Pharmacy and Pharmaceutical Sciences Commons^™

Piperine Encourages Apoptosis In Human Cervical Adenocarcinoma Cells Through Ros Generation, Dna Fragmentation, Caspase-3 Activation And Cell Cycle Arrest, Asif Jafri, Juhi Rais, Sudhir Kumar, Md Arshad

Research Symposium

Background: Cancer is one of the most common destructive diseases and the second leading cause of death in humans. Among cancer, cervical cancer is the second most common malignancy among women globally. Thus, there is a continuous need to search for chemotherapeutic chemicals or naturally occurring drugs to resolve this global health problem. Piperine (1-piperoylpeperdine) is present in the fruits of black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.). It possesses several pharmacological properties and in the present study we have evaluated its anti-cancer potential on human cervical adenocarcinoma (HeLa) cells.

Methods: The anti-proliferative effect …

Assessing Nutritional Health Knowledge In Sharing Clinic Patients With Diabetes, Minden Huntrods

Capstone Experience

Effective diabetes prevention and management relies on nutritional behaviors, thus a basic level of health knowledge is important for patients with diabetes and their caregivers in their quest to acquire acute glycemic control and minimize negative health outcomes (Ley et al., 2014). The purpose of this study was to assess the nutrition-related health knowledge of patients living with diabetes who are seen at the UNMC Sharing Clinic by use of a verbal questionnaire. This nutritional health knowledge assessment was a quantitative, prospective, survey-based study utilizing descriptive statistics. Approximately 86% of patients were proficient in food group and nutritious foods knowledge …

Screening For Iron-Deficiency Anemia In The Pediatric Population (Ages 1-17) In Gonaïves, Haiti, Cara Rose Fratianni

Doctor of Nursing Practice Final Manuscripts

Abstract

Purpose: The purpose of this pilot project is to screen for iron-deficiency anemia in pediatric patients (ages 1-17) in a primary school in Gonaïves, Haiti. Patients with anemia will be treated with oral supplemental iron for a period of four weeks according to WHO guidelines (WHO, 2011). All students will be treated empirically for helminths per WHO guidelines, unless treated elsewhere in the last six months (WHO, 2017). Nutritional status will also be assessed using MUAC according to WHO guidelines (2017).

Background Summary: Malnutrition contributes significantly to the problem of iron-deficiency anemia, with one in four children exhibiting stunting …

Gut Microbiome: Profound Implications For Diet And Disease, Ronald D. Hills Jr., Benjamin A. Pontefract, Hillary R. Mishcon, Cody A. Black, Steven C. Sutton, Cory R. Theberge

Pharmaceutical Sciences Faculty Publications

The gut microbiome plays an important role in human health and influences the development of chronic diseases ranging from metabolic disease to gastrointestinal disorders and colorectal cancer. Of increasing prevalence in Western societies, these conditions carry a high burden of care. Dietary patterns and environmental factors have a profound effect on shaping gut microbiota in real time. Diverse populations of intestinal bacteria mediate their beneficial effects through the fermentation of dietary fiber to produce short-chain fatty acids, endogenous signals with important roles in lipid homeostasis and reducing inflammation. Recent progress shows that an individual’s starting microbial profile is a key …

Exploring The Structure-Activity Relationship Of Various Seh Inhibitors In Promoting Brown Adipogenesis, Sue Lim Choi

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

Background: Brown adipose tissue has emerged as a novel target for obesity prevention and treatment due to its responsibility for heat production. Soluble epoxide hydrolase (sEH) is a cytosolic enzyme that degrades epoxy fatty acids (EpFAs) (lipid signaling molecules) into inactive diols. Potent sEH inhibitors (sEHIs) are beneficial for many chronic diseases as they stabilize endogenous EpFAs by blocking the degradation. Our preliminary results have shown that trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB), a potent sEH inhibitor, dose-dependently promotes brown adipogenesis.

Objectives: The objective of this study is to investigate the structure and activity relationship of various sEHIs with different sub-structures of …

Development Of Composite Film Coating For Freeze-Dried Fruit Slices, Nichayarach Invichian

Chulalongkorn University Theses and Dissertations (Chula ETD)

Edible film coating on food before freeze-drying process can be used for food preservation, especially in heat-sensitive food such as fruits and vegetables. Previous studies have been reported that trehalose had the cryoprotective effect and unique properties such as non-reducing sugar and low hygroscopic. However, no research has been conducted on the use of trehalose as film coatings. Therefore, this study aimed to develop a composite film consisting of alginate and trehalose and to evaluate physical properties of freeze-dried ​​fruit slices coated with a composite film. The experiment was designed to prepare a composite film consisting of various concentrations of …

Nutritional Status And Dietary Perceptions In Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy, Wipapak Raksawongsa

Chulalongkorn University Theses and Dissertations (Chula ETD)

Colorectal cancer treatment usually involves surgical resection following by adjuvant chemotherapy. Pathology and treatment are major causes of malnutrition. Therefore, this group of patients should receive specific nutritional counseling. Changes in eating behavior occur when the patients perceive the benefits of changes. Dietary perceptions information is useful in nutrition care. The aim of this prospective study was to examine the effect of individualized nutritional counseling on the nutritional status and dietary perceptions of 35 colorectal cancer patients receiving adjuvant chemotherapy at King Chulalongkorn Memorial Hospital from March to November 2019. The data were collected during the first to the third …

Effects Of Astaxanthin Supplementation On Biological Parameters In Thai Healthy Volunteers, Chuenjai Sratongfaeng

Chulalongkorn University Theses and Dissertations (Chula ETD)

Astaxanthin, a powerful antioxidant, is widely used as a dietary supplement to promote several health benefits. However, the effects of long-term supplementation on general biological parameters in healthy adults is still insufficient. The objective of this study was to investigate the effects of 12-week astaxanthin supplementation on blood glucose, lipid profile and hematological parameters in healthy volunteers. Thirty-three healthy participants (16 in the experimental group and 17 in the placebo group) were enrolled in the study. The participants in the experimental group were supplemented with 4 mg/day of astaxanthin while those in the placebo group were supplemented with soybean oil …

Radical Social Ecology As Deep Pragmatism: A Call To The Abolition Of Systemic Dissonance And The Minimization Of Entropic Chaos, Arielle Brender

Student Theses 2015-Present

This paper aims to shed light on the dissonance caused by the superimposition of Dominant Human Systems on Natural Systems. I highlight the synthetic nature of Dominant Human Systems as egoic and linguistic phenomenon manufactured by a mere portion of the human population, which renders them inherently oppressive unto peoples and landscapes whose wisdom were barred from the design process. In pursuing a radical pragmatic approach to mending the simultaneous oppression and destruction of the human being and the earth, I highlight the necessity of minimizing entropic chaos caused by excess energy expenditure, an essential feature of systems that aim …

Preparation And Antimicrobial Activity Of Caprylic Acid Emulsion For Food Coating, Raweewan Bunyovimonnat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Antimicrobial food coating is the interesting method for food preservation, especially in fruits and vegetables. Previous studies have been reported that the caprylic acid had the antimicrobial activity against a variety of microorganisms. However, little research has been conducted on the use of caprylic acid in the form of food coatings. Therefore, this study aims to determine the optimum conditions for the caprylic acid emulsion preparation and to evaluate the antimicrobial activity of the emulsion, including the effect of food coatings with caprylic acid emulsion on physical properties and microbial growth inhibition. Emulsions containing 4% w/v caprylic acid (oil) and …

Preparation And Antimicrobial Activity Of Caprylic Acid Emulsion For Food Coating, Raweewan Bunyovimonnat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Antimicrobial food coating is the interesting method for food preservation, especially in fruits and vegetables. Previous studies have been reported that the caprylic acid had the antimicrobial activity against a variety of microorganisms. However, little research has been conducted on the use of caprylic acid in the form of food coatings. Therefore, this study aims to determine the optimum conditions for the caprylic acid emulsion preparation and to evaluate the antimicrobial activity of the emulsion, including the effect of food coatings with caprylic acid emulsion on physical properties and microbial growth inhibition. Emulsions containing 4% w/v caprylic acid (oil) and …

Preparation And Antimicrobial Activity Of Caprylic Acid Emulsion For Food Coating, Raweewan Bunyovimonnat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Antimicrobial food coating is the interesting method for food preservation, especially in fruits and vegetables. Previous studies have been reported that the caprylic acid had the antimicrobial activity against a variety of microorganisms. However, little research has been conducted on the use of caprylic acid in the form of food coatings. Therefore, this study aims to determine the optimum conditions for the caprylic acid emulsion preparation and to evaluate the antimicrobial activity of the emulsion, including the effect of food coatings with caprylic acid emulsion on physical properties and microbial growth inhibition. Emulsions containing 4% w/v caprylic acid (oil) and …

Effect Of Bitter Gourd Extracts On The Mutagenicity Of 1-Aminopyrene Reacted With Nitrite Using Ames Test, Korkiat Panpasuk

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study was conducted to investigate the mutagenic activity of raw and cooked bitter gourd (Momordica charantia) including raw fruit extract (RW), blanching water (BW), hot water extract from blanched fruit (HB), stir-fried fruit extract (SF), and stir-fried fruit (pre-squeezed with salt) extract (SS). In addition, the effects of extracts in modifying the mutagenic activity of mutagen freshly prepared by the reaction between 1-aminopyrene and sodium nitrite and the effects when adding each extract at the beginning of the same reaction using Ames test on Salmonella typhimurium strains TA98 and TA100 without enzymatic activation were also determined. The data for …

Antioxidant And Antimutagenic Activity Of Extracts From Pericarp And Seed Of Zanthoxylum Limonella Alston, Patamawan Wipoosanapan

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study was conducted to investigate the antioxidant and antimutagenic activity of Zanthoxylum limonella seed extract and that of Z. limonella pericarp extract. The total phenolic contents and antioxidant activity assay including DPPH assay and FRAP assay were performed. The results showed that the antioxidant activity of pericarp extract was higher than that of the seed extract. The direct mutagenicity assay was determined, with and without nitrite treatment using the Ames test towards Salmonella typhimurium strains TA98 and TA100. The mutagenic modification assay was performed by measuring the interfering effect of the pericarp extract and the seed extract on the …

Carbohydrate Content Of The Medications For Epileptic Children Treated With Ketogenic Diet At King Chulalongkorn Memorial Hospital, Thanarat Sawangrit

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purposes of this study were to establish a database of the carbohydrate content of medications and investigate carbohydrate content of medications in epileptic children treated with ketogenic diet (KD) at King Chulalongkorn Memorial Hospital. One hundred sixty-nine KD order forms in 3 events (KD initiation, follow-up visit, and hospital re-admission) for epileptic children whose aged younger than 18 years old during 2009-2017 were selected. Clinical and nutritional data were obtained from medical records and KD order forms from the pediatric nutrition unit. The study showed that oral liquid dosage forms had the highest carbohydrate content in the formulations as …

The International Scientific Association For Probiotics And Prebiotics (Isapp) Consensus Statement On The Definition And Scope Of Prebiotics, Glenn R. Gibson, Robert W. Hutkins, Mary Ellen Sanders, Susan L. Prescott, Raylene A. Reimer, Seppo J. Salminen, Karen Scott, Catherine Stanton, Kelly S. Swanson, Patrice D. Cani, Kristin Verbeke, Gregor Reid

Department of Food Science and Technology: Faculty Publications

In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to review the definition and scope of prebiotics. Consistent with the original embodiment of prebiotics, but aware of the latest scientific and clinical developments, the panel updated the definition of a prebiotic: a substrate that is selectively utilized by host microorganisms conferring a health benefit. This definition expands the concept of prebiotics to possibly include non-carbohydrate substances, applications to body sites other than the gastrointestinal tract, and diverse categories other than food. The requirement for selective …

Preparation And Antimicrobial Activity Of Olive Oil Nanoemulsions, Kusuma Jaemsak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Due to their health benefits including antioxidant, anti-inflammatory and also antimicrobial activities, extra virgin olive oil (EVOO) has received much attention in food, cosmetics, and pharmaceutical industries. Nanoemulsions (NEs) solubilize and increase absorption and bioavailability of lipophilic substances (i.e. olive oil). However, there is insufficient data in the formation of olive oil NEs. This study aimed to investigate the formation of oil-in-water NEs containing EVOO using low-energy approach and high-energy approach. NEs were characterized for size, polydispersity and zeta potential after storage at different conditions for up to 180 days. They were determined for antimicrobial susceptibility. From the result, NEs …

The Effects Of Adaptogens On The Physical And Psychological Symptoms Of Chronic Stress, Tosin O. Ajala

DISCOVERY: Georgia State Honors College Undergraduate Research Journal

Stress is a state of disharmony or threatened homeostasis. The maintenance of homeostasis in stages of internal or external challenges, called stressors, requires constant adjustments of hormonal, behavioral, and autonomic functions. The nuances of life may bring about unwanted stress to the human body. Some of the top causes of stress in America include work, finances, relationships, and health. There are numerous physical and psychological symptoms associated with long-term “chronic” stress, which include chronic fatigue, frustration, irritability, insomnia, frequent headaches, chest and back pain, weakness, and weight gain or weight loss. These symptoms of chronic stress are associated with depression, …

Relationship Between Depression And Metabolic Syndrome In Working Age Population In Bangkok, Matthawan Sujinnapram

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this observational descriptive cross-sectional study were to determine the prevalences of depression and metabolic syndrome and to examine the relationship between depression and metabolic syndrome and dietary pattern in working age people in Bangkok. The samples were 446 participants (123 males and 323 females) aged 20 and over who received an annual health examination 2017. The metabolic syndrome was defined by NCEP ATP III criteria. The data on waist circumference, fasting blood glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure, depression score, and dietary pattern were collected. The relationship between depression and metabolic syndrome and dietary patterns were …

Sneaky Salt Contributes To High Blood Pressure, Rodney Richmond

College of Pharmacy Faculty Research ​and Publications

No abstract provided.

Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd

Franklin D. Shuler

Vitamin K is known to play an essential role in the coagulation cascade; however, a growing body of research has found that a subtype of this vitamin, vitamin K2 (menaquinone) may have a beneficial effect in osteoporosis, cardiovascular disease, and cancer. This purpose of this article is to provide a comprehensive review of recent literature regarding menaquinone and its role in human health. This review discusses the physiology of menaquinone, its clinical benefits in cardiovascular disease, osteoporosis, and cancer, and how it may interact with certain medications. The authors conclude that menaquinone supplementation has been shown to improve carboxylation of …

Drug-Induced Nutrient Depletion, Rodney Richmond

College of Pharmacy Faculty Research ​and Publications

No abstract provided.

Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd

Marshall Journal of Medicine

Vitamin K is known to play an essential role in the coagulation cascade; however, a growing body of research has found that a subtype of this vitamin, vitamin K₂ (menaquinone) may have a beneficial effect in osteoporosis, cardiovascular disease, and cancer. This purpose of this article is to provide a comprehensive review of recent literature regarding menaquinone and its role in human health. This review discusses the physiology of menaquinone, its clinical benefits in cardiovascular disease, osteoporosis, and cancer, and how it may interact with certain medications. The authors conclude that menaquinone supplementation has been shown to improve carboxylation …

Gmo Vs. Non-Gmo: Comparing The Addictiveness Of Corn In Rats, Christian A. Carroll, Sara L. Hill, Kelly A. Huston, Tyler Michael, Courtney Noll, Melissa J. Beck, Ginger D. Cameron

The Research and Scholarship Symposium (2013-2019)

Genetically modified organisms (GMOs) refer to organisms whose DNA has been altered to produce a certain characteristic. GMOs account for a significant proportion of the crops produced in the United States. Specifically, GMO corn accounted for approximately 88% of all corn grown for human and animal consumption in the year 2012. Previously conducted studies have not uniformly demonstrated the safe use of GMO corn, and no studies have been conducted to analyze the addictiveness of GMO corn.

The idea of addiction refers to more than just a physical dependence, but to a psychological dependence on something as well. Addiction is …

The Impact Of An Omega-3 Enriched Diet On Hyperactivity And Biochemistry In An Animal Model For Attention-Deficit/Hyperactivity Disorder, Nadine M. Hammoud

Open Access Theses

Attention-deficit/hyperactivity disorder (ADHD) is the most diagnosed behavioral disorder in children. It affects around 5% of children worldwide and 11% of children in the United States, with rates increasing. Pharmaceutical treatments, such as amphetamines and methylphenidates, are not effective for everyone and are known to have unwanted side effects. While the etiology of the disorder is not yet fully understood, there are clear genetic and environmental components. Nutritional insufficiencies have recently become a popular environmental risk factor under investigation. Essential fatty acids (EFA), omega-3 polyunsaturated fatty acids (PUFA) in particular, are needed for proper brain development and function. Our lab …

Munch A Bunch, Ginger D. Cameron

Pharmacy Practice Faculty Presentations

No abstract provided.

Childhood Obesity And Familial Hypercholesterolemia: Genetic Diseases That Contribute To Cardiovascular Disease, Alyssa Caudle

Senior Honors Theses

Childhood obesity occurs as the result of an imbalance between caloric intake and energy expenditure. Genetic risk factors for obesity have become an area of research due to its permanency. Mutated genes such as Fat Mass and Obesity Associated (FTO), Leptin (LEP), Leptin Receptor (LEPR), Melanocortin 4 Receptor (MC4R), Adiponectin C1Q and Collagen Domain Containing (ADIPOQ), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1), and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) all contribute to the development of childhood obesity. In the presence of high cholesterol caused by obesity, the genetic condition known as familial hypercholesterolemia is exacerbated. Familial hypercholesterolemia is caused by a …

Dietary Supplement Labeling: Cognitive Biases, Market Manipulation & Consumer Choice, Michael Mccann

Law Faculty Scholarship

There exists increasing concern that the Dietary Supplements Health and Education Act (DSHEA) has proven ineffective. Much of the concern regards the disparity in legislative treatment between dietary supplements, foods, and pharmaceutical drugs. Namely, while pharmaceutical drugs must undergo years of costly pre-market testing, most supplements, like foods, can immediately enter the market, and only after repeated instances of adverse reactions can the Food and Drug Administration (FDA) remove them. Such a framework appears to belie both consumer expectations and marketing strategies, as supplements tend to be most perceived for their apparent medicinal qualities. This philosophy of waiting for a …

North American Bioactive Plants For Human Health And Performance, Maria Pontes Ferreira, Fidji Gendron, Katrina C. Mcclure, Kelly Kindscher

Nutrition and Food Science Faculty Research Publications

Native and naturalized bioactive plants of the Canadian and American temperate biome are examined for their health and performance enhancement properties. Some of these plants are now being used as natural health products, and many have a long history as traditional foods and/or medicines with indigenous groups. This paper reviews the medicinal/cultural uses and bioactive properties of selected plant families: the Holly family (Aquifoliaceae) as stimulants, the Celery family (Apiaceae) as normoglycemic aids and analgesics, the Ginseng family (Araliaceae) as energy- boosting aids, the Sunflower family (Compositae) as anti-inflammatory aids, and the Legume family (Fabaceae) and Nightshade family (Solanaceae) as …

The Absence Of Abcd2 Reveals A Novel Role For Peroxisomes In The Protection From Metabolic Syndrome, Jingjing Liu

University of Kentucky Doctoral Dissertations

ABCD2 (D2) is a peroxisomal ATP binding cassette (ABC) transporter that is expressed in brain, adrenal and liver. D2 is transcriptionally regulated by key transcriptional factors that control lipid and glucose metabolism. Therefore, we examined its role in adipose tissue. These studies revealed that D2 is highly abundant in adipose tissue and upregulated during adipogenesis. However, D2 deficiency does not affect either adipogenesis or lipid accumulation. An examination of the lipid profile of adipose tissue revealed the accumulation of C20 and C22 fatty acids in D2 deficient (D2‐/‐) mice. When challenged with a diet enriched in erucic acid (C22:1, 10% …