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Articles 301 - 330 of 642
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Research News. Grants, 2020. Volume 3, Soumyajit Majumdar
Research News. Grants, 2020. Volume 3, Soumyajit Majumdar
Grants (2015-)
Grants and contracts awarded during July - September 2020
D01. Bms Department Poster, University Of Mississippi. Department Of Biomolecular Sciences
D01. Bms Department Poster, University Of Mississippi. Department Of Biomolecular Sciences
Annual Poster Session 2020
Corresponding author (BioMolecular Sciences): Candace Lowstuter, [email protected]
R17. Solid Crystal Suspensions Of Carbamazepine Using Hot-Melt Extrusion: A Solubility Enhancement Approach, Sagar Narala, Neeraja Komanduri, Dinesh Nyavanandi, Suresh Bandari, Michael A. Repka
R17. Solid Crystal Suspensions Of Carbamazepine Using Hot-Melt Extrusion: A Solubility Enhancement Approach, Sagar Narala, Neeraja Komanduri, Dinesh Nyavanandi, Suresh Bandari, Michael A. Repka
Annual Poster Session 2020
Corresponding author (Pharmaceutics and Drug delivery): Sagar Narala, [email protected]
D04. Department Of Pharmaceutics And Drug Delivery, Michael A. Repka, Walt G. Chambliss, Soumyajit Majumdar, S. N. Murthy, Seong Bong Jo, Chalet Tan, Mahavir Chougule, Eman Ashour
D04. Department Of Pharmaceutics And Drug Delivery, Michael A. Repka, Walt G. Chambliss, Soumyajit Majumdar, S. N. Murthy, Seong Bong Jo, Chalet Tan, Mahavir Chougule, Eman Ashour
Annual Poster Session 2020
Corresponding author (Pharmaceutics and Drug Delivery): Eman Ashour, [email protected]
R07. Identification Of Antifungal Bisphosphocholines From Medicinal Gentiana Species, Xing-Cong Li, Siyu Ren, Kejun Deng, Shi Qiu, Mei Wang, Bharathi Avula, Siddharth K. Tripathi, Melissa R. Jacob, Limin Gong, Wei Wang, Ikhlas A. Khan
R07. Identification Of Antifungal Bisphosphocholines From Medicinal Gentiana Species, Xing-Cong Li, Siyu Ren, Kejun Deng, Shi Qiu, Mei Wang, Bharathi Avula, Siddharth K. Tripathi, Melissa R. Jacob, Limin Gong, Wei Wang, Ikhlas A. Khan
Annual Poster Session 2020
Corresponding author (NCNPR): Xing-Cong Li, [email protected]
R13. Formulation Development Of Loratadine Immediate-Release Tablets Using Hot-Melt Extrusion Coupled With 3d-Printing Technology, Sundus Hussain Omari, Eman A. Ashour, Mashan Amutairi, Rasha Elkanayati, Michael A. Repka
R13. Formulation Development Of Loratadine Immediate-Release Tablets Using Hot-Melt Extrusion Coupled With 3d-Printing Technology, Sundus Hussain Omari, Eman A. Ashour, Mashan Amutairi, Rasha Elkanayati, Michael A. Repka
Annual Poster Session 2020
Corresponding author (Pharmaceutics and Drug delivery): Sundus Hussain Omari, [email protected]
R11. Challenges And Future Directions Of Potential Natural Products Leads Against 2019-Ncov Outbreak, Meirambek Ospanov, Francisco León, Janar Jenis, Ikhlas A. Khan, Mohamed A. Ibrahim
R11. Challenges And Future Directions Of Potential Natural Products Leads Against 2019-Ncov Outbreak, Meirambek Ospanov, Francisco León, Janar Jenis, Ikhlas A. Khan, Mohamed A. Ibrahim
Annual Poster Session 2020
Corresponding author (NCNPR): Mohamed A. Ibrahim, [email protected]
R08. Characterization Of Key Metabolites In Serum Of Fuzheng Huayu Phase Ii Clinical Trial, Yan-Hong Wang, Zachara Catchings, Bharathi Avula, Mei Wang, Huashi Bian, Ikhlas A. Khan
R08. Characterization Of Key Metabolites In Serum Of Fuzheng Huayu Phase Ii Clinical Trial, Yan-Hong Wang, Zachara Catchings, Bharathi Avula, Mei Wang, Huashi Bian, Ikhlas A. Khan
Annual Poster Session 2020
Corresponding author (NCNPR): Yan-Hong Wang, [email protected]
R03. Hiv Tat Protein Activates Plasma Kallikrein-Kinin System In The Doxycycline-Inducible Astrocyte Specific Hiv-1 Tat Transgenic Mice, Logan Sneed, Fakhri Mahdi, Salahoddin Mohamed, Jason J. Paris, Zia Shariat-Madar
R03. Hiv Tat Protein Activates Plasma Kallikrein-Kinin System In The Doxycycline-Inducible Astrocyte Specific Hiv-1 Tat Transgenic Mice, Logan Sneed, Fakhri Mahdi, Salahoddin Mohamed, Jason J. Paris, Zia Shariat-Madar
Annual Poster Session 2020
Corresponding author (BioMolecular Sciences): Logan Sneed, [email protected]
R18. Preparation And Characterization Of Pegylated Nanostructured Lipid Carrier Systems For The Ocular Delivery Of Antineoplastic Agent, Sushrut Marathe, Narender Dudhipala, Soumyajit Majumdar
R18. Preparation And Characterization Of Pegylated Nanostructured Lipid Carrier Systems For The Ocular Delivery Of Antineoplastic Agent, Sushrut Marathe, Narender Dudhipala, Soumyajit Majumdar
Annual Poster Session 2020
Corresponding author (Pharmaceutics and Drug delivery): Sushrut Marathe, [email protected]
D02. Ncnpr Activities At Coy Waller Complex, Mahmoud A. Elsohly, Suman Chandra, Mohamed M. Radwan, Hemant Lata, Amira Wanas, Chandrani G. Majumdar
D02. Ncnpr Activities At Coy Waller Complex, Mahmoud A. Elsohly, Suman Chandra, Mohamed M. Radwan, Hemant Lata, Amira Wanas, Chandrani G. Majumdar
Annual Poster Session 2020
Corresponding author (NCNPR, School of Pharmacy): Mohamed M. Radwan, [email protected]
R06. Identification Of The Cellular Pathways Targeted By Two Antifungal Natural Products Using Rna-Seq Analysis, Ameeta K. Agarwal, Siddharth K. Tripathi, Qin Feng, Ranga Rao Ravu, Xing-Cong Li, Alice M. Clark
R06. Identification Of The Cellular Pathways Targeted By Two Antifungal Natural Products Using Rna-Seq Analysis, Ameeta K. Agarwal, Siddharth K. Tripathi, Qin Feng, Ranga Rao Ravu, Xing-Cong Li, Alice M. Clark
Annual Poster Session 2020
Corresponding author (NCNPR): Ameeta Agarwal, [email protected]
R09. New Atractylon Derivatives Generated In Processed Rhizomes Of Atractylodes Macrocephala Koidz, Chunmei Zhai, Jianping Zhao, Amar G. Chittiboyina, Yonghai Meng, Mei Wang, Ikhlas A. Khan
R09. New Atractylon Derivatives Generated In Processed Rhizomes Of Atractylodes Macrocephala Koidz, Chunmei Zhai, Jianping Zhao, Amar G. Chittiboyina, Yonghai Meng, Mei Wang, Ikhlas A. Khan
Annual Poster Session 2020
Corresponding author (NCNPR): Jianping Zhao, [email protected]
R15. Development And Characterization Of Hot-Melt Extruded Ocular Inserts Of Moxifloxacin For Bacterial Keratitis, Ruchi Thakkar, Nagireddy Dumpa, Narendar Dudhipala, Michael A. Repka, Soumyajit Majumdar
R15. Development And Characterization Of Hot-Melt Extruded Ocular Inserts Of Moxifloxacin For Bacterial Keratitis, Ruchi Thakkar, Nagireddy Dumpa, Narendar Dudhipala, Michael A. Repka, Soumyajit Majumdar
Annual Poster Session 2020
Corresponding author (Pharmaceutics and Drug delivery): Ruchi Thakkar, [email protected]
R21. Preparation, Characterization And Stability Evaluation Of Ligand Anchored Primaquine Loaded Nanostructured Lipid Carrier Systems For Liver Targeting, Tabish Mehraj, Samir Senapati, Sushrut Marathe, Narendar Dudhipala, Babulal Tekwani, Soumyajit Majumdar
R21. Preparation, Characterization And Stability Evaluation Of Ligand Anchored Primaquine Loaded Nanostructured Lipid Carrier Systems For Liver Targeting, Tabish Mehraj, Samir Senapati, Sushrut Marathe, Narendar Dudhipala, Babulal Tekwani, Soumyajit Majumdar
Annual Poster Session 2020
Corresponding author (Pharmaceutics and Drug delivery): Tabish Mehraj, [email protected]
R10. First In Class (S,E)-11-[2-(Arylmethylene)Hydrazono]-Pbd Analogs As Selective Cb2 Modulators Targeting Neurodegenerative Disorders, Meirambek Ospanov, David Mingle, Mohamed O. Radwan, Nicole M. Ashpole, Masami Otsuka, Samir A. Ross, Larry A. Walker, Abbas G. Shilabin, Mohamed A. Ibrahim
R10. First In Class (S,E)-11-[2-(Arylmethylene)Hydrazono]-Pbd Analogs As Selective Cb2 Modulators Targeting Neurodegenerative Disorders, Meirambek Ospanov, David Mingle, Mohamed O. Radwan, Nicole M. Ashpole, Masami Otsuka, Samir A. Ross, Larry A. Walker, Abbas G. Shilabin, Mohamed A. Ibrahim
Annual Poster Session 2020
Corresponding author (NCNPR): Mohamed A. Ibrahim, [email protected]
R23. Demographics And Outcomes Of Patients Hospitalized For Covid-19, Jonathan T. Newbaker, Scott S. Malinowski
R23. Demographics And Outcomes Of Patients Hospitalized For Covid-19, Jonathan T. Newbaker, Scott S. Malinowski
Annual Poster Session 2020
Corresponding author (University of Mississippi Medical Center): Jonathan T. Newbaker, [email protected]
Novel Compounds In Fruits Of Coriander (Coşkuner & Karababa) With Anti-Inflammatory Activity, Renyikun Yuan, Zhenjie Liu, Jianping Zhao, Qin Qin Wang, Aiyuan Zuo, Liting Huang, Hongwei Gao, Qiongming Xu, Ikhlas A. Khan, Shilin Yang
Novel Compounds In Fruits Of Coriander (Coşkuner & Karababa) With Anti-Inflammatory Activity, Renyikun Yuan, Zhenjie Liu, Jianping Zhao, Qin Qin Wang, Aiyuan Zuo, Liting Huang, Hongwei Gao, Qiongming Xu, Ikhlas A. Khan, Shilin Yang
Faculty and Student Publications
© 2020 Coriander, Coriandrum Sativum L., is one of the commonest food and medicinal plants in many countries, but its chemical ingredients and pivotal role in anti-inflammatory activity have not been fully explored. The present study aimed to identify new compounds in the fruits of coriander and explore their anti-inflammatory activity. The compounds were isolated by chromatographic seperations and identified using spectroscopic and spectrometric methods. RAW264.7 macrophage cells were used to detect the anti-inflammatory activity of the compounds via Griess assay, western blotting, ELISA, and flow cytometry methods. The study resulted in the discovery of four new compounds, which were …
Marine Antithrombotics, Rohini Dwivedi, Vitor H. Pomin
Marine Antithrombotics, Rohini Dwivedi, Vitor H. Pomin
Faculty and Student Publications
Thrombosis remains a prime reason of mortality worldwide. With the available antithrombotic drugs, bleeding remains the major downside of current treatments. This raises a clinical concern for all patients undergoing antithrombotic therapy. Novel antithrombotics from marine sources offer a promising therapeutic alternative to this pathology. However, for any potential new molecule to be introduced as a real alternative to existing drugs, the exhibition of comparable anticoagulant potential with minimal off-target effects must be achieved. The relevance of marine antithrombotics, particularly sulfated polysaccharides, is largely due to their unique mechanisms of action and lack of bleeding. There have been many investigations …
Validating A Predictive Model Of Cannabinoid Inheritance With Feral, Clinical, And Industrial Cannabis Sativa, Jonathan P. Wenger, Clemon J. Dabney, Mahmoud A. Elsohly, Suman Chandra, Mohamed M. Radwan, Chandrani G. Majumdar, George D. Weiblen
Validating A Predictive Model Of Cannabinoid Inheritance With Feral, Clinical, And Industrial Cannabis Sativa, Jonathan P. Wenger, Clemon J. Dabney, Mahmoud A. Elsohly, Suman Chandra, Mohamed M. Radwan, Chandrani G. Majumdar, George D. Weiblen
Faculty and Student Publications
© 2020 The Authors. American Journal of Botany published by Wiley Periodicals LLC on behalf of Botanical Society of America Premise: How genetic variation within a species affects phytochemical composition is a fundamental question in botany. The ratio of two specialized metabolites in Cannabis sativa, tetrahydrocannabinol (THC) and cannabidiol (CBD), can be grouped into three main classes (THC-type, CBD-type, and intermediate type). We tested a genetic model associating these three groups with functional and nonfunctional alleles of the cannabidiolic acid synthase gene (CBDAS). Methods: We characterized cannabinoid content and assayed CBDAS genotypes of >300 feral C. sativa plants in Minnesota, …
Screening For More Than 1,000 Pesticides And Environmental Contaminants In Cannabis By Gc/Q-Tof, Philip L. Wylie, Jessica Westland, Mei Wang, Mohamed M. Radwan
Screening For More Than 1,000 Pesticides And Environmental Contaminants In Cannabis By Gc/Q-Tof, Philip L. Wylie, Jessica Westland, Mei Wang, Mohamed M. Radwan
Faculty and Student Publications
A method has been developed to screen cannabis extracts for more than 1,000 pesticides and environmental pollutants using a gas chromatograph coupled to a high-resolution accurate mass quadrupole time-of-flight mass spectrometer (GC/Q-TOF). An extraction procedure was developed using acetonitrile with solid phase extraction cleanup. Before analysis, extracts were diluted 125:1 with solvent. Two data mining approaches were used together with a retention-time-locked Personal Compound Database and Library (PCDL) containing high-resolution accurate mass spectra for pesticides and other environmental pollutants. (1) A Find-by-Fragments (FbF) software tool extracts several characteristic exact mass ions within a small retention time window where the compound …
Research News. Publications, 2020. Volume 2, Soumyajit Majumdar
Research News. Publications, 2020. Volume 2, Soumyajit Majumdar
Publications (2015-)
Publications that appeared during the period April 1 through June 30, 2020
Research News. Grants, 2020. Volume 2, Soumyajit Majumdar
Research News. Grants, 2020. Volume 2, Soumyajit Majumdar
Grants (2015-)
Grants and contracts awarded during April - June 2020
School Of Pharmacy Intellectual Property Report Fy20, Fourth Quarter Report, Soumyajit Majumdar
School Of Pharmacy Intellectual Property Report Fy20, Fourth Quarter Report, Soumyajit Majumdar
U. S. Patents, School of Pharmacy
School of Pharmacy Intellectual Property Report FY20, Fourth Quarter Report (as of 6/30/20)
Expression Of Poly-Adp-Ribose Polymerase (Parp) In Endometrial Adenocarcinoma: Prognostic Potential, Logan M. Lawrence, Rebecca Russell, Claire E. Denning, Nadim Bou Zgheib, Travis Salisbury, Seth T. Lirette, Jagan Valluri, Pier Paolo Claudio, Krista L. Denning
Expression Of Poly-Adp-Ribose Polymerase (Parp) In Endometrial Adenocarcinoma: Prognostic Potential, Logan M. Lawrence, Rebecca Russell, Claire E. Denning, Nadim Bou Zgheib, Travis Salisbury, Seth T. Lirette, Jagan Valluri, Pier Paolo Claudio, Krista L. Denning
Faculty and Student Publications
© 2020 Background: In the United States endometrial carcinoma is the most common female gynecologic malignancy. An average of more than 60,000 new cases of endometrial carcinomas have been diagnosed yearly over the past 5 years, with a higher incidence occurring in the central Appalachian states of Ohio and West Virginia. In the U.S., the national average of newly diagnosed endometrial carcinomas is 26.8 in every 100,000 women, while in the states of Ohio and West Virginia the average is 30.5 and 31.1 in every 100,000 women, respectively. This notable increase in the incidence of endometrial carcinomas may be due …
Extracellular Matrix Components Isolated From Diabetic Mice Alter Cardiac Fibroblast Function Through The Age/Rage Signaling Cascade, Stephanie D. Burr, James A. Stewart
Extracellular Matrix Components Isolated From Diabetic Mice Alter Cardiac Fibroblast Function Through The Age/Rage Signaling Cascade, Stephanie D. Burr, James A. Stewart
Faculty and Student Publications
© 2020 The Authors Individuals suffering from diabetes have an increased risk of developing cardiovascular complications such as heart failure. Heart failure can be a result of the stiffening of the left ventricle, which occurs when cardiac fibroblasts become “active” and begin to remodel the extracellular matrix (ECM). Fibroblast “activation” can be triggered by the AGE/RAGE signaling cascade. Advanced Glycation End products (AGEs) are produced and accumulate in the ECM over time in a healthy individual, but under hyperglycemic conditions, this process is accelerated. In this study, we investigated how the presence of AGEs in either non-diabetic or diabetic ECM …
Fluoroquinolone Versus Nonfluoroquinolone Treatment Of Bloodstream Infections Caused By Chromosomally Mediated Ampc‐Producing Enterobacteriaceae, Sarah Grace Gunter, Katie E. Barber, Jamie L. Wagner, Kayla R. Stover
Fluoroquinolone Versus Nonfluoroquinolone Treatment Of Bloodstream Infections Caused By Chromosomally Mediated Ampc‐Producing Enterobacteriaceae, Sarah Grace Gunter, Katie E. Barber, Jamie L. Wagner, Kayla R. Stover
Faculty and Student Publications
Objectives: Chromosomally mediated AmpC-producing Enterobacteriaceae (CAE) display high susceptibility to fluoroquinolones; minimal clinical data exist supporting comparative clinical outcomes. The objective of this study was to compare treatment outcomes between fluoroquinolone and nonfluoroquinolone definitive therapy of bloodstream infections caused by CAE. Methods: This retrospective cohort assessed adult patients with positive blood cultures for CAE that received inpatient treatment for 48 hours. The primary outcome was difference in clinical failure between patients who received fluoroquinolone (FQ) versus non‐FQ treatment. Secondary endpoints included microbiological cure, infection‐related length of stay, 90‐day readmission, and all‐cause inpatient mortality. Results: 56 patients were included in the …
Synthesis Of Fluorinated Pyrazoles Via Intra- And Intermolecular Cyclization Reactions, Matthew Saucier
Synthesis Of Fluorinated Pyrazoles Via Intra- And Intermolecular Cyclization Reactions, Matthew Saucier
Honors Theses
Pyrazole-based pharmaceuticals treat a wide array of diseases and conditions including obesity, diabetes, cancer, microbial and viral infections, pain and inflammation, and many neurological disorders. Syntheses for this biologically significant substrate have been well developed, but current methods to afford fluorinated pyrazoles are limited by variability and selectivity. By 2013, over 25% of all drugs available on the market contained the element fluorine due to its unique characteristics leading to improved target protein binding, bioavailability, and metabolic stability. In order to harness these pharmaceutical benefits of fluorine and overcome its difficulty in handling and stability, we set out to develop …
Synthesis Of Aromatic Fluorinated Ketones For Evaluation At The Gaba Receptor, Madeline Griffin
Synthesis Of Aromatic Fluorinated Ketones For Evaluation At The Gaba Receptor, Madeline Griffin
Honors Theses
GABA is a neurotransmitter that inhibits the excitation of neurons. Targeting this specific receptor has the potential to inhibit the central nervous system and possibly treat addiction, anxiety, or mood disorders. Previous research has shown that fluorinated ketones can have valuable applications in the medicinal chemistry of addiction. Some fluorinated ketones have shown activity at the GABA receptor. The main goal of this project was to synthesize aromatic fluorinated ketones for biological evaluation at the GABAB receptor. Another goal was to compare both the monofluorinated and difluorinated analogues synthesized in order to quantify differences in activity from fluorination state. …
Improving Diabetes Self-Management Developing A Patient Decision Aid To Improve Patient Education, Morgan Baker
Improving Diabetes Self-Management Developing A Patient Decision Aid To Improve Patient Education, Morgan Baker
Honors Theses
Type 2 diabetes is a complex disease that affects a large population of people. It is imperative that efforts are made to develop more effective and inclusive treatment strategies for patients with this condition. A promising approach being studied is the utilization of community pharmacists to individualize and implement diabetes self-management training and education. The objective of this study is to develop a preliminary version of a patient decision aid (PDA) designed to evaluate patient knowledge and behavior towards diabetes self-management for use in the community pharmacy setting. The study design used to achieve this objective was a cross-sectional survey …