Other Medicine and Health Sciences Commons^™

Yawns Are Cool, Andrew C. Gallup, Omar T. Eldakar

Biology Faculty Articles

Although we yawn each and every day, most people have little understanding of why we do it. In fact, the function of yawning has remained mysterious for centuries, even among scientists, and this has only changed quite recently. Contrary to what people have believed for a long time, it is now understood that yawns have nothing to do with breathing or the amount of oxygen we are taking in. Instead, new and growing research has revealed that yawns serve as a brain cooling mechanism. This new perspective on yawning as a response to elevated brain temperature has transformed our understanding …

Identifying The Factors For Acute Cardiac Arrest For Establishing A New Recognition Protocol In Detecting Pre-Arrest Symptoms, Sarah Power

Grace Peterson Nursing Research Colloquium

Abstract

Background: Worsening physiological symptoms can easily go overlooked or unmanaged. The early detection of clinical signs that precede cardiac arrest can reduce the risk of worsening condition or death. Determining a nursing protocol to recognize pre-arrests symptoms would allow a systematic way to evaluate patients and their health status before adverse events occur.

Objectives: The purpose of an integrative literature review was to identify signs and symptoms that precede cardiac arrest, and to specify a recognition protocol that ameliorates patient care outcomes.

Method: An integrative literature review was conducted undergoing an extensive search to identify acute cardiac arrest and …

The Roles Of Ecdysoneless In Endoplasmic Reticulum Stress And Oncogenesis, Appolinaire A. Olou

Theses & Dissertations

Tumor cells are well known to exhibit ER stress as a result of their altered environment characterized by redox and calcium imbalance, deregulation of protein synthesis to meet their oncogenic demands, and decreased vascularization associated with nutrient limitation and hypoxia, all of which are conducive of ER stress. Accordingly, markers of ER stress signaling response are up-regulated in various cancers. The outcome of ER stress signaling response varies from survival and adaption to apoptosis. Although pro-apoptotic ER stress signaling molecules are up-regulated in cancer, the mechanisms by which cancer cells seem refractory to, or evade, their apoptotic signaling are not …

Investigating The Needs Of Parents Of Premature Infants’ Interaction In The Neonatal Intensive Care Unit, Maureen A. Rinehimer

Seton Hall University Dissertations and Theses (ETDs)

Parents and/or caregivers of premature infants provide the interaction needed to promote better outcomes for these challenged infants at risk for developmental delays. This descriptive, exploratory study utilized convenience sampling. Inclusion criteria consisted of parents/caregivers who were at least 18 years of age and older with infants born 35 weeks gestation or less and currently in the NICU. This study focused on the research question: What do parents perceive they need in the NICU to enjoy interacting with their infant in the home? To collect the data needed to capture the perceptions of parent’s needs of infants in the NICU, …

Traceable Peo-Poly(Ester) Micelles For Breast Cancer Targeting: The Effect Of Core Structure And Targeting Peptide On Micellar Tumor Accumulation, Shyam M. Garg, Igor M. Paiva, Mohammad R. Vakili, Rania Soudy, Kate Agopsowicz, Amir H. Soleimani, Mary Hitt, Kamaljit Kaur, Afsaneh Lavasanifar

Pharmacy Faculty Articles and Research

Traceable poly(ethylene oxide)-poly(ester) micelles were developed through chemical conjugation of a near-infrared (NIR) dye to the poly(ester) end by click chemistry. This strategy was tried for micelles with poly(ε-caprolactone) (PCL) or poly(α-benzyl carboxylate-ε-caprolactone) (PBCL) cores. The surface of both micelles was also modified with the breast cancer targeting peptide, P18-4. The results showed the positive contribution of PBCL over PCL core on micellar thermodynamic and kinetic stability as well as accumulation in primary orthotopic MDA-MB-231 tumors within 4–96 h following intravenous administration in mice. This was in contrast to in vitro studies where better uptake of PEO-PCL versus PEO-PBCL micelles …

Alumni Journal - Volume 88, Number 2, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Features
12 | A Humble and Gentle Giant: Remembering the man named Small
15 | SDA Guidelines and PAS
18 | The Divine Thread: Dr. Bailie’s life of providential underpinning
22 | To Make Man Flourish: God’s call to decrease physician burnout
26 | APC 2017 in Review

Departments
2 | From the Editor
3 | This and That
4 | From the President
6 | From the Dean
8 | School of Medicine News
10 | The Student Fund
36 | AIMS Report
40 | Book Review
42 | Alumni News
44 | Placement and Classified Ads
45 | …

Enduring Chronic Kidney Disease: An Investigation Of Psychosocial Factors And Life Satisfaction In Older Adults Receiving Dialysis Treatment, Bailee Sobotka

Honors Program: Senior Projects (Public)

Chronic kidney disease is a condition during which the kidneys begin to shut down and no longer filter blood efficiently. Once the disease has progressed far enough, dialysis treatments are mandatory to sustain life. To further understand how older adults receiving dialysis treatments cope with their disease, psychosocial factors were evaluated to investigate possible correlations with life satisfaction using a Life Satisfaction Index Z (LSI-Z). Expected correlations with life satisfaction were sociability, financial satisfaction, importance of spirituality, and activities of daily living scores. Interviews were conducted with 30 dialysis patients and results were analyzed using various statistical measures. Significant correlations …

Assessing The Utility Of Phenylene Ethynylenes Against Candida Species Pathogens, Rina Sylejmani

Biomedical Engineering ETDs

Candida species are the cause of many bloodstream infections through contamination of indwelling medical devices. These infections account for a 40% mortality rate, posing a significant risk to immunocompromised patients. Traditional treatments against Candida infections include amphotericin B and various azole treatments. Unfortunately, these treatments are associated with high toxicity, and resistant strains have become more prevalent. As a new frontier, light-activated phenylene ethynylenes have shown promising biocidal activity against Gram-positive and -negative bacterial pathogens, as well as the environmental yeast, Saccharomyces cerevisiae. In this thesis, we monitored the viability of Candida species after treatment with a cationic conjugated …

Embracing Diversity: Confronting Disparities, Loma Linda University Health

Scope

Table of Contents:

Features

4 | Researching the biological footprint of health inequalities
8 | Modeling interfaith cooperation: Religious diversity at Loma Linda University Health
10 | New Diversity Council works towards inclusiveness as a spiritual imperative
13 | First graduating cohort of LLU San Bernardino Campus - San Manuel Gateway College
14 | Race Matters for Health {a lot!}
20 | Loma Linda University Health professor's campaign to end dangerous health disparities
22 | Questions and answers on workforce diversity with Lyndon Edwards
25 | Diversity solves disparities
26 | Gender Dysphoria: Response of the faith-based community
28 | …

Establishment Of Innovative Shared Departments To Advance Interdisciplinary Education, Ronald S. Harichandran, Brian Kench, Summer Mcgee, Michael A. Collura, Jean Nocito-Gobel, Charles David Skipton

Engineering and Applied Science Education Faculty Publications

More and more universities are pursuing interdisciplinary academic activities that span across department and college boundaries. Administrative structures to facilitate such programs are difficult to establish within traditional university frameworks consisting of disciplinary departments and colleges. Often interdisciplinary programs are housed in a traditional disciplinary department or college, or in a standalone center reporting to a college dean or the provost. The difficulty of these structures is obtaining broad buy-in from faculty across departments and having disciplinary degree programs include interdisciplinary coursework.

To overcome the difficulties described above, an innovative shared department structure that fosters collaborations to advance interdisciplinary education …

Gadgets And Grieving: A Chronological Analysis On The Ways In Which Advancements In Medical Technologies Have Altered The Grieving Process, Grace Mcnair

Dialogue & Nexus

Since the 1940s, both end-of-life care and advancements in medical technologies have expanded exponentially. This article explores the advancements in medical technologies and how these have altered the way that Western society grieves death. With the capabilities to prolong life, the family, the patient, and the medical team, all grieve the end of life in different ways. This article provides a chronological analysis of palliative care, hospice care, and various medical advancements. These changes in medicine are then paralleled with alterations in the bereavement process. This article explores historical narratives of Western society’s transformation of grief through the lens of …

Prevalence And Predictors Of Herbal Medicine Use Among Adults In The United States, Mohamed Rashrash, Jon C. Schommer, Lawrence M. Brown

Pharmacy Faculty Articles and Research

Objective: To describe the prevalence of herbal medicine use among US adults and to assess factors associated with and predictors of herbal use. Design: The data for herbal products use were collected from the 2015 National Consumer Survey on the Medication Experience and Pharmacists’ Roles. Chi-square test was used to analyz factors associated with herbal use, and predictors of herbal use were assessed with logistic regression analysis. Results: Factors associated with herbal supplement use include age older than 70, having a higher than high school education, using prescription medications or over-thecounter (OTC) medications, and using a mail-order …

Commencement Program 2017, Loma Linda University

Commencement Programs

CONTENTS

1 | Message from the President

3 | 2017 Events of Commencement

5 | The Academic Procession

7 | Significance of Academic Regalia

9 | The Good Samaritan

10 | University History Highlights

12 | Loma Linda University Song - "Healing Love"

13 | The University Honorees

26 | The Programs, The School Honorees, and The Speakers

• School of Medicine, 27
• School of Pharmacy, 52
• School of Dentistry, 64
• School of Allied Health Professions - Allied Health Studies, Cardiopulmonary Sciences, Clinical Laboratory Science, Communication Sciences and Disorders, Health Informatics and Information Management, Nutrition and Dietetics, Physician Assistant Sciences, Radiation …

Exploring Disparities In Underrepresented Minority Groups Of Children Diagnosed With Autism Spectrum Disorders Using The Biopsychosocial Theoretical Model, Varleisha Gibbs

Seton Hall University Dissertations and Theses (ETDs)

Background and Purpose of the Study

The rate of Autism continues to rise nationally. However, disparities in the age of diagnosis amongst underrepresented minority groups, still remains a major concern. Research supports that racial and ethnic disparities are key factors influencing noted age of diagnosis discrepancies. Traditionally, the medical community has used the biomedical or disability model, as revealed in the Diagnostic Statistical Manual of Mental Disorders, to explore diagnostic differences. However, these models limit the healthcare professional’s ability to examine elements outside of pathology. In attempt to address the issue with a broader perspective, this study explored the various …

Effectiveness Of Pictorial Health Warning Labels For Indonesia's Cigarette Packages, Dien Anshari

Theses and Dissertations

Pictorial health warning labels (PHWL) on cigarette packaging is a key way to communicate with consumers about the harms from tobacco, particularly in the low- and middle-income countries that do not have the resources for effective mass media campaigns. Research is needed to determine the most effective PHWL content for Indonesia, a country with one of the largest populations of smokers in the world and amongst the weakest tobacco policy environments. This research aimed to determine the most effective PHWL content for Indonesia’s cigarette packages, including the social and psychological factors that may influence PHWL effects.

Data for this study …

Looking Through The Window©: A Metacognitive Instrument To Teach Physical Exam To Pre-Clinical Pa Students, Wayne Mathews

Posters and Presentations: Physician Assistant

The initial transition from pre-clinical learning to clinical immersion is a significant and unique phase in a PA student’s education when students transition from spending more time learning in the classroom to experiential learning in the clinical setting. One essential component of that transition is the teaching of physical examination skills. The author introduces an instrument based on metacognitive theories of learning called WINDOW©. The instrument is evaluated using two consecutive PA student surveys employing a Mixed Methods approach.

Student response gauged at two phases was positive: 79.31% agreed the WINDOW© instrument was relevant to clinical problem solving; 72.42% thought …

When One Is Sick And Two Need Help: Caregivers’ Perspectives On The Negative Consequences Of Caring, Ilja Ormel, Susan Law, Courtney Abbott, Mark Yaffe, Marc Saint-Cyr, Kerry Kuluski, Debbie Josephson, Ann C. Macaulay

Patient Experience Journal

Informal or family caregivers contribute significantly to individual care, and to the Canadian healthcare system, yet receive limited support from governments, institutions, and healthcare professionals in recognition of their role, or in response to their health and social care needs – often due to the negative consequences of caregiving. Learning about the diversity of others’ experiences can positively influence personal decision-making, reduce feelings of isolation, as well as promote adjustment to a personal situation. For caregivers, however, few resources exist that provide reliable information on others’ experiences. We collected the narratives of caregivers’ experiences of caring for someone with a …

Teach-Back Method: Improving Health Outcomes, Katherine Smith

Thinking Matters Symposium Archive

To answer the Clinical PICO question: For patients managing chronic disease, how does the implementation of the teach-back method compared to usual standard of care affect health outcomes? By implementing the teach-back method, we will improve the management of chronic disease in the primary care setting.

Alumni Journal - Volume 88, Number 1, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Features
10 | 85 Years of the Alumni JOURNAL
14 | APC 2017: A Preview
18 | Interview: Brain Surgery to Global Surgery, Walter D. Johnson ’83
26 | Am I My Brother’s Keeper?

Departments
2 | Fron the Editor
3 | This and That
4 | From the President
6 | From the Dean
7 | The Student Fund
8 | School of Medicine News
38 | AIMS Report
40 | Book Review
42 | Alumni News
43 | Placement and Classified Ads
44 | In Memoriam
49 | What's Up Doc?

Extras
3 | New and Upgraded Perpetual …

Today - March / April 2017, Loma Linda University Health

TODAY

Inside this issue:

- Foundation for hospital construction project starts with 'Big Pour'
- Welcoming Alumni Home (pictorial)
- Homecoming kicks off with 'healthy people' event in healthiest community
- Adventist Church's Health Ministries director challenges alumni's ideas of service
- Research highlights featured during Homecoming weekend (pictorial)
- Homecoming vespers program spotlights history, future of outreach
- Alumni Come Together to Remember
- Loma Linda alumni share their talents
- Prayer Walk offers time for reflection
- Homecoming 5K honors memory of Soret, Schrader
- Black student group honors founder for promoting minority student opportunity
- Neurosurgery professor briefs …

Impact Of Health Policy Changes On Emergency Medicine In Maryland Stratified By Socioeconomic Status, Laura Pimentel, David Anderson, Bruce Golden, Edward Wasil, Fermin Barreuto, Jon M. Hirshon

Publications and Research

Introduction: On January 1, 2014, the financing and delivery of healthcare in the state of Maryland (MD) profoundly changed. The insurance provisions of the Patient Protection and Affordable Care Act (ACA) began implementation and a major revision of MD’s Medicare waiver ushered in a Global Budget Revenue (GBR) structure for hospital reimbursement. Our objective was to analyze the impact of these policy changes on emergency department (ED) utilization, hospitalization practices, insurance profiles, and professional revenue. We stratified our analysis by the socioeconomic status (SES) of the ED patient population.

Methods: We collected monthly mean data including patient volume, hospitalization percentages, …

Rationale And Study Protocol For The Patient-Centered Outcome Aid (Pcoa) Randomized Controlled Trial: A Personalized Decision Tool For Newly Diagnosed Ovarian Cancer Patients, Lari Wenzel, Dana Mukamel, Kathryn Osann, Laura Havrilesky, Lisa Sparks, Joseph Lipscomb, Alexi A. Wright, Joan Walker, Ronald Alvarez, Linda Van Le, Katina Robison, Robert Bristow, Robert Morgan, Bobbie Rimel, Heather Ladd, Susie Hsieh, Aditi Wahi, David Cohn

Communication Faculty Articles and Research

"The purpose of this study was to develop and test the effectiveness of a Patient-Centered Outcome Aid (PCOA) compared to a control condition of usual care, as patients chose between IV or IP therapy for advanced ovarian cancer. We developed an internet-based decision aid to improve patient-centered outcomes and tested it within a randomized clinical trial. The purpose of this paper is to describe the clinical trial development and protocol."

Lactose Intolerance: An Overview Of The Facts And Their Implications, Noelle M. Yeo

Honors Program: Senior Projects (Public)

Lactose intolerance is often blamed for the symptoms such as bloating, diarrhea, gas, abdominal pain, and nausea, that ail many people. Patients often do not seek proper diagnosis from a physician and create their own treatment plans, severely restricting lactose intake, without professional guidance. Even those who do seek the care of a physician find that diagnosis is complicated by less-than ideal testing and confusion due to the symptoms common to many other conditions. The misconceptions and inability to confirm a diagnosis of lactose intolerance can cause nutrient deficiencies in these patients, as well as begin a pattern of unnecessary …

Sex-Dependent Effects Of Ho-1 Deletion From Adipocytes In Mice, Peter A. Hosick, Mary Frances Weeks, Michael W. Hankins, Kyle H. Moore, David E. Stec

Department of Exercise Science and Physical Education Scholarship and Creative Works

Induction of heme oxygenase-1 (HO-1) has been demonstrated to decrease body weight and improve insulin sensitivity in several models of obesity in rodents. To further study the role of HO-1 in adipose tissue, we created an adipose-specific HO-1 knockout mouse model. Male and female mice were fed either a control or a high-fat diet for 30 weeks. Body weights were measured weekly and body composition, fasting blood glucose and insulin levels were determined every six weeks. Adipocyte-specific knockout of HO-1 had no significant effect on body weight in mice fed a high-fat diet but increased body weight in female mice …

Utilization Of Health Services In A Resource-Limited Rural Area In Kenya: Prevalence And Associated Household-Level Factors, Anthony Ngugi, Felix Agoi, Megan R. Mahoney, Amyn Lakhani, David Mang’Ong’O, Esther Nderitu, Robert Armstrong, Sarah Macfarlane

Faculty of Health Sciences, East Africa

Background: Knowledge of utilization of health services and asso- ciated factors is important in planning and delivery of interventions to improve health services coverage. This knowledge is however limited in many developing countries. We determined the preva- lence and factors associated with health services utilization in a rural area of Kenya. Our findings inform the local health management in development of appropriately targeted interventions.

Methods: Design: Cluster sample survey. Population: Residents of Kaloleni sub-County in Kenya.

Participants/respondents: Household key informants. Outcomes: (i) History of illness for household members and (ii) health services utilization in the preceding month, (iii) factors associated …

Metastatic Biomarkers In Synovial Sarcoma, Rosalia De Necochea-Campion, Lee M. Zuckerman, Hamid R. Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen, Saied Mirshahidi

Library Articles and Research

Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical management is the mainstay of treatment with chemotherapy and radiation typically used as adjuvant treatment. Although chemotherapy has a positive impact on survival, the prognosis is poor if metastatic disease occurs. The biology of sarcoma invasion and metastasis remain poorly understood. Chromosomal translocation with fusion of the SYT and SSX genes has been described and is currently used as a diagnostic marker, although the full impact of …

Today - January / February 2017, Loma Linda University Health

TODAY

Inside this issue:

-- Thomas L. Lemon Appointed Chair of Loma Linda University Health Board of Trustees
-- Peter Baker named administrator of Murrieta facility
-- Lowell Cooper concludes 15 years of leadership
-- LLU Medical Center CEO receives top honor
-- Loma Linda University Cancer Center seeks volunteers for new clinical trials
-- ‘One Homecoming’ Weekend designed to bring alumni together
-- “Loma Linda’s Got Talent” on display at One Homecoming’ Weekend
-- Services held for former US Congresswoman and friend of Loma Linda University Health, Shirley Neil Pettis
-- Farmer Boys donates over $111,000 to LLU Children’s Hospital …

Jpcrr Reviewers — 2016

Journal of Patient-Centered Research and Reviews

N/A

Modelling Fatigue For Management Decision Making: A Case Study, Rajee Olaganathan, Timothy B. Holt, Jacqueline Luedtke

Publications

Fatigue is one major contributing factor that reduces the human ability and leads to accidents, and threatens the safety of aircraft and human lives.

Though fatigue is seen in all the disciplines associated with the aviation industry, this paper will discuss only pilot fatigue. Based on the literature examined, this study first examines the significance of the problem.

Investigation of the inflight, pre/post flight countermeasures (both pharmacological and non - pharmacological methods) practiced at present, discusses the Fatigue Risk Management System (FRMS) – in this first, it defines the FRMS, briefly discusses its history, describes the organizational structure of FRMS …

Education Of Nurse Practitioners And Physician Assistants; What Role, If Any, For Physicians In Determining Their Scope Of Practice?, Joseph I. Shapiro

Marshall Journal of Medicine

Recent changes in legislation allow for non-physicians to independently perform many of the duties previously restricted to physicians. There are potentially benefits to these changes, but the author is concerned that some of the attributes of physicians induced by the long and rigorous training embedded in the profession may be absent in this new, independent health-care work force.