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Full-Text Articles in Animals
Estradiol Signaling Improves Extinction Memory Recall To Combat Cue-Induced Heroin Relapse In Rats, Jordan S. Carter
Estradiol Signaling Improves Extinction Memory Recall To Combat Cue-Induced Heroin Relapse In Rats, Jordan S. Carter
MUSC Theses and Dissertations
We are in the midst of an opioid use disorder (OUD) epidemic. While several treatments mitigate a range of factors contributing to return to use, or relapse, the power of drug-conditioned environmental cues to precipitate relapse have not been adequately addressed. One treatment modality targeting cue reactivity, cue exposure therapy (CET), exacerbated relapse in individuals with OUD, perhaps due to a deficit in extinction memory recall (EMR). Here, EMR is the ability to override the drug-cue association and prevent relapse. Interest remains in combatting cue-induced relapse, potentially by introducing a pharmacologic adjunct with CET to enhance EMR. In the following …
A Paraventricular Thalamo-Accumbal Circuit Necessary For Behavioral Inhibition Is Dysfunctional During Opioid Use And Dependence, Kelsey M. Vollmer
A Paraventricular Thalamo-Accumbal Circuit Necessary For Behavioral Inhibition Is Dysfunctional During Opioid Use And Dependence, Kelsey M. Vollmer
MUSC Theses and Dissertations
Suppression of dangerous or inappropriate reward-motivated behaviors is critical for survival, whereas therapeutic or recreational opioid use can unleash detrimental behaviors and opioid use disorder (OUD). Nevertheless, the neuronal systems that suppress maladaptive motivated behaviors remain unclear, and whether opioids disengage those systems is unknown. Here, we investigate the posterior paraventricular thalamus (pPVT) as a behavioral mediator due to its strong connectivity with brain structures important for reward processing, such as the nucleus accumbens (NAc). We and others have found pPVT-NAc neuronal activity is inhibited during reward seeking, but activated when such behaviors would be inappropriate, such as during stress …