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Articles 541 - 570 of 1686
Full-Text Articles in Nursing
Benefits Of Rooming-In On Infants With Neonatal Opioid Withdrawal Syndrome, Emma Ricioli
Benefits Of Rooming-In On Infants With Neonatal Opioid Withdrawal Syndrome, Emma Ricioli
Nursing | Student Research Posters
Neonatal opioid withdrawal syndrome (NOWS) is a significant public health concern, affecting infants born to mothers who use opioids during pregnancy. Those exposed in-utero exhibit numerous signs of withdrawal after delivery including tremors, gastrointestinal distress, inconsolability, and poor feeding. Typical treatment for infants suffering from NOWS included direct admission to the neonatal intensive care unit (NICU) for close observation and pharmacological interventions. However, NICU stays can interfere with bonding and breastfeeding. They can also lead to increased lengths of stay, higher costs, and more invasive pharmacological treatments. These infants typically do not have any other concerning health issues besides NOWS …
The Effect Of Delivery Method On Breastfeeding Initiation And Duration, Mariana Carina Benitez
The Effect Of Delivery Method On Breastfeeding Initiation And Duration, Mariana Carina Benitez
Nursing | Student Research Posters
There is a plethora of research focusing on the physical effects of each delivery method on a mother’s ability to initiate and sustain breastfeeding, however, there may be more psychosocial factors that influence a mothers decision to start and continue breastfeeding once they deliver. It is very common to be educated about breastfeeding after the baby has already been delivered, but it is often missed that education before may improve breastfeeding rates and increase mothers' breastfeeding self-efficacy rates. The primary purpose of this project is to evaluate the effectiveness of breastfeeding support groups that provide information, guidance, and social support …
Maternal Postnatal Depressive Symptoms And Its Effects On Infant Bonding, Tammy Nguyen
Maternal Postnatal Depressive Symptoms And Its Effects On Infant Bonding, Tammy Nguyen
Nursing | Student Research Posters
The objective of this thesis is to gain insight on precipitating factors that increase postpartum mother’s depressive symptoms, including stress and anxiety, and how attachment is influenced. Maternal-infant bonding is defined as the emotional relationship and interaction between mother and infant. Postnatal depressive symptoms typically are under-diagnosed due to a lack of education and the stigma of believing that the effects are “normal” consequences of motherhood. Those affected may not seek professional help. Unrealistic expectations about bonding with their infants can have a negative mental health impact on mothers and influence infants’ behaviors. High expectations of needing to be a …
How Implicit Bias Leads To Racial Disparities In Maternal Care And Experiences, Mia Yee
How Implicit Bias Leads To Racial Disparities In Maternal Care And Experiences, Mia Yee
Nursing | Student Research Posters
Background: Maternal mortality rates have decreased all over the world. However, in the United States, the maternal mortality rate has been steadily increasing. Women of color reportedly are forced to accept the burden of an unequal association between race and morbidity & mortality due to implicit discriminatory attitudes of healthcare professionals. Objective: To better understand the relationship between implicit bias and maternal care in the San Francisco Bay Area between non-Hispanic White & Black women and to explore racial disparities in their maternal narratives. A literature review was performed and a study is proposed. Future Directions: To Identify the differences …
Evidence-Based Change To Address Newborn Pain During Painful Procedures, Amy M. Hines
Evidence-Based Change To Address Newborn Pain During Painful Procedures, Amy M. Hines
MSN Capstone Projects
This evidenced-based practice project sought to provide evidence to change a hospital policy on addressing pain during painful procedures on newborns with the use of nonpharmacological interventions. A literature search was conducted on three databases: PubMed, Cumulated Index to Nursing and Allied Health Literature, and Cochrane. Twelve pieces of literature were included: nine randomized control trials, one systemic review, one meta-analysis, and one correlational study. The literature reviewed showed a strong positive correlation between using nonpharmacological interventions and lower pain scores of newborns during painful procedures.
Making Breastfeeding Easier With Clinician Support, Katherine Laney
Making Breastfeeding Easier With Clinician Support, Katherine Laney
MSN Capstone Projects
This benchmark project provides a template for how to implement clinician support and education in an organization with obstetric and pediatric clinics and a hospital based on the PICOT: In first-time breastfeeding mothers (P), how does clinician driven support and education during the perinatal period (I) compared to no clinician assistance (C) affect the rate of continued breastfeeding (O) within the first 3 months postpartum (T). Research demonstrates that increased clinician support and education provided to the mothers during the perinatal period increases breastfeeding rates and self-efficacy. The project would initially last for approximately 12 weeks and follow women from …
Developing A Pediatric Weight Management Program In Primary Care, Alyssa Bosse
Developing A Pediatric Weight Management Program In Primary Care, Alyssa Bosse
Masters Theses/Capstone Projects
The practicum was completed at Central Ohio Primary Care Physicians (COPC), a large group of physician owned primary care practices. COPC would like to start a program for pediatric weight management utilizing their three pediatric Registered Dietitian Nutritionists (RDNs). The first step was collecting data to see any improvements that are needed from the current nutrition program. The second step was reviewing the literature on pediatric weight management to ensure the new program is evidenced-based. All steps were evaluated by COPC leadership and collaborated with internal company resources.
Structural Foundations Of Potassium Selectivity In Channelrhodopsins, Sukyeong Lee, Sang Bum Lee, Nuri Sung, Wendy W Xu, Changsoo Chang, Hyun-Eui Kim, Andre Catic, Francis T F Tsai
Structural Foundations Of Potassium Selectivity In Channelrhodopsins, Sukyeong Lee, Sang Bum Lee, Nuri Sung, Wendy W Xu, Changsoo Chang, Hyun-Eui Kim, Andre Catic, Francis T F Tsai
Faculty, Staff and Student Publications
Mitochondria are critical to cellular and organismal health. To prevent damage, mitochondria have evolved protein quality control machines to survey and maintain the mitochondrial proteome. SKD3, also known as CLPB, is a ring-forming, ATP-fueled protein disaggregase essential for preserving mitochondrial integrity and structure. SKD3 deficiency causes 3-methylglutaconic aciduria type VII (MGCA7) and early death in infants, while mutations in the ATPase domain impair protein disaggregation with the observed loss-of-function correlating with disease severity. How mutations in the non-catalytic N-domain cause disease is unknown. Here, we show that the disease-associated N-domain mutation, Y272C, forms an intramolecular disulfide bond with Cys267 and …
Enhanced Discharge Preparation To Decrease Discharge Delays: A Quality Improvement Project, Angela Graham
Enhanced Discharge Preparation To Decrease Discharge Delays: A Quality Improvement Project, Angela Graham
Graduate Theses, Dissertations, and Capstones
Increased length of stay (LOS) is a focus in hospitals as it has implications for decreased quality of care, increased cost of care, and results in care delays for other patients (Rojas-Garcia et al., 2018). LOS is a measure of a hospital’s efficiency and throughput, which is the process of admitting, treating, and discharging patients. Micallef et al. (2020) found a longer LOS can occur from having extra days due to inefficiency in delivering care or from delays in discharge once the patient no longer needs acute care. The longer a patient stays in the hospital, the greater the risk …
The Importance Of Educating Adolescent Mothers In The Postpartum Period, Sydney Price, Madelyn Travis, Reagan Schwable
The Importance Of Educating Adolescent Mothers In The Postpartum Period, Sydney Price, Madelyn Travis, Reagan Schwable
Scholars Week
Due to the lack of policy or procedure for individualized education for adolescent mothers, we concluded that a educational checklist in the charting system would be the most effective way to properly educate young mothers during this confusing stage in their life. Specific education helps to improve perceived quality of care, safety/wellbeing in the young mother and newborn, and reducing the risks of complications such as postpartum depression or issues with pregnancy later on. In summary, ensuring that teenage mothers are fully educated before discharge will provide for better mother and baby outcomes.
Sterile Tubing Changes To Prevent Clabsis In The Nicu, Rachel Janson, Megan Meyer
Sterile Tubing Changes To Prevent Clabsis In The Nicu, Rachel Janson, Megan Meyer
Nursing Posters
Purpose Statement:
NICU patients have a decreased risk of CLABSI infections when two-person sterile central line changes are implemented into central line maintenance bundles compared to bundles that only use one-person clean line change techniques.
Background:
Neonates admitted to the neonatal care intensive care unit (NICU) often require the placement of central lines for the administration of medications, fluids, parental nutrition, and hemodynamic monitoring. Despite their many advantages, central lines can lead to serious infections, known as cental line associated bloodstream infections (CLABSI). These infections are not related to an infection from another site and develop within forty-eight hours of …
The Lived Experiences Of Icu, Med-Surg, And Er Nurses In The United States Attempting To Breastfeed During The Covid-19 Pandemic, Amy Seay
Dissertations
Breastfeeding is important to promote the health of both mothers and babies (Centers for Disease Control and Prevention [CDC], 2021). Many mothers experience workplace barriers and stress which negatively impact breastfeeding duration (McCardel & Padilla, 2020; Nagel et al., 2022). However, a gap in the literature exists surrounding specific barriers and the impact of stress on U.S. nurses who breastfeed. Specifically, workplace challenges and stress among nurses resulting from the COVID-19 pandemic lack exploration.
This interpretive phenomenological study explored the lived experiences of ICU, Med-Surg, and ER nurses who attempted to breastfeed during the COVID-19 pandemic. Roy’s adaptation model was …
Implementing Team Birth To Improve Patient Satisfaction On An Ldrp (Team Birthsingleroom ) Unit, Deanna Higgins, Alyson Willard, Teresa Rangel
Implementing Team Birth To Improve Patient Satisfaction On An Ldrp (Team Birthsingleroom ) Unit, Deanna Higgins, Alyson Willard, Teresa Rangel
Articles, Abstracts, and Reports
No abstract provided.
Kangaroo Care Education For Low Socioeconomic Status Families In The Neonatal Care Unit, Joara Peterson
Kangaroo Care Education For Low Socioeconomic Status Families In The Neonatal Care Unit, Joara Peterson
Nursing | Student Research Posters
The early contact between mother and baby is known as skin-to-skin, also referred to as “kangaroo care” (KC). It involves placing the baby on the mother’s chest as soon as it is appropriate (Thompson, 1979). This interaction was primarily for bonding but many researchers have discovered additional benefits. There is significant correlation between kangaroo care and weight gain (especially for low birth weight infants), as well as body temperature and heart rate regulation, which reduces the risk of medical complications. It also decreases levels of stress in mothers and babies by lowering the release of cortisol hormone (Mohammadi et al. …
Child Abuse From A Nursing Perspective: Assessment And Implications, Ashtyn Spring
Child Abuse From A Nursing Perspective: Assessment And Implications, Ashtyn Spring
Senior Honors Theses
Nurses experience the relationship dynamics between pediatric patients and their families firsthand. Being informed by the goals of holistic care, nurses should be assessing for unhealthy dynamics among pediatric patients and their caregivers so they can respond appropriately when a potential for abuse is present. Healthcare workers have the duty to provide safety and healing to their patients. Through the unique contact nurses have with patients, their training for accurate assessment skills, and their responsibility as healthcare workers, nurses are placed with the opportunity to help children out of abusive situations. Prompt identification of the potential for abuse can prevent …
Nurses' Preparedness For Disaster Response In Rural And Urban Primary Healthcare Settings In Tanzania, Kahabi Isangula, Mary Lyimo, Yudas Ndungile, Elisha Robert
Nurses' Preparedness For Disaster Response In Rural And Urban Primary Healthcare Settings In Tanzania, Kahabi Isangula, Mary Lyimo, Yudas Ndungile, Elisha Robert
School of Nursing & Midwifery, East Africa
Introduction: Nurses are often on the frontline of disaster management, providing care to patients with emerging physical, mental, and emotional turbulence, and acting as educators for health promotion and disaster prevention in both rural and urban contexts. However, the literature suggests that nurses are inadequately prepared for disaster response. This study examined preparedness for disaster response among nurses in rural and urban primary healthcare settings in Tanzania.
Methods: This qualitative descriptive study involved purposefully selected qualified nurses and nurse administrators working in rural (n=20) and urban (n=11) primary healthcare facilities in Tanzania. Telephone-based interviews were conducted to gather …
The Positive Effects Of Delayed Immersion Bathing For Newborns, Aubrey Stuart
The Positive Effects Of Delayed Immersion Bathing For Newborns, Aubrey Stuart
Scholars Week
Problem: Newborn infants were once bathed only 2-4 hours after birth. The rate at which newborns experienced hypothermia, hypoglycemia, and a difficulty with exclusive breastfeeding was once much higher than it is today.
Methods: This project was a meta-analysis of multiple clinical trials regarding delayed infant bathing. Three main studies that implemented a 24 hour or later bathing program were chosen and reviewed to assess for trends in hypothermia, hypoglycemia, and the exclusive breastfeeding rates of newborns.
Results: In each study reviewed, the rates of hypoglycemia and hypothermia decreased while the rates of exclusive breastfeeding increased.
Implications: By delaying newborn …
Differences In Birth Weight Between Immigrants' And Natives' Children In Europe And Australia: A Lifecycle Comparative Observational Cohort Study, Sandra Florian, Mathieu Ichou, Lidia Panico, Stéphanie Pinel-Jacquemin, Tanja G. M. Vrijkotte, Margreet W. Harskamp-Van Ginkel, Rae-Chi Huang, Jennie Carson, Loreto Santa Marina Rodriguez, Mikel Subiza-Pérez, Martine Vrijheid, Sílvia Fernández-Barrés, Tiffany C. Yang, John Wright, Eva Corpeleijn, Marloes Cardol, Elena Isaevska, Chiara Moccia, Marjolein N. Kooijman, Ellis Voerman, Vincent Jaddoe, Marieke Welten, Elena Spada, Marisa Rebagliato, Andrea Beneito, Luca Ronfani, Marie-Aline Charles
Differences In Birth Weight Between Immigrants' And Natives' Children In Europe And Australia: A Lifecycle Comparative Observational Cohort Study, Sandra Florian, Mathieu Ichou, Lidia Panico, Stéphanie Pinel-Jacquemin, Tanja G. M. Vrijkotte, Margreet W. Harskamp-Van Ginkel, Rae-Chi Huang, Jennie Carson, Loreto Santa Marina Rodriguez, Mikel Subiza-Pérez, Martine Vrijheid, Sílvia Fernández-Barrés, Tiffany C. Yang, John Wright, Eva Corpeleijn, Marloes Cardol, Elena Isaevska, Chiara Moccia, Marjolein N. Kooijman, Ellis Voerman, Vincent Jaddoe, Marieke Welten, Elena Spada, Marisa Rebagliato, Andrea Beneito, Luca Ronfani, Marie-Aline Charles
Research outputs 2022 to 2026
Objective:
Research on adults has identified an immigrant health advantage, known as the 'immigrant health paradox', by which migrants exhibit better health outcomes than natives. Is this health advantage transferred from parents to children in the form of higher birth weight relative to children of natives?
Setting:
Western Europe and Australia.
Participants:
We use data from nine birth cohorts participating in the LifeCycle Project, including five studies with large samples of immigrants' children: Etude Longitudinale Française depuis l'Enfance - France (N=12 494), the Raine Study - Australia (N=2283), Born in Bradford - UK (N=4132), Amsterdam Born Children and their Development …
Effect Of Antenatal Milk Expression Education On Lactation Outcomes In Birthing People With Pre-Pregnancy Body Mass Index ≥ 25: Protocol For A Randomized, Controlled Trial, Jill R. Demirci, Melissa Glasser, Debra L. Bogen, Susan M. Sereika, Dianxu Ren, Kristin Ray, Lisa M. Bodnar, Therese A. O'Sullivan, Katherine Himes
Effect Of Antenatal Milk Expression Education On Lactation Outcomes In Birthing People With Pre-Pregnancy Body Mass Index ≥ 25: Protocol For A Randomized, Controlled Trial, Jill R. Demirci, Melissa Glasser, Debra L. Bogen, Susan M. Sereika, Dianxu Ren, Kristin Ray, Lisa M. Bodnar, Therese A. O'Sullivan, Katherine Himes
Research outputs 2022 to 2026
Background: Birthing people with pre-pregnancy body mass indices (BMIs) ≥ 25 kg/m2, particularly those without prior breastfeeding experience, are at increased risk for suboptimal lactation outcomes. Antenatal milk expression (AME) may be one way to counteract the negative effects of early infant formula supplementation common in this population. Methods: This ongoing, randomized controlled trial in the United States evaluates the efficacy of a telelactation-delivered AME education intervention versus an attention control condition on lactation outcomes to 1 year postpartum among 280 nulliparous-to-primiparous, non-diabetic birthing people with pre-pregnancy BMI ≥ 25 kg/m2. The assigned study treatment is delivered via four weekly …
A National, Electronic Health Record-Based Study Of Perinatal Hemorrhagic And Ischemic Stroke, Stuart Fraser, Samantha M Levy, Yashar Talebi, Sean I Savitz, Alicia Zha, Gen Zhu, Hulin Wu
A National, Electronic Health Record-Based Study Of Perinatal Hemorrhagic And Ischemic Stroke, Stuart Fraser, Samantha M Levy, Yashar Talebi, Sean I Savitz, Alicia Zha, Gen Zhu, Hulin Wu
Faculty, Staff and Student Publications
BACKGROUND: Perinatal stroke occurs in approximately 1 in 1100 live births. Large electronic health record (EHR) data can provide information on exposures associated with perinatal stroke in a larger number of patients than is achievable through traditional clinical studies. The objective of this study is to assess prevalence and odds ratios of known and theorized comorbidities with perinatal ischemic and hemorrhagic stroke.
METHODS: The data for patients aged 0-28 days with a diagnosis of either ischemic or hemorrhagic stroke were extracted from the Cerner Health Facts Electronic Medical Record (EMR) database. Incidence of birth demographics and perinatal complications were recorded. …
Factors Influencing Instrumental Birth Rates: An Evidence Based Project, Douglas Nanu, Gabriel Alemayehu, Chase Eby, Teresa Rangel
Factors Influencing Instrumental Birth Rates: An Evidence Based Project, Douglas Nanu, Gabriel Alemayehu, Chase Eby, Teresa Rangel
Providence Nursing Research Conference 2023 – Present
No abstract provided.
Improve Exclusive Breastfeeding Rates Through Early Breastfeeding Initiation, Camille Chua, Beverly Holland
Improve Exclusive Breastfeeding Rates Through Early Breastfeeding Initiation, Camille Chua, Beverly Holland
Providence Nursing Research Conference 2023 – Present
No abstract provided.
Effect Of Mindfulness Training On Nicu Nurses’ Professional Quality Of Life, Susan Egami, Martha Highfield, Sherri Mendelson
Effect Of Mindfulness Training On Nicu Nurses’ Professional Quality Of Life, Susan Egami, Martha Highfield, Sherri Mendelson
Providence Nursing Research Conference 2023 – Present
No abstract provided.
Improving Nursing Education Curriculum As A Tool For Strengthening The Nurse–Client Relationships In Maternal And Child Healthcare: Insights From A Human-Centered Design Study In Rural Tanzania, Kahabi Isangula, Eunice Pallangyo, Eunice Ndirangu
Improving Nursing Education Curriculum As A Tool For Strengthening The Nurse–Client Relationships In Maternal And Child Healthcare: Insights From A Human-Centered Design Study In Rural Tanzania, Kahabi Isangula, Eunice Pallangyo, Eunice Ndirangu
School of Nursing & Midwifery, East Africa
Background. There are growing evidence of poor nurse–client relationships in maternal and child health (MCH). The nursing curriculum forms an important entry point for strengthening such relationships, consequently improving client satisfaction with nurses' competencies, confidence in the formal healthcare system, healthcare-seeking practices, continuity with care, and MCH outcomes.
Objective. MCH nurses and clients were invited to design an intervention package (prototype) to improve nurse–client relationships using a human-centered design (HCD) approach.
Methods. A multi-step HCD approach was employed to first examine the contributors of poor nurse–client relationships using nine focus group discussions with nurses and clients and 12 key informant …
Caesarean Section For Placenta Previa: A Retrospective Cohort Study Of Anaesthesia Techniques, Samina Ismail, Saima Rashid
Caesarean Section For Placenta Previa: A Retrospective Cohort Study Of Anaesthesia Techniques, Samina Ismail, Saima Rashid
Department of Anaesthesia
Objective: Placenta previa is associated with maternal and neonatal morbidity and mortality. This study aims to add to the limited literature from the developing world on the association of different anaesthetic techniques with blood loss, the need for blood transfusion, and maternal/ neonatal outcomes among women undergoing caesarean section with placenta previa.
Methods: This retrospective study was conducted at Aga University Hospital, Karachi, Pakistan. The patient population included parturients undergoing caesarean section for placenta previa from January 1, 2006, through December 31, 2019.
Results: Out of 276 consecutive cases of placenta previa progressing to caesarean section during the study period, …
Pediatric Obesity In Primary Care, Lynne C. Liggins
Pediatric Obesity In Primary Care, Lynne C. Liggins
Electronic Theses and Dissertations
The purpose of this evidence-based quantitative quasi-experimental research was to compare if providing the parents with information on the health risk associated with childhood obesity would cause the parents to make healthier food choices and encourage their children to be involved in a full hour of physical activity a day. Participants included parents and pediatric and adolescent children 5 to 18 years of age at a solo practice primary care office in a large city in Southern, California, which specializes in treating pediatric and adolescent patients. A pre- and postquantitative intervention design were used and analyzed using the paired t …
Substrate Electronics Dominate The Rate Of Reductive Dehalogenation Promoted By The Flavin-Dependent Iodotyrosine Deiodinase, Jeffrey M Carlson, Ayzsa Tannis, Kate R Woodworth, Megan R Reynolds, Neha Shinde, Breanne Anderson, Keivon Hobeheidar, Aisha Praag, Kristen Campbell, Cynthia Carpentieri, Teri Willabus, Elizabeth Burkhardt, Elizabeth Torrone, Kevin P O'Callaghan, Kathryn Miele, Dana Meaney-Delman, Suzanne M Gilboa, Emily O'Malley Olsen, Van T Tong
Substrate Electronics Dominate The Rate Of Reductive Dehalogenation Promoted By The Flavin-Dependent Iodotyrosine Deiodinase, Jeffrey M Carlson, Ayzsa Tannis, Kate R Woodworth, Megan R Reynolds, Neha Shinde, Breanne Anderson, Keivon Hobeheidar, Aisha Praag, Kristen Campbell, Cynthia Carpentieri, Teri Willabus, Elizabeth Burkhardt, Elizabeth Torrone, Kevin P O'Callaghan, Kathryn Miele, Dana Meaney-Delman, Suzanne M Gilboa, Emily O'Malley Olsen, Van T Tong
Faculty, Staff and Student Publications
Despite universal prenatal syphilis screening recommendations and availability of effective antibiotic treatment, syphilis prevalence during pregnancy and the incidence of congenital syphilis have continued to increase in the United States (1,2). Concurrent increases in methamphetamine, injection drug, and heroin use have been described in women with syphilis (3). CDC used data on births that occurred during January 1, 2018-December 31, 2021, from two states (Arizona and Georgia) that participate in the Surveillance for Emerging Threats to Pregnant People and Infants Network (SET-NET) to describe the prevalence of substance use among pregnant persons with syphilis by congenital syphilis pregnancy outcome (defined …
Parental Contextual Factors And Decision-Making Related To Periviable Birth: An Integrative Review, Amy L. Wright, Elizabeth Mens, Gausiha Rathitharan
Parental Contextual Factors And Decision-Making Related To Periviable Birth: An Integrative Review, Amy L. Wright, Elizabeth Mens, Gausiha Rathitharan
The Qualitative Report
Parents facing a periviable birth, or birth before 25 weeks of gestation, commonly engage in antenatal consultation with healthcare providers to determine a plan of care. Parents’ pre-existing contextual factors, beliefs, and values influence their decisions regarding birth and the care of their infant. This study aims to understand the role of parental contextual factors and best-practices to their integration during antenatal consultation The Whittemore and Knafl (2005) approach to conducting an integrative review along with thematic analysis was employed to determine and present the findings. Results describe three themes related to how contextual factors influence parental decision-making: personal values …
Breast Milk Jaundice (Nursing), Stephanie Bratton, Rebecca M. Cantu, Mitchell Stern, Wanda Dooley
Breast Milk Jaundice (Nursing), Stephanie Bratton, Rebecca M. Cantu, Mitchell Stern, Wanda Dooley
Nursing and Health Sciences
No abstract provided.
Metabolomics Of A Neonatal Cohort From The Alliance For Maternal And Newborn Health Improvement Biorepository: Effect Of Preanalytical Variables On Reference Intervals, Lena Jafri, Aysha Habib Khan, Muhammad Ilyas, Muhammad Imran Nisar, Javairia Khalid, Hafsa Majid, Aneeta Hotwani, Fyezah Jehan
Metabolomics Of A Neonatal Cohort From The Alliance For Maternal And Newborn Health Improvement Biorepository: Effect Of Preanalytical Variables On Reference Intervals, Lena Jafri, Aysha Habib Khan, Muhammad Ilyas, Muhammad Imran Nisar, Javairia Khalid, Hafsa Majid, Aneeta Hotwani, Fyezah Jehan
Department of Pathology and Laboratory Medicine
Background: The study was conducted to determine reference interval (RI) and evaluate the effect of preanalytical variables on Dried blood spot (DBS)-amino acids, acylcarnitines and succinylacetone of neonates.
Methodology: DBS samples were collected within 48-72 hours of life. Samples were analyzed for biochemical markers on tandem mass spectrometer at the University of Iowa. Comparison of RI across various categorical variables were performed.
Results: A total of 610 reference samples were selected based on exclusion criteria; 53.2% being females. Mean gestational age (GA) of mothers at the time of delivery was 38.7±1.6 weeks; 24.5% neonates were of low birth weight and …