Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Anatomy (2)
- Cell and Developmental Biology (2)
- Genetics and Genomics (2)
- Medical Specialties (2)
- Animal Diseases (1)
-
- Animal Structures (1)
- Animal Studies (1)
- Behavior and Behavior Mechanisms (1)
- Behavior and Ethology (1)
- Behavioral Neurobiology (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biological Psychology (1)
- Cancer Biology (1)
- Cell Biology (1)
- Chemicals and Drugs (1)
- Comparative Psychology (1)
- Computational Biology (1)
- Developmental Biology (1)
- Disease Modeling (1)
- Diseases (1)
- Ecology and Evolutionary Biology (1)
- Embryonic Structures (1)
- Experimental Analysis of Behavior (1)
- Genetics (1)
- Medical Sciences (1)
Articles 1 - 3 of 3
Full-Text Articles in Animals
Regulation Of Müllerian Duct Mesenchyme Transcription During Mammalian Sex Differentiation, Haowen Li, Richard R Behringer, Rachel D Mullen
Regulation Of Müllerian Duct Mesenchyme Transcription During Mammalian Sex Differentiation, Haowen Li, Richard R Behringer, Rachel D Mullen
Dissertations and Theses (Open Access)
Sp7/Osterix (Osx) encodes a zinc-finger transcription factor of the Specificity-protein family discovered by Nakashima et al. at the MD Anderson Cancer Center. While primarily recognized for its role in osteogenesis, Osx has also been implicated in mammalian reproductive development, particularly in male sex differentiation, where Müllerian Duct (MD) regression occurs, mediated by anti-Müllerian hormone (AMH) signaling. AMH-induced regression signals are transduced by the mesenchymal tissue surrounding the ductal structure, known as the Müllerian Duct mesenchyme (MDM). It was discovered that AMH signaling is necessary and sufficient for driving Osx expression in MDM. A previous transgenic mouse reporter …
Investigating Prefrontal Cortex Neuronal Signatures Of Opioid-Induced Risk-Taking Behavior, Cana Quave
Investigating Prefrontal Cortex Neuronal Signatures Of Opioid-Induced Risk-Taking Behavior, Cana Quave
Dissertations and Theses (Open Access)
Opioid use disorder occurs alongside impaired risk-related decision-making, but the underlying neural correlates are unclear. We developed an approach-avoidance conflict task using a modified conditioned place preference procedure to study neural signals of risky opioid seeking in the prefrontal cortex, a region implicated in executive decision-making. Following morphine conditioned place preference, rats underwent a conflict test in which fear-inducing cat odor was introduced in the previously drug-paired side of the apparatus. While the saline-exposed control group avoided cat odor, the morphine group included two subsets of rats that either maintained a preference for the paired side despite the presence of …
The Roles Of Malt1 In Nf-Κb Activation And Solid Tumor Progression, Deng Pan
The Roles Of Malt1 In Nf-Κb Activation And Solid Tumor Progression, Deng Pan
Dissertations and Theses (Open Access)
The transcription factor NF-κB plays a central role in many aspects of biological processes and diseases, such as inflammation and cancer. Although it has been suggested thatNF-κB is critical in tumorigenesis and tumor progression, the molecular mechanism by which NF-κB is activated in solid tumor remains largely unknown. In the current work, we focus on growth factor receptor-induced NF-κB activation and tumor progression, including epidermal growth factor receptor (EGFR)-induced NF-κB in lung cancer and heregulin receptor (HER2)-induced NF-κB in breast cancer. We found that Mucosa-associated lymphoma translocation protein 1 (MALT1), also known as paracaspase, is required for EGFR-induced NF-κB activation …