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Full-Text Articles in Pharmacy and Pharmaceutical Sciences

Draft Genome Sequence Of Aneurinibacillus Sp. Strain Ba2021, Isolated As A Contaminant Of A Laboratory-Cultivated Predatory Myxobacterium, Barbara I. Adaikpoh, Scot E. Dowd, D. Cole Stevens Apr 2021

Draft Genome Sequence Of Aneurinibacillus Sp. Strain Ba2021, Isolated As A Contaminant Of A Laboratory-Cultivated Predatory Myxobacterium, Barbara I. Adaikpoh, Scot E. Dowd, D. Cole Stevens

Faculty and Student Publications

During laboratory cultivation of the myxobacterium Archangium violaceum strain Cb vi76, a reoccurring contaminant was isolated and sequenced. Comparative taxonomic analysis of the draft genome suggested the contaminant to be a novel species, currently designated Aneurinibacillus sp. strain BA2021, from the genus Aneurinibacillus, members of which are considered promising biocontrol agents.

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Rap1a Overlaps The Age/Rage Signaling Cascade To Alter Expression Of Α‐Sma, P‐Nf‐Κb, And P‐Pkc‐Ζ In Cardiac Fibroblasts Isolated From Type 2 Diabetic Mice, Stephanie D. Burr, James A. Stewart Mar 2021

Rap1a Overlaps The Age/Rage Signaling Cascade To Alter Expression Of Α‐Sma, P‐Nf‐Κb, And P‐Pkc‐Ζ In Cardiac Fibroblasts Isolated From Type 2 Diabetic Mice, Stephanie D. Burr, James A. Stewart

Faculty and Student Publications

Cardiovascular disease, specifically heart failure, is a common complication for individu-als with type 2 diabetes mellitus. Heart failure can arise with stiffening of the left ventricle, which can be caused by “active” cardiac fibroblasts (i.e., myofibroblasts) remodeling the extracellular matrix (ECM). Differentiation of fibroblasts to myofibroblasts has been demonstrated to be an outcome of AGE/RAGE signaling. Hyperglycemia causes advanced glycated end products (AGEs) to accu-mulate within the body, and this process is greatly accelerated under chronic diabetic conditions. AGEs can bind and activate their receptor (RAGE) to trigger multiple downstream outcomes, such as altering ECM remodeling, inflammation, and oxidative stress. …

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Design Of Topical Ocular Ciprofloxacin Nanoemulsion For The Management Of Bacterial Keratitis, Ahmed Adel Ali Youssef, Chuntian Cai, Narendar Dudhipala, Soumyajit Majumdar Mar 2021

Design Of Topical Ocular Ciprofloxacin Nanoemulsion For The Management Of Bacterial Keratitis, Ahmed Adel Ali Youssef, Chuntian Cai, Narendar Dudhipala, Soumyajit Majumdar

Faculty and Student Publications

Bacterial keratitis (BK) is a critical ocular infection that can lead to serious visual disability. Ciprofloxacin (CIP), moxifloxacin (MOX), and levofloxacin (LFX) have been accepted as monothera-pies by the US Food and Drug Administration for BK treatment. CIP is available commercially at 0.3% w/v concentration as an ophthalmic solution and as an ointment for ocular delivery. Because of solubility issues at physiological pH, CIP precipitation can occur at the corneal surface post instillation of the solution dosage form. Consequently, the ocular bioavailability of CIP is reduced. The ointment dosage form is associated with side effects such as blurred vision, itching, …

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Entrustable Professional Activities (Epas) For Global Health, David R. Steeb, Tina P. Brock, Sarah A. Dascanio, Paul K. Drain Mar 2021

Entrustable Professional Activities (Epas) For Global Health, David R. Steeb, Tina P. Brock, Sarah A. Dascanio, Paul K. Drain

Faculty and Student Publications

Purpose As global health education and training shift toward competency-based approaches, academic institutions and organizations must define appropriate assessment strategies for use across health professions. The authors aim to develop entrustable professional activities (EPAs) for global health to apply across academic and workplace settings. Method In 2019, the authors invited 55 global health experts from medicine, nursing, pharmacy, and public health to participate in a multiround, online Delphi process; 30 (55%) agreed. Experts averaged 17 years of global health experience, and 12 (40%) were from low-to middle-income countries. In round one, participants listed essential global health activities. The authors used …

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Biologically Guided Isolation And Admet Profile Of New Factor Xa Inhibitors Fromglycyrrhiza Glabraroots Usingin Vitroandin Silicoapproaches, Reham S. Ibrahim, Rahma S. R. Mahrous, Rasha M. Abu El-Khair, Samir A. Ross Feb 2021

Biologically Guided Isolation And Admet Profile Of New Factor Xa Inhibitors Fromglycyrrhiza Glabraroots Usingin Vitroandin Silicoapproaches, Reham S. Ibrahim, Rahma S. R. Mahrous, Rasha M. Abu El-Khair, Samir A. Ross

Faculty and Student Publications

Selective factor Xa inhibitors effectively block coagulation cascade with a broader therapeutic window than multitargeted anticoagulants. They have evolved as a crucial part of prevention and treatment of thromboembolic diseases and in therapeutic protocols involved in many clinical trials in coronavirus disease 2019 (COVID-19) patients. Biologically-guided isolation of specific FXa inhibitors from licorice (Glycyrrhiza glabra) root extract furnished ten flavonoids. By detailed analysis of their1H,13C NMR and MS data, the structures of these flavonoids were established as 7,4′-dihydroxyflavone (1), formononetin (2), 3-R-glabridin (3), isoliquiritigenin (4), liquiritin (5), naringenin 5-O-glucoside (6), 3,3′,4,4′-tetrahydroxy-2-methoxychalcone (7), liquiritinapioside (8) and the two isomers isoliquiritigenin-4′-O-β-d-apiosylglucoside (9) …

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An Efficient Synthetic Route Tol-Γ-Methyleneglutamine And Its Amide Derivatives, And Their Selective Anticancer Activity, Md Imran Hossain, Ajit G. Thomas, Fakhri Mahdi, Amna T. Adam Feb 2021

An Efficient Synthetic Route Tol-Γ-Methyleneglutamine And Its Amide Derivatives, And Their Selective Anticancer Activity, Md Imran Hossain, Ajit G. Thomas, Fakhri Mahdi, Amna T. Adam

Faculty and Student Publications

In cancer cells, glutaminolysis is the primary source of biosynthetic precursors, fueling the TCA cycle with glutamine-derived α-ketoglutarate. The enhanced production of α-ketoglutarate is critical to cancer cells as it provides carbons for the TCA cycle to produce glutathione, fatty acids, and nucleotides, and contributes nitrogens to produce hexosamines, nucleotides, and many nonessential amino acids. Efforts to inhibit glutamine metabolism in cancer using amino acid analogs have been extensive.l-γ-Methyleneglutamine was shown to be of considerable biochemical importance, playing a major role in nitrogen transport inArachisandAmorphaplants. Herein we report for the first time an efficient synthetic route tol-γ-methyleneglutamine and its amide …

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Proposed Mechanism For The Antitrypanosomal Activity Of Quercetin And Myricetin Isolated From Hypericum Afrum Lam: Phytochemistry, In Vitro Testing And Modeling Studies, Farida Larit, Khaled M. Elokely, Manal A. Nael, Samira Benyahia Feb 2021

Proposed Mechanism For The Antitrypanosomal Activity Of Quercetin And Myricetin Isolated From Hypericum Afrum Lam: Phytochemistry, In Vitro Testing And Modeling Studies, Farida Larit, Khaled M. Elokely, Manal A. Nael, Samira Benyahia

Faculty and Student Publications

The in vitro activity of L. donovani (promastigotes, axenic amastigotes and intracellular amastigotes in THP1 cells) and T. brucei, from the fractions obtained from the hydroalcoholic extract of the aerial part of Hypericum afrum and the isolated compounds, has been evaluated. The chloroform, ethyl acetate and n-butanol extracts showed significant antitrypanosomal activity towards T. brucei, with IC50 values of 12.35, 13.53 and 12.93 µg/mL and with IC90 values of 14.94, 19.31 and 18.67 µg/mL, respectively. The phytochemical investigation of the fractions led to the isolation and identification of quercetin (1), myricitrin (2), biapigenin (3), myricetin (4), hyperoside (5), myricetin-3-O-β-D-galactopyranoside (6) …

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Crosstalk Of Cancer Signaling Pathways By Cyclic Hexapeptides And Anthraquinones From Rubia Cordifolia, Premalatha Balachandran, Mohamed Ali Ibrahim, Jin Zhang, Mei Wang Feb 2021

Crosstalk Of Cancer Signaling Pathways By Cyclic Hexapeptides And Anthraquinones From Rubia Cordifolia, Premalatha Balachandran, Mohamed Ali Ibrahim, Jin Zhang, Mei Wang

Faculty and Student Publications

The anticancer activities of Rubia cordifolia and its constituents have been reported earlier, but their influence on the crosstalk of complex cancer-related signaling metabolic pathways (i.e., transcription factors; TF) has not yet been fully investigated. In this study, R. cordifolia root extract was subjected to the cancer signaling assay based bioactivity-guided fractionation, which yielded the following compounds viz., three anthraquinones, namely alizarin (1), purpurin (2), and emodin (3); two lignans, namely eudesmin (4) and compound 5; and two cyclic hexapeptides, namely deoxybouvardin RA-V (6), and a mixture of 6+9 (RA-XXI). The structures of the isolated compounds were determined by NMR …

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Development And Characterization Of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology, Abdullah Alshetaili, Bjad K. Almutairy, Sultan M. Alshehri, Michael A. Repka Feb 2021

Development And Characterization Of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology, Abdullah Alshetaili, Bjad K. Almutairy, Sultan M. Alshehri, Michael A. Repka

Faculty and Student Publications

The aim of this work was to develop the sustained release formulation of donepezil hydrochloride (DH) using the hot-melt extruded solid dispersion technique via the rational screening of hydrophobic carriers. Hydrophobic carriers with different physicochemical properties such as pH-independent swellability, low-permeability (Eudragit® RS PO (E-RS)), pH-independent non-swellability (ethyl cellulose N7 (EC-N7)), and the presence of lipids (Compritol® 888 ATO (C-888)) with or without pore-forming agents were used to achieve the sustained release profile of DH. Mannitol (MNT) was chosen as the temporary pore-forming agent. The thermal analysis showed that both the drug and C-888 preserved their crystallinity within a solid …

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Cis-Trimethoxystilbene, Exhibits Higher Genotoxic And Antiproliferative Effects Than Its Isomer Trans-Trimethoxystilbene In Mcf-7 And Mcf-10a Cell Lines, Natália Dos Santos Gonçalves, Tamires Maria Silva Pereira De Mello, Cássia Suemi Mizuno, Saqlain Haider Jan 2021

Cis-Trimethoxystilbene, Exhibits Higher Genotoxic And Antiproliferative Effects Than Its Isomer Trans-Trimethoxystilbene In Mcf-7 And Mcf-10a Cell Lines, Natália Dos Santos Gonçalves, Tamires Maria Silva Pereira De Mello, Cássia Suemi Mizuno, Saqlain Haider

Faculty and Student Publications

Stilbenes are a class of natural compounds with a wide variety of biological effects, such as antitumor activity. The best-known stilbene is resveratrol, whose clinical application is limited due to its low bioavailability. Methoxylated derivatives of this stilbene, including cis-trimethoxystilbene (cis-TMS) and trans-trimethoxystilbene (trans-TMS) have demonstrated more pronounced cytotoxic and anti-proliferative effects than resveratrol. Thus, the objective of this study is to evaluate and compare the cytotoxicity and antiproliferative effects of cis-and trans-TMS in MCF-7 and its normal counterpart MCF-10A. Both compounds were cytotoxic, genotoxic, and induced G2-M accumulation and cell death in the two cell lines. These results suggested …

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The Effect Of Paternal Age On Intracytoplasmic Sperm Injection Outcome In Unexplained Infertility, Haitham Elbardisi, Mohamed Arafa, Neha Singh, Bridget Betts Jan 2021

The Effect Of Paternal Age On Intracytoplasmic Sperm Injection Outcome In Unexplained Infertility, Haitham Elbardisi, Mohamed Arafa, Neha Singh, Bridget Betts

Faculty and Student Publications

Objective: : To examine the effect of paternal age on intracytoplasmic sperm injection (ICSI) outcomes in unexplained infertility Subjects and Methods: : This retrospective study, done at the Hamad Medical Corporation, Doha, Qatar screened infertile couples who underwent ICSI between 2014 and 2019 for the inclusion and exclusion criteria defining ‘unexplained infertility’. Couples recruited were allocated into two groups: Group A (paternal age <35 years) and Group B (paternal age ≥35 years). Baseline characteristics, investigations including semen and advanced sperm function tests and ICSI records were compared for primary outcomes such as fertilisation, cleavage, clinical pregnancy, miscarriage and live birth; and secondary outcomes such as semen parameters and advanced sperm functions (DNA fragmentation index and oxidation reduction potential). Results: : We found that final pregnancy outcomes including clinical pregnancy rate (P = 0.231), live-birth rate (P = 0.143), and miscarriage rates (P = 0.466) were not significantly different between the two age groups. Normal fertilisation (P = 0.01) and cleavage rate after ICSI (P = 0.001) were statistically significant when the age groups were compared. Also, normal sperm morphology was found to be significantly different (P = 0.041). Conclusions: : Advanced paternal age affects sperm morphology, fertilisation and embryo cleavage in ICSI but does not appear to affect clinical pregnancy, miscarriage or live-birth rates. ICSI appears to be a valid fertility treatment option in advancing paternal age.

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Eucalyptus Cinerea: Microscopic Profile, Chemical Composition Of Essential Oil And Its Antioxidant, Microbiological And Cytotoxic Activities, Matheus Saukoski Pauzer, Thais De Oliveira Borsato, Valter Paes De Almeida, Vijayasankar Raman Jan 2021

Eucalyptus Cinerea: Microscopic Profile, Chemical Composition Of Essential Oil And Its Antioxidant, Microbiological And Cytotoxic Activities, Matheus Saukoski Pauzer, Thais De Oliveira Borsato, Valter Paes De Almeida, Vijayasankar Raman

Faculty and Student Publications

Eucalyptus species possess anti-inflammatory, antifungal, antibacterial, and insecticidal properties. In this study, the chemical composition and biological activities of Eucalyptus cinerea essential oil (EO) and the leaf and stem anatomy were investigated. EO was extracted by Clevenger apparatus and the compounds were identified by GC/MS. The antioxidant activity was evaluated by DPPH, ABTS, and reducing phosphomolybdenum complex. Broth microdilution was used to determine antimicrobial activity. Cytotoxicity was verified against HeLa, HRT-18, and Calu-3 cells by MTT assay. The cytotoxic mechanism was studied by cell DNA content, cell cycle, and DNA fragmentation. The microscopic analyzes of the leaves and the stems …

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The Impact Of The Covid-19 Pandemic On Self-Reported Management Of Chronic Conditions, Hyllore Imeri, Erin Holmes, Shane Desselle, Meagen Rosenthal Jan 2021

The Impact Of The Covid-19 Pandemic On Self-Reported Management Of Chronic Conditions, Hyllore Imeri, Erin Holmes, Shane Desselle, Meagen Rosenthal

Faculty and Student Publications

Chronic conditions (CCs) management during the COVID-19 pandemic and the impact of the pandemic on patient activation (PA) and health locus of control (HLOC) remain unknown. This cross-sectional online survey study examined the role of COVID-19 pandemic-related worry or fear in PA and HLOC among patients with CCs. Individuals with CCs (n = 300) were recruited through MTurk Amazon. The questionnaire included sociodemographic questions, the Patient Activation Measure, and the Multidimensional Health Locus of Control–Form B. Out of the 300 participants, 9.7% were diagnosed with COVID-19, and 7.3% were hospitalized. Patients with cancer, chronic kidney disease, chronic obstructive pulmonary disease, …

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Simultaneous Estimation Of Cinnamaldehyde And Eugenol In Essential Oils And Traditional And Ultrasound-Assisted Extracts Of Different Species Of Cinnamon Using A Sustainable/Green Hptlc Technique, Ahmed I. Foudah, Faiyaz Shakeel, Mohammed H. Alqarni, Samir A. Ross Jan 2021

Simultaneous Estimation Of Cinnamaldehyde And Eugenol In Essential Oils And Traditional And Ultrasound-Assisted Extracts Of Different Species Of Cinnamon Using A Sustainable/Green Hptlc Technique, Ahmed I. Foudah, Faiyaz Shakeel, Mohammed H. Alqarni, Samir A. Ross

Faculty and Student Publications

A wide range of analytical techniques are reported for the determination of cinnamaldehyde (CCHO) and eugenol (EOH) in plant extracts and herbal formulations either alone or in combination. Nevertheless, sustainable/green analytical techniques for the estimation of CCHO and EOH either alone or in combination are scarce in the literature. Accordingly, the present research was carried out to establish a rapid, highly sensitive, and sustainable high-performance thin-layer chromatography (HPTLC) technique for the simultaneous estimation of CCHO and EOH in the traditional and ultrasound-assisted methanolic extracts of Cinnamomum zeylanicum, C. burmannii, and C. cassia and their essential oils. The simultaneous estimation of …

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Isolation Of Catechins From Cycas Armstrongii Miq. Of An Egyptian Origin, Ahmed Ismail, Mohamed M. Radwan, Hossam M. Hassan, Abeer S. Moawad Jan 2021

Isolation Of Catechins From Cycas Armstrongii Miq. Of An Egyptian Origin, Ahmed Ismail, Mohamed M. Radwan, Hossam M. Hassan, Abeer S. Moawad

Faculty and Student Publications

The phytochemical investigation of Cycas armstrongii Miq. leaves and twigs using different chromatographic techniques led to the isolation of three catechin monomers; catechin (1), epicatechin (2), and epigallocatechin-3-gallate (3), for the first time from this species. The chemotaxonomic significance of the isolated compounds is discussed in the rest of this article.

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Hiv-1 Tat And Morphine Differentially Disrupt Pyramidal Cell Structure And Function And Spatial Learning In Hippocampal Area Ca1: Continuous Versus Interrupted Morphine Exposure, William D. Marks, Jason J. Paris, Aaron J. Barbour, Jean Moon Jan 2021

Hiv-1 Tat And Morphine Differentially Disrupt Pyramidal Cell Structure And Function And Spatial Learning In Hippocampal Area Ca1: Continuous Versus Interrupted Morphine Exposure, William D. Marks, Jason J. Paris, Aaron J. Barbour, Jean Moon

Faculty and Student Publications

About half the people infected with human immunodeficiency virus (HIV) have neurocognitive deficits that often include memory impairment and hippocampal deficits, which can be exacerbated by opioid abuse. To explore the effects of opioids and HIV on hippocampal CA1 pyramidal neuron structure and function, we induced HIV-1 transactivator of transcription (Tat) expression in transgenic mice for 14 d and co-administered time-release morphine or vehicle subcutaneous implants during the final 5 d (days 9–14) to establish steady-state morphine levels. Morphine was withheld from some ex vivo slices during recordings to begin to assess the initial pharmacokinetic consequences of opioid withdrawal. Tat …

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An Evaluation Of Antipseudomonal Dosing On The Incidence Of Treatment Failure, Brandon K. Hawkins, Mary Joyce B. Wingler, David A. Cretella, Katie E. Barber Jan 2021

An Evaluation Of Antipseudomonal Dosing On The Incidence Of Treatment Failure, Brandon K. Hawkins, Mary Joyce B. Wingler, David A. Cretella, Katie E. Barber

Faculty and Student Publications

Introduction: Significant mortality is associated with delays in appropriate antibiotic therapy in Pseudomonas aeruginosa infections. The impact of empiric dosing on clinical outcomes has been largely unreported. Methods: This retrospective cohort compared treatment failure in patients receiving guideline-concordant or guideline-discordant empiric therapy with cefepime, meropenem, or piperacillin/tazobactam. Patients with culture-positive P. aeruginosa between 1 July 2013 and 31 July 2019 were eligible for inclusion. Patients with cystic fibrosis, polymicrobial infection, and urinary or pulmonary colonization were excluded. The composite primary outcome was treatment failure, defined as (1) therapy modification due to resistance/perceived treatment failure, (2) increased/unchanged qSOFA, or (3) persistent …

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Understanding Of Pharmacy Students Towards Antibiotic Use, Antibiotic Resistance And Antibiotic Stewardship Programs: A Cross-Sectional Study From Punjab, Pakistan, Khezar Hayat, Shazia Jamshed, Meagen Rosenthal, Noman Ul Haq Jan 2021

Understanding Of Pharmacy Students Towards Antibiotic Use, Antibiotic Resistance And Antibiotic Stewardship Programs: A Cross-Sectional Study From Punjab, Pakistan, Khezar Hayat, Shazia Jamshed, Meagen Rosenthal, Noman Ul Haq

Faculty and Student Publications

Antibiotic resistance (ABR) is a significant issue for public health globally. An adequate understanding of ABR and the approaches used to tackle ABR, including antibiotic stewardship programs, are vital. This study aimed to get an insight into antibiotic use, ABR, and antibiotic stewardship programs among pharmacy students of Punjab, Pakistan. This multicenter study was undertaken among final (fifth) year undergraduate pharmacy students of 7 universities of Punjab, Pakistan. A paper-based self-administered questionnaire comprising 48-items was utilized for data collection. Descriptive and inferential statistics were employed for data analysis. This study included a total of 296 respondents with a response rate …

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A Modified Delphi Involving Laboratory Faculty To Define Essential Skills For Pharmacy Graduates, Jeanne E. Frenzel, Brandon T. Nuziale, Courtney L. Bradley, Jordan M. Ballou Jan 2021

A Modified Delphi Involving Laboratory Faculty To Define Essential Skills For Pharmacy Graduates, Jeanne E. Frenzel, Brandon T. Nuziale, Courtney L. Bradley, Jordan M. Ballou

Faculty and Student Publications

Objective. To define essential skills for Doctor of Pharmacy (PharmD) graduates that are needed in the four most common sectors of pharmacy practice as determined by expert faculty who instruct within pharmacy skills laboratories. Methods. A three-round Delphi method was used to establish consensus. In the first round, participants were asked what skills were needed by students at entry to practice in community, health-system, ambulatory care, and managed care pharmacy settings. In rounds two and three, participants were asked to rate each skill with a level of importance using a 10-point Likert scale (1=not important to 10=very important). Results. In …

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Expression Of Trefoil Factor 3 Is Decreased In Colorectal Cancer, Ingrid Espinoza, Sumit Agarwal, Amit Reddy, Veena Shenoy Jan 2021

Expression Of Trefoil Factor 3 Is Decreased In Colorectal Cancer, Ingrid Espinoza, Sumit Agarwal, Amit Reddy, Veena Shenoy

Faculty and Student Publications

In colorectal cancer (CRC), high expression of trefoil factor 3 (TFF3) is associated with tumor progression and reduced patient survival; however, bioinformatics analyses of public 'omics' databases show low TFF3 expression in CRCs as compared to normal tissues. Thus, we examined TFF3 expression in CRCs and matching normal tissues to evaluate its role in CRC progression. TFF3 gene expression was char- acterized using the bioinformatics portal UALCAN (http:// ualcan.path.uab.edu). Tissue microarrays (TMAs) of archival CRC specimens (n=96) were immunostained with anti-human TFF3 antibodies. Immunohistochemical (IHC) staining intensity was semi-quantitatively scored. For this cohort, the median follow-up was 5.4 years. Associations …

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Exploring The Chemical Space Of 1,2,3-Triazolyl Triclosan Analogs For Discovery Of New Antileishmanial Chemotherapeutic Agents, Julia Fernández De Luco, Alejandro I. Recio-Balsells, Diego G. Ghiano, Ana Bortolotti Jan 2021

Exploring The Chemical Space Of 1,2,3-Triazolyl Triclosan Analogs For Discovery Of New Antileishmanial Chemotherapeutic Agents, Julia Fernández De Luco, Alejandro I. Recio-Balsells, Diego G. Ghiano, Ana Bortolotti

Faculty and Student Publications

Triclosan and isoniazid are known antitubercular compounds that have proven to be also active againstLeishmaniaparasites. On these grounds, a collection of 37 diverse 1,2,3-triazoles based on the antitubercular molecules triclosan and 5-octyl-2-phenoxyphenol (8PP) were designed in search of novel structures with leishmanicidal activity and prepared using different alkynes and azides. The 37 compounds were assayed againstLeishmania donovani, the etiological agent of leishmaniasis, yielding some analogs with activity at micromolar concentrations and againstM. tuberculosisH37Rv resulting in scarce active compounds with an MIC of 20 μM. To study the mechanism of action of these catechols, we analyzed the inhibition activity of the …

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Multisite Study Assessing The Effect Of Cognitive Test Anxiety On Academic And Standardized Test Performance, Adam N. Pate, Stephen Neely, Daniel R. Malcom, Kimberly K. Daugherty Jan 2021

Multisite Study Assessing The Effect Of Cognitive Test Anxiety On Academic And Standardized Test Performance, Adam N. Pate, Stephen Neely, Daniel R. Malcom, Kimberly K. Daugherty

Faculty and Student Publications

Objective. To evaluate the degree of cognitive test anxiety (CTA) present in student pharmacists at multiple pharmacy programs in the United States and to determine if there are associations between self-reported CTA and relevant academic outcomes. Methods. All 2018-2019 advanced pharmacy practice experience (APPE) students from three US Doctor of Pharmacy (PharmD) programs (N=260) were invited to participate in the study. Participants completed a validated 37-question survey that included the Cognitive Test Anxiety Scale-2 (CTAS-2) along with demographics-related questions. Responses were analyzed using analysis of variance (ANOVA), Kruskal Wallace, and multiple linear regression where appropriate. Results. One hundred twenty-four students …

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The Impact Of Two Longitudinal Professionalism Courses On Student Pharmacists’ Empathy, Brent N. Reed, Stuart T. Haines, Erin R. Holmes Jan 2021

The Impact Of Two Longitudinal Professionalism Courses On Student Pharmacists’ Empathy, Brent N. Reed, Stuart T. Haines, Erin R. Holmes

Faculty and Student Publications

Objective. To determine whether empathy increased in first-year student pharmacists after completing longitudinal professionalism courses at two schools of pharmacy, identify potential moderators, and assess whether students’ conceptualization of empathy changed with time. Methods. Surveys to assess empathy and other variables were administered to student pharmacists at baseline and at the end of two professionalism courses. Baseline and follow-up scores were compared to detect changes over time. Multivariable analysis was used to identify predictors of empathy scores. Factor analysis was performed to ascertain changes in the dimensionality of empathy. Results. Students’ demographics and baseline empathy scores differed between the two …

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School Of Pharmacy Intellectual Property Report, Fy22, First Quarter Report, Soumyajit Majumdar Jan 2021

School Of Pharmacy Intellectual Property Report, Fy22, First Quarter Report, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

No abstract provided.

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New Benzoxazole Derivatives As Antiprotozoal Agents: In Silico Studies, Synthesis, And Biological Evaluation, Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Mohamed A. Zaki, Enas I.A. Mohamed Jan 2021

New Benzoxazole Derivatives As Antiprotozoal Agents: In Silico Studies, Synthesis, And Biological Evaluation, Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Mohamed A. Zaki, Enas I.A. Mohamed

Faculty and Student Publications

Background. Benzoxazole derivatives have different biological activities. In pursuit of designing novel chemical entities with antiprotozoal and antimicrobial activities, benzoxazolyl aniline was utilized as a privileged scaffold of a series of (3-benzoxazole-2-yl) phenylamine derivatives, 3-benzoxazoloyl acetamide, and butyramide derivatives. Methods. These novel analogs were synthesized in straightforward simple chemistry without any quantitative chromatographic separations in reasonable yields. The biological evaluation of all target compounds as potential antimalarial, antileishmanial, antitrypanosomal, and antimicrobial agents was performed by various well-established cell-based methods. Results. Compounds 6d and 5a showed promising biological screening data. The amidation of 3-benzoxazolyl aniline 1 with the chloroacetyl functional group …

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Effect Of Lutrol® F Grades (Poloxamer) On Dissolution Of Hot-Melt Extruded Kollidon® Va64-Felodipine Matrices, Saad M. Alshahrani, Abdullah Alshetaili, Bjad K. Almutairy, Michael A. Repka Jan 2021

Effect Of Lutrol® F Grades (Poloxamer) On Dissolution Of Hot-Melt Extruded Kollidon® Va64-Felodipine Matrices, Saad M. Alshahrani, Abdullah Alshetaili, Bjad K. Almutairy, Michael A. Repka

Faculty and Student Publications

The objective of this study was to assess the potential of Lutrol® F grades as polymeric surfactants for dissolution enhancement of Kollidon®VA64-drug matrices produced by hot-melt extrusion (HME). The poorly soluble model drug felodipine (FEL) with a medium melting point was selected for this study. Two different grades of Lutrol® F (also called Kolliphor® P grades) were added into the HME systems to investigate their influence on the drug-incorporated matrices. Two grades of Lutrols i.e., Lutrol® F 68 (Kolliphor®P 188) and Lutrol® F 127 (Kolliphor®P 407) were studied as polymeric solubilizers. FEL was mixed with Kollidon®VA64, with or without Lutrol®F …

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Use Of Adaptive Learning Technology To Promote Self-Directed Learning In A Pharmacists’ Patient Care Process Course, Jennifer Toth, Meagen Rosenthal, Kristen Pate Jan 2021

Use Of Adaptive Learning Technology To Promote Self-Directed Learning In A Pharmacists’ Patient Care Process Course, Jennifer Toth, Meagen Rosenthal, Kristen Pate

Faculty and Student Publications

Objective. To evaluate student changes in self-directed learning (SDL) in a Pharmacists’ Patient Care Process (PPCP) course using adaptive learning technology (ALT). Methods. The Pharmacists’ Patient Care Process was delivered using traditional teaching methods in fall 2018 and ALT in spring 2019. First-year student pharmacists were surveyed three times throughout the academic year on SDL factors. Focus groups were conducted at the end of the spring semester to identify perceptions of course delivery. Multilevel linear modeling and qualitative content analysis were used to evaluate survey responses and focus group feedback, respectively. Results. Ninety-two of 106 students completed all three surveys. …

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Hot-Melt Extruded Amorphous Solid Dispersion For Solubility, Stability, And Bioavailability Enhancement Of Telmisartan, Bhupendra Raj Giri, Jaewook Kwon, Anh Q. Vo, Ajinkya M. Bhagurkar Jan 2021

Hot-Melt Extruded Amorphous Solid Dispersion For Solubility, Stability, And Bioavailability Enhancement Of Telmisartan, Bhupendra Raj Giri, Jaewook Kwon, Anh Q. Vo, Ajinkya M. Bhagurkar

Faculty and Student Publications

Telmisartan (TEL, an antihypertensive drug) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its poor aqueous solubility. In this study, we enhanced the solubility, bioavailability, and stability of TEL through the fabrication of TEL-loaded pH-modulated solid dispersion (TEL pHM-SD) using hot-melt extrusion (HME) technology. We prepared different TEL pHM-SD formulations by varying the ratio of the drug (TEL, 10–60% w/w), the hydrophilic polymer (Soluplus®, 30–90% w/w), and pH-modifier (sodium carbonate, 0–10% w/w). More so, the tablets prepared from an optimized formulation (F8) showed a strikingly improved in vitro dissolution profile (~30-fold) compared to the free drug …

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Isolation Of Marker Compounds From Copaiba Essential Oil And Mimosa Pigra For Quality Evaluation Of Dietary Supplements, Mohammed Hawwal Jan 2021

Isolation Of Marker Compounds From Copaiba Essential Oil And Mimosa Pigra For Quality Evaluation Of Dietary Supplements, Mohammed Hawwal

Electronic Theses and Dissertations

Natural products have been used as a primary means of treating illness since ancient times, and they remain an important pool of U.S. FDA approved drugs. Approximately 33% of all current pharmaceutical medications discovered between 1981 and 2014 are either natural products or derived from natural products (Newman and Cragg 2016). The process of isolating specialized metabolites from medicinal plants has led to the development of particularly important medicines worldwide (Rakotomalala, Agard et al. 2013) such as Taxol® from Taxus brevifolia Nutt. (Taxaceae) and salicylic acid from the bark of Salix spp. This research is composed of five chapters; the …

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School Of Pharmacy Intellectual Property Report Fy21, Second Quarter Report - Revised July 6, 2021, Soumyajit Majumdar Jan 2021

School Of Pharmacy Intellectual Property Report Fy21, Second Quarter Report - Revised July 6, 2021, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

School of Pharmacy Intellectual Property Report FY21, Fourth Quarter Report (as of 12/31/2020) - Revised July 6, 2021

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