoms common to the disorder. This article discusses the medical evidence and …
Implications And Concerns Regarding The Mammogram Debate, Kristen Quertinmont, Breanne Rizzo, Caitlin Swan, Mary E. Klein, Lindsay Coram, Whitney N. Detillion, Anne F. Gentry, Natalie Dipietro, Brenda Rizzo
Implications And Concerns Regarding The Mammogram Debate, Kristen Quertinmont, Breanne Rizzo, Caitlin Swan, Mary E. Klein, Lindsay Coram, Whitney N. Detillion, Anne F. Gentry, Natalie Dipietro, Brenda Rizzo
Pharmacy and Wellness Review
Screening procedures that detect breast cancer in its early stages are an important element of preventative health care for all women. When official guidelines and recommendations for screening are modified, their changes impact health care at both the population and individual patient levels. Recently, the United States Preventive Service Task Force (USPSTF) has developed new recommendations regarding when to start mammogram screening for breast cancer in women of average risk for the development of breast cancer. This article discusses the rationale behind the updated USPSTF recommendations and also presents the current American Cancer Society (ACS) guidelines.
Prescription Drug Abuse: A Guide For Pharmacists, Brieann J. Miller, Amanda C. Mcdavid, Nicholas J. Edmonds, Joshua P. Stevens, Cynthia C. Nguyen, Ryan W. Naseman, Michael M. Milks
Prescription Drug Abuse: A Guide For Pharmacists, Brieann J. Miller, Amanda C. Mcdavid, Nicholas J. Edmonds, Joshua P. Stevens, Cynthia C. Nguyen, Ryan W. Naseman, Michael M. Milks
Pharmacy and Wellness Review
Millions of Americans use prescription psychotherapeutc drugs for nonmedical purposes. The most commonly abused prescription drugs are painkillers, followed by sedatives and stimulants. The first step towards ending prescription drug abuse must be taken by the pharmacist. Professional and student organizations, as well the as the newly founded Ohio Rx Abuse Prevention (OhioRAP) Coalition, provide resources to pharmacists and pharmacy students who want to reduce prescription drug abuse. This article discusses these various resources and provides a guide for pharmacists to take an active role in reducing prescription drug abuse and positively impact patient outcomes and their communities.
Pharmacogenomics: Your Medical Identity, Hilary Stewart, Lisa Berni, Tyler Bulcher, Joel Rittenhouse, Ryan W. Naseman, Jon E. Sprague
Pharmacogenomics: Your Medical Identity, Hilary Stewart, Lisa Berni, Tyler Bulcher, Joel Rittenhouse, Ryan W. Naseman, Jon E. Sprague
Pharmacy and Wellness Review
Pharmacogenomics, the fusion of pharmacology and genomics, shows strong potential to solve many of today's dosing problems. lnter-patient dosing requirements, mainly due to genetic variability between patients, represent significant challenges for prescribers. Certain receptors, drug-targeted proteins, drug-transport mechanisms and drug-metabolizing enzymes are genetically established. Hence, any defect, absence or abnormality in the gene could alter how an affected individual will respond to a given drug. Due to advancements in technology, health care professionals who utilize pharmacogenomics may assess a patient's genetic profile and determine a predicted response to specific medications. This may result in potentially optimal dosing at the onset …
Role Of The Pharmacist In Improving Treatment For Children With Concurrent Gastrointestinal And Autism Spectrum Disorders, Whitney R. Henry, Kaitlin A. Sanders, Jenna L. Schaffner, Leslie M. Hart, Whitney N. Detillion, Anne F. Gentry
Role Of The Pharmacist In Improving Treatment For Children With Concurrent Gastrointestinal And Autism Spectrum Disorders, Whitney R. Henry, Kaitlin A. Sanders, Jenna L. Schaffner, Leslie M. Hart, Whitney N. Detillion, Anne F. Gentry
Pharmacy and Wellness Review
Over the last several years, a noteworthy association between gastrointestinal (GI) disorders and autism spectrum disorders (ASD) has been documented, although no large population-based studies exist. GI disorders in ASD children may stem from the underlying behavioral, communication, sensory or neurological issues intrinsic to the autistic disorder itself; therefore, the incorporation of alternative therapies, including behavioral modification, may be compelling treatment additions to the GI care traditionally recommended in children. To improve GI symptoms and quality of life in ASD children, a multidisciplinary approach is optimal, with pharmacists playing an active role in determining appropriate pharmacotherapy. Although there is a …
Options For Breast Cancer Prevention In High-Risk Patients, Ashley M. Overy, Lacey A. Shumate, Sarah M. Webb, Ashley E. Lehnert, Monica A. Weisenberger, Whitney N. Detillion, Andrew M. Roecker
Options For Breast Cancer Prevention In High-Risk Patients, Ashley M. Overy, Lacey A. Shumate, Sarah M. Webb, Ashley E. Lehnert, Monica A. Weisenberger, Whitney N. Detillion, Andrew M. Roecker
Pharmacy and Wellness Review
Breast cancer is the most frequently diagnosed non-skin cancer in women, and one in eight women will develop breast cancer within their Iifetimes. Unfortunately, the strongest risk factors for breast cancer (i.e. age, family history, hormonal factors) are not easily modified. There is some evidence that chemopreventative drugs may be able to prevent breast cancer in high-risk patients. Tamoxifen and raloxifene have been shown to reduce the risk of breast cancer in high-risk women but may be associated with several serious adverse events. Clinical trials are currently in progress to determine if aromatase inhibitors are a viable alternative for breast …
A Review Of Dabigatran, An Oral Anticoagulant, Lindsey A. Hallman, Chad A. Rounds, Rebecca A. Carey, Nicole R. Hume, Karen L. Kier, James Spicer
A Review Of Dabigatran, An Oral Anticoagulant, Lindsey A. Hallman, Chad A. Rounds, Rebecca A. Carey, Nicole R. Hume, Karen L. Kier, James Spicer
Pharmacy and Wellness Review
Serious clinical complications associated with venous thrombotic embolism (VTE) necessitate prophylaxis in patient groups who are at high risk of VTE, specifically those recovering from orthopedic surgery with atrial fibrillation, with mechanical heart valves, at increased risk for stroke, or recovering post-MI. Currently, prophylaxis with warfarin, enoxaparin, or fondaparinux has been the standard of therapy, but these therapies each have their limitations. Dabigatran etexilate is an orally available pro-drug of dabigatran, a competitive, reversible, direct inhibitor thrombin (Factor lla). The agent is converted by esterases, and, thus, not associated with the complications of the CYP enzyme system. Dabigatran follows a …
Introduction & Medical Communications And Writing, Maggie Allen, Kate Klyczek, Anne F. Gentry
Introduction & Medical Communications And Writing, Maggie Allen, Kate Klyczek, Anne F. Gentry
Pharmacy and Wellness Review
No abstract provided.
Good Publication Practice Guidelines: Integrity, Completeness, Transparency, Accountability And Responsibility, Anne F. Gentry
Good Publication Practice Guidelines: Integrity, Completeness, Transparency, Accountability And Responsibility, Anne F. Gentry
Pharmacy and Wellness Review
No abstract provided.
Professional Leadership Development, Jena Schlabach, Meagan Brandt, Olivia Vanscoy, Kasie Bellmann, Jenelle Sobotka, Marianne F. Ivey
Professional Leadership Development, Jena Schlabach, Meagan Brandt, Olivia Vanscoy, Kasie Bellmann, Jenelle Sobotka, Marianne F. Ivey
Pharmacy and Wellness Review
No abstract provided.
Healthcare Delivery And Pharmacy Workforce: Pharmacy (Wo)Manpower - 2016 And Beyond..., Crystal Zheng, Mariah Steele, Noori Lee, Sabrina Hamman, Stanley Kent
Healthcare Delivery And Pharmacy Workforce: Pharmacy (Wo)Manpower - 2016 And Beyond..., Crystal Zheng, Mariah Steele, Noori Lee, Sabrina Hamman, Stanley Kent
Pharmacy and Wellness Review
No abstract provided.
Population Health Management, Data And Technology, Helena Ladd, Cody Hepp, Anna Mccloud, Hannah Granger, Mary Ellen Hethcox, Samuel Calabrese
Population Health Management, Data And Technology, Helena Ladd, Cody Hepp, Anna Mccloud, Hannah Granger, Mary Ellen Hethcox, Samuel Calabrese
Pharmacy and Wellness Review
No abstract provided.
Discussing The Future Of Drug Development And The Pharmaceutical Marketplace, Brittiany Feher, Brady Giles, Gina Jones, Karen Kier, Chet Kaczor
Discussing The Future Of Drug Development And The Pharmaceutical Marketplace, Brittiany Feher, Brady Giles, Gina Jones, Karen Kier, Chet Kaczor
Pharmacy and Wellness Review
No abstract provided.
Professional Priorities To Optimize Patient Outcomes, Megan Bishop, Joelle Hall, Mikayla Shea, Katherine Liu, Steven J. Martin, John Armistead
Professional Priorities To Optimize Patient Outcomes, Megan Bishop, Joelle Hall, Mikayla Shea, Katherine Liu, Steven J. Martin, John Armistead
Pharmacy and Wellness Review
No abstract provided.
The Road To Provider Status: Legislative Obstacles And Precursors, Todd A. Tucker Jr., Sarah Turley, Kaila Bollinger, Lara Long, Jenelle Sobotka, Amy Fanous
The Road To Provider Status: Legislative Obstacles And Precursors, Todd A. Tucker Jr., Sarah Turley, Kaila Bollinger, Lara Long, Jenelle Sobotka, Amy Fanous
Pharmacy and Wellness Review
No abstract provided.
Accountable Care Organizations: What Pharmacists Should Know, Kaitlin M. Horton, Rachel J. Pucel, Alison L. Streinbrunner, Lindsay A. Fleegle, Donald L. Sullivan
Accountable Care Organizations: What Pharmacists Should Know, Kaitlin M. Horton, Rachel J. Pucel, Alison L. Streinbrunner, Lindsay A. Fleegle, Donald L. Sullivan
Pharmacy and Wellness Review
No abstract provided.
Metformin And Cancer: Pharmacoepidemiology Considerations, Sarah Kradel, Christina Spinaris, Victoria Pennington, Adam Trimble, Lara Long, Natalie Dipietro
Metformin And Cancer: Pharmacoepidemiology Considerations, Sarah Kradel, Christina Spinaris, Victoria Pennington, Adam Trimble, Lara Long, Natalie Dipietro
Pharmacy and Wellness Review
No abstract provided.
Sterile Compounding: Regulations Addressed After The Meningitis Outbreak Of 2012, Kelly M. Dye, Tara M. Tokar, Halle M. Orlinski, Heather Helsel, Marcia M. Worley
Sterile Compounding: Regulations Addressed After The Meningitis Outbreak Of 2012, Kelly M. Dye, Tara M. Tokar, Halle M. Orlinski, Heather Helsel, Marcia M. Worley
Pharmacy and Wellness Review
No abstract provided.
Adderall®: Understanding And Preventing Its Abuse Amongst College-Aged Students, Adam Trimble, Cody Hay, Lindsay Mark, Heather Helsel, Tom Kier
Adderall®: Understanding And Preventing Its Abuse Amongst College-Aged Students, Adam Trimble, Cody Hay, Lindsay Mark, Heather Helsel, Tom Kier
Pharmacy and Wellness Review
No abstract provided.
Different Types Of Board Certified Pharmacists, Taylor Alane Beale, Megan Ruffner, Joanne Kien Tran, Lindsay A. Fleegle, Jennifer J. Kline, Pat Parteleno
Different Types Of Board Certified Pharmacists, Taylor Alane Beale, Megan Ruffner, Joanne Kien Tran, Lindsay A. Fleegle, Jennifer J. Kline, Pat Parteleno
Pharmacy and Wellness Review
No abstract provided.
Common Questions And Answers Regarding Oarrs For Pharmacists, Brittany M. Dye, Victoria S. Pennington, Rachel J. Pucel, Lindsay A. Fleegle, Donald L. Sullivan
Common Questions And Answers Regarding Oarrs For Pharmacists, Brittany M. Dye, Victoria S. Pennington, Rachel J. Pucel, Lindsay A. Fleegle, Donald L. Sullivan
Pharmacy and Wellness Review
No abstract provided.
How To Set Up An Outreach Event: A Guide For Pharmacists, Kimberly Baucher, Andrew Skouby, Tanya Wilsmann, Eric Stack, Kristen Finley Sobota
How To Set Up An Outreach Event: A Guide For Pharmacists, Kimberly Baucher, Andrew Skouby, Tanya Wilsmann, Eric Stack, Kristen Finley Sobota
Pharmacy and Wellness Review
No abstract provided.
Prescription Drug Abuse: What Are We Doing About It?, Heather Helsel, Thomas Otroba, Juliana Zschoche, Brandon Haas
Prescription Drug Abuse: What Are We Doing About It?, Heather Helsel, Thomas Otroba, Juliana Zschoche, Brandon Haas
Pharmacy and Wellness Review
No abstract provided.
Genetic Predispositions To Opioid Addiction, Legislative Action And Implications To Pharmacy Practice, Adam N. Trimble, David N. Jones, Courtney L. Salvino, Michael M. Milks, David Kisor
Genetic Predispositions To Opioid Addiction, Legislative Action And Implications To Pharmacy Practice, Adam N. Trimble, David N. Jones, Courtney L. Salvino, Michael M. Milks, David Kisor
Pharmacy and Wellness Review
Prescription pain-relievers can be powerfully effective agents in the treatment of moderate to severe pain; however, these drugs are also strongly associated with drug abuse and addiction. In the brain, opioid analgesics bind to various receptors in the mesocorticolimbic dopaminergic pathways, which play a multifaceted interaction of role in reward. Several specific single nucleotide polymorphisms (SNPs) have been identified as potential genetic factors that increase an individual's risk for addiction; however, confounding studies and lack of large trials prohibit definitive conclusions from being drawn. As a result of genetic testing, federal and state laws have been enacted to protect individuals …
Decoding The Prescription, Kim Baucher, Jessica Langhals, Ross Robison, Kristen Finley Sobota
Decoding The Prescription, Kim Baucher, Jessica Langhals, Ross Robison, Kristen Finley Sobota
Pharmacy and Wellness Review
No abstract provided.
The Role Of The Pharmacist In Patient-Centered Medical Homes, Eric Stack, Kevin Stack, Stelios Theophanous, Karen L. Kier
The Role Of The Pharmacist In Patient-Centered Medical Homes, Eric Stack, Kevin Stack, Stelios Theophanous, Karen L. Kier
Pharmacy and Wellness Review
No abstract provided.