Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (4)
- Microbiology (3)
- Diseases (2)
- Virology (2)
- Anatomy (1)
-
- Bacteria (1)
- Bacteriology (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biotechnology (1)
- Chemistry (1)
- Civil and Environmental Engineering (1)
- Disorders of Environmental Origin (1)
- Engineering (1)
- Engineering Science and Materials (1)
- Environmental Engineering (1)
- Genetics and Genomics (1)
- Immunology and Infectious Disease (1)
- Industrial Technology (1)
- Mechanics of Materials (1)
- Medicinal-Pharmaceutical Chemistry (1)
- Molecular Biology (1)
- Molecular Genetics (1)
- Operational Research (1)
- Operations Research, Systems Engineering and Industrial Engineering (1)
- Other Engineering Science and Materials (1)
- Pathogenic Microbiology (1)
- Keyword
-
- Allostery (1)
- Autoimmune diseases (1)
- Autoimmunity (1)
- COVID-19 pandemic (1)
- Coexpression (1)
-
- Collagen Mimetic Peptides (1)
- Covid-19 (1)
- Dysbiosis (1)
- Hvac (1)
- Hvac Ducts (1)
- Hvac systems (1)
- Hydroxyproline (1)
- IAQ (1)
- Indoor air quality (1)
- Molecular mimicry (1)
- Pathobionts and gut microbiome (1)
- Pathogens (1)
- Post Translational Modifications (1)
- Preventative maintenance (1)
- Prolyl-4-hydroxylase (1)
- Protein flexibility (1)
- Protein structure (1)
- SLE (1)
- Sars-Cov-2 (1)
- Sars-Cov-2 mitigation (1)
- Solvent (1)
- UV (1)
- UV Treatment (1)
- Uv array (1)
- Uv lamps (1)
- Publication Type
- File Type
Articles 1 - 5 of 5
Full-Text Articles in Viruses
Developing Coexpression Systems To Introduce Hydroxyproline Into Protein Engineered Collagen Peptides Utilizing Hydroxylase From Acanthamoeba Polyphaga Mimivirus, Jennifer Soldatich
Developing Coexpression Systems To Introduce Hydroxyproline Into Protein Engineered Collagen Peptides Utilizing Hydroxylase From Acanthamoeba Polyphaga Mimivirus, Jennifer Soldatich
Theses and Dissertations
A major challenge of developing collagen mimetic peptides (CMPs) by bacterial expression is to include hydroxyproline for biomedical applications. Coexpression of Prolyl-4-hydroxylase from A.mimivirus with CMPs was investigated. Additionally, four expression designs were created for potential applications in mammalian cells to utilize their natural ability of proline-hydroxylation by post-translational modification.
The Temperature-Dependent Conformational Ensemble Of Sars-Cov-2 Main Protease (Mpro), Ali Ebrahim, Blake T. Riley, Desigan Kumaran, Babak Andi, Martin R. Fuchs, Sean Mcsweeney, Daniel A. Keedy
The Temperature-Dependent Conformational Ensemble Of Sars-Cov-2 Main Protease (Mpro), Ali Ebrahim, Blake T. Riley, Desigan Kumaran, Babak Andi, Martin R. Fuchs, Sean Mcsweeney, Daniel A. Keedy
Publications and Research
The COVID-19 pandemic, instigated by the SARS-CoV-2 coronavirus, continues to plague the globe. The SARS-CoV-2 main protease, or Mpro, is a promising target for development of novel antiviral therapeutics. Previous X-ray crystal structures of Mpro were obtained at cryogenic temperature or room temperature only. Here we report a series of high-resolution crystal structures of unliganded Mpro across multiple temperatures from cryogenic to physiological, and another at high humidity. We interrogate these datasets with parsimonious multiconformer models, multi-copy ensemble models, and isomorphous difference density maps. Our analysis reveals a temperature-dependent conformational landscape for Mpro, including …
Editorial: Pathogens, Pathobionts, And Autoimmunity, Linda A. Spatz, Gregg J. Silverman, Judith A. James
Editorial: Pathogens, Pathobionts, And Autoimmunity, Linda A. Spatz, Gregg J. Silverman, Judith A. James
Publications and Research
No abstract provided.
Preventing Transmission Of Covid 19 In Hvac Duct Systems: Implementations Of Hvac System Design Upgrade, Jacob S. Lopez, Adama Barro
Preventing Transmission Of Covid 19 In Hvac Duct Systems: Implementations Of Hvac System Design Upgrade, Jacob S. Lopez, Adama Barro
Publications and Research
The recent pandemic outbreak has triggered a global alarm to increase efforts on finding the best methods to mitigate contagious viral pathogens. This project is a continuation of our mission to study engineering guidelines needed to implement upgrades to HVAC Systems in order to deter airborne pathogens such as the covid-19 virus. In our previous projects we researched how covid-19 can possibly flow through the ambient air inside of restaurants, office spaces, and locomotive train cabins. As we continued our research, we were able to find some solutions that will be best used to deactivate and prevent the virus from …
Anomaly Detection In Host Signaling Pathways For The Early Prognosis Of Acute Infection, Kun Wang, Stanley Langevin, Corey S. O'Hern, Mark D. Shattuck, Serenity Ogle, Adriana Forero, Juliet Morrison, Richard Slayden, Michael G. Katze, Michael Kirby
Anomaly Detection In Host Signaling Pathways For The Early Prognosis Of Acute Infection, Kun Wang, Stanley Langevin, Corey S. O'Hern, Mark D. Shattuck, Serenity Ogle, Adriana Forero, Juliet Morrison, Richard Slayden, Michael G. Katze, Michael Kirby
Publications and Research
Clinical diagnosis of acute infectious diseases during the early stages of infection is critical to administering the appropriate treatment to improve the disease outcome. We present a data driven analysis of the human cellular response to respiratory viruses including influenza, respiratory syncytia virus, and human rhinovirus, and compared this with the response to the bacterial endotoxin, Lipopolysaccharides (LPS). Using an anomaly detection framework we identified pathways that clearly distinguish between asymptomatic and symptomatic patients infected with the four different respiratory viruses and that accurately diagnosed patients exposed to a bacterial infection. Connectivity pathway analysis comparing the viral and bacterial diagnostic …