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Articles 181 - 210 of 1263
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
October / November / December 2024, Randy Curry, Cindy Brooks
October / November / December 2024, Randy Curry, Cindy Brooks
RURAL ROCKS
This is the October - November - December issue of Rural Rocks from the SWOSU College of Pharmacy.
Synthesis Of Photocleavable Molecules For Neurological Applications, Nishal Madujith Egodawaththa Arachchilage Don
Synthesis Of Photocleavable Molecules For Neurological Applications, Nishal Madujith Egodawaththa Arachchilage Don
Theses and Dissertations
In recent biomedical research, the precise control of molecular dynamics through light activation has emerged as a powerful tool, particularly in the field of neurobiology. This approach involves the use of photocleavable cages or photoprotective groups (PPGs) that are chemically tethered to biologically active molecules such as neurotransmitters or calcium chelators. These cages remain inert until exposed to specific wavelengths of light, typically in the visible range, triggering the release of the active compound with high spatiotemporal precision.
For neurotransmitter systems, such as glutamate (Glu), which plays a critical role in synaptic transmission and memory formation, researchers have developed novel …
Unravelling The Erythropoietin Heterodimeric Complex: In Silico Analysis Of Complex Assembly And Binding Interface, Atiya Habib, Urooj Qureshi, Mohammad Nur-E-Alam, Aftab Ahmed, Zaheer Ul-Haq
Unravelling The Erythropoietin Heterodimeric Complex: In Silico Analysis Of Complex Assembly And Binding Interface, Atiya Habib, Urooj Qureshi, Mohammad Nur-E-Alam, Aftab Ahmed, Zaheer Ul-Haq
Pharmacy Faculty Articles and Research
Erythropoietin (Epo), a glycosylated protein categorized as a member of the cytokine family, is responsible for the modulation of erythrogenesis. Besides this, the nonhaematopoietic effects of Epo are associated with tissue-protective activity via an antiapoptotic pathway. This function of Epo is linked with its heterodimeric form, i.e. EpoR/βcR belonging to the cytokine family as well. Both receptors are dissected into three domains: extracellular (also known as ligand-binding domain), transmembrane and cytoplasmic domain. The transmembrane and cytoplasmic domains are assumed to play a paramount role in dimerization and tissue protection. However, the tertiary structure of cytoplasmic domains of both …
Effects Of Sex And Estrous Cycle On Extended-Access Oxycodone Self-Administration And Cue-Induced Drug Seeking Behavior, Bhumiben P Patel, Jessica A Loweth
Effects Of Sex And Estrous Cycle On Extended-Access Oxycodone Self-Administration And Cue-Induced Drug Seeking Behavior, Bhumiben P Patel, Jessica A Loweth
Rowan-Virtua School of Osteopathic Medicine Departmental Research
INTRODUCTION: Increasing evidence indicates that sex is a factor that impacts the abuse liability and relapse vulnerability of prescription opioids like oxycodone. However, while women are more likely than men to be prescribed and to use these drugs, the impact of sex and ovarian hormones on prescription opioid use and relapse vulnerability remains unclear. Accurately assessing these measures is complicated by the fact that chronic opioid exposure can lower ovarian hormone levels and cause cycle irregularities.
METHODS: Adult male and female Sprague-Dawley rats self-administered oxycodone (0.1 mg/kg/infusion) under extended-access conditions (6 h/day, 10 days) followed by forced abstinence. Separate groups …
Synthesis And Evaluation Of Cyclic Peptide-Dasatinib Conjugates As Anti-Melanoma Agents, Shaban Darwish, Dorna Davani-Davari, Shirley Tong, Rakesh Kumar Tiwari, Sun Yang, Keykavous Parang
Synthesis And Evaluation Of Cyclic Peptide-Dasatinib Conjugates As Anti-Melanoma Agents, Shaban Darwish, Dorna Davani-Davari, Shirley Tong, Rakesh Kumar Tiwari, Sun Yang, Keykavous Parang
Pharmacy Faculty Articles and Research
Herein, we synthesized two amphiphilic cyclic peptides, incorporating tryptophan and arginine residues, linked to dasatinib via a Cathepsin B-sensitive tetrapeptide (Gly-Phe-Leu-Gly). To mitigate steric hindrance and optimize drug release, we integrated two different linkers, succinate and glutarate, between the drug and peptide. The synthesis involved solid-phase techniques for the assembly of the peptide, followed by the coupling of the peptide on-resin with the linker, mild cleavage, and solution-phase cyclization. Conjugation of the peptide-attached linker with dasatinib was conducted in the presence of N-methylmorpholine and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), generating the novel prodrugs. The synthesized compounds were characterized by high-resolution mass …
Table B: Impacts Of Utensil Use In Preparation, Robert Yokel
Table B: Impacts Of Utensil Use In Preparation, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Coffee Beans, Robert Yokel
Coffee Beans, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Creamer, Non-Dairy, Robert Yokel
Creamer, Non-Dairy, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Tea Infusion, Unspecified Tea Type, Robert Yokel
Tea Infusion, Unspecified Tea Type, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Puer Tea Infusion, Robert Yokel
Puer Tea Infusion, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Energy, Isotonic, Sports, And Nutritional Drinks, Robert Yokel
Energy, Isotonic, Sports, And Nutritional Drinks, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Butter, Robert Yokel
Butter, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Sugar, Syrup And Molasses, Robert Yokel
Sugar, Syrup And Molasses, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Oils, Fats, And Their Products, Robert Yokel
Oils, Fats, And Their Products, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Pepper, Robert Yokel
Pepper, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Rice, Robert Yokel
Rice, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Cookies And Snacks, Robert Yokel
Cookies And Snacks, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Barley, Robert Yokel
Barley, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Mango And Mango Juice, Robert Yokel
Mango And Mango Juice, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Cherries And Cherry Juices, Robert Yokel
Cherries And Cherry Juices, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Table I: Aluminum Material Age Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel
Table I: Aluminum Material Age Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Table C: Ph Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel
Table C: Ph Influence On Aluminum Mobilization Into Beverages And Foods, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Potato, Robert Yokel
Potato, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Cauliflower, Robert Yokel
Cauliflower, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Carrot And Parsnip, Robert Yokel
Carrot And Parsnip, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Processed Cheese, Robert Yokel
Processed Cheese, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Jellyfish, Robert Yokel
Jellyfish, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Seaweeds, Robert Yokel
Seaweeds, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Plums, Prunes And Their Juices, Robert Yokel
Plums, Prunes And Their Juices, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Onion. Garlic, And Other Alliums, Robert Yokel
Onion. Garlic, And Other Alliums, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.