Nanomedicine Commons^™

Smart Hydrogels For Infection Control, Varaprasad Kokkarachedu, Matías Araneda Cistemas, Nicolás Nicolás Valdés Gangas

Research Symposium

Background: Infection control is a critical area of concern in healthcare, mainly owing to the rising incidence of antibiotic-resistant bacteria. Traditional antibacterial agents often face challenges, such as limited efficacy, toxicity, and the potential for resistance development. This necessitates innovative approaches to combat infections. Hydrogels are biocompatible hydrophilic polymeric materials that can deliver nanomedicines with complications. They have emerged as promising candidates for infection control applications. Incorporating nanotoxicity nanomaterials, especially curcumin-layered silver nanoparticles, significantly enhances the antibacterial properties of hydrogels, making them promising candidates for infection control applications.

Methods: The smart antimicrobial hydrogels were synthesised from Poluronic and curcumin-layered polyvinylpyrrolidone/silver …

Reconstitution Of Mirna-205 In Docetaxel Resistant Prostate Cancer Cells: A Nanotherapeutic Approach, Neeraj Chauhan, Eswara Naga Hanuma Kumar Ghali, Rahul Tiwari, Iris Enriquez, Rajasekhar Baru, Subhash C. Chauhan, Murali M. Yallapu

Research Symposium

Background: Prostate cancer (PrCa) is the second most diagnosed cancer and cause of death in men globally. Docetaxel (Dtxl) based first line chemotherapy is the main available therapeutic choice for PrCa patients. However, most (almost all) patients develop resistance to Dtxl treatment, making it difficult to treat such patients with no effective adjuvant therapy. Although cabazitaxel may be used to treat these patients, it is associated with many severe side effects including low white blood cells and allergic reactions. Therefore, finding an alternative strategy to reduce Dtxl resistance is of high importance for treating PrCa. miR-205 is a widely studied …

Development Of Liposomes Using Microfluids For Delivery Of Mir-205, Victoria Herrera, Rahul Tiwari, Meghana Kolli, Neeraj Chauhan, Amber M. Garza, Eswara Naga Hanuma Kumar Ghali, Subhash C. Chauhan, Murali Yallapu

Research Symposium

Background: The therapeutic application of microRNA(s) in the field of cancer has generated significant attention in research. miR-205 is a tumor suppressor in various cancers. However, the delivery of miR-205 is an unmet clinical need. Thus, the development of liposomal formulation platform to deliver miR-205 is highly sought. The most common applications of liposome formulations are vaccines and anticancer formulations (e.g., mRNA, small molecule drugs). However, large-scale production with precise control of size and size distribution of the lipid-based drug delivery systems (DDSs) is one of the major challenges in the pharmaceutical industry. The objective of this study is to …

Smoking And Drinking Activates Nf-Κb /Il-6 Axis To Promote Inflammation During Cervical Carcinogenesis, Vivek Kumar Kashyap, Prashanth Kb Nagesh, Ajay K. Singh, Andrew Massey, Godwin P. Darkwah, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

Research Symposium

Background: High-risk strains of HPV are known to cause cervical cancer. Multiple clinical studies have emphasized that smoking and drinking are critical risk factors for cervical cancer and its high-grade precursors. In this study, we investigated the molecular mechanisms involved in the interplay of smoking and/or drinking with HPV infectivity and defined a systematic therapeutic approach for their attenuation in cervical cancer.

Methods: The impact of benzo[a]pyrene (B[a]P) and/or ethanol (EtOH) exposure on cervical cancer cells was assessed by measuring changes in cell proliferation, clonogenicity, biophysical properties, cell migration, and invasion. Expression of HPV16 E6/E7, NF-κB, cytokines, cell cycle, and …

Development And Evaluation Of A Nanofiber Membrane In Vitro As A Therapeutic Alternative For The Post Treatment In Breast Cancer Cell In A Murine Model, Bruno A. Valades-Aguilar, Diana Ginette Zarate-Triviño, José Raúl Rángel-López, Moises Armides Franco-Molina, Jorge Luis Menchaca-Arredondo, María Cristina Rodríguez-Padilla

Research Symposium

Worldwide female breast cancer is the most commonly diagnosed cancer, with an estimated 2.3 million new cases in 2020, reason for the need of targeted therapies that can maximize treatment success and minimize toxicity. Nanoparticles of gold (AuNps) exhibit cytotoxic properties against certain types of cancer cell lines. Nanofibers have been use in the drug delivery systems due to its degradability and high surface area. We proposed a membrane with nanometric fibers using polivinilic alcohol (PVA) and chitosan (Qts) loaded with AuNps and Doxorubicin (Doxo) with the purpose of diminish tumor regression.

PVA-Qts membrane was develop with electrospinning, the injection, …