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Articles 31 - 60 of 93
Full-Text Articles in Other Medicine and Health Sciences
Current Prevalence Rate Of Latex Allergy: Why It Remains A Problem?, Miaozong Wu, James Mcintosh, Jian Liu
Current Prevalence Rate Of Latex Allergy: Why It Remains A Problem?, Miaozong Wu, James Mcintosh, Jian Liu
Jian Liu
OBJECTIVES: This article aims to review the current prevalence rate of latex allergy among healthcare workers, susceptible patients, and the general public, and to investigate why latex is still a ubiquitous occupational health hazard.
METHODS: Scientific publications on PubMed, particularly those published within the last five years, and current regulations from agencies such as Food and Drug Administration (FDA) were reviewed. Consumer and commercial products that may contain latex were also surveyed.
RESULTS: Approximately 12 million tons of natural rubber latex is produced annually and is widely used to manufacture millions of consumer and commercial products. Only limited number of …
Current Prevalence Rate Of Latex Allergy: Why It Remains A Problem?, Miaozong Wu, James Mcintosh, Jian Liu
Current Prevalence Rate Of Latex Allergy: Why It Remains A Problem?, Miaozong Wu, James Mcintosh, Jian Liu
James McIntosh
OBJECTIVES: This article aims to review the current prevalence rate of latex allergy among healthcare workers, susceptible patients, and the general public, and to investigate why latex is still a ubiquitous occupational health hazard.
METHODS: Scientific publications on PubMed, particularly those published within the last five years, and current regulations from agencies such as Food and Drug Administration (FDA) were reviewed. Consumer and commercial products that may contain latex were also surveyed.
RESULTS: Approximately 12 million tons of natural rubber latex is produced annually and is widely used to manufacture millions of consumer and commercial products. Only limited number of …
Enduring Chronic Kidney Disease: An Investigation Of Psychosocial Factors And Life Satisfaction In Older Adults Receiving Dialysis Treatment, Bailee Sobotka
Enduring Chronic Kidney Disease: An Investigation Of Psychosocial Factors And Life Satisfaction In Older Adults Receiving Dialysis Treatment, Bailee Sobotka
Honors Theses
Chronic kidney disease is a condition during which the kidneys begin to shut down and no longer filter blood efficiently. Once the disease has progressed far enough, dialysis treatments are mandatory to sustain life. To further understand how older adults receiving dialysis treatments cope with their disease, psychosocial factors were evaluated to investigate possible correlations with life satisfaction using a Life Satisfaction Index Z (LSI-Z). Expected correlations with life satisfaction were sociability, financial satisfaction, importance of spirituality, and activities of daily living scores. Interviews were conducted with 30 dialysis patients and results were analyzed using various statistical measures. Significant correlations …
Alumni Journal - Volume 88, Number 2, Loma Linda University School Of Medicine
Alumni Journal - Volume 88, Number 2, Loma Linda University School Of Medicine
Alumni Journal, School of Medicine
Features
12 | A Humble and Gentle Giant: Remembering the man named Small
15 | SDA Guidelines and PAS
18 | The Divine Thread: Dr. Bailie’s life of providential underpinning
22 | To Make Man Flourish: God’s call to decrease physician burnout
26 | APC 2017 in Review
Departments
2 | From the Editor
3 | This and That
4 | From the President
6 | From the Dean
8 | School of Medicine News
10 | The Student Fund
36 | AIMS Report
40 | Book Review
42 | Alumni News
44 | Placement and Classified Ads
45 | …
Assessing The Utility Of Phenylene Ethynylenes Against Candida Species Pathogens, Rina Sylejmani
Assessing The Utility Of Phenylene Ethynylenes Against Candida Species Pathogens, Rina Sylejmani
Biomedical Engineering ETDs
Candida species are the cause of many bloodstream infections through contamination of indwelling medical devices. These infections account for a 40% mortality rate, posing a significant risk to immunocompromised patients. Traditional treatments against Candida infections include amphotericin B and various azole treatments. Unfortunately, these treatments are associated with high toxicity, and resistant strains have become more prevalent. As a new frontier, light-activated phenylene ethynylenes have shown promising biocidal activity against Gram-positive and -negative bacterial pathogens, as well as the environmental yeast, Saccharomyces cerevisiae. In this thesis, we monitored the viability of Candida species after treatment with a cationic conjugated …
Assessment Of Physical Activity And Sedentary Behavior Using Wearable Sensors: Measurement Considerations And Clinical Applications, Amanda Hickey
Assessment Of Physical Activity And Sedentary Behavior Using Wearable Sensors: Measurement Considerations And Clinical Applications, Amanda Hickey
Doctoral Dissertations
The aims of study one of this dissertation were two-fold: 1) To understand the variability of sedentary behavior (SB) throughout a seven-day measurement period and 2) To determine the number of days of SB measurement required to reliably estimate seven-days of measurement. To address these aims, we utilized activPAL (AP) data from two existing data sets from the Physical Activity (PA) and Health Laboratory. Data were from 62 adults and 34 adolescents who had seven consecutive days of valid monitor wear. We found that adults were more sedentary on weekdays compared to weekend days, but there were no differences by …
Embracing Diversity: Confronting Disparities, Loma Linda University Health
Embracing Diversity: Confronting Disparities, Loma Linda University Health
Scope
Table of Contents:
Features
4 | Researching the biological footprint of health inequalities
8 | Modeling interfaith cooperation: Religious diversity at Loma Linda University Health
10 | New Diversity Council works towards inclusiveness as a spiritual imperative
13 | First graduating cohort of LLU San Bernardino Campus - San Manuel Gateway College
14 | Race Matters for Health {a lot!}
20 | Loma Linda University Health professor's campaign to end dangerous health disparities
22 | Questions and answers on workforce diversity with Lyndon Edwards
25 | Diversity solves disparities
26 | Gender Dysphoria: Response of the faith-based community
28 | …
A Rare Association Of Giant Cell Arteritis With Recurrent Corneal Ulcer, Sailaja Bondalapati, Kay Khine, Maya Bitar, David Chesnutt, Richard M. Davis
A Rare Association Of Giant Cell Arteritis With Recurrent Corneal Ulcer, Sailaja Bondalapati, Kay Khine, Maya Bitar, David Chesnutt, Richard M. Davis
Maya S. Bitar
We report a rare case of association of temporal arteritis with recurrent central corneal ulcer. A 91-year-old male with a remote history of clinically diagnosed giant cell arteritis (GCA) and penetrating keratoplasty (PK) for corneal edema in 1990’s in the left eye presented with irritation and severe dry eye. He progressively developed central corneal ulcer regardless of treatment with aggressive lubrication and patching. The clinical course, blood tests and temporal artery biopsy results yielded the diagnosis of recurrent GCA. The clinical course improved after starting oral steroids. The case report illustrates the importance of ruling out GCA in patients with …
Establishment Of Innovative Shared Departments To Advance Interdisciplinary Education, Ronald S. Harichandran, Brian Kench, Summer Mcgee, Michael A. Collura, Jean Nocito-Gobel, Charles David Skipton
Establishment Of Innovative Shared Departments To Advance Interdisciplinary Education, Ronald S. Harichandran, Brian Kench, Summer Mcgee, Michael A. Collura, Jean Nocito-Gobel, Charles David Skipton
Engineering and Applied Science Education Faculty Publications
More and more universities are pursuing interdisciplinary academic activities that span across department and college boundaries. Administrative structures to facilitate such programs are difficult to establish within traditional university frameworks consisting of disciplinary departments and colleges. Often interdisciplinary programs are housed in a traditional disciplinary department or college, or in a standalone center reporting to a college dean or the provost. The difficulty of these structures is obtaining broad buy-in from faculty across departments and having disciplinary degree programs include interdisciplinary coursework.
To overcome the difficulties described above, an innovative shared department structure that fosters collaborations to advance interdisciplinary education …
Gadgets And Grieving: A Chronological Analysis On The Ways In Which Advancements In Medical Technologies Have Altered The Grieving Process, Grace Mcnair
Dialogue & Nexus
Since the 1940s, both end-of-life care and advancements in medical technologies have expanded exponentially. This article explores the advancements in medical technologies and how these have altered the way that Western society grieves death. With the capabilities to prolong life, the family, the patient, and the medical team, all grieve the end of life in different ways. This article provides a chronological analysis of palliative care, hospice care, and various medical advancements. These changes in medicine are then paralleled with alterations in the bereavement process. This article explores historical narratives of Western society’s transformation of grief through the lens of …
Prevalence And Predictors Of Herbal Medicine Use Among Adults In The United States, Mohamed Rashrash, Jon C. Schommer, Lawrence M. Brown
Prevalence And Predictors Of Herbal Medicine Use Among Adults In The United States, Mohamed Rashrash, Jon C. Schommer, Lawrence M. Brown
Pharmacy Faculty Articles and Research
Objective: To describe the prevalence of herbal medicine use among US adults and to assess factors associated with and predictors of herbal use. Design: The data for herbal products use were collected from the 2015 National Consumer Survey on the Medication Experience and Pharmacists’ Roles. Chi-square test was used to analyz factors associated with herbal use, and predictors of herbal use were assessed with logistic regression analysis. Results: Factors associated with herbal supplement use include age older than 70, having a higher than high school education, using prescription medications or over-thecounter (OTC) medications, and using a mail-order …
Commencement Program 2017, Loma Linda University
Commencement Program 2017, Loma Linda University
Commencement Programs
CONTENTS
1 | Message from the President
3 | 2017 Events of Commencement
5 | The Academic Procession
7 | Significance of Academic Regalia
9 | The Good Samaritan
10 | University History Highlights
12 | Loma Linda University Song - "Healing Love"
13 | The University Honorees
26 | The Programs, The School Honorees, and The Speakers
- School of Medicine, 27
- School of Pharmacy, 52
- School of Dentistry, 64
- School of Allied Health Professions - Allied Health Studies, Cardiopulmonary Sciences, Clinical Laboratory Science, Communication Sciences and Disorders, Health Informatics and Information Management, Nutrition and Dietetics, Physician Assistant Sciences, Radiation …
Commonest Cancers In Pakistan - Findings And Histopathological Perspective From A Premier Surgical Pathology Center In Pakistan., Zubair Ahmad, Romana Idress, Saira Fatima, Nasir Uddin, Arsalan Ahmed, Khurram Minhas, Aisha Memon, Syeda Samia Fatima, Muhammad Arif, Sheema H Hasan, Rashida Ahmed, Shahid Pervez, Naila Kayani Naila Kayani
Commonest Cancers In Pakistan - Findings And Histopathological Perspective From A Premier Surgical Pathology Center In Pakistan., Zubair Ahmad, Romana Idress, Saira Fatima, Nasir Uddin, Arsalan Ahmed, Khurram Minhas, Aisha Memon, Syeda Samia Fatima, Muhammad Arif, Sheema H Hasan, Rashida Ahmed, Shahid Pervez, Naila Kayani Naila Kayani
Zubair Ahmad
Abstract CONTEXT: There are no recent authoritative data about incidence and prevalence of various types of cancers in Pakistan. AIM: To determine the frequency of malignant tumors seen in our practice and provide a foundation for building a comprehensive cancer care strategy. MATERIALS AND METHODS: 10,000 successive cases of solid malignant tumors reported in 2014 were included. All cases had formalin fixed, paraffin embedded specimens available and diagnosis was based on histological examination of H and E stained slides plus ancillary studies at the Section of Histopathology, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi. The latest …
Commonest Cancers In Pakistan - Findings And Histopathological Perspective From A Premier Surgical Pathology Center In Pakistan., Zubair Ahmad, Romana Idress, Saira Fatima, Nasir Uddin, Arsalan Ahmed, Khurram Minhas, Aisha Memon, Syeda Samia Fatima, Muhammad Arif, Sheema H Hasan, Rashida Ahmed, Shahid Pervez, Naila Kayani Naila Kayani
Commonest Cancers In Pakistan - Findings And Histopathological Perspective From A Premier Surgical Pathology Center In Pakistan., Zubair Ahmad, Romana Idress, Saira Fatima, Nasir Uddin, Arsalan Ahmed, Khurram Minhas, Aisha Memon, Syeda Samia Fatima, Muhammad Arif, Sheema H Hasan, Rashida Ahmed, Shahid Pervez, Naila Kayani Naila Kayani
Rashida Ahmed
Abstract CONTEXT: There are no recent authoritative data about incidence and prevalence of various types of cancers in Pakistan. AIM: To determine the frequency of malignant tumors seen in our practice and provide a foundation for building a comprehensive cancer care strategy. MATERIALS AND METHODS: 10,000 successive cases of solid malignant tumors reported in 2014 were included. All cases had formalin fixed, paraffin embedded specimens available and diagnosis was based on histological examination of H and E stained slides plus ancillary studies at the Section of Histopathology, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi. The latest …
Do Dietary Patterns Explain High Prevalence Of Cardiovascular Risk Factors Among Pakistani Urban Adults? A Cross-Sectional Study, Nilofer F. Safdar, Elizabeth Bertone-Johnson, Lorraine Cordeiro, Tazeen H. Jafar, Nancy L. Cohen
Do Dietary Patterns Explain High Prevalence Of Cardiovascular Risk Factors Among Pakistani Urban Adults? A Cross-Sectional Study, Nilofer F. Safdar, Elizabeth Bertone-Johnson, Lorraine Cordeiro, Tazeen H. Jafar, Nancy L. Cohen
Lorraine Cordeiro
Background The prevalence of cardiovascular disease (CVD) in South Asia is higher than in any other developing countries. The diversity of diets in populations among developing countries may be one explanation for the differences in CVD. This study was carried out to explore the association between dietary patterns and the presence of cardiovascular risk factors among Pakistani low income urban adults. Methods Socio demographic, physical activity and dietary information was collected from 1546 Pakistani subjects aged ≥40 years from the Control of Hypertension and Risk Attenuation (COBRA) study. Anthropometric, clinical and biomarker measures were assessed. Cluster analysis was used to …
Exploring Disparities In Underrepresented Minority Groups Of Children Diagnosed With Autism Spectrum Disorders Using The Biopsychosocial Theoretical Model, Varleisha Gibbs
Seton Hall University Dissertations and Theses (ETDs)
Background and Purpose of the Study
The rate of Autism continues to rise nationally. However, disparities in the age of diagnosis amongst underrepresented minority groups, still remains a major concern. Research supports that racial and ethnic disparities are key factors influencing noted age of diagnosis discrepancies. Traditionally, the medical community has used the biomedical or disability model, as revealed in the Diagnostic Statistical Manual of Mental Disorders, to explore diagnostic differences. However, these models limit the healthcare professional’s ability to examine elements outside of pathology. In attempt to address the issue with a broader perspective, this study explored the various …
Looking Through The Window©: A Metacognitive Instrument To Teach Physical Exam To Pre-Clinical Pa Students, Wayne Mathews
Looking Through The Window©: A Metacognitive Instrument To Teach Physical Exam To Pre-Clinical Pa Students, Wayne Mathews
Posters and Presentations: Physician Assistant
The initial transition from pre-clinical learning to clinical immersion is a significant and unique phase in a PA student’s education when students transition from spending more time learning in the classroom to experiential learning in the clinical setting. One essential component of that transition is the teaching of physical examination skills. The author introduces an instrument based on metacognitive theories of learning called WINDOW©. The instrument is evaluated using two consecutive PA student surveys employing a Mixed Methods approach.
Student response gauged at two phases was positive: 79.31% agreed the WINDOW© instrument was relevant to clinical problem solving; 72.42% thought …
Housing Adjustment Behaviors Of Korean Elderly Immigrants Residing In Affordable Housing: The Cultural Aspects Of Residential Experiences, Myounghee Jorn
Housing Adjustment Behaviors Of Korean Elderly Immigrants Residing In Affordable Housing: The Cultural Aspects Of Residential Experiences, Myounghee Jorn
Theses and Dissertations
The present study is an explorative study that employs mixed methods for examining the daily life patterns and housing adjustment behaviors of low-income elderly Korean immigrants residing in public housing in the Chicago metropolitan area. It particularly focuses on identifying the cultural practices of research participants and the influence of those cultural practices on using residential features, evaluating them, and developing coping responses to satisfy dwelling needs.
The study develops upon Canter’s theories of place (1977; 1991; 1997) and Weisman’s model of place (2001), and integrates Rapoport’s concepts of culture (1980; 2008) for exploring the residential experiences of elderly Korean …
Exploring The Costs And Values Of The Household Model In Long Term Care, Mark Alan Proffitt
Exploring The Costs And Values Of The Household Model In Long Term Care, Mark Alan Proffitt
Theses and Dissertations
As part of the culture change movement in long term care, nursing homes are transforming into person centered living settings that reject the previous medical emphasis that dominated the industry. The household model is one approach to achieve this goal by systemically altering the traditional nursing home’s organization, routines and physical setting with an emphasis on recreating familiar, domestic places for its residents. The household model is hallmarked by three key characteristics: 1) the creation of a smaller functional group of residents within the nursing home that is delineated by the environment (24 residents or less) with the 2) intent …
Effectiveness Of Pictorial Health Warning Labels For Indonesia's Cigarette Packages, Dien Anshari
Effectiveness Of Pictorial Health Warning Labels For Indonesia's Cigarette Packages, Dien Anshari
Theses and Dissertations
Pictorial health warning labels (PHWL) on cigarette packaging is a key way to communicate with consumers about the harms from tobacco, particularly in the low- and middle-income countries that do not have the resources for effective mass media campaigns. Research is needed to determine the most effective PHWL content for Indonesia, a country with one of the largest populations of smokers in the world and amongst the weakest tobacco policy environments. This research aimed to determine the most effective PHWL content for Indonesia’s cigarette packages, including the social and psychological factors that may influence PHWL effects.
Data for this study …
Pilot Project To Teach Current And Future Healthcare Professionals How To Address Patients With Health Literacy In Mind.Pdf, Skye Bickett, Christine Willis, Carolann Curry, Tara Douglas-Williams
Pilot Project To Teach Current And Future Healthcare Professionals How To Address Patients With Health Literacy In Mind.Pdf, Skye Bickett, Christine Willis, Carolann Curry, Tara Douglas-Williams
Christine Willis
No abstract provided.
When One Is Sick And Two Need Help: Caregivers’ Perspectives On The Negative Consequences Of Caring, Ilja Ormel, Susan Law, Courtney Abbott, Mark Yaffe, Marc Saint-Cyr, Kerry Kuluski, Debbie Josephson, Ann C. Macaulay
When One Is Sick And Two Need Help: Caregivers’ Perspectives On The Negative Consequences Of Caring, Ilja Ormel, Susan Law, Courtney Abbott, Mark Yaffe, Marc Saint-Cyr, Kerry Kuluski, Debbie Josephson, Ann C. Macaulay
Patient Experience Journal
Informal or family caregivers contribute significantly to individual care, and to the Canadian healthcare system, yet receive limited support from governments, institutions, and healthcare professionals in recognition of their role, or in response to their health and social care needs – often due to the negative consequences of caregiving. Learning about the diversity of others’ experiences can positively influence personal decision-making, reduce feelings of isolation, as well as promote adjustment to a personal situation. For caregivers, however, few resources exist that provide reliable information on others’ experiences. We collected the narratives of caregivers’ experiences of caring for someone with a …
Ludwig's Angina, Tanisha M. Stephens
Ludwig's Angina, Tanisha M. Stephens
Georgia State Undergraduate Research Conference
No abstract provided.
Today - March / April 2017, Loma Linda University Health
Today - March / April 2017, Loma Linda University Health
TODAY
Inside this issue:
- Foundation for hospital construction project starts with 'Big Pour'
- Welcoming Alumni Home (pictorial)
- Homecoming kicks off with 'healthy people' event in healthiest community
- Adventist Church's Health Ministries director challenges alumni's ideas of service
- Research highlights featured during Homecoming weekend (pictorial)
- Homecoming vespers program spotlights history, future of outreach
- Alumni Come Together to Remember
- Loma Linda alumni share their talents
- Prayer Walk offers time for reflection
- Homecoming 5K honors memory of Soret, Schrader
- Black student group honors founder for promoting minority student opportunity
- Neurosurgery professor briefs …
Impact Of Health Policy Changes On Emergency Medicine In Maryland Stratified By Socioeconomic Status, Laura Pimentel, David Anderson, Bruce Golden, Edward Wasil, Fermin Barreuto, Jon M. Hirshon
Impact Of Health Policy Changes On Emergency Medicine In Maryland Stratified By Socioeconomic Status, Laura Pimentel, David Anderson, Bruce Golden, Edward Wasil, Fermin Barreuto, Jon M. Hirshon
Publications and Research
Introduction: On January 1, 2014, the financing and delivery of healthcare in the state of Maryland (MD) profoundly changed. The insurance provisions of the Patient Protection and Affordable Care Act (ACA) began implementation and a major revision of MD’s Medicare waiver ushered in a Global Budget Revenue (GBR) structure for hospital reimbursement. Our objective was to analyze the impact of these policy changes on emergency department (ED) utilization, hospitalization practices, insurance profiles, and professional revenue. We stratified our analysis by the socioeconomic status (SES) of the ED patient population.
Methods: We collected monthly mean data including patient volume, hospitalization percentages, …
Alumni Journal - Volume 88, Number 1, Loma Linda University School Of Medicine
Alumni Journal - Volume 88, Number 1, Loma Linda University School Of Medicine
Alumni Journal, School of Medicine
Features
10 | 85 Years of the Alumni JOURNAL
14 | APC 2017: A Preview
18 | Interview: Brain Surgery to Global Surgery, Walter D. Johnson ’83
26 | Am I My Brother’s Keeper?
Departments
2 | Fron the Editor
3 | This and That
4 | From the President
6 | From the Dean
7 | The Student Fund
8 | School of Medicine News
38 | AIMS Report
40 | Book Review
42 | Alumni News
43 | Placement and Classified Ads
44 | In Memoriam
49 | What's Up Doc?
Extras
3 | New and Upgraded Perpetual …
Teach-Back Method: Improving Health Outcomes, Katherine Smith
Teach-Back Method: Improving Health Outcomes, Katherine Smith
Thinking Matters Symposium Archive
To answer the Clinical PICO question: For patients managing chronic disease, how does the implementation of the teach-back method compared to usual standard of care affect health outcomes? By implementing the teach-back method, we will improve the management of chronic disease in the primary care setting.
Rationale And Study Protocol For The Patient-Centered Outcome Aid (Pcoa) Randomized Controlled Trial: A Personalized Decision Tool For Newly Diagnosed Ovarian Cancer Patients, Lari Wenzel, Dana Mukamel, Kathryn Osann, Laura Havrilesky, Lisa Sparks, Joseph Lipscomb, Alexi A. Wright, Joan Walker, Ronald Alvarez, Linda Van Le, Katina Robison, Robert Bristow, Robert Morgan, Bobbie Rimel, Heather Ladd, Susie Hsieh, Aditi Wahi, David Cohn
Rationale And Study Protocol For The Patient-Centered Outcome Aid (Pcoa) Randomized Controlled Trial: A Personalized Decision Tool For Newly Diagnosed Ovarian Cancer Patients, Lari Wenzel, Dana Mukamel, Kathryn Osann, Laura Havrilesky, Lisa Sparks, Joseph Lipscomb, Alexi A. Wright, Joan Walker, Ronald Alvarez, Linda Van Le, Katina Robison, Robert Bristow, Robert Morgan, Bobbie Rimel, Heather Ladd, Susie Hsieh, Aditi Wahi, David Cohn
Communication Faculty Articles and Research
"The purpose of this study was to develop and test the effectiveness of a Patient-Centered Outcome Aid (PCOA) compared to a control condition of usual care, as patients chose between IV or IP therapy for advanced ovarian cancer. We developed an internet-based decision aid to improve patient-centered outcomes and tested it within a randomized clinical trial. The purpose of this paper is to describe the clinical trial development and protocol."
Lactose Intolerance: An Overview Of The Facts And Their Implications, Noelle M. Yeo
Lactose Intolerance: An Overview Of The Facts And Their Implications, Noelle M. Yeo
Honors Theses
Lactose intolerance is often blamed for the symptoms such as bloating, diarrhea, gas, abdominal pain, and nausea, that ail many people. Patients often do not seek proper diagnosis from a physician and create their own treatment plans, severely restricting lactose intake, without professional guidance. Even those who do seek the care of a physician find that diagnosis is complicated by less-than ideal testing and confusion due to the symptoms common to many other conditions. The misconceptions and inability to confirm a diagnosis of lactose intolerance can cause nutrient deficiencies in these patients, as well as begin a pattern of unnecessary …
Sex-Dependent Effects Of Ho-1 Deletion From Adipocytes In Mice, Peter A. Hosick, Mary Frances Weeks, Michael W. Hankins, Kyle H. Moore, David E. Stec
Sex-Dependent Effects Of Ho-1 Deletion From Adipocytes In Mice, Peter A. Hosick, Mary Frances Weeks, Michael W. Hankins, Kyle H. Moore, David E. Stec
Department of Exercise Science and Physical Education Scholarship and Creative Works
Induction of heme oxygenase-1 (HO-1) has been demonstrated to decrease body weight and improve insulin sensitivity in several models of obesity in rodents. To further study the role of HO-1 in adipose tissue, we created an adipose-specific HO-1 knockout mouse model. Male and female mice were fed either a control or a high-fat diet for 30 weeks. Body weights were measured weekly and body composition, fasting blood glucose and insulin levels were determined every six weeks. Adipocyte-specific knockout of HO-1 had no significant effect on body weight in mice fed a high-fat diet but increased body weight in female mice …