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University of Central Florida

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Full-Text Articles in Organisms

From Bloom To Bust: Harmful Algae Blooms And Their Impacts On The Waterfront Economy, Sergio Alvarez Jul 2021

From Bloom To Bust: Harmful Algae Blooms And Their Impacts On The Waterfront Economy, Sergio Alvarez

Rosen Research Review

The true costs of harmful algae blooms (HABs) and the mechanics that determine their socio-economic impacts are for the most part unknown. Florida’s 2017–2019 red tide (Karenia brevis) bloom is a historical case study of the ever-growing threats to coastal welfare posed by HABs. A new research project at Rosen College of Hospitality Management has this at its heart. The central objective of the project is the identification of direct, indirect, and induced socioeconomic impacts caused by the 2017–2019 K. brevis bloom in Florida.


Valuing The Negative Impacts Of Harmful Algae Blooms, Sergio Alvarez Jul 2021

Valuing The Negative Impacts Of Harmful Algae Blooms, Sergio Alvarez

Rosen Research Review

Ecological disturbances can impact several ecosystem services, including cultural services such as outdoor recreation opportunities. In Florida, one ecological disturbance that is negatively impacting recreation is the occurrence of harmful algae blooms. In recent work, Dr. Sergio Alvarez at UCF Rosen College of Hospitality Management has assessed the impact that harmful algae blooms have on human wellbeing by using random utility models to estimate changes in the value of recreation in coastal ecosystems resulting from these blooms. The results indicate that harmful algae blooms, which reduced boating access between June and September 2018, may have resulted in losses of up …


Bacterial Association Networks From Healthy And Cancer-Associated Gut Microbiomes, Mark Loftus Jan 2021

Bacterial Association Networks From Healthy And Cancer-Associated Gut Microbiomes, Mark Loftus

Electronic Theses and Dissertations, 2020-

The human gastrointestinal tract is colonized by a diverse community of symbiotic microorganisms, mainly bacteria, that are known to play essential roles in maintaining the health of their human host. Disruption of this bacterial community has been associated with numerous diseases, including Colorectal Cancer (CRC). CRC is one of the leading causes of cancer-related deaths worldwide. As such, focus has been placed on the modulation of the bacterial community within the cancer-associated gut microbiome as the next step in possible CRC treatment and prevention strategies. To use the bacterial community for these purposes, a better understanding of the associations that …


Characterization Of The Physical And Chemical Effect Of Membrane Disruption And Protein Inhibiting Treatments On E. Coli, Khadijah Wright Jan 2020

Characterization Of The Physical And Chemical Effect Of Membrane Disruption And Protein Inhibiting Treatments On E. Coli, Khadijah Wright

Honors Undergraduate Theses

The increase in antibacterial resistance has placed the issue of microbial multi-drug resistance on a global stage (Gurunathan, 2019). This issue poses a threat to human and animal health as well as to the environment (Aslam et al., 2018). It affects not only the efficacy of treatment but also how those treatments are conducted (Friedman, Temkin, & Carmeli, 2016). As a result of this ongoing threat, new treatments that have potent effects on bacteria are necessary. One scientific response to this issue has been the development of multifunctional nanoparticles (NPs)(H. Wang et al., 2018). NPs have the ability to be …


Studies Of Norspermidine Uptake In Drosophila Suggest The Existence Of Multiple Polyamine Transport Pathways, Michael Dieffenbach Jan 2018

Studies Of Norspermidine Uptake In Drosophila Suggest The Existence Of Multiple Polyamine Transport Pathways, Michael Dieffenbach

Honors Undergraduate Theses

Polyamines are a class of essential nutrients involved in many basic cellular processes such as gene expression, cell proliferation, and apoptosis. Without polyamines, cell growth is delayed or halted. Cancerous cells require an abundance of polyamines through a combination of synthesis and transport from the extracellular environment. An FDA-approved drug, D,L-α-difluoromethylornithine (DFMO), blocks polyamine synthesis but is ineffective at inhibiting cell growth due to polyamine transport. Thus, there is a need to develop drugs that inhibit polyamine transport to use in combination with DFMO. Surprisingly, little is known about the polyamine transport system in humans and other eukaryotes. Understanding the …


The Effect Of Mismatch Primers On The Efficiency Of Amplification In Quantitative Polymerase Chain Reactions, Molly C. Dawkins Jan 2018

The Effect Of Mismatch Primers On The Efficiency Of Amplification In Quantitative Polymerase Chain Reactions, Molly C. Dawkins

Honors Undergraduate Theses

Polymerase chain reaction (PCR) is a method used in many research protocols to amplify a small amount of a short segment of DNA to millions of copies. PCR is used for many taxonomic studies, as well as for some medical diagnostic procedures. Through PCR, short DNA primers bind to the template DNA to allow the thermostable DNA polymerase to copy the DNA. Often, researchers create universal primers to target a conserved region of DNA in multiple species, for example, the 16S rRNA gene in bacteria. The problem with these universal primers is that they do not always perfectly match the …


An Rnai Screen To Identify Components Of A Polyamine Transport System, Adam J. Foley Jan 2017

An Rnai Screen To Identify Components Of A Polyamine Transport System, Adam J. Foley

Honors Undergraduate Theses

Polyamines, specifically putrescine, spermidine, and spermine, are small cationic molecules found in all organisms. Cells can biosynthetically make these molecules, or alternatively, they can be transported from the extracellular environment. Malignant cells have been shown to require relatively high amounts of polyamines. There is a chemotherapeutic agent, DFMO, used to block the biosynthesis of polyamines. Many malignant cells can circumvent DFMO therapy by activating their transport system. A potential solution is to simultaneously block biosynthesis and transport of polyamines. However, little is known about the polyamine transport system in higher eukaryotes.

This thesis aims to add to the basic biological …


Expression Levels Of Virulence Genes In Group A Streptococci: A Response To Aerosolized Propylene Glycol, Michael S. Costello Jan 2016

Expression Levels Of Virulence Genes In Group A Streptococci: A Response To Aerosolized Propylene Glycol, Michael S. Costello

Honors Undergraduate Theses

Electronic cigarette usage is becoming increasingly prevalent among school age children and young adults. A known bactericidal agent, propylene glycol, is often used as a carrier for nicotine, flavoring, and additional constituents of electronic cigarette juice. This study examined the relationship between propylene glycol and virulence gene expression in Streptococcus pyogenes, a respiratory tract pathogen commonly found in school-age individuals. A variety of virulence genes controlled by the three stand alone regulators mga, RofA, and Rgg/RopB were sampled in an effort to understand the pathway by which virulence is affected. The genes chosen encode C5a peptidase, fibronectin binding protein, hyaluronate …