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Full-Text Articles in Pharmacy and Pharmaceutical Sciences

Comparison Of Chemical Compositions Of The Pepper Eos From Different Cultivars And Their Ache Inhibitory Activity, Shu Xia Chen, Kong Yang, Jia Yao Xiang, Osafo Raymond Kwaku, Jia Xin Han, Xian Ai Zhu, Ya Ting Huang, Le Jiang Liu, Shao Bin Shen, Hai Zhou Li, Xing Cong Li, Yang Feng, Min Xu Jan 2020

Comparison Of Chemical Compositions Of The Pepper Eos From Different Cultivars And Their Ache Inhibitory Activity, Shu Xia Chen, Kong Yang, Jia Yao Xiang, Osafo Raymond Kwaku, Jia Xin Han, Xian Ai Zhu, Ya Ting Huang, Le Jiang Liu, Shao Bin Shen, Hai Zhou Li, Xing Cong Li, Yang Feng, Min Xu

Faculty and Student Publications

© The Author(s) 2020. Pepper is one of the most popular spices over the world and is called the King of Spices. Its essential oils (EOs) could alleviate neuronal ailments due to the inhibitory effect against acetylcholinesterase (AChE). In this study, the chemical compositions of 26 EOs prepared from white and black pepper collecting from 6 different cultivars were analyzed by gas chromatography-mass spectrometry (GC-MS). A total of 133 compounds were identified in the white and black pepper EOs. Monoterpenes and sesquiterpenes were found to be riched in these EOs, of which α-pinene, β-pinene, sabinene, 3-carene, limonene, and (E)-β-caryophyllene were …

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Primary Healthcare Policy And Vision For Community Pharmacy And Pharmacists In The United States, Teresa M. Salgado, Meagen M. Rosenthal, Antoinette B. Coe, Tana N. Kaefer, Dave L. Dixon, Karen B. Farris Jan 2020

Primary Healthcare Policy And Vision For Community Pharmacy And Pharmacists In The United States, Teresa M. Salgado, Meagen M. Rosenthal, Antoinette B. Coe, Tana N. Kaefer, Dave L. Dixon, Karen B. Farris

Faculty and Student Publications

© 2020, Grupo de Investigacion en Atencion Farmaceutica. All rights reserved. The United States (US) has a complex healthcare system with a mix of public, private, nonprofit, and for-profit insurers, healthcare institutions and organizations, and providers. Unlike other developed countries, there is not a single payer healthcare system or a national pharmaceutical benefits scheme/plan. Despite spending over USD 10,000 per capita in healthcare, the US is among the worst performers compared to other developed countries in outcomes including life expectancy at birth, infant mortality, safety during childbirth, and unmanaged chronic conditions (e.g., asthma, diabetes). Primary care is delivered by physicians …

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Variability In Antibacterial Activity In The Caribbean Sponge Amphimedon Compressa, Mackenzie Reilly Jan 2020

Variability In Antibacterial Activity In The Caribbean Sponge Amphimedon Compressa, Mackenzie Reilly

Honors Theses

Coral reefs are essential ecosystems that provide an abundance of natural resources. Sponges, common reef inhabitants, produce a diversity of secondary metabolites that are known to serve as chemical defenses. Secondary metabolites often have ecological functions, such as antipredator and antibacterial activities. I studied the common Caribbean sponge species, Amphimedon compressa, which is known to be chemically defended. Samples were collected from three sites in Belize, two sites in Grand Cayman, and three sites in St. Croix, U.S. Virgin Islands. To determine whether antibacterial activity varied across broad or local geographic scales, sponge extracts were tested against four bacterial strains …

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Research News. Publications, 2019. Volume 4, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Dec 2019

Research News. Publications, 2019. Volume 4, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period October 1 through December 31, 2019

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Research News. Grants, 2019. Volume 4, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Dec 2019

Research News. Grants, 2019. Volume 4, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during October-December 2019

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Development And Validation Of A High-Performance Thin-Layer Chromatographic Method For The Quantitative Analysis Of Vitexin In Passiflora Foetida Herbal Formulations, Ahmed Ibrahim Foudah, Prawez Alam, Y. T. Kamal, Saleh Ibrahim Alqasoumi, Mohammed Hamed Alqarni, Samir A. Ross, Hasan Soliman Yusufoglu Dec 2019

Development And Validation Of A High-Performance Thin-Layer Chromatographic Method For The Quantitative Analysis Of Vitexin In Passiflora Foetida Herbal Formulations, Ahmed Ibrahim Foudah, Prawez Alam, Y. T. Kamal, Saleh Ibrahim Alqasoumi, Mohammed Hamed Alqarni, Samir A. Ross, Hasan Soliman Yusufoglu

Faculty and Student Publications

© 2019 Dehon et al. Introduction: Formative evaluations of clinical teaching for emergency medicine (EM) faculty are limited. The goal of this study was to develop a behaviorally-based tool for evaluating and providing feedback to EM faculty based on their clinical teaching skills during a shift. Methods: We used a three-phase structured development process. Phase 1 used the nominal group technique with a group of faculty first and then with residents to generate potential evaluation items. Phase 2 included separate focus groups and used a modified Delphi technique with faculty and residents, as well as a group of experts to …

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Research News. Publications, 2019. Volume 3, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Oct 2019

Research News. Publications, 2019. Volume 3, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period July 1 through September 30, 2019

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A Baker's Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2018, Elias B. Chahine, Spencer H. Durham, Krutika N. Mediwala, Daniel B. Chastain, Timothy P. Gauthier, Brandon K. Hill, Bruce M. Jones, Jamie J. Kisgen, Ashley H. Marx, Kayla R. Stover, Marylee V. Worley, Christopher M. Bland, P. Brandon Bookstaver Oct 2019

A Baker's Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2018, Elias B. Chahine, Spencer H. Durham, Krutika N. Mediwala, Daniel B. Chastain, Timothy P. Gauthier, Brandon K. Hill, Bruce M. Jones, Jamie J. Kisgen, Ashley H. Marx, Kayla R. Stover, Marylee V. Worley, Christopher M. Bland, P. Brandon Bookstaver

Faculty and Student Publications

© The Author(s) 2019 Phytochemical investigation of methanolic extract of Limonium leptophyllum (Plumbaginaceae), led to the isolation of 1 new isoflavonoid with a rare 5-membered dihydrofuran ring (1, leptoisoflavone A) and 8 known compounds. The known isolated compounds were identified as euchrenone b9 (2), auriculasin (3), kaempferol (4), avicularoside (5), myrice-tin-3-arabinoside (6), trans-N-feruloyltyramine (7), trans-N-caffeoyltyramine (8), and β-sitosterol (9). The crude methanolic extract exhibited moderate activity toward endocannabinoid receptors. Auriculasin (3) showed activity toward cannabinoid receptor type 1 (86.7% displacement with IC50 8.92 μM).

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Persistent Organic Pollutants (Pops) Increase Rage Signaling To Promote Downstream Cardiovascular Remodeling, Jackson B. Coole, Stephanie S. Burr, Amber M. Kay, Jaime A. Singh, Sandeep Kondakala, Eun Ju Yang, Barbara L.F. Kaplan, George E. Howell, James A. Stewart Oct 2019

Persistent Organic Pollutants (Pops) Increase Rage Signaling To Promote Downstream Cardiovascular Remodeling, Jackson B. Coole, Stephanie S. Burr, Amber M. Kay, Jaime A. Singh, Sandeep Kondakala, Eun Ju Yang, Barbara L.F. Kaplan, George E. Howell, James A. Stewart

Faculty and Student Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Background: Antimicrobial resistance (AMR) is a global threat and the antimicrobial stewardship program (ASP) is a globally used tool to combat AMR. There is little information on the views among Pakistani physicians regarding AMR and the benefits of hospital antimicrobial stewardship implementation. This study was designed to explore the physicians’ views about ASP. Methods: Qualitative face-to-face and telephonic interviews were conducted by using purposive sampling method with 22 physicians working in seven tertiary care public hospitals of Punjab, Pakistan. All interviews were audio recorded and transcribed verbatim. Qualitative software was used, …

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Silver Nanoparticle Synthesis By Acalypha Wilkesiana Extract: Phytochemical Screening, Characterization, Influence Of Operational Parameters, And Preliminary Antibacterial Testing, Adewumi Oluwasogo Dada, Folahan Amoo Adekola, Fehintoluwa Elizabeth Dada, Adunola Tabitha Adelani-Akande, Micheal Oluwasesan Bello, Chidiogo Rita Okonkwo, Adejumoke Abosede Inyinbor, Abimbola Peter Oluyori, Adeniyi Olayanju, Kolawole Oluseyi Ajanaku, Charles Oluwaseun Adetunji Oct 2019

Silver Nanoparticle Synthesis By Acalypha Wilkesiana Extract: Phytochemical Screening, Characterization, Influence Of Operational Parameters, And Preliminary Antibacterial Testing, Adewumi Oluwasogo Dada, Folahan Amoo Adekola, Fehintoluwa Elizabeth Dada, Adunola Tabitha Adelani-Akande, Micheal Oluwasesan Bello, Chidiogo Rita Okonkwo, Adejumoke Abosede Inyinbor, Abimbola Peter Oluyori, Adeniyi Olayanju, Kolawole Oluseyi Ajanaku, Charles Oluwaseun Adetunji

Faculty and Student Publications

© 2019, The Author(s). Introduction: The application of skin bleaching products to inhibit melanogenesis is a common practice within the African diaspora. Despite the adverse health effects of skin bleaching, rigorous studies investigating skin bleaching behavior among these populations in the United States are limited. In our P30 pilot study, we explored predictors of skin bleaching practice intensity among African and Afro-Caribbean women. Methods: In collaboration with our Community Engagement Core, we conducted a cross-sectional study to investigate the relationship between demographic and psychosocial predictors and skin-bleaching-related practice patterns among African and Afro-Caribbean women in New York City. Results: Among …

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Determining The Binding Site Of Org27569 Within The Cb1 Receptor, Ayooluwa O. Aderibigbe, Pankaj Pandey, Robert J. Doerksen Oct 2019

Determining The Binding Site Of Org27569 Within The Cb1 Receptor, Ayooluwa O. Aderibigbe, Pankaj Pandey, Robert J. Doerksen

Annual Poster Session 2019

Computational studies to determine the binding site of ORG27569, a negative allosteric modulator, within the cannabinoid receptor 1 (CB1) reveal an intracellular binding domain as the most favorable binding site for ORG27569.

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Research News. Grants, 2019. Volume 3, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Oct 2019

Research News. Grants, 2019. Volume 3, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during July-September 2019

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Promising Activity Of Anthemis Austriaca Jacq. On The Endometriosis Rat Model And Isolation Of Its Active Constituents, Mert Ilhan, Zulfiqar Ali, Ikhlas A. Khan, Hakkı Taştan, Esra Küpeli Akkol Sep 2019

Promising Activity Of Anthemis Austriaca Jacq. On The Endometriosis Rat Model And Isolation Of Its Active Constituents, Mert Ilhan, Zulfiqar Ali, Ikhlas A. Khan, Hakkı Taştan, Esra Küpeli Akkol

Faculty and Student Publications

© 2019, The Author(s). Heparin and heparan sulfate (Hp/HS) are linear complex glycosaminoglycans which are involved in diverse biological processes. The structural complexity brings difficulties in separation, making the study of structure-function relationships challenging. Here we present a separation method for Hp/HS oligosaccharide fractionation with cross-compatible solvent and conditions, combining size exclusion chromatography (SEC), ion-pair reversed phase chromatography (IPRP), and hydrophilic interaction chromatography (HILIC) as three orthogonal separation methods that do not require desalting or extensive sample handling. With this method, the final eluent is suitable for structure-function relationship studies, including tandem mass spectrometry and microarray printing. Our data indicate …

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Δ9-Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure In Normotensive Rabbits, Pranjal S. Taskar, Akash Patil, Prit Lakhani, Eman Ashour, Waseem Gul, Mahmoud A. Elsohly, Brian Murphy, Soumyajit Majumdar Sep 2019

Δ9-Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure In Normotensive Rabbits, Pranjal S. Taskar, Akash Patil, Prit Lakhani, Eman Ashour, Waseem Gul, Mahmoud A. Elsohly, Brian Murphy, Soumyajit Majumdar

Faculty and Student Publications

No abstract provided.

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Research News. Publications, 2019. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Jul 2019

Research News. Publications, 2019. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period April 1 through June 30, 2019

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Research News. Grants, 2019. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Jul 2019

Research News. Grants, 2019. Volume 2, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during April-June 2019

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Interventions To Increase Uptake Of The Human Papillomavirus Vaccine In Unvaccinated College Students: A Systematic Literature Review, Marie Barnard, Anna C. Cole, Lori Ward, Emily Gravlee, Mariah L. Cole, Caroline Compretta Jun 2019

Interventions To Increase Uptake Of The Human Papillomavirus Vaccine In Unvaccinated College Students: A Systematic Literature Review, Marie Barnard, Anna C. Cole, Lori Ward, Emily Gravlee, Mariah L. Cole, Caroline Compretta

Faculty and Student Publications

© 2019, American Association of Colleges of Pharmacy. All rights reserved. The Committee was charged with the responsibility for examining the need for change in pharmacy education and the models of leadership that would enable that change to occur across the academy. They also examined the question of faculty wellbeing in a time of change and made several recommendations and suggestions regarding both charges. Building upon the work of the previous Academic Affairs Committee, the 2018-19 AAC encourages the academy to implement new curricular models supporting personalized learning that creates engaged and lifelong learners. This will require transformational leadership and …

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Molecular Nickel-Catalysts For Photocatalytic Reduction Of Co2, Harshin U. Sanjanwala May 2019

Molecular Nickel-Catalysts For Photocatalytic Reduction Of Co2, Harshin U. Sanjanwala

Honors Theses

Increased atmospheric CO2 has been the result of prominent usage of fossil fuels as a fuel source. As fossil fuels are a nonrenewable energy source, scientists are looking towards more renewable energy resources capable of both efficiently producing energy and reducing atmospheric CO2-emissions. A photocatalyst with an earth-abundant metal capable of chemically reducing CO2 paired with only water and photon inputs would provide a solution to these pressing issues. Here, studies were performed on three catalysts, each with a nickel metal center. Each catalyst went through a series of photocatalytic tests in various conditions to identify whether a catalyst was …

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Modification Of Hiv-1 Protease Inhibitor Pharmacophore To Assess Anti-Malarial Properties, Margaret Ann Street May 2019

Modification Of Hiv-1 Protease Inhibitor Pharmacophore To Assess Anti-Malarial Properties, Margaret Ann Street

Honors Theses

For years, the human immunodeficiency virus type 1 (HIV-1) and malarial parasites have both been prevalent in sub-Saharan Africa. Coinfections of HIV-1 and malaria are common in areas of geographic overlap as both infections seem to increase the severity of the other. HIV-1 treatments have shown to decrease the Plasmodium infections resulting in a lower malarial incidence. HIV-1 protease inhibitors target a crucial step in the life cycle required for viral maturation and have demonstrated a lower level of resistance compared with other therapies. Recent studies have shown the treatment of HIV-1 with protease inhibitors has resulted in inhibitory effects …

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A Comprehensive Examination Of University Of Mississippi Early Entry Students’ Perceptions Of Mental Illness, Brianna Gray May 2019

A Comprehensive Examination Of University Of Mississippi Early Entry Students’ Perceptions Of Mental Illness, Brianna Gray

Honors Theses

Mental disorders affect nearly 1 in 5 adults in the United States in a given year, and that number is steadily increasing. Pharmacists, being some of the most accessible and frequently contacted health care professionals, must be prepared to provide support for these patients. They can play a key role in whether or not there is a positive patient outcome. Education can play a role in pharmacists’ comfort with and knowledge of mental illness. The primary objective of this study was to determine if University of Mississippi early-entry pharmacy students’ mental illness knowledge, familiarity, and acceptable social distance affected their …

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Neurotoxic Effects Of Hiv-1 Gp120 And Interaction With Allopregnanolone, Kimberly A. Thornton May 2019

Neurotoxic Effects Of Hiv-1 Gp120 And Interaction With Allopregnanolone, Kimberly A. Thornton

Honors Theses

With increasing incidence of HIV and its associated neurocognitive disorders, there has emerged a need for an antiviral with improved delivery to the CNS. In searching for drug candidates that meet these criteria, some have noted that certain steroid hormones like estrogen and progesterone that naturally accumulate in the CNS show neuroprotective effects in cells exposed to HIV proteins. This investigation focused on testing the potential protective effects of the progesterone metabolite, allopregnanolone (AlloP), against HIV protein gp120-mediated neurotoxicity. Experiments were conducted using SH-SY5Y neuroblastoma cells that were exposed to varying concentrations of AlloP (0-100 nM) in conjunction with one …

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A New Prenylated Isoflavonoid From Limonium Leptophyllum, Asset Dizamatova, Kamila Zhumanova, Galiya E. Zhusupova, Aizhan I. Zhussupova, Radhakrishnan Srivedavyasasri, Mohamed A. Ibrahim, Samir A. Ross May 2019

A New Prenylated Isoflavonoid From Limonium Leptophyllum, Asset Dizamatova, Kamila Zhumanova, Galiya E. Zhusupova, Aizhan I. Zhussupova, Radhakrishnan Srivedavyasasri, Mohamed A. Ibrahim, Samir A. Ross

Faculty and Student Publications

© 2019, Mary Ann Liebert, Inc., publishers 2019. Purpose: Cannabidiol (CBD), active component of plant Cannabis sativa, has anti-inflammatory properties that could potentially help treat diabetic retinopathy-induced pain and inflammation. However, CBD is a lipophilic molecule making its topical delivery to back of the eye challenging. This study aims at improving ocular penetration of CBD by means of analog derivatization. Methods: Analogs were designed using various ligands, such as amino acids (AAs) and dicarboxylic acids (DCAs) and their combinations. Select analogs were screened in vitro with respect to their stability in ocular tissue homogenates. Based on in vitro stability, analogs …

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Dietary Supplement Safety: A 25 Year Retrospective Assessment, Bill Gurley Apr 2019

Dietary Supplement Safety: A 25 Year Retrospective Assessment, Bill Gurley

Oxford ICSB

Passage of the Dietary Supplement Health & Education Act (DSHEA) in 1994 ushered in a new category of consumer products known as dietary supplements (DS). DSHEA’s definition of a dietary supplement encompasses a wide variety of products from multivitamins and single-ingredient botanical extracts, to “proprietary blends” of multiple botanical extracts and/or vitamins and minerals. Almost from their inception, safety concerns regarding certain categories of “proprietary blends” have plagued the DS industry. Most notable of these involved Ephedra-containing DS, whose questionable safety record led to their removal from the U.S. market in 2004 by the FDA after a 10-year period of …

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Research News. Grants, 2019. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Apr 2019

Research News. Grants, 2019. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during January-March 2019

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Research News. Publications, 2019. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar Apr 2019

Research News. Publications, 2019. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period January 1 through March 31, 2019

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Arabinoxyloglucan Oligosaccharides May Contribute To The Antiadhesive Properties Of Porcine Urine After Cranberry Consumption, Christina M. Coleman, Kimberly M. Auker, K. Brian Killday, Parastoo Azadi, Ian Black, Daneel Ferreira Mar 2019

Arabinoxyloglucan Oligosaccharides May Contribute To The Antiadhesive Properties Of Porcine Urine After Cranberry Consumption, Christina M. Coleman, Kimberly M. Auker, K. Brian Killday, Parastoo Azadi, Ian Black, Daneel Ferreira

Faculty and Student Publications

© 2019 As part of our continuing investigation for interesting biological activities of native medicinal plants, thirty-nine plants, obtained from diverse areas in Saudi Arabia and Yemen, were screened for insecticidal activity against yellow fever mosquito Aedes aegypti (L.). Out of the 57 organic extracts, Saussurea lappa, Ocimum tenuiflorum, Taraxacum officinale, Nigella sativa, and Hyssopus officinalis exhibited over 80% mortality against adult female Ae. aegypti at 5 μg/mosquito. In the larvicidal bioassay, the petroleum ether extract of Aloe perryi flowers showed 100% mortality at 31.25 ppm against 1st instar Ae. aegypti larvae. The ethanol extract of Saussurea lappa roots was …

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Predator Diet Affects Perceived Oviposition Site Quality For Mosquitoes, Brandon Mcdaniel Feb 2019

Predator Diet Affects Perceived Oviposition Site Quality For Mosquitoes, Brandon Mcdaniel

Honors Theses

Ovipositing freshwater organisms rely primarily on cues to determine site quality (Silberbush and Blaustein 2008) and to select an ideal habitat for their offspring (Resetarits 2014). Characteristics of high quality oviposition sites that yield the greatest fitness for offspring include the absence of predators and high resource availability that allows for optimal growth and development (Kershenbaum et al. 2012). It has been shown that predator presence is a large deterrent of oviposition due to threats of offspring survival, however, there is a little information about the predatory cues mosquitoes experience before ovipositing (Angelon and Petranka 2002). One hypothesis is that …

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Constituents Of Talisia Nervosa With Potential Utility Against Metabolic Syndrome, Yelkaira Vásquez, Jianping Zhao, Shabana I. Khana, Mahabir P. Gupta, Ikhlas A. Khana Jan 2019

Constituents Of Talisia Nervosa With Potential Utility Against Metabolic Syndrome, Yelkaira Vásquez, Jianping Zhao, Shabana I. Khana, Mahabir P. Gupta, Ikhlas A. Khana

Faculty and Student Publications

© 2019, The Author(s). As coral cover has declined on Caribbean reefs, space has become occupied by other benthic taxa, including sponges, which may affect the recruitment of new corals, thereby affecting the ability of reefs to recover to coral-dominated states. Sponges may inhibit coral recruitment by pre-empting potential recruitment space, overgrowing recruits, or through allelopathy. This study examined coral recruitment across six coral reef sites surrounding St. Thomas, US Virgin Islands, and the impact of one species of sponge and the sponge community as a whole on coral recruitment. To test the effect of a single species of sponge …

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Schinus Molle: Anatomy Of Leaves And Stems, Chemical Composition And Insecticidal Activities Of Volatile Oil Against Bed Bug (Cimex Lectularius), Camila D. Machado, Vijayasankar Raman, Junaid U. Rehman, Beatriz H.L.N.S. Maia, Emanuelle K. Meneghetti, Valter P. Almeida, Rosi Z. Silva, Paulo V. Farago, Ikhlas A. Khan, Jane M. Budel Jan 2019

Schinus Molle: Anatomy Of Leaves And Stems, Chemical Composition And Insecticidal Activities Of Volatile Oil Against Bed Bug (Cimex Lectularius), Camila D. Machado, Vijayasankar Raman, Junaid U. Rehman, Beatriz H.L.N.S. Maia, Emanuelle K. Meneghetti, Valter P. Almeida, Rosi Z. Silva, Paulo V. Farago, Ikhlas A. Khan, Jane M. Budel

Faculty and Student Publications

© 2019 by the authors The investigation of the constituents that were isolated from Turnera diffusa (damiana) for their inhibitory activities against recombinant human monoamine oxidases (MAO-A and MAO-B) in vitro identified acacetin 7-methyl ether as a potent selective inhibitor of MAO-B (IC50 = 198 nM). Acacetin 7-methyl ether (also known as 5-hydroxy-40, 7-dimethoxyflavone) is a naturally occurring flavone that is present in many plants and vegetables. Acacetin 7-methyl ether was four-fold less potent as an inhibitor of MAO-B when compared to acacetin (IC50 = 50 nM). However, acacetin 7-methyl ether was >500-fold selective against MAO-B over MAO-A as compared …

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Optimization And Characterization Of Hot-Melt Extruded Anti-Inflammatory And Local Anesthetic Bio-Adhesive Semisolid Formulation Using Design Of Experiments (Doe), Rishi Chinmay Thakkar Jan 2019

Optimization And Characterization Of Hot-Melt Extruded Anti-Inflammatory And Local Anesthetic Bio-Adhesive Semisolid Formulation Using Design Of Experiments (Doe), Rishi Chinmay Thakkar

Electronic Theses and Dissertations

Hot melt extrusion is a versatile continuous manufacturing process extensively investigated for its applications with production of oral solid dosage forms, the aim of this study was to venture the applicability of HME in continuous manufacturing of topical semi-solid ointment formulations. Novel combination of a topical corticosteroid (Triamcinolone Acetonide) and local anesthetic (Lidocaine hydrochloride) were selected to be formulated with a water-soluble ointment base consisting of PEG 4000, PEG 1500 and Propylene glycol after performing appropriate drug-excipient compatibility studies. To determine the ratios of the solid to liquid components of the macrogol base, ‘quality by design’ approach was employed by …

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