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Articles 121 - 150 of 194
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Enantioselective Interactions Of Anti-Infective 8-Aminoquinoline Therapeutics With Human Monoamine Oxidases A And B, Narayan D. Chaurasiya, Haining Liu, Robert J. Doerksen, N. P. Dhammika Nanayakkara
Enantioselective Interactions Of Anti-Infective 8-Aminoquinoline Therapeutics With Human Monoamine Oxidases A And B, Narayan D. Chaurasiya, Haining Liu, Robert J. Doerksen, N. P. Dhammika Nanayakkara
Faculty and Student Publications
8-Aminoquinolines (8-AQs) are an important class of anti-infective therapeutics. The monoamine oxidases (MAOs) play a key role in metabolism of 8-AQs. A major role for MAO-A in metabolism of primaquine (PQ), the prototypical 8-AQ antimalarial, has been demonstrated. These investigations were further extended to characterize the enantioselective interactions of PQ and NPC1161 (8-[(4-amino-1-methylbutyl) amino]-5-[3, 4-dichlorophenoxy]-6-methoxy-4-methylquinoline) with human MAO-A and-B. NPC1161B, the (R)-(−) enantiomer with outstanding potential for malaria radical cure, treatment of visceral leishmaniasis and pneumocystis pneumonia infections is poised for clinical development. PQ showed moderate inhibition of human MAO-A and-B. Racemic PQ and (R)-(−)-PQ both showed marginally greater (1.2-and …
Hiv-1 Tat Protein Promotes Neuroendocrine Dysfunction Concurrent With The Potentiation Of Oxycodone’S Psychomotor Effects In Female Mice, Mohammed F. Salahuddin, Fakhri Mahdi, Suresh P. Sulochana, Jason J. Paris
Hiv-1 Tat Protein Promotes Neuroendocrine Dysfunction Concurrent With The Potentiation Of Oxycodone’S Psychomotor Effects In Female Mice, Mohammed F. Salahuddin, Fakhri Mahdi, Suresh P. Sulochana, Jason J. Paris
Faculty and Student Publications
Human immunodeficiency virus (HIV) is associated with neuroendocrine dysfunction which may contribute to co-morbid stress-sensitive disorders. The hypothalamic-pituitary-adrenal (HPA) or-gonadal (HPG) axes are perturbed in up to 50% of HIV patients. The mechanisms are not known, but we have found the HIV-1 trans-activator of transcription (Tat) protein to recapitulate the clinical phenotype in male mice. We hypothesized that HPA and/or HPG dysregulation contrib-utes to Tat-mediated interactions with oxycodone, an opioid often prescribed to HIV patients, in females. Female mice that conditionally-expressed the Tat1–86 protein [Tat(+) mice] or their counter-parts that did not [Tat(−) control mice] were exposed to forced swim …
Measurement Of The Anomalous Precession Frequency Of The Muon In The Fermilab Muon G-2 Experiment, T. Albahri, A. Anastasi, A. Anisenkov, K. Badgley
Measurement Of The Anomalous Precession Frequency Of The Muon In The Fermilab Muon G-2 Experiment, T. Albahri, A. Anastasi, A. Anisenkov, K. Badgley
Faculty and Student Publications
The Muon g-2 Experiment at Fermi National Accelerator Laboratory (FNAL) has measured the muon anomalous precession frequency ωam to an uncertainty of 434 parts per billion (ppb), statistical, and 56 ppb, systematic, with data collected in four storage ring configurations during its first physics run in 2018. When combined with a precision measurement of the magnetic field of the experiment's muon storage ring, the precession frequency measurement determines a muon magnetic anomaly of aμ(FNAL)=116 592 040(54)×10-11 (0.46 ppm). This article describes the multiple techniques employed in the reconstruction, analysis, and fitting of the data to measure the precession frequency. It …
Science Teaching Excites Medical Interest: A Qualitative Inquiry Of Science Education During The 2020 Covid-19 Pandemic, Xiaoshan Z. Gordy, Wesley Sparkmon, Hyllore Imeri, Andrew Notebaert
Science Teaching Excites Medical Interest: A Qualitative Inquiry Of Science Education During The 2020 Covid-19 Pandemic, Xiaoshan Z. Gordy, Wesley Sparkmon, Hyllore Imeri, Andrew Notebaert
Faculty and Student Publications
The national or local lockdowns in response to COVID-19 forced education systems to rapidly shift from in-person to distance learning. The hasty transition undoubtedly imposed tremendous challenges on teachers, students and distance learning infrastructure. The purpose of this study was to investigate how high school science teachers who had previously been trained in flipped-learning and advanced educational technology through the Science Teaching Excites Medical Interest (STEMI) program perceived their transition to distance learning during this pandemic. In this study eleven teachers were interviewed with a semi-structured interview guide. Data were analyzed using the deductive-inductive content analytic approach. Our results indicated …
High-Performance Thin-Layer Chromatography For Rutin, Chlorogenic Acid, Caffeic Acid, Ursolic Acid, And Stigmasterol Analysis In Periploca Aphylla Extracts, Raha Orfali, Shagufta Perveen, Hanan Y. Aati, Perwez Alam
High-Performance Thin-Layer Chromatography For Rutin, Chlorogenic Acid, Caffeic Acid, Ursolic Acid, And Stigmasterol Analysis In Periploca Aphylla Extracts, Raha Orfali, Shagufta Perveen, Hanan Y. Aati, Perwez Alam
Faculty and Student Publications
Periploca aphylla (PA), an interesting Saudi medicinal plant, is used in folk medicine to treat urticaria, cerebral fever, tumors, and swelling. To prove its use in folk medicine, two different extracts from the aerial parts of the plant: chloroform P-1, and n-butanol P-2 were subjected to biological assays to screen peroxisome proliferator-activated receptors (PPARα and PPARγ) agnostic, antiinflammatory, antioxidant, cytotoxic, and estrogenic activities. In addition, five bioactive secondary metabolites were isolated from the aerial parts of the plant: rutin, chlorogenic acid, caffeic acid, ursolic acid, and stigmasterol. P-1 and P-2 decreased cellular oxidative stress by 47.0% and 62.0%, respectively, compared …
Beam Dynamics Corrections To The Run-1 Measurement Of The Muon Anomalous Magnetic Moment At Fermilab, T. Albahri, A. Anastasi, K. Badgley, S. Baeßler
Beam Dynamics Corrections To The Run-1 Measurement Of The Muon Anomalous Magnetic Moment At Fermilab, T. Albahri, A. Anastasi, K. Badgley, S. Baeßler
Faculty and Student Publications
This paper presents the beam dynamics systematic corrections and their uncertainties for the Run-1 dataset of the Fermilab Muon g-2 Experiment. Two corrections to the measured muon precession frequency ωam are associated with well-known effects owing to the use of electrostatic quadrupole (ESQ) vertical focusing in the storage ring. An average vertically oriented motional magnetic field is felt by relativistic muons passing transversely through the radial electric field components created by the ESQ system. The correction depends on the stored momentum distribution and the tunes of the ring, which has relatively weak vertical focusing. Vertical betatron motions imply that the …
Magnetic-Field Measurement And Analysis For The Muon G-2 Experiment At Fermilab, T. Albahri, A. Anastasi, K. Badgley, S. Baeßler
Magnetic-Field Measurement And Analysis For The Muon G-2 Experiment At Fermilab, T. Albahri, A. Anastasi, K. Badgley, S. Baeßler
Faculty and Student Publications
The Fermi National Accelerator Laboratory (FNAL) Muon g-2 Experiment has measured the anomalous precession frequency aμ(gμ-2)/2 of the muon to a combined precision of 0.46 parts per million with data collected during its first physics run in 2018. This paper documents the measurement of the magnetic field in the muon storage ring. The magnetic field is monitored by systems and calibrated in terms of the equivalent proton spin precession frequency in a spherical water sample at 34.7C. The measured field is weighted by the muon distribution resulting in ωp′, the denominator in the ratio ωa/ωp′ that together with known fundamental …
Draft Genome Sequence Of Aneurinibacillus Sp. Strain Ba2021, Isolated As A Contaminant Of A Laboratory-Cultivated Predatory Myxobacterium, Barbara I. Adaikpoh, Scot E. Dowd, D. Cole Stevens
Draft Genome Sequence Of Aneurinibacillus Sp. Strain Ba2021, Isolated As A Contaminant Of A Laboratory-Cultivated Predatory Myxobacterium, Barbara I. Adaikpoh, Scot E. Dowd, D. Cole Stevens
Faculty and Student Publications
During laboratory cultivation of the myxobacterium Archangium violaceum strain Cb vi76, a reoccurring contaminant was isolated and sequenced. Comparative taxonomic analysis of the draft genome suggested the contaminant to be a novel species, currently designated Aneurinibacillus sp. strain BA2021, from the genus Aneurinibacillus, members of which are considered promising biocontrol agents.
Rap1a Overlaps The Age/Rage Signaling Cascade To Alter Expression Of Α‐Sma, P‐Nf‐Κb, And P‐Pkc‐Ζ In Cardiac Fibroblasts Isolated From Type 2 Diabetic Mice, Stephanie D. Burr, James A. Stewart
Rap1a Overlaps The Age/Rage Signaling Cascade To Alter Expression Of Α‐Sma, P‐Nf‐Κb, And P‐Pkc‐Ζ In Cardiac Fibroblasts Isolated From Type 2 Diabetic Mice, Stephanie D. Burr, James A. Stewart
Faculty and Student Publications
Cardiovascular disease, specifically heart failure, is a common complication for individu-als with type 2 diabetes mellitus. Heart failure can arise with stiffening of the left ventricle, which can be caused by “active” cardiac fibroblasts (i.e., myofibroblasts) remodeling the extracellular matrix (ECM). Differentiation of fibroblasts to myofibroblasts has been demonstrated to be an outcome of AGE/RAGE signaling. Hyperglycemia causes advanced glycated end products (AGEs) to accu-mulate within the body, and this process is greatly accelerated under chronic diabetic conditions. AGEs can bind and activate their receptor (RAGE) to trigger multiple downstream outcomes, such as altering ECM remodeling, inflammation, and oxidative stress. …
Design Of Topical Ocular Ciprofloxacin Nanoemulsion For The Management Of Bacterial Keratitis, Ahmed Adel Ali Youssef, Chuntian Cai, Narendar Dudhipala, Soumyajit Majumdar
Design Of Topical Ocular Ciprofloxacin Nanoemulsion For The Management Of Bacterial Keratitis, Ahmed Adel Ali Youssef, Chuntian Cai, Narendar Dudhipala, Soumyajit Majumdar
Faculty and Student Publications
Bacterial keratitis (BK) is a critical ocular infection that can lead to serious visual disability. Ciprofloxacin (CIP), moxifloxacin (MOX), and levofloxacin (LFX) have been accepted as monothera-pies by the US Food and Drug Administration for BK treatment. CIP is available commercially at 0.3% w/v concentration as an ophthalmic solution and as an ointment for ocular delivery. Because of solubility issues at physiological pH, CIP precipitation can occur at the corneal surface post instillation of the solution dosage form. Consequently, the ocular bioavailability of CIP is reduced. The ointment dosage form is associated with side effects such as blurred vision, itching, …
Entrustable Professional Activities (Epas) For Global Health, David R. Steeb, Tina P. Brock, Sarah A. Dascanio, Paul K. Drain
Entrustable Professional Activities (Epas) For Global Health, David R. Steeb, Tina P. Brock, Sarah A. Dascanio, Paul K. Drain
Faculty and Student Publications
Purpose As global health education and training shift toward competency-based approaches, academic institutions and organizations must define appropriate assessment strategies for use across health professions. The authors aim to develop entrustable professional activities (EPAs) for global health to apply across academic and workplace settings. Method In 2019, the authors invited 55 global health experts from medicine, nursing, pharmacy, and public health to participate in a multiround, online Delphi process; 30 (55%) agreed. Experts averaged 17 years of global health experience, and 12 (40%) were from low-to middle-income countries. In round one, participants listed essential global health activities. The authors used …
Biologically Guided Isolation And Admet Profile Of New Factor Xa Inhibitors Fromglycyrrhiza Glabraroots Usingin Vitroandin Silicoapproaches, Reham S. Ibrahim, Rahma S. R. Mahrous, Rasha M. Abu El-Khair, Samir A. Ross
Biologically Guided Isolation And Admet Profile Of New Factor Xa Inhibitors Fromglycyrrhiza Glabraroots Usingin Vitroandin Silicoapproaches, Reham S. Ibrahim, Rahma S. R. Mahrous, Rasha M. Abu El-Khair, Samir A. Ross
Faculty and Student Publications
Selective factor Xa inhibitors effectively block coagulation cascade with a broader therapeutic window than multitargeted anticoagulants. They have evolved as a crucial part of prevention and treatment of thromboembolic diseases and in therapeutic protocols involved in many clinical trials in coronavirus disease 2019 (COVID-19) patients. Biologically-guided isolation of specific FXa inhibitors from licorice (Glycyrrhiza glabra) root extract furnished ten flavonoids. By detailed analysis of their1H,13C NMR and MS data, the structures of these flavonoids were established as 7,4′-dihydroxyflavone (1), formononetin (2), 3-R-glabridin (3), isoliquiritigenin (4), liquiritin (5), naringenin 5-O-glucoside (6), 3,3′,4,4′-tetrahydroxy-2-methoxychalcone (7), liquiritinapioside (8) and the two isomers isoliquiritigenin-4′-O-β-d-apiosylglucoside (9) …
An Efficient Synthetic Route Tol-Γ-Methyleneglutamine And Its Amide Derivatives, And Their Selective Anticancer Activity, Md Imran Hossain, Ajit G. Thomas, Fakhri Mahdi, Amna T. Adam
An Efficient Synthetic Route Tol-Γ-Methyleneglutamine And Its Amide Derivatives, And Their Selective Anticancer Activity, Md Imran Hossain, Ajit G. Thomas, Fakhri Mahdi, Amna T. Adam
Faculty and Student Publications
In cancer cells, glutaminolysis is the primary source of biosynthetic precursors, fueling the TCA cycle with glutamine-derived α-ketoglutarate. The enhanced production of α-ketoglutarate is critical to cancer cells as it provides carbons for the TCA cycle to produce glutathione, fatty acids, and nucleotides, and contributes nitrogens to produce hexosamines, nucleotides, and many nonessential amino acids. Efforts to inhibit glutamine metabolism in cancer using amino acid analogs have been extensive.l-γ-Methyleneglutamine was shown to be of considerable biochemical importance, playing a major role in nitrogen transport inArachisandAmorphaplants. Herein we report for the first time an efficient synthetic route tol-γ-methyleneglutamine and its amide …
Proposed Mechanism For The Antitrypanosomal Activity Of Quercetin And Myricetin Isolated From Hypericum Afrum Lam: Phytochemistry, In Vitro Testing And Modeling Studies, Farida Larit, Khaled M. Elokely, Manal A. Nael, Samira Benyahia
Proposed Mechanism For The Antitrypanosomal Activity Of Quercetin And Myricetin Isolated From Hypericum Afrum Lam: Phytochemistry, In Vitro Testing And Modeling Studies, Farida Larit, Khaled M. Elokely, Manal A. Nael, Samira Benyahia
Faculty and Student Publications
The in vitro activity of L. donovani (promastigotes, axenic amastigotes and intracellular amastigotes in THP1 cells) and T. brucei, from the fractions obtained from the hydroalcoholic extract of the aerial part of Hypericum afrum and the isolated compounds, has been evaluated. The chloroform, ethyl acetate and n-butanol extracts showed significant antitrypanosomal activity towards T. brucei, with IC50 values of 12.35, 13.53 and 12.93 µg/mL and with IC90 values of 14.94, 19.31 and 18.67 µg/mL, respectively. The phytochemical investigation of the fractions led to the isolation and identification of quercetin (1), myricitrin (2), biapigenin (3), myricetin (4), hyperoside (5), myricetin-3-O-β-D-galactopyranoside (6) …
Crosstalk Of Cancer Signaling Pathways By Cyclic Hexapeptides And Anthraquinones From Rubia Cordifolia, Premalatha Balachandran, Mohamed Ali Ibrahim, Jin Zhang, Mei Wang
Crosstalk Of Cancer Signaling Pathways By Cyclic Hexapeptides And Anthraquinones From Rubia Cordifolia, Premalatha Balachandran, Mohamed Ali Ibrahim, Jin Zhang, Mei Wang
Faculty and Student Publications
The anticancer activities of Rubia cordifolia and its constituents have been reported earlier, but their influence on the crosstalk of complex cancer-related signaling metabolic pathways (i.e., transcription factors; TF) has not yet been fully investigated. In this study, R. cordifolia root extract was subjected to the cancer signaling assay based bioactivity-guided fractionation, which yielded the following compounds viz., three anthraquinones, namely alizarin (1), purpurin (2), and emodin (3); two lignans, namely eudesmin (4) and compound 5; and two cyclic hexapeptides, namely deoxybouvardin RA-V (6), and a mixture of 6+9 (RA-XXI). The structures of the isolated compounds were determined by NMR …
Development And Characterization Of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology, Abdullah Alshetaili, Bjad K. Almutairy, Sultan M. Alshehri, Michael A. Repka
Development And Characterization Of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology, Abdullah Alshetaili, Bjad K. Almutairy, Sultan M. Alshehri, Michael A. Repka
Faculty and Student Publications
The aim of this work was to develop the sustained release formulation of donepezil hydrochloride (DH) using the hot-melt extruded solid dispersion technique via the rational screening of hydrophobic carriers. Hydrophobic carriers with different physicochemical properties such as pH-independent swellability, low-permeability (Eudragit® RS PO (E-RS)), pH-independent non-swellability (ethyl cellulose N7 (EC-N7)), and the presence of lipids (Compritol® 888 ATO (C-888)) with or without pore-forming agents were used to achieve the sustained release profile of DH. Mannitol (MNT) was chosen as the temporary pore-forming agent. The thermal analysis showed that both the drug and C-888 preserved their crystallinity within a solid …
Cis-Trimethoxystilbene, Exhibits Higher Genotoxic And Antiproliferative Effects Than Its Isomer Trans-Trimethoxystilbene In Mcf-7 And Mcf-10a Cell Lines, Natália Dos Santos Gonçalves, Tamires Maria Silva Pereira De Mello, Cássia Suemi Mizuno, Saqlain Haider
Cis-Trimethoxystilbene, Exhibits Higher Genotoxic And Antiproliferative Effects Than Its Isomer Trans-Trimethoxystilbene In Mcf-7 And Mcf-10a Cell Lines, Natália Dos Santos Gonçalves, Tamires Maria Silva Pereira De Mello, Cássia Suemi Mizuno, Saqlain Haider
Faculty and Student Publications
Stilbenes are a class of natural compounds with a wide variety of biological effects, such as antitumor activity. The best-known stilbene is resveratrol, whose clinical application is limited due to its low bioavailability. Methoxylated derivatives of this stilbene, including cis-trimethoxystilbene (cis-TMS) and trans-trimethoxystilbene (trans-TMS) have demonstrated more pronounced cytotoxic and anti-proliferative effects than resveratrol. Thus, the objective of this study is to evaluate and compare the cytotoxicity and antiproliferative effects of cis-and trans-TMS in MCF-7 and its normal counterpart MCF-10A. Both compounds were cytotoxic, genotoxic, and induced G2-M accumulation and cell death in the two cell lines. These results suggested …
The Effect Of Paternal Age On Intracytoplasmic Sperm Injection Outcome In Unexplained Infertility, Haitham Elbardisi, Mohamed Arafa, Neha Singh, Bridget Betts
The Effect Of Paternal Age On Intracytoplasmic Sperm Injection Outcome In Unexplained Infertility, Haitham Elbardisi, Mohamed Arafa, Neha Singh, Bridget Betts
Faculty and Student Publications
Objective: : To examine the effect of paternal age on intracytoplasmic sperm injection (ICSI) outcomes in unexplained infertility Subjects and Methods: : This retrospective study, done at the Hamad Medical Corporation, Doha, Qatar screened infertile couples who underwent ICSI between 2014 and 2019 for the inclusion and exclusion criteria defining ‘unexplained infertility’. Couples recruited were allocated into two groups: Group A (paternal age <35 years) and Group B (paternal age ≥35 years). Baseline characteristics, investigations including semen and advanced sperm function tests and ICSI records were compared for primary outcomes such as fertilisation, cleavage, clinical pregnancy, miscarriage and live birth; and secondary outcomes such as semen parameters and advanced sperm functions (DNA fragmentation index and oxidation reduction potential). Results: : We found that final pregnancy outcomes including clinical pregnancy rate (P = 0.231), live-birth rate (P = 0.143), and miscarriage rates (P = 0.466) were not significantly different between the two age groups. Normal fertilisation (P = 0.01) and cleavage rate after ICSI (P = 0.001) were statistically significant when the age groups were compared. Also, normal sperm morphology was found to be significantly different (P = 0.041). Conclusions: : Advanced paternal age affects sperm morphology, fertilisation and embryo cleavage in ICSI but does not appear to affect clinical pregnancy, miscarriage or live-birth rates. ICSI appears to be a valid fertility treatment option in advancing paternal age.
Eucalyptus Cinerea: Microscopic Profile, Chemical Composition Of Essential Oil And Its Antioxidant, Microbiological And Cytotoxic Activities, Matheus Saukoski Pauzer, Thais De Oliveira Borsato, Valter Paes De Almeida, Vijayasankar Raman
Eucalyptus Cinerea: Microscopic Profile, Chemical Composition Of Essential Oil And Its Antioxidant, Microbiological And Cytotoxic Activities, Matheus Saukoski Pauzer, Thais De Oliveira Borsato, Valter Paes De Almeida, Vijayasankar Raman
Faculty and Student Publications
Eucalyptus species possess anti-inflammatory, antifungal, antibacterial, and insecticidal properties. In this study, the chemical composition and biological activities of Eucalyptus cinerea essential oil (EO) and the leaf and stem anatomy were investigated. EO was extracted by Clevenger apparatus and the compounds were identified by GC/MS. The antioxidant activity was evaluated by DPPH, ABTS, and reducing phosphomolybdenum complex. Broth microdilution was used to determine antimicrobial activity. Cytotoxicity was verified against HeLa, HRT-18, and Calu-3 cells by MTT assay. The cytotoxic mechanism was studied by cell DNA content, cell cycle, and DNA fragmentation. The microscopic analyzes of the leaves and the stems …
The Impact Of The Covid-19 Pandemic On Self-Reported Management Of Chronic Conditions, Hyllore Imeri, Erin Holmes, Shane Desselle, Meagen Rosenthal
The Impact Of The Covid-19 Pandemic On Self-Reported Management Of Chronic Conditions, Hyllore Imeri, Erin Holmes, Shane Desselle, Meagen Rosenthal
Faculty and Student Publications
Chronic conditions (CCs) management during the COVID-19 pandemic and the impact of the pandemic on patient activation (PA) and health locus of control (HLOC) remain unknown. This cross-sectional online survey study examined the role of COVID-19 pandemic-related worry or fear in PA and HLOC among patients with CCs. Individuals with CCs (n = 300) were recruited through MTurk Amazon. The questionnaire included sociodemographic questions, the Patient Activation Measure, and the Multidimensional Health Locus of Control–Form B. Out of the 300 participants, 9.7% were diagnosed with COVID-19, and 7.3% were hospitalized. Patients with cancer, chronic kidney disease, chronic obstructive pulmonary disease, …
Simultaneous Estimation Of Cinnamaldehyde And Eugenol In Essential Oils And Traditional And Ultrasound-Assisted Extracts Of Different Species Of Cinnamon Using A Sustainable/Green Hptlc Technique, Ahmed I. Foudah, Faiyaz Shakeel, Mohammed H. Alqarni, Samir A. Ross
Simultaneous Estimation Of Cinnamaldehyde And Eugenol In Essential Oils And Traditional And Ultrasound-Assisted Extracts Of Different Species Of Cinnamon Using A Sustainable/Green Hptlc Technique, Ahmed I. Foudah, Faiyaz Shakeel, Mohammed H. Alqarni, Samir A. Ross
Faculty and Student Publications
A wide range of analytical techniques are reported for the determination of cinnamaldehyde (CCHO) and eugenol (EOH) in plant extracts and herbal formulations either alone or in combination. Nevertheless, sustainable/green analytical techniques for the estimation of CCHO and EOH either alone or in combination are scarce in the literature. Accordingly, the present research was carried out to establish a rapid, highly sensitive, and sustainable high-performance thin-layer chromatography (HPTLC) technique for the simultaneous estimation of CCHO and EOH in the traditional and ultrasound-assisted methanolic extracts of Cinnamomum zeylanicum, C. burmannii, and C. cassia and their essential oils. The simultaneous estimation of …
Isolation Of Catechins From Cycas Armstrongii Miq. Of An Egyptian Origin, Ahmed Ismail, Mohamed M. Radwan, Hossam M. Hassan, Abeer S. Moawad
Isolation Of Catechins From Cycas Armstrongii Miq. Of An Egyptian Origin, Ahmed Ismail, Mohamed M. Radwan, Hossam M. Hassan, Abeer S. Moawad
Faculty and Student Publications
The phytochemical investigation of Cycas armstrongii Miq. leaves and twigs using different chromatographic techniques led to the isolation of three catechin monomers; catechin (1), epicatechin (2), and epigallocatechin-3-gallate (3), for the first time from this species. The chemotaxonomic significance of the isolated compounds is discussed in the rest of this article.
Hiv-1 Tat And Morphine Differentially Disrupt Pyramidal Cell Structure And Function And Spatial Learning In Hippocampal Area Ca1: Continuous Versus Interrupted Morphine Exposure, William D. Marks, Jason J. Paris, Aaron J. Barbour, Jean Moon
Hiv-1 Tat And Morphine Differentially Disrupt Pyramidal Cell Structure And Function And Spatial Learning In Hippocampal Area Ca1: Continuous Versus Interrupted Morphine Exposure, William D. Marks, Jason J. Paris, Aaron J. Barbour, Jean Moon
Faculty and Student Publications
About half the people infected with human immunodeficiency virus (HIV) have neurocognitive deficits that often include memory impairment and hippocampal deficits, which can be exacerbated by opioid abuse. To explore the effects of opioids and HIV on hippocampal CA1 pyramidal neuron structure and function, we induced HIV-1 transactivator of transcription (Tat) expression in transgenic mice for 14 d and co-administered time-release morphine or vehicle subcutaneous implants during the final 5 d (days 9–14) to establish steady-state morphine levels. Morphine was withheld from some ex vivo slices during recordings to begin to assess the initial pharmacokinetic consequences of opioid withdrawal. Tat …
An Evaluation Of Antipseudomonal Dosing On The Incidence Of Treatment Failure, Brandon K. Hawkins, Mary Joyce B. Wingler, David A. Cretella, Katie E. Barber
An Evaluation Of Antipseudomonal Dosing On The Incidence Of Treatment Failure, Brandon K. Hawkins, Mary Joyce B. Wingler, David A. Cretella, Katie E. Barber
Faculty and Student Publications
Introduction: Significant mortality is associated with delays in appropriate antibiotic therapy in Pseudomonas aeruginosa infections. The impact of empiric dosing on clinical outcomes has been largely unreported. Methods: This retrospective cohort compared treatment failure in patients receiving guideline-concordant or guideline-discordant empiric therapy with cefepime, meropenem, or piperacillin/tazobactam. Patients with culture-positive P. aeruginosa between 1 July 2013 and 31 July 2019 were eligible for inclusion. Patients with cystic fibrosis, polymicrobial infection, and urinary or pulmonary colonization were excluded. The composite primary outcome was treatment failure, defined as (1) therapy modification due to resistance/perceived treatment failure, (2) increased/unchanged qSOFA, or (3) persistent …
Understanding Of Pharmacy Students Towards Antibiotic Use, Antibiotic Resistance And Antibiotic Stewardship Programs: A Cross-Sectional Study From Punjab, Pakistan, Khezar Hayat, Shazia Jamshed, Meagen Rosenthal, Noman Ul Haq
Understanding Of Pharmacy Students Towards Antibiotic Use, Antibiotic Resistance And Antibiotic Stewardship Programs: A Cross-Sectional Study From Punjab, Pakistan, Khezar Hayat, Shazia Jamshed, Meagen Rosenthal, Noman Ul Haq
Faculty and Student Publications
Antibiotic resistance (ABR) is a significant issue for public health globally. An adequate understanding of ABR and the approaches used to tackle ABR, including antibiotic stewardship programs, are vital. This study aimed to get an insight into antibiotic use, ABR, and antibiotic stewardship programs among pharmacy students of Punjab, Pakistan. This multicenter study was undertaken among final (fifth) year undergraduate pharmacy students of 7 universities of Punjab, Pakistan. A paper-based self-administered questionnaire comprising 48-items was utilized for data collection. Descriptive and inferential statistics were employed for data analysis. This study included a total of 296 respondents with a response rate …
A Modified Delphi Involving Laboratory Faculty To Define Essential Skills For Pharmacy Graduates, Jeanne E. Frenzel, Brandon T. Nuziale, Courtney L. Bradley, Jordan M. Ballou
A Modified Delphi Involving Laboratory Faculty To Define Essential Skills For Pharmacy Graduates, Jeanne E. Frenzel, Brandon T. Nuziale, Courtney L. Bradley, Jordan M. Ballou
Faculty and Student Publications
Objective. To define essential skills for Doctor of Pharmacy (PharmD) graduates that are needed in the four most common sectors of pharmacy practice as determined by expert faculty who instruct within pharmacy skills laboratories. Methods. A three-round Delphi method was used to establish consensus. In the first round, participants were asked what skills were needed by students at entry to practice in community, health-system, ambulatory care, and managed care pharmacy settings. In rounds two and three, participants were asked to rate each skill with a level of importance using a 10-point Likert scale (1=not important to 10=very important). Results. In …
Expression Of Trefoil Factor 3 Is Decreased In Colorectal Cancer, Ingrid Espinoza, Sumit Agarwal, Amit Reddy, Veena Shenoy
Expression Of Trefoil Factor 3 Is Decreased In Colorectal Cancer, Ingrid Espinoza, Sumit Agarwal, Amit Reddy, Veena Shenoy
Faculty and Student Publications
In colorectal cancer (CRC), high expression of trefoil factor 3 (TFF3) is associated with tumor progression and reduced patient survival; however, bioinformatics analyses of public 'omics' databases show low TFF3 expression in CRCs as compared to normal tissues. Thus, we examined TFF3 expression in CRCs and matching normal tissues to evaluate its role in CRC progression. TFF3 gene expression was char- acterized using the bioinformatics portal UALCAN (http:// ualcan.path.uab.edu). Tissue microarrays (TMAs) of archival CRC specimens (n=96) were immunostained with anti-human TFF3 antibodies. Immunohistochemical (IHC) staining intensity was semi-quantitatively scored. For this cohort, the median follow-up was 5.4 years. Associations …
Exploring The Chemical Space Of 1,2,3-Triazolyl Triclosan Analogs For Discovery Of New Antileishmanial Chemotherapeutic Agents, Julia Fernández De Luco, Alejandro I. Recio-Balsells, Diego G. Ghiano, Ana Bortolotti
Exploring The Chemical Space Of 1,2,3-Triazolyl Triclosan Analogs For Discovery Of New Antileishmanial Chemotherapeutic Agents, Julia Fernández De Luco, Alejandro I. Recio-Balsells, Diego G. Ghiano, Ana Bortolotti
Faculty and Student Publications
Triclosan and isoniazid are known antitubercular compounds that have proven to be also active againstLeishmaniaparasites. On these grounds, a collection of 37 diverse 1,2,3-triazoles based on the antitubercular molecules triclosan and 5-octyl-2-phenoxyphenol (8PP) were designed in search of novel structures with leishmanicidal activity and prepared using different alkynes and azides. The 37 compounds were assayed againstLeishmania donovani, the etiological agent of leishmaniasis, yielding some analogs with activity at micromolar concentrations and againstM. tuberculosisH37Rv resulting in scarce active compounds with an MIC of 20 μM. To study the mechanism of action of these catechols, we analyzed the inhibition activity of the …
Multisite Study Assessing The Effect Of Cognitive Test Anxiety On Academic And Standardized Test Performance, Adam N. Pate, Stephen Neely, Daniel R. Malcom, Kimberly K. Daugherty
Multisite Study Assessing The Effect Of Cognitive Test Anxiety On Academic And Standardized Test Performance, Adam N. Pate, Stephen Neely, Daniel R. Malcom, Kimberly K. Daugherty
Faculty and Student Publications
Objective. To evaluate the degree of cognitive test anxiety (CTA) present in student pharmacists at multiple pharmacy programs in the United States and to determine if there are associations between self-reported CTA and relevant academic outcomes. Methods. All 2018-2019 advanced pharmacy practice experience (APPE) students from three US Doctor of Pharmacy (PharmD) programs (N=260) were invited to participate in the study. Participants completed a validated 37-question survey that included the Cognitive Test Anxiety Scale-2 (CTAS-2) along with demographics-related questions. Responses were analyzed using analysis of variance (ANOVA), Kruskal Wallace, and multiple linear regression where appropriate. Results. One hundred twenty-four students …
The Impact Of Two Longitudinal Professionalism Courses On Student Pharmacists’ Empathy, Brent N. Reed, Stuart T. Haines, Erin R. Holmes
The Impact Of Two Longitudinal Professionalism Courses On Student Pharmacists’ Empathy, Brent N. Reed, Stuart T. Haines, Erin R. Holmes
Faculty and Student Publications
Objective. To determine whether empathy increased in first-year student pharmacists after completing longitudinal professionalism courses at two schools of pharmacy, identify potential moderators, and assess whether students’ conceptualization of empathy changed with time. Methods. Surveys to assess empathy and other variables were administered to student pharmacists at baseline and at the end of two professionalism courses. Baseline and follow-up scores were compared to detect changes over time. Multivariable analysis was used to identify predictors of empathy scores. Factor analysis was performed to ascertain changes in the dimensionality of empathy. Results. Students’ demographics and baseline empathy scores differed between the two …