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Articles 1051 - 1052 of 1052
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
Calcium Diluents As Matrix Forming Agents In Sustained Release Dosage Forms, Jones W. Bryan Jr.
Calcium Diluents As Matrix Forming Agents In Sustained Release Dosage Forms, Jones W. Bryan Jr.
MUSC Theses and Dissertations
The purpose of this research was to evaluate the effect of the poorly soluble diluents; calcium sulfate dihydrate, dibasic calcium phosphate dihydrate, and tribasic calcium phosphate on medicament release from solid dosage forms. Initial findings led to an investigation of the use of these diluents as matrix forming agents in the formulation of sustained release solid dosage farms. An existing single station tablet press was instrumented with a transducer strain gauge apparatus to monitor compression force applied during tablet manufacture. An automated dissolution system was used to determine medicament release from the dosage forms under investigation. These three diluents when …
Glucose Oxidase As A Pharmaceutical Antioxidant, Thomas F. Berg
Glucose Oxidase As A Pharmaceutical Antioxidant, Thomas F. Berg
MUSC Theses and Dissertations
Oxygen sensitive drugs in aqueous solutions are very susceptible to oxidative degradation. Antioxidants are frequently used to protect these drugs from oxidation. A 2-level resolution VI factorial was used to evaluate a glucose oxidase-catalase-glucose system and compare it to commonly used aqueous antioxidants. The drug models used to test the effectiveness of the enzyme system were ascorbic acid, morphine sulfate, and isoproterenol hydrochloride. The glucose oxidase system successfully protected the isoproterenol hydrochloride and was significantly better than the other systems tested. The glucose oxidase system was just as effective as the other antioxidants in protecting morphine sulfate. None of the …