Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Animal Experimentation and Research (2)
- Life Sciences (2)
- Research Methods in Life Sciences (2)
- Small or Companion Animal Medicine (2)
- Veterinary Medicine (2)
-
- Animal Sciences (1)
- Animal Studies (1)
- Business (1)
- Comparative and Laboratory Animal Medicine (1)
- Laboratory and Basic Science Research (1)
- Medical Sciences (1)
- Medical Specialties (1)
- Musculoskeletal, Neural, and Ocular Physiology (1)
- Ophthalmology (1)
- Other Animal Sciences (1)
- Other Business (1)
- Other Pharmacy and Pharmaceutical Sciences (1)
- Other Veterinary Medicine (1)
- Pharmacy and Pharmaceutical Sciences (1)
- Social and Behavioral Sciences (1)
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Organisms
An Analysis Of The Use Of Dogs In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls
An Analysis Of The Use Of Dogs In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls
Jarrod Bailey, PhD
Dogs remain the main non-rodent species in preclinical drug development. Despite the current dearth of new drug approvals and meagre pipelines, this continues, with little supportive evidence of its value or necessity. To estimate the evidential weight provided by canine data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive dataset of 2,366 drugs with both animal and human data, including tissue-level effects and Medical Dictionary for Regulatory Activities (MedDRA) Level 1–4 biomedical observations. The resulting LRs show that the absence of toxicity in dogs provides virtually no …
Molecular Mechanisms Of Suberoylanilide Hydroxamic Acid In The Inhibition Of Tgf-Β1-Mediated Canine Corneal Fibrosis, Kristina M. Gronkiewicz, Elizabeth A. Giuliano, Ajay Sharma, Rajiv R. Mohan
Molecular Mechanisms Of Suberoylanilide Hydroxamic Acid In The Inhibition Of Tgf-Β1-Mediated Canine Corneal Fibrosis, Kristina M. Gronkiewicz, Elizabeth A. Giuliano, Ajay Sharma, Rajiv R. Mohan
Pharmacy Faculty Articles and Research
Objective—To investigate molecular mechanisms mediating anti-fibrotic effect of SAHA in the canine cornea using an in vitro model. We hypothesized that SAHA attenuates corneal fibrosis by modulating Smad-dependent and, to a lesser extent, Smad-independent signaling pathways activated by TGF-β1, as well as matrix metalloproteinase (MMP) activity.
Methods—Cultured canine corneal fibroblasts (CCF) were incubated in the presence/absence of TGF-β1 (5ng/ml) and SAHA (2.5μM) for 24hrs. Western blot analysis was used to quantify non-phosphorylated and phosphorylated isoforms of Smad2/3, p38 MAP kinase (MAPK), ERK1/2 and JNK1. Real-time PCR and zymography were utilized to quantify MMP1, MMP2, MMP8 and MMP9 mRNA expression and …
A Study Of The Nutritional Effect Of Grains In The Diet Of A Dog, Kristyn M. Souliere
A Study Of The Nutritional Effect Of Grains In The Diet Of A Dog, Kristyn M. Souliere
Honors College
The present study was designed to address the prevalence of the lack of knowledge for what owners are feeding their dogs, and to determine if grain should be within the diet. It was hypothesized that a bag of feed containing protein at no specific level, with a low level of grain will be more beneficial for the animal, and that a diet needs to contain grains. The crude protein, crude fat, and first five ingredients listed were compared for four bags chosen, and to the nutritional requirements for a dog. “Holistic Blend Grain Free”, contained an extremely high amount of …