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Daptomycin Non-Susceptible Mrsa Bacteremia: A Case Report, Jaclyn Cusumano, Pharmd, Anna Marie Morlino, Pharmd, Andrew Moyer, Pharmd
Daptomycin Non-Susceptible Mrsa Bacteremia: A Case Report, Jaclyn Cusumano, Pharmd, Anna Marie Morlino, Pharmd, Andrew Moyer, Pharmd
College of Pharmacy Posters
Background
Staphylococcus aureus1, 2, 3
- One of the most common pathogens causing community-acquired and nosocomial infections
- Has rapidly developed resistance to many antibiotics:
Daptomycin 2
- Bactericidal cyclic lipopeptide antibiotic
- Possesses negative charge which attracts calcium to form cationic complex
- Interacts with negatively charged phospholipid heads on bacterial cell membranes, leading to membrane depolarization and cell death
Daptomycin non-susceptible (DNS) S. aureus 2, 4, 5
- Extremely rare - About 60 clinical cases reported
- Defined by an MIC greater than 1 mcg/mL
- Potential mechanisms include:
– Changes in cell membrane and cell wall structure alter daptomycin’s permeability2
- Overexpression and dysregulation …