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- Adenosine triphosphate (1)
- Ammonium compounds (1)
- Antineoplastic agents (1)
- Bacterial cocaine esterase (1)
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- Cocaine esterase polypeptides (1)
- Cocaine hydrolysis (1)
- Colon cancer cells (1)
- Halogenated diarylacetylenes (1)
- Inflammatory pain (1)
- Magic angle spinning (1)
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- Se-adenosyl-L-methionine (1)
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Articles 1 - 6 of 6
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Mutants Of Cocaine Esterase, Donald Landry, Chang-Guo Zhan
Mutants Of Cocaine Esterase, Donald Landry, Chang-Guo Zhan
Pharmaceutical Sciences Faculty Patents
Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.
Methods For Treating Neuropathic Pain, Joseph R. Holtman, Peter Anthony Crooks, Linda Phyliss Dwoskin, Michael J. Mcintosh, Elzbieta Pogonowska Wala
Methods For Treating Neuropathic Pain, Joseph R. Holtman, Peter Anthony Crooks, Linda Phyliss Dwoskin, Michael J. Mcintosh, Elzbieta Pogonowska Wala
Pharmaceutical Sciences Faculty Patents
Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
Static Multiple-Sample Nmr Probe, Eric Jon Munson, Matthew Jon Nethercott
Static Multiple-Sample Nmr Probe, Eric Jon Munson, Matthew Jon Nethercott
Pharmaceutical Sciences Faculty Patents
A static solid-state nuclear magnetic resonance (NMR) probe includes multiple probe subunits each configured for holding a sample. Each probe subunit includes at least an associated magic angle spinning (MAS) module, a radio-frequency (RF) coil and an RF transmission line together defining an RF circuit. Each of the multiple probe subunits is individually held in a conducting housing isolating the RF circuit of the each of the probe subunit from any other of the plurality of probe subunits. The static solid-state NMR probe may include four or more probe subunits including four or more MAS modules.
Halogenated Diarylacetylenes And Methods Of Treating Cancer, Vitaliy M. Sviripa, Wen Zhang, Chunming Liu, David S. Watt
Halogenated Diarylacetylenes And Methods Of Treating Cancer, Vitaliy M. Sviripa, Wen Zhang, Chunming Liu, David S. Watt
Pharmaceutical Sciences Faculty Patents
Halogenated diarylacetylenes, e.g., diarylacetylenes having at least one halo substituent in one aryl ring and an amine in the opposing aryl ring, can inhibit the proliferation of LSI 74T colon cancer cells through the inhibition of c-myc and induction of the cyclin-dependent kinase inhibitor-I (i.e., p21(Wifl/Cipl)). Such compounds are useful as antineoplastic agents.
High Activity Mutants Of Cocaine Esterase For Cocaine Hydrolysis, Chang-Guo Zhan, Fang Zheng, Lei Fang
High Activity Mutants Of Cocaine Esterase For Cocaine Hydrolysis, Chang-Guo Zhan, Fang Zheng, Lei Fang
Pharmaceutical Sciences Faculty Patents
The Bacterial cocaine esterase (CocE) mutants disclosed herein each have enhanced catalytic efficiency for ( -)cocaine, as compared to CocE mutants in the prior art, including CocE mutant E172-173. The presently-disclosed subject matter further includes a pharmaceutical composition including a mutant of bacterial cocaine hydrolase, as described herein, and a suitable pharmaceutical carrier. The presently-disclosed subject matter further includes a method of treating a cocaine-induced condition comprising administering to an individual an effective amount of a mutant of bacterial cocaine hydrolase variant, as disclosed herein, to accelerate cocaine metabolism and produce biologically inactive metabolites.
Synthesis Of Non-Natural Cofactor Analogs Of S-Adenosyl-L-Methionine Using Methionine Adenosyltransferase, Jon S. Thorson, Tyler Huber, Jianjun Zhang, Shanteri Singh
Synthesis Of Non-Natural Cofactor Analogs Of S-Adenosyl-L-Methionine Using Methionine Adenosyltransferase, Jon S. Thorson, Tyler Huber, Jianjun Zhang, Shanteri Singh
Pharmaceutical Sciences Faculty Patents
The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl- L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes.
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