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Full-Text Articles in Organisms
Tracking The Source Of Helicobacter Pylori In Watersheds Of San Juan, Puerto Rico, Mary Elizabeth Sailors
Tracking The Source Of Helicobacter Pylori In Watersheds Of San Juan, Puerto Rico, Mary Elizabeth Sailors
Biology Theses
Helicobacter pylori is a pathogenic bacterium that infects more than half of the world’s population. The large number of H. pylori infections in Puerto Rico could be related to the waterborne transmission of the pathogen. While the San Juan Bay Estuary (SJBE) system is home to over three million people, water quality studies in this area of Puerto Rico are lacking. The goal of this study is to determine seasonal and yearly (2020-2021) shifts and relationships between the presence of H. pylori and host-specific (human and dog) Bacteroides in streams that flow through the northern coastal zone of Puerto Rico …
Interactions Of Francisella Tularensis With Components Of The Host Fibrinolytic System, Shawn Russell Clinton
Interactions Of Francisella Tularensis With Components Of The Host Fibrinolytic System, Shawn Russell Clinton
Theses and Dissertations (ETD)
Francisella tularensis (FT) is a Gram-negative coccobacillus and causative agent of a life-threatening disease commonly referred to as tularemia. Due to the highly infectious nature of the organism, its previous development as a biowarfare agent and its potential use in acts of bioterrorism, this bacterium is listed as a Category A select agent by the Centers for Disease Control and Prevention (CDC). Efforts to understand the pathogenic mechanisms of FT within the host environment are vital for the development of safe and effective vaccines, as well as treatments, against tularemia. Though considered an intracellular pathogen, FT research of late has …
Downstream Pathway Activation In Cultured Hepatocytes Following Treatment With Francisella Tularensis, Nicole Wakefield
Downstream Pathway Activation In Cultured Hepatocytes Following Treatment With Francisella Tularensis, Nicole Wakefield
Undergraduate Theses and Capstone Projects
Francisella tularensis, the intracellular pathogen that causes tularemia, was investigated to determine how it infects and replicates within mammalian hepatocytes. To date, it has been shown that hepatocytes can be infected by F. tularensis and that this causes considerable change in the protein phosphorylation state of several vital signaling molecules within the host cell. Protein kinase pathways can be mapped as signatures of infection. Hepatocytes tend to be susceptible to infection by F. tularensis, thus stimulating internal signaling. The Francisella strains used were selected with the goal of producing a model that can be used to elucidate the cell signaling …