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Articles 481 - 504 of 504

Full-Text Articles in Pharmacy and Pharmaceutical Sciences

Chemical Constituents Of Cryptocarya Densiflora., Nurul Nazneem Wan Othman Jan 2010

Chemical Constituents Of Cryptocarya Densiflora., Nurul Nazneem Wan Othman

Student Works (2010-2019)

The extraction of alkaloids from the Malaysian Cryptocarya densiflora has been carried out in this study. The alkaloids were extracted from the bark and leaves of this species using acid base extraction and the crude alkaloids obtained were subjected to extensive chromatographic techniques such as thin layer and column chromatography. The structural elucidation of the purified alkaloids were performed with the aid of spectroscopic methods i.e. 1H NMR, 13C NMR, 2D NMR, IR, UV and LCMS. Investigation of the alkaloidal content from the bark of Cryptocarya densiflora afforded six alkaloids and their structures were elucidated as laurotetanine 63, isocaryachine 64, …

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The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3a Receptor-Mediated Currents In Xenopus Laevis Oocytes, Keun-Hang Susan Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S. Shippenberg, Murat Oz Jan 2010

The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3a Receptor-Mediated Currents In Xenopus Laevis Oocytes, Keun-Hang Susan Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S. Shippenberg, Murat Oz

Mathematics, Physics, and Computer Science Faculty Articles and Research

The effect of the plant-derived nonpsychotropic cannabinoid, cannabidiol (CBD), on the function of hydroxytryptamine (5-HT)3A receptors expressed in Xenopus laevis oocytes was investigated using two-electrode voltage-clamp techniques. CBD reversibly inhibited 5-HT (1 μM)-evoked currents in a concentration-dependent manner (IC50 = 0.6 μM). CBD (1 μM) did not alter specific binding of the 5-HT3A antagonist [3H]3-(5-methyl-1H-imidazol-4-yl)-1-(1-methylindol-3-yl)propan-1-one (GR65630), in oocytes expressing 5-HT3A receptors. In the presence of 1 μM CBD, the maximal 5-HT-induced currents were also inhibited. The EC50 values were 1.2 and 1.4 μM, in the absence and presence of CBD, indicating that CBD acts as a noncompetitive antagonist of 5-HT3 …

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Mass Stranding Of Marine Birds Caused By A Surfactant-Producing Red Tide., David A. Jessup, Melissa A. Miller, John P. Ryan, Hannah M. Nevins, Heather A. Kerkering, Abdou Mekebri, David B. Crane, Tyler A. Johnson, Raphael M. Kudela Jan 2009

Mass Stranding Of Marine Birds Caused By A Surfactant-Producing Red Tide., David A. Jessup, Melissa A. Miller, John P. Ryan, Hannah M. Nevins, Heather A. Kerkering, Abdou Mekebri, David B. Crane, Tyler A. Johnson, Raphael M. Kudela

Natural Sciences and Mathematics | Faculty Scholarship

In November-December 2007 a widespread seabird mortality event occurred in Monterey Bay, California, USA, coincident with a massive red tide caused by the dinoflagellate Akashiwo sanguinea. Affected birds had a slimy yellow-green material on their feathers, which were saturated with water, and they were severely hypothermic. We determined that foam containing surfactant-like proteins, derived from organic matter of the red tide, coated their feathers and neutralized natural water repellency and insulation. No evidence of exposure to petroleum or other oils or biotoxins were found. This is the first documented case of its kind, but previous similar events may have gone …

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Kajian Keamanan Pemakaian Obat Anti-Hipertensi Di Poliklinik Usia Lanjut Instalasi Rawat Jalan Rs Dr Sardjito, Zullies Ikawati Dec 2008

Kajian Keamanan Pemakaian Obat Anti-Hipertensi Di Poliklinik Usia Lanjut Instalasi Rawat Jalan Rs Dr Sardjito, Zullies Ikawati

Majalah Ilmu Kefarmasian

Increasing age is generally followed by increasing chronic diseases so that the elderly needs much therapy using drugs for therapy of numerous diseases they have. Hyper-tension is one of diseases of which its prevalence increases along with increasing age. Most of the elderly diagnosed as having hypertension finally take therapy using anti-hypertension drugs. Physiological changes that happen to the elderly lead to use of drugs for side effect diseases of which their consumption should be considered while having anti-hypertension drugs. Changes in biological system to the elderly will af-fect the process of drug molecular interaction, which finally affects clinical efficacy …

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Synthesis Of Marine Chemicals And Derivatives As Potential Anti-Cancer Drugs., Laude Bannerman-Akwei Dec 2008

Synthesis Of Marine Chemicals And Derivatives As Potential Anti-Cancer Drugs., Laude Bannerman-Akwei

Electronic Theses and Dissertations

Two natural marine compounds, 3-bromo-4,5-dihydroxybenzaldehyde 2 and 2,3-dibromo-4,5-dihydroxybenzaldehyde 5 together with two novel derivatives, 3-bromo-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxybenzaldehyde 3 and 1-bromo-2,3-dimethoxy-5-nitrooxy-methylbenzene 9, were synthesized. Compounds 2, 3, and 5 were evaluated for their biological activity towards the inhibition of prostate cancer cell growth using staurosporine a a positive control. All three compounds have shown significant inhibition of prostate cancer cell growth. Compound 9 is yet to be evaluated.

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Rapid Enzyme-Linked Immunosorbent Assay For Detection Of The Algal Toxin Domoic Acid, R Wayne Litaker, Thomas N. Stewart, Bich-Thuy L. Eberhart, John C. Wekell, Vera L. Trainer, Raphael M. Kudela, Peter E. Miller, Alice Roberts, Cassandra Hertz, Tyler A. Johnson, Greg Frankfurter, G. Jason Smith, Astrid Schnetzer, Joe Schumacker, Jonnette L. Bastian, Anthony Odell, Patrick Gentien, Dominique Le Gal, D Ransom Hardison, Patricia A. Tester Jan 2008

Rapid Enzyme-Linked Immunosorbent Assay For Detection Of The Algal Toxin Domoic Acid, R Wayne Litaker, Thomas N. Stewart, Bich-Thuy L. Eberhart, John C. Wekell, Vera L. Trainer, Raphael M. Kudela, Peter E. Miller, Alice Roberts, Cassandra Hertz, Tyler A. Johnson, Greg Frankfurter, G. Jason Smith, Astrid Schnetzer, Joe Schumacker, Jonnette L. Bastian, Anthony Odell, Patrick Gentien, Dominique Le Gal, D Ransom Hardison, Patricia A. Tester

Natural Sciences and Mathematics | Faculty Scholarship

Domoic acid (DA) is a potent toxin produced by bloom-forming phytoplankton in the genus Pseudo-nitzschia, which is responsible for causing amnesic shellfish poisoning (ASP) in humans. ASP symptoms include vomiting, diarrhea, and in more severe cases confusion, loss of memory, disorientation, and even coma or death. This paper describes the development and validation of a rapid, sensitive, enzyme linked immunosorbent assay test kit for detecting DA using a monoclonal antibody. The assay gives equivalent results to those obtained using standard high performance liquid chromatography, fluorenylmethoxycarbonyl high performance liquid chromatography, or liquid chromatography—mass spectrometry methods. It has a linear range …

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Discovery Of Platelet-Type 12-Human Lipoxygenase Selective Inhibitors By High-Throughput Screening Of Structurally Diverse Libraries., Joshua D. Deschamps, Jeffrey T. Gautschi, Stephanie Whitman, Tyler A. Johnson, Nadine C. Gassner, Phillip Crews, Theodore R. Holman Nov 2007

Discovery Of Platelet-Type 12-Human Lipoxygenase Selective Inhibitors By High-Throughput Screening Of Structurally Diverse Libraries., Joshua D. Deschamps, Jeffrey T. Gautschi, Stephanie Whitman, Tyler A. Johnson, Nadine C. Gassner, Phillip Crews, Theodore R. Holman

Natural Sciences and Mathematics | Faculty Scholarship

Human lipoxygenases (hLO) have been implicated in a variety of diseases and cancers and each hLO isozyme appears to have distinct roles in cellular biology. This fact emphasizes the need for discovering selective hLO inhibitors for both understanding the role of specific lipoxygenases in the cell and developing pharmaceutical therapeutics. To this end, we have modified a known lipoxygenase assay for high-throughput (HTP) screening of both the National Cancer Institute (NCI) and the UC Santa Cruz marine extract library (UCSC-MEL) in search of platelet-type 12-hLO (12-hLO) selective inhibitors. The HTP screen led to the characterization of five novel 12-hLO inhibitors …

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Amankah Pengawet Makanan Bagi Manusia ?, Harmita Harmita Apr 2006

Amankah Pengawet Makanan Bagi Manusia ?, Harmita Harmita

Majalah Ilmu Kefarmasian

No abstract provided.

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Identifikasi Senyawa Antioksidan Dalam Spons Callyspongia Sp Dari Kepulauan Seribu, Endang Hanani Dec 2005

Identifikasi Senyawa Antioksidan Dalam Spons Callyspongia Sp Dari Kepulauan Seribu, Endang Hanani

Majalah Ilmu Kefarmasian

Antioxidant activity and identification of antioxidative compounds of Callyspongia sponge from Seribu Island (Kepulauan Seribu) were investigated. The sponge was extracted with acetone and the extract was concentrated using rotary vacuum evaporator. DPPH and tiocyanate methods were used to examine the antioxidant activity of the extract. The extract exhibited strong antioxidant activity in DPPH method with IC50 of 41.21 µg/ml. Chemical analysis indicated that the antioxidative compound in the sponge was alkaloid group.

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Rna Therapeutic, Pendekatan Baru Dalam Terapi Gen, Amarila Malik Aug 2005

Rna Therapeutic, Pendekatan Baru Dalam Terapi Gen, Amarila Malik

Majalah Ilmu Kefarmasian

Some diseases, such as cancer, hereditary and genetic diseases, as well as viral infectious diseases, have been treated unsatisfied by the conventional therapy so far, and even more, by the gene therapy. Together with the pharmaceutical industries, researchers put their best effort to hunt some molecules that can be more favorable for such kind of therapy. After a pivotal study reported in May, 2001, it is certain that Ribonucleic acid (RNA) could effectively silence gene expression in mammalian cell line, so it was then proposed in 2004 the term RNA therapeutics. Antisense RNA therapy which came into the stage earlier …

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Pembuatan Niosom Berbasis Maltodekstrin De 5-10 Dari Pati Singkong (Manihot Utilissima), Mahdi Jufri, Effionora Anwar, Joshita Djajadisastra Apr 2004

Pembuatan Niosom Berbasis Maltodekstrin De 5-10 Dari Pati Singkong (Manihot Utilissima), Mahdi Jufri, Effionora Anwar, Joshita Djajadisastra

Majalah Ilmu Kefarmasian

Niosomes are non ionic surfactant vesicles that have potential application in the delivery of hydrophobic or amphilic drugs. We developed proniosomes, a dry formulation using a maltodextrin as a carrier coated with non ionic surfactant, which can be used to produce niosomes within a minutes by addition of hot water followed by agitation. A novel method is reported here for rapid preparation of proniosomes with wide range of surfactant loading. Maltodextrin DE 5-10 was hidrolyzed from tapioca starch using Thermamyl L 120 da Novo at 85ºC. The result from SEM analyses shown that proniosomes appear very similar to the maltodextrin, …

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Penyuluhan Penggunaan Oralit Untuk Menanggulangi Diare Di Masyarakat, Harianto Harianto Apr 2004

Penyuluhan Penggunaan Oralit Untuk Menanggulangi Diare Di Masyarakat, Harianto Harianto

Majalah Ilmu Kefarmasian

Diarrhea is one of the common deseases and a attack any level of ages. Diarrhea can be tuated effectively by using oralit to replace the lost of body water. To increase the use of oralit against diarrhea, this trestment should be socialized to public with undergo a general lecture to enhanced the public knowledges cncerning diarrhea and causing factors, to make a group discussion of senior citizen and public figures to build positive attitude in using oralit, and to demonstrate the processing of oralit/LGG and how to use it to people.

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Pemberian Vaksin Melalui Tanaman Transgenik, Maksum Radji Apr 2004

Pemberian Vaksin Melalui Tanaman Transgenik, Maksum Radji

Majalah Ilmu Kefarmasian

Vaccines have played an important role in preventive medicine since Edward Jenner discovered that cowpox induced protection against human smallpox. Until recently, a vaccination has meant a needle in the arm. However, with the increasing need for inexpensive, easily administered vaccines, along with the improvements in genetic engineering, the concept of edible vaccines is fast becoming reality. This is especially important in developing countries, where it is estimated that three to five million children die each year from common diseases, which could have easily been prevented with the proper vaccination. Compared to traditional lab-synthesized vaccines, plants are capable of producing …

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Pengaruh Kandungan Pati Singkong Terpregelatinasi Terhadap Karakteristik Fisik Tablet Lepas Terkontrol Teofilin, Juheini Juheini, Iskandarsyah Iskandarsyah, Animar J.A, Jenny Jenny Apr 2004

Pengaruh Kandungan Pati Singkong Terpregelatinasi Terhadap Karakteristik Fisik Tablet Lepas Terkontrol Teofilin, Juheini Juheini, Iskandarsyah Iskandarsyah, Animar J.A, Jenny Jenny

Majalah Ilmu Kefarmasian

In order to make use of pregelatinized Manihot starch in controlled release tablet, the research was done by heating the starch suspension up to its gelatinized temperatur, then dried. The particle size of pregelatinized Manihot starch used were (100-150 mesh) : (150-250 mesh) : smaller than 200 mesh = 3,5 : 1 : 1. The effect of pregelatinized Manihot starch on physical characteristic of Theophyllin controlled relase tablet was known by using 4 formulas containing variety of pregelatinized starch as follows: 30%, 40%, 50%, and 60%. Evaluation on the tablet results including tablet mass and size uniformity, hardness and friability. …

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Pemanfaatan Maltodekstrin Pati Terigu Sebagai Eksipien Dalam Formula Sediaan Tablet Dan Niosom, Effionora Anwar, Joshita Djajadisastra, Arry Yanuar, Anton Bahtiar Apr 2004

Pemanfaatan Maltodekstrin Pati Terigu Sebagai Eksipien Dalam Formula Sediaan Tablet Dan Niosom, Effionora Anwar, Joshita Djajadisastra, Arry Yanuar, Anton Bahtiar

Majalah Ilmu Kefarmasian

The Use of Maltodextrin from Wheat Starch as an Exipient in Formula Tablet and Niosom dosage form. Wheat starch normally can be used as a tablet filler only, because the flow rate and binding capacity are not good enough. The wheat starch should be treated as follows : protein and amine free Bogasari wheat flour starch were hydrolyzed by α-amylase enzyme (Liquezym EX®) at variable temperature and time incubation to produce maltodextrin with different Dextrose Equivalent (DE) value. The maltodextrin could be used as tablet binder on wet granulation, tablet filler and binder on direct compress, a proniosom carrier to …

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Optimasi Biotransformasi Total Sterol Limbah Tahu Menggunakan Mycobacterium Phlei Dsm 43286 Menjadi 1,4-Androstadien-3,17-Dion, Dengan Pengaruh Variasi Konsentrasi Inhibitor A, A’- Dipiridil, Maryati Kurniadi, Usman Sumo Friend Tambunan, Harmita Harmita Apr 2004

Optimasi Biotransformasi Total Sterol Limbah Tahu Menggunakan Mycobacterium Phlei Dsm 43286 Menjadi 1,4-Androstadien-3,17-Dion, Dengan Pengaruh Variasi Konsentrasi Inhibitor A, A’- Dipiridil, Maryati Kurniadi, Usman Sumo Friend Tambunan, Harmita Harmita

Majalah Ilmu Kefarmasian

Isolation of total sterol from waste product of soy bean cake has been conducted, followed by biotransformation to 1,4-androstadien-3,17-dione (ADD). The waste product consist of; β-sitosterol, stigmasterol, kaemfesterol, which are isolated by column chromatography technique using silica gel as stationary phase and chloroform as mobile phase. Biotransformation was conducted by using Mycobacterium phlei DSM 43286 in the present of α, α’- dipiridil as an inhibitor with concentration of 0,5; 1; 1,5; 2,0 mM. The main product of biotransformation were ADD and pregnenolon. The optimum yield of ADD 0,48% is achieved by adding 1,5 mM α, α’- dipiridil are two hours …

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Knowledge And Attitudes Of Pharmacists In A Midwestern State Regarding Natural Products, Kevin A. Clauson, Cydney E. Mcqueen, Kelly M. Shields, Patrick J. Bryant Jan 2003

Knowledge And Attitudes Of Pharmacists In A Midwestern State Regarding Natural Products, Kevin A. Clauson, Cydney E. Mcqueen, Kelly M. Shields, Patrick J. Bryant

Pharmacy Faculty Scholarship

Objectives. The purpose of this descriptive investigation was to determine the perceived knowledge of and attitudes toward natural products by pharmacists in Missouri. Methods. A questionnaire was mailed to 2921 licensed pharmacists. Assessments were conducted regarding the venues and specific resources these pharmacists utilized in order to gain knowledge in the area of natural products. Results. Over half (56.9%) of those surveyed indicated that they received natural product questions on a weekly basis, but only a minority (2.4%) felt they could “always answer natural product questions.” The most commonly used means for education was printed continuing education (70.2%). Only 12.5% …

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Natural Product Education In Schools Of Pharmacy In The United States, Kelly M. Shields, Cydney E. Mcqueen Jan 2003

Natural Product Education In Schools Of Pharmacy In The United States, Kelly M. Shields, Cydney E. Mcqueen

Pharmacy Faculty Scholarship

Objective. The purpose of this study was to describe pharmacy school curriculum offerings in the areas of natural products and complementary/alternative medicine. Methods. Eighty-one schools of pharmacy in the United States were surveyed to determine the extent to which coursework addressing natural product or complementary/alternative medicine had been incorporated into their curriculum. Results. Usable responses were obtained from 64 schools (79 percent). Of these, 51 schools offered some exposure to these topics, while 40 offered courses exclusively on these topics. Most of these schools offered this instruction as an elective course focused primarily on natural products. Conclusion. These results indicate …

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Chemical Constituents Of Desmos Dumosus, Roxb., Mazdida Sulaiman Jan 2001

Chemical Constituents Of Desmos Dumosus, Roxb., Mazdida Sulaiman

Student Works (2000-2009)

The chemical content of the 'leaves and bark of Des mos dumosus has been carried out in this study. The leaves yielded nine isoquinoline type of alkaloids and two flavones. The isoquinoline alkaloids isolated were pronuciferine 37, stepharine 39, nomuciferine 40, (-) - 3 - hydroxynomuciferine 41, norlirioferine 42, asimilobine 43, liriodenine 44, lysicamine 45 and O - methylmoschatoline 46. The flavones were 5 - hydroxy - 6,7 - dimethoxyflavone 47 and 5 - hydroxy - 7,8 - dimethoxyflavone 48. The same flavones, 47 and 48 and the alkaloids 45 and 46 were also present in the bark of this …

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Investigations Of The Absorption And Metabolismof Antioxidant Flavonols, Abdul Aziz Azlina Jan 2000

Investigations Of The Absorption And Metabolismof Antioxidant Flavonols, Abdul Aziz Azlina

Student Works (2000-2009)

Flavonols are polyphenols, secondary plant metabolites commonly found in plants and foods of plant origin. They have widespread biological properties in the human body. The recent discovery of their potential antioxidant activities has prompted extensive research. Flavonols particularly quercetin are potent antioxidants with higher antioxidant properties than the well known antioxidant vitamins C and E. Several epidemiology studies have demonstrated a strong inverse association between flavonoid intake and risk of coronary heart disease. The association with cancer is less defined with only some studies showing an inverse association and others not. In view of their potential to act as antioxidants …

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Sistem Maklumat Perubatan Tradisional Melayu, Omar Rosfazila Jan 2000

Sistem Maklumat Perubatan Tradisional Melayu, Omar Rosfazila

Student Works (2000-2009)

Sistem Maklumat Perubatan Tradisional Melayu adalah merupakan satu sistem makumat berkomputer yang dibangunkan di halaman web. Ia bertujuan untuk membantu pengguna mencapai maklumat mengenai (ubatan tradisional serta tumbuhan berubat yang) diamalkan oleh orang Melayu. Sistem ini akan menceritakan serba sedikit tentang sejarah penggunaan perubatan tradisional. Pengguna sistem juga dijangka dapat mengemukan pertanyaan dan memberi sebarang komen yang berkaitan dengan sistem. Bantuan kepada pengguna sistem tentang cara menggunakan sistem turut dipaparkan dalam pembangunan system ini nanti. Sistem ini juga membolehkan pihak pentadbir membuat pengemaskinian maklumat mengikut kesesuaian semasa dan pembaharuan. Ia adalah sejajar dengan matlamat untuk memastikan penyimpanan maklwnat yang lebih …

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Outpatient Administration Of Paclitaxel, Siu Fun Wong Jan 1994

Outpatient Administration Of Paclitaxel, Siu Fun Wong

Pharmacy Faculty Articles and Research

Paclitaxel (Taxol®, Bristol-Meyers Squibb), anti neoplastic agent made from the bark of the Pacific yew tree, is undoubtedly one of the most exciting agents to be evaluated over the past decade. Paclitaxel has demonstrated significant promise against ovarian and metastatic breast cancer, and appears to be the most effective single agent to date for non-small-cell lung cancer in trials conducted by Eastern Cooperative Oncology Group (ECOG).

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0458: Brad Dent Papers, 1987, Marshall University Special Collections Jan 1987

0458: Brad Dent Papers, 1987, Marshall University Special Collections

Guides to Manuscript Collections

` Marijuana cultivation: A comparison study of New Hanover and Brunswick Counties in coastal North Carolina and Cabell and Wayne Counties in the mountainous ranges of West Virginia,' a paper written for a psychology class at the University of North Carolina-Wilmington in the spring of 1987.

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Is "Natural" Better?, Russell W. Maatman Jun 1978

Is "Natural" Better?, Russell W. Maatman

Pro Rege

No abstract provided.

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