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Articles 1 - 6 of 6
Full-Text Articles in Organisms
Elucidating The Impact Of Sos-Response Timing In On Escherichia Coli Survival Following Treatment With Fluoroquinolone Topoisomerase Inhibitors, Stephanie Schofield
Elucidating The Impact Of Sos-Response Timing In On Escherichia Coli Survival Following Treatment With Fluoroquinolone Topoisomerase Inhibitors, Stephanie Schofield
Honors Scholar Theses
Antibiotic treatment failure is a public health crisis, with a 2019 report stating that roughly 35,000 deaths occur in the United States yearly due to bacterial infections that are unresponsive to antibiotics (1). One complication in the treatment of bacterial infection is antibiotic persistence which further compromises our battle to effectively treat infection. Bacterial persisters can exist in clonal bacterial cultures and can tolerate antibiotic treatment by undergoing reversible phenotypic changes. They can survive drug concentrations that their genetically identical kin cannot. Some persisters remain in a slow growing state and are difficult to target with current antibiotics. A specific …
A Dna-Peptide Crosslink (Dpc) Increases Mutagenicity In Sos-Induced Escherichia Coli, Alessandra Bassani
A Dna-Peptide Crosslink (Dpc) Increases Mutagenicity In Sos-Induced Escherichia Coli, Alessandra Bassani
Honors Scholar Theses
Bacteria, such as Escherichia coli, have an inducible system in response to DNA damage termed the SOS response. This system is activated when the replicative DNA polymerase (Pol) III encounters a lesion, uncouples from DNA helicase, and single-stranded DNA (ssDNA) accumulates at the replication fork. In this study, we investigated DNA-peptide crosslink (DpC), a common lesion that results from cross-linking of proteins or peptides, UV irradiation, and alkylating agents. To increase survival following formation of a lesion, the SOS response can utilize homologous recombination, translesion synthesis (TLS), or excision repair. With TLS, the levels of DNA Pol II, IV, …
Using Citizen Science To Determine The Age Of Alewife Fish, Rodchill-Paul Jules
Using Citizen Science To Determine The Age Of Alewife Fish, Rodchill-Paul Jules
Honors Scholar Theses
Aging scales of economically important fish like the Alewife (Alosa pseudoharengus) is a critical task in the fisheries industry, which can benefit from the help that citizen science offers. In order for those benefits to take effect, common people should be comfortable and fairly knowledgeable about what is expected of them in the study. Then, results can be generated in a way that gives all types of citizens a good opportunity to participate and produces reliable data that can be used for scientific purposes. This experiment studied the effects of simple word instructions versus diagramed instructions on the …
Lymphoid Hematopoiesis And The Role Of B-Cells In Transgenic Mouse Model Of Sickle Cell Disease, Christina Cotte
Lymphoid Hematopoiesis And The Role Of B-Cells In Transgenic Mouse Model Of Sickle Cell Disease, Christina Cotte
University Scholar Projects
Sickle cell disease (SCD) has been shown to be associated with decreased baseline immunity and thus increased susceptibility to infection. I sought to discern possible causes of this by looking into the correlations between SCD and hematopoiesis, the immune system and the neuroendocrine system, and ultimately by conducting experiments surrounding the impaired immune system of SCD. These experiments focused on the potential causes and effects of the diminution of B-1a cells in the SCD spleen. Adoptive transfers, infections with Streptococcus pneumoniae, and histologic imaging were conducted to establish if the diminution of the B-1a cells in the SCD spleen …
A Preliminary Study On The Role Of Enhancer Of Flavonoid Production (Efp) In Flavonoid Biosynthesis, Jia Guo
A Preliminary Study On The Role Of Enhancer Of Flavonoid Production (Efp) In Flavonoid Biosynthesis, Jia Guo
Honors Scholar Theses
Flavonoids are involved in a variety of biological roles ranging from pathogen protection, pigment intensity, antioxidant effects, and even prevention from cancer or cardiovascular diseases. Because of the diverse and beneficial functions that flavonoids have, the flavonoid biosynthetic pathway has been well studied. Recently, a gene called the Enhancer of Flavonoid Production (EFP) was discovered when mutations in this gene caused the Japanese morning glory flowers to exhibit a pale-colored phenotype. Although EFP is known to increase flavonoid production, the direct mechanism to how EFP enhances enzymes in the flavonoid biosynthetic pathway has yet to be discovered. It …
Programming Heart Disease: Does Poor Maternal Nutrition Alter Expression Of Cardiac Markers Of Proliferation, Hypertrophy, And Fibrosis In Offspring?, Cathy Chun
Honors Scholar Theses
Maternal malnutrition can affect fetal organogenesis, metabolic processes, and factors involved in developmental regulation. Of the many physiological effects poor maternal nutrition can induce in offspring, one of the most important organs affected is the heart. Cardiovascular disease has been associated with poor maternal diet. It also been suggested that hypertension can originate during impaired intrauterine growth and development. Hypertension can trigger hypertensive heart disease and is associated with numerous heart complications. We hypothesized that poor maternal nutrition would alter critical growth factors associated with normal heart development, specifically, insulin-like growth factor (IGF)-1, IGF-2, transforming growth factor (TGF)β, and connective …