Pharmacy and Pharmaceutical Sciences Commons^™

Does The Mediterranean Diet Or Botanicals Influence Alzheimer’S Disease?, Hannah Jester, Antoine Al-Achi

Pharmaceutical Sciences

No abstract provided.

Phenotyping And Genotyping Of Cyp2c19 Using Comparative Metabolism Of Proguanil In Sickle‐Cell Disease Patients And Healthy Controls In Nigeria, O. E. Adejumo, T. R. Kotila, A. G. Falusi, B. O. Silva, J. N. Nwogu, P. S. Fasinu, C. P. Babalola

Pharmaceutical Sciences

No abstract provided.

Pathway-Specific Inhibition Of Primaquine Metabolism By Chloroquine/Quinine, P. S. Fasinu, B. L. Tekwani, B. Avula, N. D. Chaurasiya, D. Nanayakkara, Y. Wang, I. A. Khan, L. A. Walker

Pharmaceutical Sciences

No abstract provided.

Complex Acylation Of Angiotensin Ii By N-Hydroxysulfosuccinimide Linked Biotin Reagents, Q. Liu, A. Lam, A. Kathuria

Pharmaceutical Sciences

N-Hydroxysulfosuccinimide-linked biotins (sulfoNHS-biotins) are water soluble biotin tags commonly used to conjugate a biotin moiety to proteins by rapid N-acylation of primary amines. Unexpected O-acylation by sulfoNHSbiotin on tyrosine of Angiotensin II (Ag-II) and an acylation on third site unable to characterize were identified by LC-MS in addition to the expected N-acylation on the N-terminal of Ag-II. The N-acylation only undergoes incomplete hydrolysis in 0.1% formic acid not at pH 7.2 and 8.0, while two unexpected acylation hydrolyze at both conditions, but their hydrolysis in 0.1% formic acid was much more rapid. Dithiothreitol treatment selectively catalyzed hydrolysis of both of …

Weight Loss Reduces Basal-Like Breast Cancer Through Kinome Reprogramming, Y. Qin, S. Sundaram, L. Essaid, X. Chen, S. M. Miller, F. Yan, D. B. Darr, J. A. Galanko, S. A. Montgomery, M. B. Major, G. L. Johnson, M. A. Troester, L. Makowski

Pharmaceutical Sciences

No abstract provided.

Direct Current Stimulation To Increase Cerebrovascular Function, V. M. Pulgar

Pharmaceutical Sciences

No abstract provided.

Direct Current Stimulation To Increase Cerebrovascular Function, V. M. Pulgar

Pharmaceutical Sciences

No abstract provided.

Local Uterine Ang-(1–7) Infusion Augments The Expression Of Cannabinoid Receptors And Differentially Alters Endocannabinoid Metabolizing Enzymes In The Decidualized Uterus Of Pseudopregnant Rats, K. B. Brosnihan, V. M. Pulgar, P. E. Gallagher, L. A. Neves, L. M. Yamaleyeva

Pharmaceutical Sciences

Background

Endocannabinoids (ECs) are important contributors to implantation and decidualization and are suppressed in early pregnancy. Elevated levels of anandamide (AEA), the endogenous ligand for the CB1 and CB2 receptors (R), interfere with receptivity of the blastocyst. Ang-(1–7) is down-regulated in the implantation site (IS) in normal pregnancy at day 7 of gestation. We determined the effects of intra-uterine angiotensin-(1–7) [Ang-(1–7)] (24 microg/kg/h) or vehicle given into the left uterine horn on the ECs in the decidualized uterus.

Methods

Ovariectomized rats were sensitized for the decidual cell reaction by steroid treatment and decidualization was induced by a bolus of oil …

Local Uterine Ang-(1-7) Infusion Augments The Expression Of Cannabinoid Receptors And Differentially Alters Endocannabinoid Metabolizing Enzymes In The Decidualized Uterus Of Pseudopregnant Rats, K. B. Brosnihan, V. M. Pulgar, P. E. Gallagher, L. A. Neves, L. M. Yamaleyeva

Pharmaceutical Sciences

No abstract provided.

Is Kava Safe To Be Used By The Public?, Antoine Al-Achi

Pharmaceutical Sciences

No abstract provided.

Does Epigallocatechin-3-Gallate-Insulin Complex Protect Human Insulin From Proteolytic Enzyme Action?, Antoine Al-Achi, Deepthi Kota

Pharmaceutical Sciences

No abstract provided.

Physical Characteristics Of Sixteen Non-Prescription Medications: Specific Gravity, Ph, Surface Tension, And Rheological Characteristics, Antoine Al-Achi, A. Kathuria, M. Zahid Khan

Pharmaceutical Sciences

No abstract provided.

Inhibition Of Lapatinib-Induced Kinome Reprogramming In Erbb2-Positive Breast Cancer By Targeting Bet Family Bromodomains, T. J. Stuhlmiller, S. M. Miller, J. S. Zawistowski, K. Nakamura, A. S. Beltran, J. S. Duncan, S. P. Angus, K. A. L. Collins, D. A. Granger, R. A. Reuther, L. M. Graves, S. M. Gomez, P-F Kuan, J. S. Parker, X. Chen, N. Sciaky, L. A. Carey, H. S. Earp, J. Jin, G. L. Johnson

Pharmaceutical Sciences

No abstract provided.

Local Intra-Uterine Ang-(1-7) Infusion Attenuates Pge2 And 6-Keto Pgf1Α In Decidualized Uterus Of Pseudopregnant Rats, K. B. Brosnihan, V. M. Pulgar, M. S. Bharadwaj, L. A. Neves, L. M. Yamaleyeva

Pharmaceutical Sciences

Background: Cyclooxygenase (COX)-derived prostanoids (PGE2, PGI2) are important contributors to the process of decidualization. Previous studies showed the presence of Ang-(1-7) in the primary and secondary decidualized zones of the implantation site at early pregnancy. Decreased concentrations of Ang-(1-7) were found in the decidualized uterus compared to the non-decidualized uterus of pseudopregnant rats, suggesting that low levels of Ang-(1-7) are required for successful decidualization at early pregnancy.

Methods: To understand the role of Ang-(1-7) in prostaglandin production in a decidualized uterus, induced by a bolus injection of sesame oil, Ang-(1-7) (24 μg/kg/h) or vehicle was then infused directly into the …

Morphine Overdose In A 6 1/2 Week-Old Infant: A Case Report, D. H. Eagerton, N. H. Goodbar, M. C. Dansby, S. N. Abel, W. C. Bell

Pharmaceutical Sciences

No abstract provided.

Enantioselective Metabolism Of Primaquine By Human Cyp2d6, P. S. Fasinu, B. L. Tekwani, N. P. Nanayakkara, B. Avula, B. H. Herath, Y. H. Wang, V. R. Adelli, M. A. Elsohly, S. I. Khan, I. A. Khan, B. S. Pybus, S. R. Marcisism, G. A. Reichard, J. D. Mccheseny, L. A. Walker

Pharmaceutical Sciences

No abstract provided.

Associations Between Dietary Intake Of Fruits And Vegetables In Relation To Urinary Estrogen Dna Adduct Ratio, K. W. Reding, M. Zahid, E. Cavalieri, E. G. Rogan, B. S. Raccor, C. Atkinson, M. Yong, K. M. Newton, J. W. Lampe

Pharmaceutical Sciences

No abstract provided.

Acclimatization To Chronic Intermittent Hypoxia In Mine Workers: A Challenge To Mountain Medicine In Chile, J. G. Farias, D. Jimenez, J. Osario, A. B. Zepeda, C. A. Figueroa, V. M. Pulgar

Pharmaceutical Sciences

In the past two decades, Chile has developed intense mining activity in the Andes mountain range, whose altitude is over 4,000 meters above sea level. It is estimated that a workforce population of over 55,000 is exposed to high altitude hypobaric hypoxia. The miners work under shift systems which vary from 4 to 20 days at the worksite followed by rest days at sea level, in a cycle repeated for several years. This Chronic Intermittent Hypoxia (CIH) constitutes an unusual condition for workers involving a series of changes at the physiological, cellular and molecular levels attempting to compensate for the …

Micelles: Chemotherapeutic Drug Delivery, Antoine Al-Achi, Jonathon Lawrence

Pharmaceutical Sciences

No abstract provided.

Acclimatization To Chronic Intermittent Hypoxia In Mine Workers: A Challenge To Mountain Medicine In Chile, J. G. Farias, D. Jimenez, J. Osorio, A. B. Zepeda, C. A. Figueroa, V. M. Pulgar

Pharmaceutical Sciences

No abstract provided.

Blood Pressure Homeostasis Is Maintained By A P311-Tgf-Β Axis, K. R. Badri, M. Yue, O. A. Carretero, S. L. Aramgam, J. Cao, S. M. Sharkady, G. H. Kim, G. A. Taylor, K. L. Bryon, L. Schuger

Pharmaceutical Sciences

No abstract provided.

Sex Hormones And Vascular Function, M. Bowling, S. Oparil, F. Hage, R. H. Hilgers, D. Xing

Pharmaceutical Sciences

No abstract provided.

Botanical Medicine: The Need For Better Quality Research, Antoine Al-Achi

Pharmaceutical Sciences

No abstract provided.

So2426 Is A Positive Regulator Of Siderophore Expression, K. L. Henne, X. -F. Wan, W. Wei, D. K. Thompson

Pharmaceutical Sciences

No abstract provided.

Role Of The At2 Receptor In Modulating The Angiotensin Ii Contractile Response Of The Uterine Artery At Mid-Gestation, V. M. Pulgar, H. Yamashiro, J. C. Rose, L. G. Moore

Pharmaceutical Sciences

Introduction: During human pregnancy, circulating concentrations of components of the renin—angiotensin system increase, but pressor refractoriness to angiotensin II (Ang-II) is observed. Given the importance of the Ang-II pressor response in deciding susceptibility to preeclampsia and of the Ang-II system for controlling uterine vasoreactivity, we sought to address the effects of pregnancy on the reactivity of the isolated uterine artery (UA) in mice.

Materials and methods : Blood pressure was measured throughout pregnancy in awake C57BL/6J mice. UA segments were isolated from three groups of animals (non-pregnant, mid [day 12—13] and late [day 18—19] gestation) and studied by wire …

Role Of The At2 Receptor In Modulating The Angiotensin Ii Contractile Response Of The Uterine Artery At Mid-Gestation, V. M. Pulgar, H. Yamashiro, J. C. Rose, L. G. Moore

Pharmaceutical Sciences

No abstract provided.

Surface-Enhanced Raman Imaging Of Intracellular Bioreduction Of Chromate, S. P. Ravindranath, K. L. Henne, D. K. Thompson, J. Irudayaraj

Pharmaceutical Sciences

No abstract provided.

Proteomics Reveals A Core Molecular Response Of Pseudomonas Putida F1 To Acute Chromate Challenge, D. K. Thompson, K. Chourey, G. S. Wickham, S. B. Thieman, N. C. Verberkmoes, B. Zhang, A. T. Mccarthy, M. A. Rudisil, M. Shah, R. L. Hettich

Pharmaceutical Sciences

No abstract provided.

High-Level Chromate Resistance In Arthrobacter Sp. Strain Fb24 Requires Previously Uncharacterized Accessory Genes, K. L. Henne, C. H. Nakatsu, D. K. Thompson, A. E. Konopka

Pharmaceutical Sciences

No abstract provided.

Effects Of Neurotensin 1 Receptor And D2 Dopamine Receptor Antagonist In Amygdaloid Learning Mechanisms, K. Laszlo, K. Toth, A. Molnar, E. Kertes, L. Peczely, L. Lenard

Pharmaceutical Sciences

No abstract provided.