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Full-Text Articles in Pharmacy and Pharmaceutical Sciences

Evaluation Of New Antimalarial Drug Combinations, Robert Tyrone Higginbotham Jan 2018

Evaluation Of New Antimalarial Drug Combinations, Robert Tyrone Higginbotham

Honors Theses

Malaria is a disease that has affected people throughout the world for centuries and is still responsible for over 200 million clinical cases per year. While a number of developed countries have eradicated the disease, its prevalence in tropical regions poses a significant global health challenge. The disease is caused by the Plasmodium genus, an obligate, intracellular parasite that is carried by the female Anopheles mosquito. While there are effective antimalarial drugs in clinical use, Plasmodium's resilient nature has allowed it to develop resistance to multiple drugs. This fact makes it imperative to seek out novel drugs to combat resistant …

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An Evaluation Of Mobile Apps For The Collation Of Materials To Propose An App For Type-2 Diabetes Self-Management, Sydney Watson Jan 2018

An Evaluation Of Mobile Apps For The Collation Of Materials To Propose An App For Type-2 Diabetes Self-Management, Sydney Watson

Honors Theses

This study is an evaluation of mobile application (apps) with the intention to collate materials appropriate for the proposal of a mobile app for type 2 diabetes self-management. In order to decipher the most vital aspects to be included in the app, an evaluation of mobile apps pertaining to nutrition and diabetes management were investigated. It was found that there is a lack of mobile apps that have all-encompassing features regarding the management of the disease. Future app developers looking to develop a mobile app that is efficient in type 2 diabetes self-management should include each feature as follows: blood …

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Synthesis Of (2r,6r)-Hydroxy-Norketamine For Evaluation Of Antidepressant Effects, Savannah Fairley Jan 2018

Synthesis Of (2r,6r)-Hydroxy-Norketamine For Evaluation Of Antidepressant Effects, Savannah Fairley

Honors Theses

Major Depressive Disorder, colloquially known as depression, is a devastating mental illness that affects a large portion of today's population. Following a drug side-effect that caused depression, the monoamine theory of depression was created, stating that depressive symptoms were caused by a decrease in concentrations of vital monoamine neurotransmitters at the synaptic cleft. Pharmaceutical remedies to combat depression were first introduced in the 1950s and to this date, most available drugs follow the monoamine theory. These drugs have a large loading dose lag time, numerous negative side effects, and still many patients do not experience relief from symptoms. In 2000, …

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Research News. Grants, 2017. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Dec 2017

Research News. Grants, 2017. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during July-December 2017

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Research News. Publications, 2017. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Dec 2017

Research News. Publications, 2017. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period July 1 through December 31, 2017

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Research News. Grants, 2017. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Aug 2017

Research News. Grants, 2017. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during January-June 2017

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Research News. Publications, 2017. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Jul 2017

Research News. Publications, 2017. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period January 1 through June 30, 2017

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Synthesis And Characterization Of Ph/Temperature Dual Sensitive Multiblock Copolymer For Drug Delivery, Hyung Kyung Lee Jan 2017

Synthesis And Characterization Of Ph/Temperature Dual Sensitive Multiblock Copolymer For Drug Delivery, Hyung Kyung Lee

Electronic Theses and Dissertations

The objective of this study was to develop a novel multiblock copolymer (MBCP) with temperature/pH dual-sensitivity which undergoes gelation at body temperature and degradation at acidic pH for controlled drug delivery applications. The MBCP with molecular weight of 42000 Da was synthesized by polycondensation between an acid-labile ketal linker, 2,2-bis(aminoethoxy)propane (BAP) and Pluronic® P104 using L-lysine diisocyanate ethyl ester (LDI) or 1,6-Diisocyanatohexane (HDI). The gelation temperature of 20% (w/v) MBCP was in the range of 29 to 31 ºC when tested with three different techniques: rheometer, test tube inversion method, and falling ball method. The polymer shopH-triggered degradation and drug …

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Patient Friendly Formulations Utilizing Hot Melt Extrusion Technology, Manjeet Bhagwan Pimparade Jan 2017

Patient Friendly Formulations Utilizing Hot Melt Extrusion Technology, Manjeet Bhagwan Pimparade

Electronic Theses and Dissertations

This research work exhibited the new outlook of hot melt extrusion technology for orally disintegrating tablet, fast disintegration films and fixed dose combinations. Previous research demonstrated these applications by conventional formulation techniques which has inherent shortcoming of use of large amount of solvent and batch size manufacturing. This present work addressed some of the unique challenges which could provide patients ease of administration and reduce dosing frequencies, and moreover, mitigate the manufacturing challenges. For orally disintegrating tablet study, ethylcellulose, along with a suitable plasticizer, was used as a polymeric carrier. Pore forming agents were incorporated into the extruded matrix to …

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Preparation And Characterization Of Acitretin-Loaded Niosomes For Psoriasis Treatment, Marey Abdulmootani Almaghrabi Jan 2017

Preparation And Characterization Of Acitretin-Loaded Niosomes For Psoriasis Treatment, Marey Abdulmootani Almaghrabi

Electronic Theses and Dissertations

Psoriasis is a chronic skin disease that manifests as impaired epidermal differentiation. The disease is typically treated with acitretin, an effective oral cytotoxic agent. However, due to its side effects, its use is highly limited. Topical delivery of acitretin may decrease the systemic toxicity and increase the drug’s bioavailability at the pathological site. However, this approach has some limitations. The decrease in skin integrity due to psoriasis could lead to escape of drug into the systemic circulation system and consequently compromise the topical approach. Also, the high instability of acitretin in the presence of heat could limit its topical application. …

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Burden Of Depression Among Individuals With Irritable Bowel Syndrome(Ibs) In The Medicaid Population, Kaustuv Bhattacharya Jan 2017

Burden Of Depression Among Individuals With Irritable Bowel Syndrome(Ibs) In The Medicaid Population, Kaustuv Bhattacharya

Electronic Theses and Dissertations

Objective: to determine the period prevalence of IBS and comorbid depression among individuals with Irritable Bowel Syndrome (IBS) in multi-state Medicaid population, and to assess the impact of comorbid depression on healthcare utilization and costs among individuals with IBS enrolled in fee-for-service Medicaid program. Methods: a retrospective cohort study was conducted using 2006-2008 Medicaid analytic extract files for 39 states. Beneficiaries with IBS were identified based on any medical claims for the disease. Beneficiaries with one or more medical claims for depression during the study period were considered to have had comorbid depression. For each beneficiary, the first claim for …

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Development And Evaluation Of Quercetin Nanoparticles And Hot Melt Cast Films For Retinal Neuroprotection, Chau Truong Jan 2017

Development And Evaluation Of Quercetin Nanoparticles And Hot Melt Cast Films For Retinal Neuroprotection, Chau Truong

Honors Theses

The aim of this study was to prepare optimized nanoparticles and hot melt cast films of quercetin and to investigate the release and permeability profile across corneal membranes. The results demonstrate that all formulations can be successfully employed for delivery of quercetin into the eye through the topical route of administration, with films showing significantly better transcorneal permeability.

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Knowledge Of Epilepsy In Students Attending The University Of Mississippi Oxford Campus, Alyssa Reid Jan 2017

Knowledge Of Epilepsy In Students Attending The University Of Mississippi Oxford Campus, Alyssa Reid

Honors Theses

Epilepsy is thought to be a very rare condition, and therefore many people do not know how to react or what to do when a person has a seizure. Epilepsy is in fact twice as common as cerebral palsy, muscular dystrophy, multiple sclerosis, and cystic fibrosis combined. Furthermore, there is not a cure to stop the seizures for many people. Attending college is a challenging experience, but managing epilepsy while in college can be even more difficult. Hence it is important for all students to learn the basics of epilepsy and especially how to help a person having a seizure. …

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Needs Assessment Of Healthcare Services For Transitioning College Students, Victoria M. Miller Jan 2017

Needs Assessment Of Healthcare Services For Transitioning College Students, Victoria M. Miller

Honors Theses

Investigators measured students' needs for healthcare services during their transition from pediatric to adult healthcare at The University of Mississippi. Also, investigators examined chronically ill students' adherence to their conditions needs and measured a baseline of college freshman's knowledge about healthcare. Data was collected using a self-administered cross-sectional survey online through Qualtrics. This study was divided into four focuses in order to assess the subject's health status, health knowledge, healthcare practices, and barriers to transitioning. The investigator found that most of the students' health status compares to the national average with minor differences, a number of students have little knowledge …

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525,600 Minutes: A Study On The Knowledge And Perceptions Of College Students About Hiv/Aids, Olivia Griffis Jan 2017

525,600 Minutes: A Study On The Knowledge And Perceptions Of College Students About Hiv/Aids, Olivia Griffis

Honors Theses

Human Immunodeficiency Virus (HIV), which subsequently leads to the disease Acquired Immune Deficiency Syndrome (AIDS), is a highly prevalent virus throughout the world, yet it is a commonly misunderstood disease. HIV/AIDS comes with a stigma that can hinder the prevention, diagnosis, and treatment of the disease. This study evaluated the knowledge and perceptions of the students at the University of Mississippi. A sample of University of Mississippi students was randomly selected and asked through email to participate in a 26-item survey assessing their knowledge, awareness, and empathy towards people with HIV/AIDS through true/false, multiple choice, and Likert scale questions. The …

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Molecular Characterization Of The Opioid Receptors: Design, Development, And Preclinical Evaluation Of Salvinorin A-Based Molecular Probes., Adam Keasling Jan 2017

Molecular Characterization Of The Opioid Receptors: Design, Development, And Preclinical Evaluation Of Salvinorin A-Based Molecular Probes., Adam Keasling

Electronic Theses and Dissertations

The field of salvinorin chemistry represents a novel and emerging field of opioid research. The novelty is derived from the lead pharmacophore: salvinorin A — a neoclerodane diterpenoid natural product isolated from Salvia divinorum. Salvinorin A represents a pharmacologically unique compound in that it is the first known non-nitrogenous KOR subtype-selective agonist, exhibits a comparatively safe physiological profile with no reports of toxicological effects in clinical trials, and, most importantly, has a steadily growing body of literature indicating potentially useful clinical applications (e.g. antinociceptive, anti-addictive, antipruritic, neuroprotective, etc.). This has encouraged the development of analogues as essential molecular probes to …

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Development Of Phenotypic Drug Discovery Models For Tropical Parasitic Diseases, Surendra Kumar Jain Jan 2017

Development Of Phenotypic Drug Discovery Models For Tropical Parasitic Diseases, Surendra Kumar Jain

Electronic Theses and Dissertations

Malaria and visceral leishmaniasis are major killer parasitic diseases. These diseases though occur primarily in tropical countries; economic burden and overall health impacts of malaria and leishmaniasis are global. The emergence of drug-resistant and more-virulent strains of the pathogens has further amplified the problems. New drug discovery approaches primarily rely on in vitro and in vivo models of the disease. The pathogens causing leishmaniasis and malaria are intracellular. Leishmania parasite grows as amastigotes in macrophages cells, and malaria parasite grows within the hepatocytes or erythrocytes. The intracellular forms of the pathogens are responsible for the pathophysiology of the diseases. New …

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Phytochemical Investigation Of Psychoactive Medicinal Plants For The Treatment Of Neurological Disorders, Vedanjali Gogineni Jan 2017

Phytochemical Investigation Of Psychoactive Medicinal Plants For The Treatment Of Neurological Disorders, Vedanjali Gogineni

Electronic Theses and Dissertations

Neurological disorders include disorders such as migraine, tension-type headaches, Parkinson’s disease (PD), epilepsy, dementia, and Alzheimer’s disease (AD). Globally, PD is the second most comneurodegenerative disorder following AD. In developed countries, PD affects 1% of all population over 60 years of age. The prevalence of PD is increasing over the years and is expected to double by 2030. It is proposed that combination of dopaminergic drugs with monoamine oxidase B (MAO-B) inhibitors, anticholinergics, catechol-O-methyl transferase inhibitors, and other non-dopaminergic drugs can better alleviate levodopa-induced motor complications along with better control of motor symptoms. MAO-B inhibitors play a significant role in …

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Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs, Mohamed Elsideiq Jihan Jan 2017

Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs, Mohamed Elsideiq Jihan

Electronic Theses and Dissertations

The prevention and cure of malaria is difficult as it thrives under poor socio- and pharmacoeconomic conditions in third world, tropical and subtropical regions. It is a parasitic disease spread through the bite of an infected Anopheles mosquito. In humans, malaria can be caused by several Plasmodium species that include: Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae and Plasmodium knowlesi. The natural product artemisinin is a sesquiterpene lactone with an endoperoxide bridge isolated from the Chinese annual herb qinghao (Artemisia annua L or sweet wormwood). The relatively stable endoperoxide bridge is essential for their antimalarial activity. The synthesis of …

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Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye, Sai Prachetan Balguri Jan 2017

Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye, Sai Prachetan Balguri

Electronic Theses and Dissertations

Lipid based systems and topical ocular inserts of various drugs were developed for the intervention/treatment of posterior segment ocular complications. Indomethacin (IN) was developed into solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs). Effect of surface functionalization using chitosan (CS) on lipid nanocarriers was tested to evaluate corneal penetration. Surface modification of SLNs with CS increased ocular penetration of IN. NLCs maintained significantly higher IN concentrations in all ocular tissues tested, compared to the other formulations evaluated in vivo. Effect of surface poly (ethylene) glycol (PEG) functionalization of the NLCs on ocular disposition was studied using Ciprofloxacin (CIP) as …

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Predictors Of Medication Nonadherence In Children/Adolescents With Attention Deficit Hyperactivity Disorder (Adhd) In Mississippi Medicaid Program, Wahidullah Noori Jan 2017

Predictors Of Medication Nonadherence In Children/Adolescents With Attention Deficit Hyperactivity Disorder (Adhd) In Mississippi Medicaid Program, Wahidullah Noori

Electronic Theses and Dissertations

Objectives: To examine adherence to ADHD stimulant medications and determined the condition-related, therapy-related, patient-related, health-system related, and social and economic related predictors of medication nonadherence in children/adolescents (4 – 18 years) with ADHD enrolled in Mississippi Medicaid Program. Methods: This was a retrospective cohort study of the Mississippi Medicaid administrative claims data. Data was analyzed from March 01, 2014 to February 29, 2016. Adherence was calculated as the proportion of days covered (PDC). PDC was calculated including and excluding summer break (June – August) and at two different timelines, at 6 months and 12 months depending upon the length of …

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Intravenous Solution Wastage In Hospital Pharmacy At Baptist Memorial Hospital-North Mississippi (Oxford), Yujing Zhang Jan 2017

Intravenous Solution Wastage In Hospital Pharmacy At Baptist Memorial Hospital-North Mississippi (Oxford), Yujing Zhang

Honors Theses

Introduction: IV solution wastage refers to IV medications made for a patient that remain unused by that patient for a variety of reasons, and have subsequently expired, or for other reasons cannot be used for another patient (recycled), and therefore must be disposed of. This problem is widespread across hospital pharmacies in the U.S. and the world. BMH-NM (Oxford) pharmacy utilizes many waste reduction strategies but has never monitored its IV solution wastage. Therefore, the objective of this study was to identify the number of IV solutions wasted in a month and the subsequent financial loss in terms of drug …

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Effects Of Dioscin On Dna Methyltransferase 1 Protein Expression In Human Breast Cancer Cell Lines, David Andrew Means Jan 2017

Effects Of Dioscin On Dna Methyltransferase 1 Protein Expression In Human Breast Cancer Cell Lines, David Andrew Means

Honors Theses

In previous experiments, the steroidal saponin, dioscin, which was extracted from the roots of the wild yam (Dioscorea villosa), was observed to have potent anti-proliferative effects on the human breast cancer cell lines MCF-7 and MDA-MB-231. Dioscin was also able to activate the transcription of tumor suppressor genes GATA3 and CDH1 in these cell lines. We hypothesize that the anti-proliferative effect of dioscin on human breast cancer cells could be mediated through the epigenome. Consequently, in order to explore this hypothesis, we have analyzed the expression of DNA methyltransferase 1 (DNMT1) protein in these cells. MCF-7 and MDA-MB-231 cells were …

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Mississippi Pharmacists' Knowledge And Perceptions Of Adhd In Children, Anna Crider Jan 2017

Mississippi Pharmacists' Knowledge And Perceptions Of Adhd In Children, Anna Crider

Honors Theses

Attention-deficit/hyperactivity disorder (ADHD) is a condition that has garnered more attention in the profession of pharmacy in recent years as a result of being more commonly diagnosed in both adult and pediatric populations. With new medications available, pharmacists need to be knowledgeable about how these products may affect patients, especially children. It is crucial to understand pharmacists' perceptions and knowledge of ADHD and its treatments to optimize their provision of treatment for these patients. Due to the lack of literature dedicated to pharmacists' knowledge, familiarity, confidence, and perceptions as it relates the condition of ADHD and its treatments, the objectives …

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Healthcare Professionals Knowledge And Attitudes Regarding Biosimilars In Northern Mississippi, Amanda Seals Jan 2017

Healthcare Professionals Knowledge And Attitudes Regarding Biosimilars In Northern Mississippi, Amanda Seals

Honors Theses

The emergence of biologics over the past the past few decades has led to a new interest in the production of a classification of drugs known as biosimilars. The vast complexity involved in the discovery, development, and manufacturing of biologics and biosimilars has made researching the knowledge and perceptions among healthcare professionals important. Healthcare professionals must have an understanding of biologics, as these medications are used for some of the most rare diseases. Healthcare professionals in northern Mississippi were surveyed on their knowledge of and attitudes towards biologics and biosimilars in order to gain insight on the current status of …

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Pharmacists' Perceptions Of Rapid Diagnostic Testing In Community Pharmacies In Mississippi: A Diffusion Of Innovations Approach, Erin Ann Hoevelmann Jan 2017

Pharmacists' Perceptions Of Rapid Diagnostic Testing In Community Pharmacies In Mississippi: A Diffusion Of Innovations Approach, Erin Ann Hoevelmann

Honors Theses

Objectives: The broad purpose of this study is to describe community pharmacists' perceptions of rapid diagnostic tests (RDTs) in community pharmacies in Mississippi. The focused goal of this study is to determine the correlation between Everett M. Rogers' attributes of the diffusion of innovations (including relative advantage, compatibility, complexity, trialability, and observability) and the willingness of community pharmacists to offer RDTs in community pharmacies in Mississippi. Methods: This study was approved by the University of Mississippi IRB. A list of licensed pharmacists was obtained from the Mississippi Board of Pharmacy. An email with study details and a link to the …

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Research News. Publications, 2016. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Dec 2016

Research News. Publications, 2016. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period July 1 through December 31, 2016

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Research News. Grants, 2016. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Dec 2016

Research News. Grants, 2016. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during July-December 2016

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Research News. Publications, 2016. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Jul 2016

Research News. Publications, 2016. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period January 1, 2016 through June 30, 2016

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Research News. Grants, 2016. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Jul 2016

Research News. Grants, 2016. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during January-June 2016

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