Pharmacy and Pharmaceutical Sciences Commons^™

Evaluation Of The Impact Of The Covid-19 Pandemic On The Teaching Of Otolaryngology And Cervico-Facial Surgery, I. Tahiri, H. Bensouda, O. Haddani, O. El Houari, S. Anajar, L. Taali, A. Hajjij, M. Essaadi, M. Jahidi, F. Benariba, M. Zalagh, F. Guessous, S. Chaouir

Health Sciences

Background: During the Covid-19 pandemic, distance learning is increasingly present in the field of education, particularly in the health sciences. This type of teaching has emerged as the appropriate solution to the problem of knowledge transfer. The objective of this study is to evaluate the impact of distance learning of the ENT (ear, nose and throat) and CFS (cervico-facial surgery) module on students and the impact of the pandemic on their quality of life. Methods: We conducted a survey on students' feelings about distance learning courses, the impact of the pandemic on their lifestyle and the consequences of the protective …

Student Evaluation Of Pre-Clinical Teaching On A Dental Simulator, Manal Elhijazi, Hafsa Elmrini, Ihsane Benyahya

Health Sciences

Context: Student evaluation of teaching (SET) is a pedagogical tool which is part of a quality control process of teaching. Material and methods: An anonymous and voluntary e-questionnaire was sent to all 3rd year students of the Faculty of Dentistry in university Mohamed VI of sciences and health at the end of the academic year 2021-2022 in order to evaluate the progress of practical pre-clinical learning by dental simulator in conservative dentistry. The aim was to evaluate the teaching tools, the organization of the lessons, the content of the program as well as their overall perceptions of this practical pre-clinical …

Pharmacy Students' Perception And Satisfaction With Chemistry Education: A Crosssectional Study, Fayssal Jhilal, Lamia Slimani, Lamia Zaari Lambarki, Ali Jafri, Samy Iskandar, Mariam El Jemli, Najib Alidrissi, Samir Ahid

Health Sciences

Chemistry is an important part of the curriculum for pharmacy students, as there are many disciplines within chemistry that are actually involved in the design and development of drugs, namely; general chemistry, synthetic organic chemistry, analytical chemistry, biochemistry, pharmaceutical chemistry (or therapeutic chemistry), pharmacognosy and materials chemistry for the design of dosage forms. The learning of chemistry by pharmacy students is generally influenced by their perception of theoretical courses, tutorials or practical work. In order to evaluate this perception, we conducted a cross-sectional study based on an anonymous electronic questionnaire distributed to students of all the Moroccan Faculty of Pharmacy …

Instrumental Fracture In Endodontics: A Short Review, Fatima Zohra Rouggani, Ayoub Belkamel

Health Sciences

Oneofthemostfrequentaccidentsthattakeplaceduringstandardendodontictreatment is instrument fracture. The fractured instrument such as a metallic obstruction inthe root canal system, hinders cleaning and shaping operations, and affects the effectivenessofendodontictherapy.Themanagementofinstrumentfracture,factorsthataffe ctinstrumentfracture,andprecautionsforinstrumentfracturearethethreeheadingsusedtoel aborateonthistopicin thisreview.

Psychological Burden Of Second Line Healthcare Workers In Morocco During Covid-19 Outbreak: A Cross-Sectional Study, Ismail Hanine, Khadija Benallel, Roukaya Benjelloun, Mohamed Kadiri

Health Sciences

Background: Second-line healthcare workers have played a crucial role during the covid-19 pandemic, providing essential support to frontline workers and ensuring the smooth functioning of healthcare systems. Aim: Our subjects were not the focus of many research studies. Our aim was to explore the relationship between the outbreak and the experience of the second line of defense and if they endured the psychological burden of the pandemic as much as those on the frontline, despite not being in direct contact with infected or suspected cases in the first wave. Methods: In this study, we focused our attention on those not …

Unveiling Similarities And Differences Between Cutaneous And Ocular Melanomas, Abdallah Badou, Nour El Imane Issam Salah, Mohamed Elbelhadji

Health Sciences

Melanomas are outstandingly aggressive cancers, still their incidence is increasing. They can occur in the skin as cutaneous melanoma or in the eye as ocular melanoma. Their pathogenesis is generally similar; however, the prognosis of ocular melanoma patients is still poor, due to its special genetic profile and tumor microenvironment. Here we review the similarities and differences between cutaneous and ocular melanoma, with a focus on their prognostic significance, their molecular signature, and their tumor microenvironment, in order to understand the strategies adopted to escape immune response. Gathering and understanding available knowledge of melanomas and their specificities may help to …

Portable Hepa Filtration Successfully Augments Natural-Ventilation-Mediated Airborne Particle Clearance In A Legacy Design Hospital Ward, Mehael Fennelly, S. Hellebust, J. Wenger, D. O'Connor, G.W. Griffith, B.J. Plant, A.P.C. Microbiome Institute

Articles

As the severe acute respiratory syndrome coronavirus-2 pandemic has proceeded, ventilation has been recognized increasingly as an important tool in infection control. Many hospitals in Ireland and the UK do not have mechanical ventilation and depend on natural ventilation. The effectiveness of natural ventilation varies with atmospheric conditions and building design. In a challenge test of a legacy design ward, this study showed that portable air filtration significantly increased the clearance of pollutant aerosols of respirable size compared with natural ventilation, and reduced spatial variation in particle persistence. A combination of natural ventilation and portable air filtration is significantly more …

Chronic Anemia Revealing An Idiopathic Watermelon Stomach: Case Report, Hanane Delsa, Imane Rahmouni, Yassamin Benhayoun Sadafyine, Fatima Belabbes, Anass Nadi, Fedoua Rouibaa

Health Sciences

Watermelon stomach, also known as gastric antral vascular ectasia (GAVE) syndrome, is a rare entity. Patients often present with profound unexplained anemia with or without bleeding externalization. We made the diagnosis during a digestive endoscopy for an etiological assessment of this anemia. Endoscopically, antral erythematous lesions in stripes with a punctate appearance, sometimes hemorrhagic, may suggest a watermelon stomach. The pathophysiology of the watermelon stomach remains complex and unclear. Although several pathologies remain implicated, sometimes, it can be idiopathic. The effectiveness of numerous treatments has been evaluated with relatively satisfactory results. This is a rare case of an idiopathic watermelon …

The Strength Of Motivation For Dental Students, Manal Elhijazi, Ihsane Benyahya

Health Sciences

Context: Motivation plays a key role in academic success. It is a dynamic process that maintains perseverance and tenacity in the face of difficulty. The purpose of our study was to measure and compare the strength of dental students' motivation at the beginning and the end of their training Material and methods: an anonymous self-administered voluntary questionnaire was distributed to 1st and 6th year students at the Faculty of Dentistry in Casablanca This questionnaire consisted of 30 closed questions divided into 3 sections, the first of which provided information on socio-demographic data, the second is devoted to measuring the strength …

Electromechanical Effects On Micro And Nano Particles Generated From Drug Delivery Devices And Their Implications In Flow And Deposition Efficiency, Mohammed Ali, Mark Miller

Technology Faculty Publications and Presentations

This experimental investigation was undertaken to quantify the electrostatic charge and aerodynamic size distribution of the medicinal drug particles inhaled through an in-vitro mouth-throat (MT) in order to compare the amount of drugs can be delivered to the human lung while mimicking a patient is either sitting or lying. The MT model is a cadaver-based replica cast of human oral-pharyngeal-laryngeal region. Tested drug aerosols were generated by a commercially available metered dose inhaler (MDI). The MT model was placed inside a humidity (95%) and temperature (37^oC) controlled chamber. Its mouth-inlet was positioned horizontally and vertically to simulate sitting …

Synthesis Of Alginate/Hydroxyapatite Beads For Acetaminophen Delivery, Anesylvia Angan, Nonni Soraya Sambudi

Makara Journal of Science

Conventional drug delivery systems usually involve the intake of multiple drugs, which could amplify the risk of overdosing. Acetaminophen is a widely used pain relief substance that is prone to accidental overdosing. Hence, a controlled drug delivery system is needed to ensure its efficacy. A nanocomposite hydroxyapatite/alginate system that was used as a drug carrier for acetaminophen was synthesized through the sol-gel method, and the mechanism underlying its controlled drug delivery was investigated. Spherical nanocomposite bead samples were synthesized by incorporating 5 wt%, 10 wt%, and 15 wt% hydroxyapatite into mixtures containing alginate. The mixtures were then dropped into calcium …

Behavioral Intention Factors For Prescription Deliveries By Small Unmanned Aircraft In Rural Communities, Sarah M. Talley

Doctoral Dissertations and Master's Theses

Nearly half of the U.S. population regularly use and depend on prescription medications; however, pharmacy availability and access to pharmacy services are often lacking, particularly in rural communities. In an effort to meet local healthcare needs, delivery by sUAS is proposed to ensure the nearly 60 million rural residents have access to their prescription medications.

As an emerging technology with little research into home delivery applications, the successful implementation of sUAS for prescription medication delivery requires public acceptance and positive behavioral intention toward its use. At the time of the current research, no prior studies have specifically focused on the …

A Detailed Parameter Study Into The Dermal Absorption Of Chemical Warfare Agents And The Effects Of Pharmacokinetics, Koko Lear

Theses

Chemical warfare agents (CWAs) are substances of varying toxicity profiles. These chemicals exhibit complex dynamics and pose a serious health risk when released into the environment. A mathematical model based on Fick’s second law of diffusion was developed to comprehend how these compounds were absorbed into the skin. The analysis applied to both small and large doses and, successfully, predicted experimental results. This work also includes the effects of CWA physicochemical properties on evaporation and dermal absorption through the stratum corneum. A sensitivity analysis was conducted to assess the impacts of small variations in the initial dose, environmental conditions, and …

The Synthesis And Characterization Of Ionic Liquids Using Nitrogen-Based Cations For Transdermal Delivery, Jo Galloway

Honors Theses

The purpose of this research was to explore the synthesis mechanisms of water-soluble ionic liquids with nitrogen-containing cationic bases for future use in transdermal drug delivery and forensic science applications. Ionic liquids are salts with an organic cation and either an organic or inorganic anion. They have asymmetric structures, which means that the molecules don’t pack together as neatly as other salts do, therefore, they don’t crystallize as easily, and their melting points are lower. Ionic liquids have melting points below 100°C, and many are liquid at room temperature. Mechanistic studies reveal that the potency of ILs in enhancing transdermal …

Nanoparticles For Biomedical Applications, Joseph Kim

Dissertations and Theses (Open Access)

This thesis presents development and evaluation of the potential of three new nanoparticles for biomedical applications. With the rapid growth of the field of nanoscience, researchers have explored developing nanoparticles for various biomedical applications, including imaging, therapy, and drug delivery. This thesis demonstrates the development of two C­₆₀ fullerene based nanoparticles and one boron based nanoparticle to answer key questions related to their biological potential.

In the first part of the thesis, we describe synthesis and characterization of a pure boron nanoparticle containing asolectin phospholipid-based liposome construct prepared using a water-in-oil emulsion method, as a novel alternative agent for …

A Meshless Approach To Computational Pharmacokinetics, Anthony Matthew Khoury

Doctoral Dissertations and Master's Theses

The meshless method is an incredibly powerful technique for solving a variety of problems with unparalleled accuracy and efficiency. The pharmacokinetic problem of transdermal drug delivery (TDDD) is one such topic and is of significant complexity. The locally collocated meshless method (LCMM) is developed in solution to this topic. First, the meshless method is formulated to model this transport phenomenon and is then validated against an analytical solution of a pharmacokinetic problem set, to demonstrate this accuracy and efficiency. The analytical solution provides a locus by which convergence behavior are evaluated, demonstrating the super convergence of the locally collocated meshless …

Bladder Tumor In A Young Leukemic Patient Cured By Chemotherapy: A Case Report, Mohamed Tebaa, Mamoutou Dit Mody, Sylla Mahamadou, Mohamed Amine Lakmichi

Health Sciences

Adult bladder tumor is estimated to be the 10th most common tumor worldwide. However, its incidence is much less common in children. It is a disease of the elderly that peaks in the sixth decade of life. Nevertheless, bladder tumors could also affect children, adolescents, and young adults with a prevalence of

Prostacyclin Promotes Degenerative Pathology In A Model Of Alzheimer’S Disease, Tasha R. Womack, Craig T. Vollert, Odochi Ohia-Nwoko, Monika Schmitt, Saghi Montazari, Tina L. Beckett, David Mayerich, M. Paul Murphy, Jason L. Eriksen

Molecular and Cellular Biochemistry Faculty Publications

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is the most common form of dementia in aged populations. A substantial amount of data demonstrates that chronic neuroinflammation can accelerate neurodegenerative pathologies. In AD, chronic neuroinflammation results in the upregulation of cyclooxygenase and increased production of prostaglandin H2, a precursor for many vasoactive prostanoids. While it is well-established that many prostaglandins can modulate the progression of neurodegenerative disorders, the role of prostacyclin (PGI2) in the brain is poorly understood. We have conducted studies to assess the effect of elevated prostacyclin biosynthesis in a mouse model of AD. Upregulated prostacyclin expression …

Therapeutic Treatment With The Anti-Inflammatory Drug Candidate Mw151 May Partially Reduce Memory Impairment And Normalizes Hippocampal Metabolic Markers In A Mouse Model Of Comorbid Amyloid And Vascular Pathology, David J. Braun, David K. Powell, Christopher J. Mclouth, Saktimayee M. Roy, D. Martin Watterson, Linda J. Van Eldik

Neuroscience Faculty Publications

Alzheimer's disease (AD) is the leading cause of dementia in the elderly, but therapeutic options are lacking. Despite long being able to effectively treat the ill-effects of pathology present in various rodent models of AD, translation of these strategies to the clinic has so far been disappointing. One potential contributor to this situation is the fact that the vast majority of AD patients have other dementia-contributing comorbid pathologies, the most common of which are vascular in nature. This situation is modeled relatively infrequently in basic AD research, and almost never in preclinical studies. As part of our efforts to develop …

Swosu Research And Scholarly Activity Fair 2022, Swosu Office Of Sponsored Programs

SWOSU Research and Scholarly Activity Fair Programs

On behalf of Southwestern Oklahoma State University, welcome to the Thirtieth Research and Scholarly Activity Fair! We are proud to host students and faculty from universities and community colleges from across the state at this meeting of scholars. Research and scholarly activity ranging from Business Administration, Education and Professional Studies, Fine Arts and Design, Liberal Arts, and Mathematics and Science.
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Sincerely, SWOSU Office of Sponsored Programs and URSAC

Biomarkers Of Inflammation And Oxidative Stress In The Prediction And Management Of Acute Coronary Syndrome, Udaya Ralapanawa, Sivakanesan R

Health Sciences

The assessment of patients presenting with chest pain or symptoms indicative of cardiac ischemia remains a diagnostic challenge. Many types of research have focused on the search for ideal biological markers for the rapid detection of cardiac cell injuries. Markers of inflammation and oxidative stress are the way forward. At present, the biomarker most widely used for diagnosing acute coronary syndrome is cardiac troponin though it has some limitations. Apart from cardiac troponin, several other biomarkers, especially inflammation and oxidative stress markers in acute coronary syndrome, have been investigated. However, most of them still require validation in further studies. As …

Development And Optimization Of A Low Volume Air-Jet Dry Powder Inhaler (Dpi) Platform For The Delivery Of High Dose Aerosolized Powder To Infants, Connor Howe

Theses and Dissertations

The goal of this research project was to develop an infant air-jet dry powder inhaler (DPI) platform for high-efficiency nose-to-lung (N2L) aerosol administration to infants through optimization of individual system components followed by expansion of the system to higher doses and different formulations using a new approach. Primary challenges associated with aerosol delivery to infants using the N2L route include the extremely narrow extrathoracic airways, short inspiratory times (~0.2 sec), low safe airway pressure (H₂O), and very low volumes of air (~10 mL) available to form the aerosol. The infant air-jet DPI system was comprised of three main …

Hydrodynamic Characterization Of Laboratory And Production Equipment For Pharmaceutical Testing And Manufacturing Using Experimental And Computational Approaches, Chadakarn Sirasitthichoke

Dissertations

The hydrodynamics of process units used in pharmaceutical industry, i.e., the distribution of velocity profiles and shear stresses within the vessel, often controls the process performance, significantly affecting product quality. The hydrodynamics is strongly influenced by several factors such as the vessel shape, stirrer type, presence of internals and baffles, agitation intensity, and liquid properties. Most of these parameters can be varied by the process designers and the operators to achieve the desired process outcomes. The impact of the hydrodynamics on the process outcome can be profound in both large vessels (e.g., reactors) and smaller vessels (e.g., dissolution vessels), involving …

Siderophore-Mediated Zinc Acquisition Enhances Enterobacterial Colonization Of The Inflamed Gut, Judith Behnsen, Hui Zhi, Allegra T. Aron, Venkateswaran Subramanian, William Santus, Michael H. Lee, Romana R. Gerner, Daniel Petras, Janet Z. Liu, Keith D. Green, Sarah L. Price, Jose Camacho, Hannah Hillman, Joshua Tjokrosurjo, Nicola P. Montaldo, Evelyn M. Hoover, Sean Treacy-Abarca, Benjamin A. Gilston, Eric P. Skaar, Walter J. Chazin, Sylvie Garneau-Tsodikova, Matthew B Lawrenz, Robert D Perry, Sean-Paul Nuccio, Pieter C. Dorrestein, Manuela Raffatellu

Pharmacy Nuclear Magnetic Resonance Center Faculty Publications

Zinc is an essential cofactor for bacterial metabolism, and many Enterobacteriaceae express the zinc transporters ZnuABC and ZupT to acquire this metal in the host. However, the probiotic bacterium Escherichia coli Nissle 1917 (or “Nissle”) exhibits appreciable growth in zinc-limited media even when these transporters are deleted. Here, we show that Nissle utilizes the siderophore yersiniabactin as a zincophore, enabling Nissle to grow in zinc-limited media, to tolerate calprotectin-mediated zinc sequestration, and to thrive in the inflamed gut. We also show that yersiniabactin’s affinity for iron or zinc changes in a pH-dependent manner, with increased relative zinc binding as the …

Covid-19 Et Gestion Des Troubles Gastro-Intestinaux : Expérience D’Un Centre Hospitalier Marocaincovid-19, Gastrointestinal Disorders, Pandemic., Hanane Delsa, Mohamed Cherkaoui Jaouad Reda, Amine Benfaida, Anass Nadi, Fedoua Rouibaa

Health Sciences

Pandemic Covid-19 is a real challenge for the medical profession. SARS-CoV-2 virus attacks several human organs, including the digestive tract. Digestive disorders have been described as revealing symptoms or accompanying signs of infection. The treatment of these symptoms must be early and codified. At Cheikh Khalifa International University Hospital in Casablanca, a codified treatment protocol has been proposed to facilitate the management of these disorders.

Fabrication And Comparative Study Of Horizontal And Vertical Electrospun Protein-Polysaccharide Nanofiber Biomaterials, Ashley Rivera-Galleti

Theses and Dissertations

The use of biocompatible and biodegradable composite materials for biomedical applications has attracted the attention of many researchers in the past few years. In this study, we fabricated nanofibers of silk fibroin and cellulose and its derivatives to amalgamate their unique properties into a single material. The production of these nanofibers via electrospinning is of particular interest, and whereas several studies have been done on normal nanofibers, the formation of branched nanofibers is an exciting area not currently explored. Blend solutions are formed by dissolving silk and cellulose/cellulose acetate in formic acid separately and mixing to achieve the desired ratios. …

Towards Quality By Design (Qbd) Of Pharmaceutical Oral Films Loaded With Poorly Watersoluble Drugs, Eylul Cetindag

Dissertations

Oral films are an emerging drug delivery dosage form with numerous advantages such as ease of handling, the possibility to circumvent the first-pass metabolism, better patient compliance, capability for continuous manufacturing, and as a platform for personalized medicine. As films are different from other final dosages by their dimensions and their matrix form, further research is required to better understand the impact of excipient and drug on product performance to assure a consistent and good quality product. Therefore, this dissertation aims to contribute towards the processability and manufacturability of films by examining the impact of the materials and processes. First, …

Exploring Fused Deposition Modeling (Fdm) Three-Dimensional Printing Tablet Design Options For Pharmaceutical Dosage Forms, Guluzar Gorkem Buyukgoz

Dissertations

This dissertation examines the use of Fused Deposition Modeling (FDM) based three-dimensional (3D) printing approach for developing patient-specific dosage forms and addressing related technical challenges in such drug delivery systems. The first main objective is to explore pharmaceutical tablet design options using novel FDM 3D printing technology as the drug delivery platform such that drug form and tablet properties are tailored by considering patient age-specific formulations and dissolution control. Of the five different design options, two proposed options meet the main objective of providing similar drug release, whereas the popular option of fixed drug concentration but differing tablet size could …

Innovative Computational Methods For Pharmaceutical Problem Solving A Review Part Ii: Serious Gaming, Heather R. Campbell, Robert A. Lodder

Pharmaceutical Sciences Faculty Publications

Serious gaming has begun to take a foothold in pharmaceutical problem-solving. Companies such as Akili's Interactive are seeing success in the form of positive clinical trial results and FDA approval of digital therapeutics. Academic researchers have begun exploring novel uses for serious gaming in the way of protein design and more with promising results. This paper provides a review of such topics in addition to topics of game repurposing- repurposing a game originally intended for entertainment into a serious game-such as Minecraft and America's Army. Reviewing these topics this paper shows the utility of serious gaming as a tool for …

Innovative Computational Methods For Pharmaceutical Problem Solving A Review Part I: The Drug Development Process, Heather R. Campbell, Robert A. Lodder

Pharmaceutical Sciences Faculty Publications

Computational methods have provided pharmaceutical scientists and engineers a means to go beyond what's possible with experimental testing alone. Providing a means to study active pharmaceutical ingredients (API), excipients, and drug interactions at or near-atomic levels. This paper provides a review of this and other innovative computational methods used for solving pharmaceutical problems throughout the drug development process. Part one of two this paper will emphasize the role of computational methods and game theory in solving pharmaceutical challenges.