Pharmacy and Pharmaceutical Sciences Commons^™

Effectiveness Of Training In Changing Allied Health Students’ Cultural Competency Skills, Gisela Van Kessel, Caroline Fryer, Bernadette Flynn, Katia Ferrar, Susan Roush

Internet Journal of Allied Health Sciences and Practice

Purpose: Allied health students require cultural competence training to help them act as caring, ethical, and socially responsible health professionals. There is a lack of evidence for the effectiveness of cultural competence training changing the cultural skill level of allied health students or their behaviour in clinical practice. Method: We conducted a systematic search of the literature to examine the effectiveness of cultural competence training in changing allied health student cultural competency skills. CINAHL, Embase, ERIC, Medline and Scopus databases were searched from inception until August 2017. Search terms represented the population (e.g. allied health students), and cultural competence training. …

Cholinergic Anti-Inflammatory Pathway And Covid-19, Danial Mehranfard, Robert C. Speth

HPD Articles

The cholinergic anti-inflammatory pathway (CAP) first described by Wang et al, 2003 has contemporary interest arising from the COVID-19 pandemic. While tobacco smoking has been considered an aggravating factor in the severity of COVID-19 infections, it has been suggested by some that the nicotine derived from tobacco could lessen the severity of COVID-19 infections. This spotlight briefly describes the CAP and its potential role as a therapeutic target for the treatment of COVID-19 infections using vagus nerve stimulation or selective alpha7 nicotinic acetylcholine receptor agonists.

Educational Initiative In An Ncats Tl1 Training Program To Address The Impact Of Systemic Racism On Human Health, Biomedical Research, And The Translational Scientist, Martha D. Gay, Kimberly A. Bell, Emily A. Bujold, Marilla Geraci, Dexter L. Lee, Kathryn Sandberg, Robert C. Speth

HPD Articles

INTRODUCTION: The goal of clinical and translational science (CTS) is to fill gaps in medical knowledge toward improving human health. However, one of our most pressing challenges does not reside within the biological map we navigate to find sustainable cures but rather the moral compass to recognize and overcome racial and ethnic injustices that continue to influence our society and hinder diverse research rigor. The Georgetown-Howard Universities Center for Clinical and Translational Science includes an inter-institutional TL1-funded training program for predoctoral/postdoctoral trainees in Translational Biomedical Science (TBS). METHODS: In the fall of 2020, the TBS program responded to the national …

An Opinion On The Impacts Of Covid-19 Worldwide, Robert C. Speth

HPD Articles

No abstract provided.

Sharksrx Newsletter Fall 2021, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Sharksrx Newsletter Summer 2021, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Male Bias In Ace2 Basic Science Research: Missed Opportunity For Discovery In The Time Of Covid-19, Branka Miličić Stanić, Sydney Maddox, Aline M. De Souza, Xie Wu, Danial Mehranfard, Hong Ji, Robert C. Speth, Kathryn Sandberg

HPD Articles

Throughout the world, including the United States, men have worse outcomes from COVID-19 than women. SARS-CoV-2, the causative virus of the COVID-19 pandemic, uses angiotensin-converting enzyme 2 (ACE2) to gain cellular entry. ACE2 is a member of the renin-angiotensin system (RAS) and plays an important role in counteracting the harmful effects mediated by the angiotensin type 1 receptor. Therefore, we conducted Ovid MEDLINE and Embase database searches of basic science studies investigating the impact of the biological variable of sex on ACE2 expression and regulation from 2000, the year ACE2 was discovered, through December 31, 2020. Out of 2,131 publications, …

Chronic Administration Of Pharmacological Doses Of Angiotensin 1-7 And Iodoangiotensin 1-7 Has Minimal Effects On Blood Pressure, Heart Rate, And Cognitive Function Of Spontaneously Hypertensive Rats, Filipe F. Stoyell-Conti, Alesa Chabbra, Joseph Puthentharayil, Katya Rigatto, Robert C. Speth

HPD Articles

Cardiovascular diseases are the principal cause of death worldwide, with hypertension being the most common cardiovascular disease risk factor. High blood pressure (BP) is also associated with an increased risk of poor cognitive performance and dementia including Alzheimer's disease. Angiotensin 1-7 (Ang 1-7), a product of the renin-angiotensin system (RAS), exhibits central and peripheral actions to reduce BP. Recent data from our lab reveals that the addition of a non-radioactive iodine molecule to the tyrosine in position 4 of Ang 1-7 (iodoAng 1-7) makes it ~1000-fold more potent than Ang 1-7 in competing for the I-Ang 1-7 binding site (Stoyell-Conti …

Discovery Of Molecular Interactions Of The Human Melanocortin-4 Receptor (Hmc4r) Asp189 (D189) Amino Acid With The Endogenous G-Protein-Coupled Receptor (Gpcr) Antagonist Agouti-Related Protein (Agrp) Provides Insights To Agrp's Inverse Agonist Pharmacology At The Hmc4r, Mark D. Ericson, Erica M. Haslach, Sathya M. Schnell, Katie T. Freeman, Zhimin M. Xiang, Frederico P. Portillo, Robert Speth, Sally A. Litherland, Carrie Haskell-Luevano

HPD Articles

The melanocortin receptors (MCRs) are important for numerous biological pathways, including feeding behavior and energy homeostasis. In addition to endogenous peptide agonists, this receptor family has two naturally occurring endogenous antagonists, agouti and agouti-related protein (AGRP). At the melanocortin-4 receptor (MC4R), the AGRP ligand functions as an endogenous inverse agonist in the absence of agonist and as a competitive antagonist in the presence of agonist. At the melanocortin-3 receptor (MC3R), AGRP functions solely as a competitive antagonist in the presence of agonist. The molecular interactions that differentiate AGRP's inverse agonist activity at the MC4R have remained elusive until the findings …

Nsu Cop Students On Rotations Contribute To The Vaccination Efforts, Silverman College Of Pharmacy

Archived News and Events

Broward Health Medical Center began administering the COVID19 vaccine to healthcare workers, EMS and patients aged 65 and over in January 2021. They opened a community vaccination site at Inter Miami CF Stadium in Fort Lauderdale. NSU students taking introductory and advanced pharmacy practice rotations within a Broward Health Hospital or Clinic had an opportunity to contribute to the vaccination effort.

NSU P4 student Angela Sanichar immunized her preceptor and alumni, Dr. Kaleed Mohammed ('09), Regional Manager of Pharmacy Services at Broward Health. Dr. Mohammed said, "Vaccine dose number 2 done! How cool is it to have your student give …

Alterations In Gene Expression Of Renin-Angiotensin System Components And Related Proteins In Colorectal Cancer, Danial Mehranfard, Gabriela Perez, Andres Rodriguez, Julia M. Ladna, Christopher T. Neagra, Benjamin Goldstein, Timothy Carroll, Alice Tran, Malav Trivedi, Robert C. Speth

HPD Articles

MATERIALS AND METHODS: Quantitative expression of the RNA of these 17 genes in normal and cancerous tissues obtained using chip arrays from the public functional genomics data repository, Gene Expression Omnibus (GEO) application, was compared statistically. RESULTS: Expression of four genes, (angiotensinogen), (aminopeptidase A) (neprilysin), and (prolyl endopeptidase), was significantly upregulated in CRC specimens. Expression of (renin), (thimet oligopeptidase), (neurolysin), (prolyl carboxypeptidase), (aminopeptidase N), and (Mas receptor) was downregulated in CRC specimens. CONCLUSIONS: Presuming gene expression parallel protein expression, these results suggest that increased production of the angiotensinogen precursor of angiotensin (ANG) peptides, with the reduction of the enzymes that …

Nsu College Of Pharmacy_Brochure_2021, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Two Pharm.D. Students Had A Once In A Lifetime Opportunity To Reconstitute..., Silverman College Of Pharmacy

Archived News and Events

On the first day the COVID-19 vaccine became available, two third-year students, Ashley Dabalsa (’22) and Laura Perez-Gutierrez (’22) had an experience of a lifetime - they were involved in reconstituting for administration the COVID-19 vaccine at Memorial Healthcare System (MHS), which was the first institution that started providing the vaccines today in South Florida.

The Possible Role Of A Bacterial Aspartate Β-Decarboxylase In The Biosynthesis Of Alamandine, Shalinee Jha, Robert C. Speth, Peter Macheroux

HPD Articles

The understanding of the renin-angiotensin system (RAS) has significantly expanded over the last two decades. The elucidation of angiotensin-converting enzyme 2 (ACE2) that converts angiotensin (Ang) II into Ang (1-7) led to the discovery of the cardio-protective axis of the RAS. In addition, novel components of the system, Angiotensin A (Ang A) and alamandine have been identified. Like Ang (1-7), alamandine is a vasodilator and can counteract the effects of Ang II by increasing nitric oxide release from the endothelium and decreasing nicotinamide adenine dinucleotide phosphate oxidase (NADPH)-related superoxide production. Theoretically, alamandine can be derived from Ang (1-7) by decarboxylation …

The Apoptotic Effect Of Gsk-3 Inhibitors: Bio And Chir 98014 On H1975 Lung Cancer Cells Through Ros Generation And Mitochondrial Dysfunction., Theodore Lemuel Mathuram, Thiagarajan Venkatesan, Jayanta Das, Umamaheswari Natarajan, Appu Rathinavelu

HPD Articles

OBJECTIVE: GSK-3 has been reported to be upregulated in malignant diseases, including lung cancers, thus suggesting it to be a valid target for cancer treatment. The study elucidates the possible mechanism involved in the ability of GSK-3 inhibitors: BIO and CHIR 98014 to regulate proteins involved in cell death of H1975 lung cancer cells.

RESULTS: BIO and CHIR 98014 successfully induced apoptosis at lower concentrations in H1975 cells but not in H460 lung cancer cells. Moreover, increased ROS generation and depolarization of mitochondrial membrane potential were observed in both treatments. Cleavage of caspase-3 was observed in both BIO and CHIR …

Sex-Specific Modulation Of Blood Pressure And The Renin-Angiotensin System By Ace (Angiotensin-Converting Enzyme) 2, Hong Ji, Aline M. De Souza, Bilkish Bajaj, Wei Zheng, Xie Wu, Robert C. Speth, Kathryn Sandberg

HPD Articles

We showed ACE (angiotensin-converting enzyme) 2 is higher in the kidney of male compared with female mice. To further investigate this sex difference, we examined the role of ACE2 in Ang-[1-8] (angiotensin [1-8])-induced hypertension and regulation of the renin-angiotensin system in the kidney of WT (wild type) and Ace2 KO (knockout) mice. Mean arterial pressure rose faster in WT male than WT female mice after Ang-[1-8] infusion. This sex difference was attenuated in ACE2 KO mice. Ang-[1-8] infusion reduced glomerular AT1R (angiotensin type 1 receptor) binding in WT female mice by 30%, and deletion of abolished this effect. In contrast, …

Psychedelics: A Window To Mental Illness; Psilocybin And Depression, Kiomary Rivera Quintana

College of Pharmacy Student Research

No abstract provided.

Psychedelics And Mental Health, Angelica Milla

College of Pharmacy Student Research

No abstract provided.

Angiotensin Ii Administration To Covid-19 Patients Is Not Advisable, Robert C. Speth

HPD Articles

No abstract provided.

Identifying And Managing Substance Abuse In The Emergency Department, Nelsy M. Zuniga

College of Pharmacy Student Research

No abstract provided.

Cancer Pain And The Risks Of Opioid Abuse, Yarelis Diaz

College of Pharmacy Student Research

No abstract provided.

Keep Taking Your Ace Inhibitors And Arbs During The Covid 19 Pandemic, Robert C. Speth

HPD Articles

No abstract provided.

Incorporation Of Agouti-Related Protein (Agrp) Human Single Nucleotide Polymorphisms (Snps) In The Agrp-Derived Macrocyclic Scaffold C[Pro-Arg-Phe-Phe-Asn-Ala-Phe-Dpro] Decreases Melanocortin-4 Receptor Antagonist Potency And Results In The Discovery Of Melanocortin-5 Receptor Antagonists, Zoe M. Koerperich, Mark D. Ericson, Katie T. Freeman, Robert C. Speth, Irina D. Pogozheva, Henry I. Mosberg, Carrie Haskell-Luevano

HPD Articles

While the melanocortin receptors (MCRs) are known to be involved in numerous biological pathways, the potential roles of the MC5R have not been clearly elucidated in humans. Agouti-related protein (AgRP), an MC3R/MC4R antagonist and MC4R inverse agonist, contains an exposed β-hairpin loop composed of six residues (Arg-Phe-Phe-Asn-Ala-Phe) that is imperative for binding and function. Within this active loop of AgRP, four human missense polymorphisms were deposited into the NIH Variation Viewer database. These polymorphisms, Arg111Cys, Arg111His, Phe112Tyr, and Ala115Val (AgRP full-length numbering), were incorporated into the peptide macrocycles c[Pro-Arg-Phe-Phe-Xaa-Ala-Phe-dPro], where Xaa was Dap or Asn, to explore the functional effects …

Gabapentin Abuse, Tuyet-Anh Nguyen

College of Pharmacy Student Research

No abstract provided.

Addiction After Taking Pain Relief Medicine For Post-Surgery, Kelie A. Nicholson Vélez

College of Pharmacy Student Research

No abstract provided.

Severe Food Restriction Activates The Central Renin Angiotensin System, Aline Maria De Souza, Andrea Linares, Robert C. Speth, Glenda V. Campos, Hong Ji, Deoclécio Chianca, Kathryn Sandberg, Rodrigo C. De Menezes

HPD Articles

We previously showed that 2 weeks of a severe food restricted (sFR) diet (40% of the caloric intake of the control (CT) diet) up-regulated the circulating renin angiotensin (Ang) system (RAS) in female Fischer rats, most likely as a result of the fall in plasma volume. In this study, we investigated the role of the central RAS in the mean arterial pressure (MAP) and heart rate (HR) dysregulation associated with sFR. Although sFR reduced basal mean MAP and HR, the magnitude of the pressor response to intracerebroventricular (icv) microinjection of Ang-[1-8] was not affected; however, HR was 57 ± 13 …

College Of Pharmacy 2020, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Exploring Healthcare Services Utilization And Medication Adherence Of The Arab Descent Americans In South Florida, Haifa Abdulrahman Fadil

Student Theses, Dissertations and Capstones

Research into health outcomes of Arab-descent Americans (ADAs) is sparse. ADAs identify as “White,” instead of in a separate census category, contributing to their underrepresentation in the census and the limited amount of research on their health outcomes. In the current U.S. sociopolitical climate, better understandings are needed of the impact of discrimination and Arabic culture, including level of health literacy, on ADAs’ general health and health outcomes. This study employed mixed methods to explore the impact of health literacy level and perceived discrimination on HSU and medication adherence for ADAs in South Florida. In its qualitative phase, a convenience …

Nsu Sharks Rx_Winter 2020, Nova Southeastern University

NSU Sharks Rx

Newsletter

Interprofessional Peer Teaching: Assistive Device Training And Medications Impacting Safe Ambulation, Niamh M. Tunney, Melissa Chesson, Gina J. Ryan

Internet Journal of Allied Health Sciences and Practice

ABSTRACT

Purpose: An interprofessional peer teaching activity was designed and implemented to provide students with an opportunity to practice interprofessional education collaborative (IPEC) competencies while improving student knowledge of assistive devices for gait and medications impacting safe ambulation. Method: During the activity, second year physical therapy students instructed third year pharmacy students in the accurate fit and counseling for use of canes, crutches, and walkers. Pharmacy students then demonstrated these skills and were checked off on their ability to accurately fit and instruct consumers on basic gait patterns. The pharmacy students in turn educated the physical therapy students about medications …