Pharmacy and Pharmaceutical Sciences Commons^™

Strategies And Emerging Mechanisms In Managing Pseudomonas Aeruginosa Biofilm-Associated Antibiotic Resistance In Renal Catheters, Ahmed Fadhil Kadhim

Al-Esraa University College Journal for Medical Sciences

Strategies and mechanisms in controlling Pseudomonas aeruginosa resistance to biofilm-associated with renal catheters are a serious concern. Renal catheters are widely used in hospitals for numerous urological disorders. However, they are the main cause of bacterial infections, especially P. aeruginosa, when used for a long time. The mechanism of biofilm-associated antibiotic resistance of P. aeruginosa in renal catheters is complex and has not been efficiently managed. This review debates certain strategies and mechanisms associated with P. aeruginosa biofilm antibiotic resistance in cases with renal catheters, including the prevention of biofilm formation, eradication of biofilm, and reducing biofilm-associated antibiotic resistance and …

Distribution Of Epidemiological Characteristics Among Drug Addiction Patients Admitted To Alqana Center For Social Rehabilitation, Ali Abdul Alkhudhur Murad, Atta Ah. Mousa Al-Sarray, Zeena Jamal Alkhazraji

Al-Esraa University College Journal for Medical Sciences

Background: Drug addiction is a worldwide issue; 5.6% of the world's population aged 15 to 64 took drugs at least once in 2016. For the majority of medicines, younger individuals use them more than older people do. Drug abuse seems to be on the increase in several ASEAN (Association of Southeast Asian Nations) countries, particularly among young men aged 15 to 30. Illicit drug abuse account for around 14% of the overall health burden among young males. Younger individuals are also more prone to die from drug abuse issues. Aim: To assess the severity of problems related to drug …

Immunological Markers And Clinical Features With Systemic Lupus Erythematosus In Iraqi Women Patients, Ali Yahya. Zeki, Ali Hussein. Al-Hafid, Haider Hafudh Humaish

Al-Esraa University College Journal for Medical Sciences

Background: Systemic Lupus Erythematosus is a complicated condition caused by the immune system attacking disease with unclear causes, affecting mainly women. It manifests with various symptoms and is diagnosed based on clinical and serological signs. Aims: To investigate the prevalence and the type of immunological and hematologic manifestations in SLE from pathologist's perspective. Methods: The study was done on 60 SLE patients and 60 controls from the Consulting Rheumatology Clinic in Baghdad Teaching Hospital in Baghdad City during the first half of the year 2024, from 25^th January 2024 until 25^th April 2024. Results: Marital state …

Cathepsin D And Its Relation With Lipid Profile In Coronary Atherosclerosis Patients, Israa Saad Salim, Walaa Ismael Jassim, Ahmed Saadi Hassan

Al-Esraa University College Journal for Medical Sciences

Background: Coronary atherosclerosis is a long lasting and continuously evolving disease with multiple clinical manifestations ranging from asymptomatic to stable angina, acute coronary syndrome (ACS), heart failure (HF) and sudden cardiac death (SCD). The onset and advancement of coronary atherosclerosis are influenced by both genetic and environmental factors. Objectives: The study aimed to find out if cathepsin D a good indicator to diagnose atherosclerosis and cardiovascular diseases and its relation with lipid profile. Materials and Methods: The study conducted with the participation of 150 subjects (100 patients with coronary atherosclerosis and 50 healthy control). Age for all subject was in …

Secretor Status And Anxiety Are Risk Factors For Getting Irritable Bowel Syndrome, Ola Amer Jasim, Khalid Mahdi Salih

Al-Esraa University College Journal for Medical Sciences

Irritable Bowel Syndrome (IBS) is a functional disease of gastrointestinal tract (GIT) that affects 10-20% of the population worldwide and is distinguished by abdominal pain/discomfort and changes in bowel habits that is accompanied by diarrhea, constipation, or both. Control-based study was conducted on 50 Iraqi patients with IBS who were presented at private clinics for gastrointestinal diseases (GIDs), along with 20 healthy individuals matched in their age and gender to act as control group. The study lasted from November 2021 to May 2022 and aimed to determine the frequency of IBS subtypes among Iraqi patients, as well as the influence …

Complement Component C3 And C4 Levels In Juvenile And Adult Sle Iraqi Patients, Sahar S. Aldhahir, Izzat A. M. Al-Rayahi, Salwa S. Muhsin

Al-Esraa University College Journal for Medical Sciences

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease, with about 15-20% of patients being children. The causes of the disease are a mix of genetic and environmental factors. Complement C3 and C4 play a significant role in the diagnosis and monitoring of disease severity. Additionally, renal function tests are important for monitoring the disease, as the disease affects the kidneys in a large percentage of patients. Aim: The study was primarily conducted to compare complement C3 and C4 levels in Iraqi adult and juvenile patients with systemic lupus erythematosus. Patient and methods: The study consisted of 70 patients, …

Some Biological Markers In Diabetic Patients, Ahmed Malk Hassan, Hasan Ali Hussein, Radhwan Mohmmed Hussein, Maryam Hiyder Kadhum

Al-Esraa University College Journal for Medical Sciences

Endstage renal disease (ESRD) usually comes on by diabetic nephropathy (DN) and is one of the most dreaded chronic microvascular complications of diabetes. The objective of this study is to provide an overview of the DN-biomarker landscape with a particular emphasis on new approaches that improve the sensitivity of biomarkers for identifying patients who will develop DN or who are at risk of developing ESRD. This study was designed as a case-control study. 120 individuals were involved, divided into three groups: a control group diabetic without nephropathy, Early stage and end stage of nephropathy, 40 patients were taken for each …

Association Between Leptin And Lipid Profile In Patients With Type 2 Diabetes Mellitus, Wafa Zughair Mohi, Khawla A. Shemran, Yasameen Al-Saffar

Al-Esraa University College Journal for Medical Sciences

Diabetes Mellitus (DM) is worldwide disease, the levels of lipids are too affected in a patient with diabetes mellitus due to a variety of factors, one of them carbohydrate metabolism. This investigation evaluated liptin as an indicator to the levels of the lipids in people with DM. The study included a total of 90 patients divided into 30 healthy controls (Group 1), 30 DM type 2 patients (Group 2) as well as 30 DM with atherosclerosis (Group 3). The high value where observed by ELISA and spectrophotometer in DM patients (Group 2) compared to the controls (Group 1) (54.68±9.67 vs. …

Nanoparticles Used In Treatment And Diagnosis Of Leishmaniasis In Iraq: A Review, Harith S. Al-Warid, Layla M. Hasan

Al-Esraa University College Journal for Medical Sciences

The aim of this paper is to identify Nano-particles that have been used in diagnosis and treatment of leishmaniasis in Iraq. All experiments conducted in this field were based on the following nanoparticles: gold nanoparticles, silver nanoparticles, zinc nanoparticles, and sodium chloride nanoparticles. Most of these experiments were reviewed in terms of differences in the concentrations of nanoparticles and the method that was used in the experiments whether it was in vivo or in vitro. These particles used in most experiments succeeded in inhibiting the growth of Leishmania parasites.

Pseudomonas Aeruginosa Epidemiology And Antibiotic Resistance: A Five Years Retrospective Study In Iraq., Huda Ghassan Hameed

Al-Esraa University College Journal for Medical Sciences

One of the leading causes of diseases and deaths across the world are bacterial infections, and the situation is only going to grow worse as antibiotic resistance spreads. Antimicrobial resistance must be closely monitored so as to control the spread of multi-antibiotic-resistant microorganisms. As a result, the goal for the study was to estimate the prevalence of Pseudomonas aeruginosa infection on top of that to look into the antibacterial pattern over the last five years. This retrospective investigation was carried out in various hospitals in Iraq like Central Children's Teaching Hospital for Children, Al Kindi Teaching Hospital, Al-Numan Hospital, Yarmouk …

Cariesthe Effect Of Sweet Taste Perception On Dental Caries Experience In Relation To Age And Gender In Primary School Children, Mohammed H. Abdulaziz, Suha T. Abd

Al-Esraa University College Journal for Medical Sciences

This study aims to investigate the impact of sweet taste perception (sweet taste threshold and preference) on dental caries experience in relation to age and gender among a sample of schoolchildren. The research follows a cross-sectional observational design and includes 181 schoolchildren of both genders aged between 6 and 12 years from the Al-Risafa district of Baghdad city. The participants were divided into two age groups (6-8 and 9-12). Dental caries were assessed using the decayed, missing, and filled indices for primary and permanent teeth (dmfs, dmft, DMFS, and DMFT). Additionally, the sweet taste threshold and sweet taste preference were …

Determination The Effect Of Glucose On Btp, Lfabp Levels In The Patients With Diabetic Nephropathy, Zahraa Khalid Mahmood, Suhayr Aesa Al-Qaysi, Alaa Jafear Mahrath

Al-Esraa University College Journal for Medical Sciences

Everywhere in the globe, kidney illness is becoming more common, and there is no medication that can stop the progression of chronic kidney disease to end-stage renal disease, which is extremely expensive. Diabetes, kidney stones, accidents, and bleeding are the main contributors to kidney disease. The study was designed as a case control study. The study was involved (80) participants, only (36) were involved in this study and divided into two groups patients with nephropathy (23) and diabetic nephropathy (13) with age (20-65years) and BMI (19 -29 kg/m2). All these patients were diagnosed by nephrologist conducted in nephrology Clinic at …

Genetic Polymorphisms Of Aqp1 Rs10244884 Associated With Iron Deficiency Anemia In Baghdad City, Sawsan Hashim Hoshe, Moead E. Al Gazally, Hussein Naji Al-Shammari

Al-Esraa University College Journal for Medical Sciences

Most people throughout the world suffer from iron deficiency anemia (IDA). The morbidity rate is relatively high for such a complicated illness. Importantly, it has been identified that the aquaporin-1 polymorphism rs10244884 plays a critical role in iron homeostasis in the human body. The rs10244884 (T > C) polymorphism is significantly associated with iron levels and a variety of blood factors, leading to iron deficiency anemia (IDA). Venous blood samples were collected from (100) people in this analytical (case and control) investigation, including (50) patients with iron deficiency anemia and (50) healthy volunteers as a control group. The following parameters were …

Assessment Of A Pharmacist-Led Antibiotic Time-Out For Transition Of Iv Vancomycin To Oral Linezolid, Mary S. Vogel, Jefferson Cua, Erika Dittmar, Timothy Gauthier, Kelsey N. Williams

Nursing & Health Sciences Research Journal

Introduction: Intravenous (IV) vancomycin requires therapeutic drug monitoring and line placement and may prolong hospital stay. Linezolid requires less monitoring, is orally bioavailable, and may expedite transitions of care. This study assessed the impact of a pharmacist-led antibiotic timeout for the transition from IV vancomycin to oral linezolid. Methods: This single-center, quasi-experimental study included admitted adult patients receiving IV vancomycin for over 48 hours. Patients receiving vasopressors, of immunocompromised status, or with specific antibiotic indications were excluded. The primary outcome was the pharmacist intervention acceptance rate. Secondary outcomes included median hospital length of stay, median antibiotic treatment days, and incidence …

Promoting Mammography Screenings In African American Women: Media, Church, And Health Providers, Lasonya Little, Debra C. Wallace, K.Jay Poole

Journal of Health Disparities Research and Practice

Due to the underutilization of screening mammography, African American women (AAW) are more likely to experience negative health outcomes after receiving a late-stage breast cancer diagnosis than White Women (WW). The purpose of this article is to examine the roles of the media, health community and the African American church and pastor and their potential impact in AAW screening decisions. Fifteen AAW, ages 45 and older, were invited to participate in a semi-structured interview. Most women agreed the African American pastor and church as well as the health community, and media are an integral part of their lives. Therefore, specific …

Conference Proceedings: Select Abstracts Presented At 2023 Advocate Aurora Scientific Day

Journal of Patient-Centered Research and Reviews

This abstract supplement includes findings presented at the 49th annual Advocate Aurora Scientific Day on May 24, 2023. The Scientific Day symposium provides a virtual forum for the sharing of preliminary results from research and case studies conducted by faculty, fellows, residents, and other health professionals associated with Illinois-based Advocate Health Care and Wisconsin-based Aurora Health Care.

Pharmacogenomic Precision Medicine: Best Practice Toolkit For Improving Patient Screening For Adult Metastatic Cancer Patients, Rena L. Stewart

Student Scholarly Projects

Precision medicine utilizes pharmacogenomic testing as a therapeutic approach. Genomic testing can assess the impact of an individual's genome on their reaction to specific medications. The main objective is to find variants that may affect an individual's response to a given medication. The implementation of pharmacogenomics in oncology facilitates informed decision-making by clinicians in drug selection and dosage determination.

Dietary Analysis For Hashimoto’S Thyroiditis: An Integrative Review, Evan Thompson, Alison Hultquist

Master of Science in Nursing Final Projects

Abstract

Hashimoto’s Thyroiditis (HT) is the leading cause of primary hypothyroidism in the United States. In HT, there is an infiltration by lymphocytes which leads to the production of autoantibodies against the thyroid gland. Throughout this integrative review, the aim was to evaluate the effectiveness of micronutrient supplementation and dietary management as adjunct treatments in HT. The purpose was to assist primary care providers in the development of a more holistic plan of care. Literature published within the past seven years was gathered and reviewed from PubMed, CINAHL, and Cochrane Library. Findings indicate that many patients with HT may benefit …

Primary Care Intervention: Medication Reconciliation Reduces Rehospitalizations, Dianna Twombly

Student Scholarly Projects

Practice Problem: Patients are put at risk for adverse medications events when diligent care is not taken by healthcare staff. Medication discrepancies and oversights from medical personal can lead to severe illness or even death of a patient.

PICOT: The PICOT question for this project is: For patients 65 years and older (P) does a review of a hard copy of discharge instructions (I)compared to current practice during a visit, (C) impact the number of hospital readmission (O)in eight weeks (T)?

Evidence: Medication reconciliation at each point of care, patient education on medication management, and involving patients in their own …

The Effect Of An Electric Current On Human Body (A Review), Yasir Khaleel Almusawi, Maha Raad Hashim Al-Sammarraie, Mukaram D. Shikara

Al-Esraa University College Journal for Medical Sciences

According to the World Health Organization (WHO), four people are killed every week by electrocution in the last decade, while 3% of people (suffering from electrical injuries) were admitted to emergency wards. The severity of electric injury depends on the electrical resistance of the human body, which depends on several factors such as the long duration of electric contact, type of the current (AC or DC), intensity of the current (amperes/voltages), sites of entry and exit points, wet or dry body, individual metabolism of the person, sweat gland activity, human body mass, type of tissue it travels through and its …

Biological Activity Of Rats Treated With Riboflavin In Polymeric Plga As Injectable Form, Sarah A. Hamood, Jabar A. Faraj, Ziad T. Al-Dahan

Al-Esraa University College Journal for Medical Sciences

The current study aims to optimize a fast, reproducible, reliable, and effective technique for estimating the biological activity of Vitamin B2 in injectable dose form using reversed-phase high-performance liquid chromatography (RP-HPLC). A biodegradable polymer, PLGA (Poly (lactic-co-glycolic acid) 50:50 type, approved as an active ingredient for parenteral administration, was used to load the vitamin in the injection volume of 1mg. Rats, both male and female, were employed as the animal models. Each animal was hosted for a duration of 40 days, and the activity of vitamin B2 was monitored at rapid intervals over six weeks using an HPLC device on …

Analysis Of Chloramphenicol, Sulphamethoxazole, And Sulfanilamide Drugs By Reversed-Phase High-Performance Liquid Chromatography With Fluorescent Detector, Tariq Y. Mahmoud, Aziz L. Jarallah, Isam S. Hamza

Al-Esraa University College Journal for Medical Sciences

This study proposed to analyze chloramphenicol (CPA), sulfamethoxazole (SMX), and sulfanilamide (SNA) drugs by reverse-phase liquid chromatography method in the form of pharmaceutical preparations and synthetic mixture. For this method, column C18-ODS (25 cm x 4.6 mm) was used with an isocratic elution mobile phase composed of methanol and 2% orthophosphoric acid, fluorescent detector (Ex= 310 nm, Em= 440 nm). It was found that the time of retention for CPA, SMX, and SNA was 8.99 ± 0.02, 10.76 ± 0.2, and 8.21 ± 0.2 min, respectively. The suggested method has been validated for limit of detection, limit of quantitation, linearity, …

Hyaluronic Acid Gel Effectiveness As An Adjunctive Treatment In Patients With Perio Dontal Disease, Ban Zuhair Ahmed

Al-Esraa University College Journal for Medical Sciences

Background: Both hard and soft periodontal components require hyaluronic acid (HA) for extracellular matrices to function properly. HA is crucial to understanding how inflammation and wound healing work. Different amounts of HA are found in periodontal tissues, including non-mineralized tissues like gingiva and periodontal ligament, and lesser levels in mineralized tissues like cementum and alveolar bone. Preliminary research indicates that HA can control periodontal tissue regeneration and treat periodontal disease. In both deeper periodontal tissues and marginal gingiva, HA helps to relieve symptoms. Aims: This research aimed to detect the influence of hyaluronic acid 1% gel as an adjunctive therapy …

Influence Of Il-1ss, Anti-Cdtb And Histamine In Irritable Bowel Syndrome, Khalid Mahdi Salih, Ola Amer Jasim

Al-Esraa University College Journal for Medical Sciences

Irritable Bowel Syndrome (IBS) is a common gut disorder that affects approximately 11% of the global population and negatively affects the quality of life of patients and imposes a significant socioeconomic burden. A control-based study was conducted on 42 Iraqi patients with IBS who presented at private clinics for gastrointestinal diseases (GIDs), along with 20 healthy individuals matched in age and gender to act as a control group. The study aimed to determine the frequency of IBS among Iraqi patients, as well as the influence of biomarkers on the disease's initiation, type, and severity such as IL-1ß, anti-Cytolethal distending toxin …

The Relationship Between The Nervous System And Dna Expression(A Review), Maha Raad Hashim Al-Sammarraie, Yasir Khaleel Almusawi, Mukaram D. Shikara

Al-Esraa University College Journal for Medical Sciences

Neurotransmitters travel through synapses mediated by neurons. The DNA inside the neurons does not replicate since it arrests in the G1 phase of the cell cycle, which explains the absence of replication as DNA replication occurs during the S phase, which is preceded by the G1 phase. Experiments have shown that environmental factors can influence the DNA code and have been tried in both plant and animal kingdoms over the last two centuries with great success, leading to the belief that environmental factors can prompt the brain to send signals (neurotransmitters) to somatic cells. The next question will be: "Is …

Commencement Program 2023, Loma Linda University

Commencement Programs

CONTENTS

1 | Message from the President

3 | 2023 Events of Commencement

5 | The Academic Procession

6 | Institutional Administration

7 | Board of Trustees

8 | Significance of Academic Regalia

9 | University History Highlights

11 | Criteria for Institutional Awards

13 | Loma Linda University Health and Loma Linda University Honorees

25 | The Program, The School Honorees, and The Speakers

• School of Medicine, 26
• School of Pharmacy, 52
• School of Dentistry, 69
• School of Public Health, 93
• San Manuel Gateway College, 108
• School of Allied Health Professions—Allied Health Studies, Cardiopulmonary Sciences, Clinical Laboratory Science, Communication …

Mitigating Risks To Improve Hypertension Medication Adherence In A Medically Vulnerable Population, Donna Hales-Teat

Doctor of Nursing Practice Projects

This project assessed the effect of an evidence-based medication adherence intervention on adherence rates at a Northern Indiana clinic led by a sole nurse practitioner, receptionist, and continuous rotation of graduate nursing students from several nursing programs in the Northern Indiana area. Patient education and comprehension were poor in terms of understanding disease process, treatment options, and disease management that led to poor communication with the medical provider. The process and steps in which patients matriculate through was described by Johnson’s (2002) Medication Adherence Model (MAM) with concepts of purposeful action, pattern behavior, and feedback; these helped to construct, steer, …

Antibiotic Over Prescription For Upper Respiratory Tract Infections, Amina Boudaia

Evidence-Based Practice Project Reports

Antibiotic overuse is a major contributor to antibiotic resistance that is estimated to be responsible for 23,000 deaths annually in the United States (Durante et al., 2017; Garcia et al., 2016). Upper respiratory tract infections (URTIs) are speculated to be a leading contributor to the overprescribing of antibiotics (Aplin-Snider et al., 2020). The purpose of this project was to address the PICOT question: Does the implementation of patient education posters and protocol plus online training modules for providers (I) over an 8-week period or 30 patient charts (T) help to decrease antibiotic overprescription (O) in upper respiratory tract infections (P) …

Treating Opioid Use Disorder: One Shot At A Time, Shelly Haferkamp, Michael P. Kinney, Daniel Yang, Lindsey Cunningham, Anna Davey, Amy G Burns

View All Graduate Medical Education Content

No abstract provided.

A Metabolic, Mechanical, Multi-Organ Masterpiece: Dural Device Support Bridge To En-Bloc Heart-Liver Transplantation In Propionic Acidemia, Rebecca Juhl, Brian Birnbaum, Aliessa P. Barnes, William Gibson, Bhargava Mullapudi, Beth Lang, Megan Faseler, Daniel E. Heble, Victoria Urban, Ryan T. Fischer, Jennifer L. Gannon, David Sutcliffe

Posters

Introduction: Propionic Acidemia (PA) is a disorder related to abnormal protein and lipid metabolism resulting in progressive neurological injury and dilated cardiomyopathy (DCM). Interventions for PA and secondary disease manifestations can require multi-organ transplantation. Herein we report the case of a child with PA and end-stage DCM requiring left ventricular assist device (LVAD) support with eventual heart-liver transplant. Case Report: A 17 year old male diagnosed in childhood with PA developed chronically progressive DCM culminating in end stage heart failure with acute decompensations. In a recurrent admission, he progressed to require dual inotropic support and systemic anticoagulation for new LV …