Open Access. Powered by Scholars. Published by Universities.®

Pharmacy and Pharmaceutical Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

University of Mississippi

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 181 - 210 of 642

Full-Text Articles in Pharmacy and Pharmaceutical Sciences

Mapping The Impact Of The Covid-19 Pandemic On Pharmacy Graduate Students’ Wellness, Hyllore Imeri, Saumil Jadhav, Marie Barnard, Meagen Rosenthal Nov 2021

Mapping The Impact Of The Covid-19 Pandemic On Pharmacy Graduate Students’ Wellness, Hyllore Imeri, Saumil Jadhav, Marie Barnard, Meagen Rosenthal

Faculty and Student Publications

Background: The COVID-19 pandemic has resulted in significant changes in pharmacy graduate students' (PhGS) lives. While pharmacy graduate programs across the U.S. have reported adjustments due to the pandemic, there is currently no data on the PhGS’ wellness, and the impact on and extent to which offered supports and guidance has met PhGS needs. Objective: This study's objectives were 1) to explore PhGS′ perspectives on their challenges and the impact of these challenges on their wellness, and 2) to identify PhGS′ suggestions for pharmacy graduate programs to improve guidance and support offered during the COVID-19 pandemic. Methods: This study conducted …

Go to article

Research News, Publications, 2021, Volume 3, Soumyajit Majumdar Nov 2021

Research News, Publications, 2021, Volume 3, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of July 30 through September 30, 2021

Go to article

Expression Of Mhc Class I Polypeptide-Related Sequence A (Mica) In Colorectal Cancer, Ingrid Espinoza, Sumit Agarwal, Marcelo Sakiyama, Veena Shenoy Oct 2021

Expression Of Mhc Class I Polypeptide-Related Sequence A (Mica) In Colorectal Cancer, Ingrid Espinoza, Sumit Agarwal, Marcelo Sakiyama, Veena Shenoy

Faculty and Student Publications

Background: The major histocompatibility complex class I polypeptide-related sequence A (MICA) is one of the ligands of the natural killer group 2D (NKG2D) activating receptor. MICA stimulates NKG2D, which further triggers activation of natural killer cells and leads to killing of infected target cells. To subvert the biological function of NKG2D, tumor cells utilize an escape strategy by shedding overexpressed MICA. In this study, we determined the levels of MICA in colorectal cancers (CRCs). Additionally, we established correlations between MICA expression and clinical characteristics. Publicly available data and bioinformatics tools were used for validation purposes. Methods: We determined the MICA …

Go to article

Glycoscience Center Of Research Excellence (Glycore), Karin King Ballering Oct 2021

Glycoscience Center Of Research Excellence (Glycore), Karin King Ballering

Annual Poster Session 2021

Presenter: Karin King Ballering

Go to article

Coupling Fdm 3d Printing With Hot-Melt Extrusion To Produce Hypertensive Dual Therapy Fixed Dose Combination Tablet, Abdullah Alzahrani, Sagar Narala, Dinesh Nyavanandi, Mashan Almutairi, Ahmed Almotairy, Suresh Bandari, Michael Repka Oct 2021

Coupling Fdm 3d Printing With Hot-Melt Extrusion To Produce Hypertensive Dual Therapy Fixed Dose Combination Tablet, Abdullah Alzahrani, Sagar Narala, Dinesh Nyavanandi, Mashan Almutairi, Ahmed Almotairy, Suresh Bandari, Michael Repka

Annual Poster Session 2021

Presenter: Abdullah Alzahrani

Go to article

Schottiin, A New Prenylated Isoflavone From Psorothamnus Schottii And Antibacterial Synergism Studies Between Methicillin And Fremontone Against Mrsa, Mallika Kumarihamy, Siddharth K. Tripathi, Shabana Khan, Ilias Muhammad Oct 2021

Schottiin, A New Prenylated Isoflavone From Psorothamnus Schottii And Antibacterial Synergism Studies Between Methicillin And Fremontone Against Mrsa, Mallika Kumarihamy, Siddharth K. Tripathi, Shabana Khan, Ilias Muhammad

Annual Poster Session 2021

Presenter: Mallika Kumarihamy

Go to article

New Hydroxy-1,4-Naphthoquinone And Phenoxy-Phenyl-Naphthoquinone Compounds As Drug-Resistant Antimalarials, Seong Jong Kim, Md Imdadul H. Khan, Yuexin Li, Benjamin Sawyer, Michael K. Riscoe, Shabana I. Khan, Babu L. Tekwani, Hoang V. Le Oct 2021

New Hydroxy-1,4-Naphthoquinone And Phenoxy-Phenyl-Naphthoquinone Compounds As Drug-Resistant Antimalarials, Seong Jong Kim, Md Imdadul H. Khan, Yuexin Li, Benjamin Sawyer, Michael K. Riscoe, Shabana I. Khan, Babu L. Tekwani, Hoang V. Le

Annual Poster Session 2021

Presenter: Benjamin Sawyer

Go to article

Negative Impacts Of Flood-Associated Water Quality Stressors On Early Oyster Life Stages, Jessica Pruett, Ann Fairly Pandelides, Kristine Willett, Stephanie Showalter Otts, Deborah Gochfeld Oct 2021

Negative Impacts Of Flood-Associated Water Quality Stressors On Early Oyster Life Stages, Jessica Pruett, Ann Fairly Pandelides, Kristine Willett, Stephanie Showalter Otts, Deborah Gochfeld

Annual Poster Session 2021

Presenter: Jessica Pruett

Go to article

Discovery Of 5Α-Pregnan-2Β,3Α-Diol-20-One As A Neurohiv Protective Agent, Md Imdadul H. Khan, Mohammed F. Salahuddin, Nicholas S. Akins, Fakhri Mahdi, Seong Jong Kim, Jing Li, Jason J. Paris, Hoang V. Le Oct 2021

Discovery Of 5Α-Pregnan-2Β,3Α-Diol-20-One As A Neurohiv Protective Agent, Md Imdadul H. Khan, Mohammed F. Salahuddin, Nicholas S. Akins, Fakhri Mahdi, Seong Jong Kim, Jing Li, Jason J. Paris, Hoang V. Le

Annual Poster Session 2021

Presenter: Md Imdadul Khan

Go to article

Liquid Chromatography- Tandem Mass Spectrometry (Lc-Ms-Ms) As A Detection Method For Cocaine As A Perfomance Enhancing Drug, Isha Kalaria, Shrishti Dubey Oct 2021

Liquid Chromatography- Tandem Mass Spectrometry (Lc-Ms-Ms) As A Detection Method For Cocaine As A Perfomance Enhancing Drug, Isha Kalaria, Shrishti Dubey

Annual Poster Session 2021

Presenters: Isha Kalaria, Shrishti Dubey

Go to article

Scanning Electron Microscopy Core, Vijayasankar Raman, Soumyajit Majumdar Oct 2021

Scanning Electron Microscopy Core, Vijayasankar Raman, Soumyajit Majumdar

Annual Poster Session 2021

Presenter: Vijayasankar Raman

Go to article

Biomolecular Sciences, University Of Mississippi. Department Of Biomolecular Sciences Oct 2021

Biomolecular Sciences, University Of Mississippi. Department Of Biomolecular Sciences

Annual Poster Session 2021

Presenter: Department of BioMolecular Sciences

Go to article

Hiv-1 Tat Protein Promotes Neuroendocrine Dysfunction Concurrent With The Potentiation Of Oxycodone’S Psychomotor Behavioral Effects In Female Transgenic Mice, Salahuddin Mohammed, Fakhri Mahdi, Jason J. Paris Oct 2021

Hiv-1 Tat Protein Promotes Neuroendocrine Dysfunction Concurrent With The Potentiation Of Oxycodone’S Psychomotor Behavioral Effects In Female Transgenic Mice, Salahuddin Mohammed, Fakhri Mahdi, Jason J. Paris

Annual Poster Session 2021

Presenter: Salahuddin Mohammed

Go to article

Environmental Enrichment Provided To Adult Zebra Finches (Taeniopygia Guttata) Differentially Influences Sexes On A Spatial Learning Task, Arma'rosa Wilks-Mohead, Laura West, Lainy B. Day Oct 2021

Environmental Enrichment Provided To Adult Zebra Finches (Taeniopygia Guttata) Differentially Influences Sexes On A Spatial Learning Task, Arma'rosa Wilks-Mohead, Laura West, Lainy B. Day

Annual Poster Session 2021

Presenter: Arma'Rosa Wilks-Mohead

Go to article

Age-Related Neuroendocrine, Cognitive, And Behavioral Co-Morbidities Are Promoted By Hiv-1 Tat Expression In Male Mice, Alaa Qraeya, Fakhri Mahdi, Marc Kaufman, Nicole M. Ashpole, Jason J. Paris Oct 2021

Age-Related Neuroendocrine, Cognitive, And Behavioral Co-Morbidities Are Promoted By Hiv-1 Tat Expression In Male Mice, Alaa Qraeya, Fakhri Mahdi, Marc Kaufman, Nicole M. Ashpole, Jason J. Paris

Annual Poster Session 2021

Presenter: Alaa Qraeya

Go to article

Incident Light And Morphology Determine Coral Productivity Along A Shallow To Mesophotic Depth Gradient, Michael P. Lesser, Marc Slattery, Curtis D. Mobley Oct 2021

Incident Light And Morphology Determine Coral Productivity Along A Shallow To Mesophotic Depth Gradient, Michael P. Lesser, Marc Slattery, Curtis D. Mobley

Faculty and Student Publications

While the effects of irradiance on coral productivity are well known, corals along a shallow to mesophotic depth gradient (10–100 m) experience incident irradiances determined by the optical properties of the water column, coral morphology, and reef topography. Modeling of productivity (i.e., carbon fixation) using empirical data shows that hemispherical colonies photosynthetically fix significantly greater amounts of carbon across all depths, and throughout the day, compared with plating and branching morphologies. In addition, topography (i.e., substrate angle) further influences the rate of productivity of corals but does not change the hierarchy of coral morphologies relative to productivity. The differences in …

Go to article

Computationally Assisted Lead Optimization Of Novel Potent And Selective Mao-B Inhibitors, Vedanjali Gogineni, Manal A. Nael, Narayan D. Chaurasiya, Khaled M. Elokely Oct 2021

Computationally Assisted Lead Optimization Of Novel Potent And Selective Mao-B Inhibitors, Vedanjali Gogineni, Manal A. Nael, Narayan D. Chaurasiya, Khaled M. Elokely

Faculty and Student Publications

A series of dietary flavonoid acacetin 7-O-methyl ether derivatives were computationally designed aiming to improve the selectivity and potency profiles against monoamine oxidase (MAO) B. The designed compounds were evaluated for their potential to inhibit human MAO-A and-B. Compounds 1c, 2c, 3c, and 4c were the most potent with a Ki of 37 to 68 nM against MAO-B. Compounds 1c–4c displayed more than a thousand-fold selectivity index towards MAO-B compared with MAO-A. Moreover, compounds 1c and 2c showed reversible inhibition of MAO-B. These results provide a basis for further studies on the potential application of these modified flavonoids for the …

Go to article

Sequentialdynamics Of Stearoyl-Coa Desaturase-1(Scd1)/Ligand Binding And Unbinding Mechanism: A Computational Study, Anna B. Petroff, Rebecca L. Weir, Charles R. Yates, Joseph D. Ng Oct 2021

Sequentialdynamics Of Stearoyl-Coa Desaturase-1(Scd1)/Ligand Binding And Unbinding Mechanism: A Computational Study, Anna B. Petroff, Rebecca L. Weir, Charles R. Yates, Joseph D. Ng

Faculty and Student Publications

Stearoyl-CoA desaturase-1 (SCD1 or delta-9 desaturase, D9D) is a key metabolic protein that modulates cellular inflammation and stress, but overactivity of SCD1 is associated with diseases, including cancer and metabolic syndrome. This transmembrane endoplasmic reticulum protein converts saturated fatty acids into monounsaturated fatty acids, primarily stearoyl-CoA into oleoyl- CoA, which are critical products for energy metabolism and membrane composition. The present computational molecular dynamics study characterizes the molecular dynamics of SCD1 with substrate, product, and as an apoprotein. The modeling of SCD1:fatty acid interactions suggests that: (1) SCD1:CoA moiety interactions open the substrate-binding tunnel, (2) SCD1 stabilizes a substrate conformation …

Go to article

Preparation And In Vitro/In Vivo Evaluation Of Orally Disintegrating/Modified-Release Praziquantel Tablets, Xuemei Wen, Zhaoyou Deng, Yangfeng Xu, Guoqing Yan Oct 2021

Preparation And In Vitro/In Vivo Evaluation Of Orally Disintegrating/Modified-Release Praziquantel Tablets, Xuemei Wen, Zhaoyou Deng, Yangfeng Xu, Guoqing Yan

Faculty and Student Publications

This study was designed to develop orally disintegrating/sustained-release praziquantel (PZQ) tablets using the hot-melt extrusion (HME) technique and direct compression, and subse-quently evaluate their release in in vitro and in vivo pharmacokinetics. For the extrusion process, hypromellose acetate succinate (HPMCAS)-LG was the carrier of pure PZQ, with a standard screw configuration used at an extrusion temperature of 140◦ C and a screw rotation speed of 100 rpm. Differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), powder X-ray diffraction (PXRD) and Fourier-transform infrared spectroscopy (FTIR) were performed to characterize the extru-date. Orally disintegrating/sustained-release praziquantel tablets (PZQ ODSRTs) were prepared by direct compression …

Go to article

Structural And Kinetic Analyses Of Holothurian Sulfated Glycans Suggest Potential Treatment For Sars-Cov-2 Infection, Rohini Dwivedi, Priyanka Samanta, Poonam Sharma, Fuming Zhang Oct 2021

Structural And Kinetic Analyses Of Holothurian Sulfated Glycans Suggest Potential Treatment For Sars-Cov-2 Infection, Rohini Dwivedi, Priyanka Samanta, Poonam Sharma, Fuming Zhang

Faculty and Student Publications

Certain sulfated glycans, including those from marine sources, can show potential effects against SARS-CoV-2. Here, a new fucosylated chondroitin sulfate (FucCS) from the sea cucumber Pentacta pygmaea (PpFucCS) (MW ∼10.60 kDa) was isolated and structurally characterized by NMR. PpFucCS is composed of {→3)-β-GalNAcX-(1→4)-β-GlcA-[(3→1)Y]- (1→}, where X = 4S (80%), 6S (10%) or nonsulfated (10%), Y = α- Fuc2,4S (40%), α-Fuc2,4S-(1→4)-α-Fuc (30%), or α-Fuc4S (30%), and S = SO3-. The anti-SARS-CoV-2 activity of PpFucCS and those of the FucCS and sulfated fucan isolated from Isostichopus badionotus (IbFucCS and IbSF) were compared with that of heparin. IC50 values demonstrated the activity of …

Go to article

Growth And Feeding In The Sponge Agelas Tubulata From Shallow To Mesophotic Depths On Grand Cayman Island, Keir J. Macartney, Amelia Clayshulte Abraham, Marc Slattery, Michael P. Lesser Sep 2021

Growth And Feeding In The Sponge Agelas Tubulata From Shallow To Mesophotic Depths On Grand Cayman Island, Keir J. Macartney, Amelia Clayshulte Abraham, Marc Slattery, Michael P. Lesser

Faculty and Student Publications

On Caribbean coral reefs, sponges are important members of the benthic community and play multiple roles in ecosystem structure and function. They have an important role in benthic-pelagic coupling, consuming particulate organic matter (POM) and dissolved organic matter (DOM) and in turn providing food in the form of sponge biomass or the release of detritus for a variety of coral reef organisms. Throughout the Caribbean, sponges show consistent increases in their abundance and growth rates as depth increases into the mesophotic zone (30–150 m). This has been hypothesized to be driven by bottom-up forces, particularly the increased supply of nitrogen-rich …

Go to article

Targeted Downregulation Of Myc Through G-Quadruplex Stabilization By Dnai, Alexandra Maria Psaras, Katarina T. Chang, Taisen Hao, Tracy A. Brooks Sep 2021

Targeted Downregulation Of Myc Through G-Quadruplex Stabilization By Dnai, Alexandra Maria Psaras, Katarina T. Chang, Taisen Hao, Tracy A. Brooks

Faculty and Student Publications

Modulating the expression or function of the enigmatic MYC protein has demonstrated efficacy in an array of cancer types and a marked potential therapeutic index and safety profile. Despite its high therapeutic value, specific and selective inhibitors or downregulating therapeutics have proven difficult to develop. In the current study, we expanded our work on a MYC promoter G-quadruplex (G4) stabilizing DNA clamp to develop an oligonucleotide interfering DNA (DNAi) therapeutic. We explored six DNAi for G4-stabilization through EMSA, DMS footprinting, and thermal stability studies, focusing on the DNAi 5T as the lead therapeutic. 5T, but not its scramble control 5Tscr, …

Go to article

Tissue-Specific Regulation Of Hnk-1 Biosynthesis By Bisecting Glcnac, Haruka Kawade, Jyoji Morise, Sushil K. Mishra, Shuta Tsujioka Sep 2021

Tissue-Specific Regulation Of Hnk-1 Biosynthesis By Bisecting Glcnac, Haruka Kawade, Jyoji Morise, Sushil K. Mishra, Shuta Tsujioka

Faculty and Student Publications

Human natural killer—1 (HNK-1) is a sulfated glyco-epitope regulating cell adhesion and synaptic functions. HNK-1 and its non-sulfated forms, which are specifically expressed in the brain and the kidney, respectively, are distinctly biosynthesized by two homologous glycosyltransferases: GlcAT-P in the brain and GlcAT-S in the kidney. However, it is largely unclear how the activity of these isozymes is regulated in vivo. We recently found that bisecting GlcNAc, a branching sugar in N-glycan, suppresses both GlcAT-P activity and HNK-1 expression in the brain. Here, we observed that the expression of non-sulfated HNK-1 in the kidney is unexpectedly unaltered in mutant mice …

Go to article

Adapting Decarbonylation Chemistry For The Development Of Prodrugs Capable Ofin Vivodelivery Of Carbon Monoxide Utilizing Sweeteners As Carrier Molecules, Ladie Kimberly De La Cruz, Xiaoxiao Yang, Anna Menshikh, Maya Brewer Aug 2021

Adapting Decarbonylation Chemistry For The Development Of Prodrugs Capable Ofin Vivodelivery Of Carbon Monoxide Utilizing Sweeteners As Carrier Molecules, Ladie Kimberly De La Cruz, Xiaoxiao Yang, Anna Menshikh, Maya Brewer

Faculty and Student Publications

Carbon monoxide as an endogenous signaling molecule exhibits pharmacological efficacy in various animal models of organ injury. To address the difficulty in using CO gas as a therapeutic agent for widespread applications, we are interested in developing CO prodrugs through bioreversible caging of CO in an organic compound. Specifically, we have explored the decarboxylation-decarbonylation chemistry of 1,2-dicarbonyl compounds. Examination and optimization of factors favorable for maximal CO release under physiological conditions led to organic CO prodrugs using non-calorific sweeteners as leaving groups attached to the 1,2-dicarbonyl core. Attaching a leaving group with appropriate properties promotes the desired hydrolysis-decarboxylation-decarbonylation sequence of …

Go to article

The Degree Of Polymerization And Sulfation Patterns In Heparan Sulfate Are Critical Determinants Of Cytomegalovirus Entry Into Host Cells, Dipanwita Mitra, Mohammad H. Hasan, John T. Bates, Michael A. Bierdeman Aug 2021

The Degree Of Polymerization And Sulfation Patterns In Heparan Sulfate Are Critical Determinants Of Cytomegalovirus Entry Into Host Cells, Dipanwita Mitra, Mohammad H. Hasan, John T. Bates, Michael A. Bierdeman

Faculty and Student Publications

Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host membrane fusion and virus entry. Interfering with HS-herpesvirus interactions has long been known to result in significant reduction in virus infectivity indicating that HS play important roles in initiating virus entry. In this study, we provide a series of evidence to prove that specific sulfations as well as the degree of polymerization (dp) of HS govern human cytomegalovirus (CMV) binding and infection. First, purified CMV extracellular virions preferentially bind to sulfated longer …

Go to article

(E)-2,6,10-Trimethyldodec-8-En-2-Ol: An Undescribed Sesquiterpenoid From Copaiba Oil, Mohammed F. Hawwal, Zulfiqar Ali, Mei Wang, Jianping Zhao Aug 2021

(E)-2,6,10-Trimethyldodec-8-En-2-Ol: An Undescribed Sesquiterpenoid From Copaiba Oil, Mohammed F. Hawwal, Zulfiqar Ali, Mei Wang, Jianping Zhao

Faculty and Student Publications

The use of copaiba oil has been reported since the 16th century in Amazon traditional medicine, especially as an anti-inflammatory ingredient and for wound healing. The use of copaiba oil continues today, and it is sold in various parts of the world, including the United States. Copaiba oil contains mainly sesquiterpenes, bioactive compounds that are popular for their positive effect on human health. As part of our ongoing research endeavors to identify the chemical constituents of broadly consumed herbal supplements or their adulterants, copaiba oil was investigated. In this regard, copaiba oil was subjected to repeated silica gel column chromatography …

Go to article

Red Algal Sulfated Galactan Binds And Protects Neural Cells From Hiv-1 Gp120 And Tat, Vitor H. Pomin, Fakhri Mahdi, Weihua Jin, Fuming Zhang Aug 2021

Red Algal Sulfated Galactan Binds And Protects Neural Cells From Hiv-1 Gp120 And Tat, Vitor H. Pomin, Fakhri Mahdi, Weihua Jin, Fuming Zhang

Faculty and Student Publications

The potential neuroprotective capacity of four different sulfated glycans: Botryocladia occidentalis-derived sulfated galactan (BoSG) (MW > 100 kDa), Lytechinus variegatus-derived sulfated fucan (LvSF) (MW~90 kDa), high-molecular weight dextran sulfate (DxS) (MW 100 kDa), and unfractionated heparin (UFH) (MW~15 kDa), was assessed in response to the HIV-1 proteins, R5-tropic glycoprotein 120 (gp120) and/or trans-activator of transcription (Tat), using primary murine neurons co-cultured with mixed glia. Compared to control-treated cells in which HIV-1 proteins alone or combined were neurotoxic, BoSG was, among the four tested sulfated glycans, the only one capable of showing significant concentration-dependent neuroprotection against Tat and/or gp120, alone or combined. …

Go to article

Critical Interactions Between Opioid And Cannabinoid Receptors During Tolerance And Physical Dependence Development To Opioids In The Murine Gastrointestinal Tract: Proof Of Concept, Agata Szymaszkiewicz, Mikołaj Świerczyński, Marcin Talar, Prabhakar Reddy Polepally Aug 2021

Critical Interactions Between Opioid And Cannabinoid Receptors During Tolerance And Physical Dependence Development To Opioids In The Murine Gastrointestinal Tract: Proof Of Concept, Agata Szymaszkiewicz, Mikołaj Świerczyński, Marcin Talar, Prabhakar Reddy Polepally

Faculty and Student Publications

Introduction: Tolerance (TOL) and physical dependence (PD) constitute important limitations of opioid therapy. The aim of our study was to validate research tools to investigate TOL and PD and to characterize the interactions between opioid (OR) and cannabinoid (CB) receptors in these processes in the GI tract. Methods: TOL was assessed through the comparison of morphine ability to inhibit electrically evoked smooth muscles contractility in the mouse ileum that was previously incubated with/without morphine for 1 h. To evaluate the PD, the ileum was incubated with morphine for 10 min, then challenged with naloxone to induce withdrawal response (WR). The …

Go to article

School Of Pharmacy Intellectual Property Report Fy21, Fourth Quarter Report, Soumyajit Majumdar Jul 2021

School Of Pharmacy Intellectual Property Report Fy21, Fourth Quarter Report, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

School of Pharmacy Intellectual Property Report FY21, Fourth Quarter Report (as of 6/30/21)

Go to article

Research News, Publications, 2021, Volume 2, Soumyajit Majumdar Jul 2021

Research News, Publications, 2021, Volume 2, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of April 1 through June 30, 2021

Go to article

First Prev Next Last