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Halogenated Diarylacetylenes And Methods Of Treating Cancer, Vitaliy M. Sviripa, Wen Zhang, Chunming Liu, David S. Watt
Halogenated Diarylacetylenes And Methods Of Treating Cancer, Vitaliy M. Sviripa, Wen Zhang, Chunming Liu, David S. Watt
Pharmaceutical Sciences Faculty Patents
Halogenated diarylacetylenes, e.g., diarylacetylenes having at least one halo substituent in one aryl ring and an amine in the opposing aryl ring, can inhibit the proliferation of LSI 74T colon cancer cells through the inhibition of c-myc and induction of the cyclin-dependent kinase inhibitor-I (i.e., p21(Wifl/Cipl)). Such compounds are useful as antineoplastic agents.