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Selected Works

2006

Articles 1 - 8 of 8

Full-Text Articles in Pharmacy and Pharmaceutical Sciences

Organochlorine Levels In Seawater And Sediment From The Florida Gulf Coast, If Present, Are Low., Richard B. Philp Nov 2006

Organochlorine Levels In Seawater And Sediment From The Florida Gulf Coast, If Present, Are Low., Richard B. Philp

Richard B. Philp

Abstract Seawater and bottom sediment from two areas of the Gulf of Mexico near-shore waters along the Florida panhandle, one near Panacea (South of Tallahassee) and the other, St. Joseph Bay, about 100 km to the west, were analyzed for organochlorines (OCs). The first area is contiguous with the open water of Apalachee Bay and receives significant fresh water inflow. The second is a long, narrow bay with a north-facing mouth adjacent to the mainland and little fresh water inflow. Samples were analyzed for a panel of 28 OCs including several insecticides and metabolites as well as hexaxhlorobenzene and total …

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Current Controversies In Critical Care Pharmacotherapy: Incorporating Evidence Into Practice. How Can We Start Nutrition, Jane Gervasio Sep 2006

Current Controversies In Critical Care Pharmacotherapy: Incorporating Evidence Into Practice. How Can We Start Nutrition, Jane Gervasio

Jane M. Gervasio

No abstract provided.

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Exploiting The Enhanced Permeability And Retention Effect For Tumor Targeting., Arun Iyer Aug 2006

Exploiting The Enhanced Permeability And Retention Effect For Tumor Targeting., Arun Iyer

Arun Iyer

Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is a key mechanism for solid tumor targeting, and considered a gold standard for novel drug design. In this review, we discuss various endogenous factors that can positively impact the EPR effect in tumor tissues. Further, we discuss ways to augment the EPR effect by use of exogenous agents, as well as practical methods available in the clinical setting. Some innovative examples developed by researchers to combat cancer by the EPR mechanism are also discussed.

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Antioxidant Effect Of Zinc And Zinc-Metallothionein In The Acute Cytotoxicity Of Hydrogen Peroxide In Ehrlich Ascites Tumour Cells, Zacharias Suntres, Ed Lui Jul 2006

Antioxidant Effect Of Zinc And Zinc-Metallothionein In The Acute Cytotoxicity Of Hydrogen Peroxide In Ehrlich Ascites Tumour Cells, Zacharias Suntres, Ed Lui

Edmund M. K. Lui

This study was concerned with the role of zinc (Zn) and zinc-metallothionein (Zn-MT) in oxidative stress. Hydrogen peroxide-induced oxidative injury was examined in Ehrlich ascites tumour cells isolated from control host mice, mice pretreated with 10 mg/kg ZnSO4 (i.p.) to increase cellular Zn/Zn-MT levels, and mice exposed to Zn-deficient diet to reduce the cellular Zn/Zn-MT levels. The results of the present study showed that Ehrlich cells with seven-fold differences in Zn-MT concentrations could be obtained by manipulating the Zn status of host mice and that high Zn and Zn-MT levels can make Ehrlich cells more resistant to H2O2-induced oxidative injury …

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Clinical Trials, Jane Gervasio Jun 2006

Clinical Trials, Jane Gervasio

Jane M. Gervasio

No abstract provided.

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Research, Precepting And The Irb, Jane Gervasio May 2006

Research, Precepting And The Irb, Jane Gervasio

Jane M. Gervasio

No abstract provided.

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Bowel Necrosis Associated With Enteral Nutrition, Jane Gervasio Jan 2006

Bowel Necrosis Associated With Enteral Nutrition, Jane Gervasio

Jane M. Gervasio

No abstract provided.

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Prooxidative Effect Of Copper-Metallothionein In The Acute Cytotoxicity Of Hydrogen Peroxide In Ehrlich Ascites Tumour Cells, Zacharias Suntres, Ed Lui Jan 2006

Prooxidative Effect Of Copper-Metallothionein In The Acute Cytotoxicity Of Hydrogen Peroxide In Ehrlich Ascites Tumour Cells, Zacharias Suntres, Ed Lui

Edmund M. K. Lui

This study was concerned with the role of copper (Cu) and Cu-metallothionein (Cu-MT) in oxidative stress. Hydrogen peroxide (H(2)O(2))-induced oxidative injury was examined in Ehrlich ascites tumour cells isolated from host mice pretreated with 0, 1 or 2mg of CuSO(4) (ip) 24h earlier. Control Ehrlich cells contained low levels of Cu and Cu treatment produced dose-related increases in cellular Cu and Cu-MT levels and corresponding increases in sensitivity to oxidative toxicity of H(2)O(2) (LC(50), cell blebbing, lipid peroxidation, GSH depletion, and increase in intracellular free [Ca(2+)](i)). Hydrogen peroxide treatment also resulted in the oxidation of MT thiolates, reduction in the …

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