Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- Nanoparticles (6)
- Calcium phosphate (5)
- Drug delivery (5)
- Osteomyelitis (5)
- Gadolinium nanoparticles (3)
-
- Osteogenesis (3)
- Antioxidant (2)
- Biomaterials (2)
- Drug delivery systems (2)
- Gene Therapy (2)
- Hydroxyapatite (2)
- Metal nanoparticles (2)
- Nanocarriers (2)
- Nanomedicine (2)
- Selenium nanoparticles (2)
- SiRNA delivery (2)
- 2 (1)
- 4-hydroxy-[2 (1)
- 6 (1)
- 6-tetramethylpiperidin- 1-yl]oxidanyl (1)
- AIDS (1)
- Alveolar bone (1)
- Antibiotics (1)
- Anticancer activity (1)
- Antidiabetic (1)
- Antiinfectives (1)
- Antimicrobial activity (1)
- Antimicrobial peptides (1)
- Antimicrobial silver nanoparticles (1)
- Antimicrobials (1)
- Publication Year
- Publication
- Publication Type
Articles 31 - 33 of 33
Full-Text Articles in Nanomedicine
Phase Composition Control Of Calcium Phosphate Nanoparticles For Tunable Drug Delivery Kinetics And Treatment Of Osteomyelitis. Part 2: Antibacterial And Osteoblastic Response, Vuk Uskoković, Tejal A. Dasai
Phase Composition Control Of Calcium Phosphate Nanoparticles For Tunable Drug Delivery Kinetics And Treatment Of Osteomyelitis. Part 2: Antibacterial And Osteoblastic Response, Vuk Uskoković, Tejal A. Dasai
Pharmacy Faculty Articles and Research
Osteomyelitis has been traditionally treated by the combination of long-term antibiotic therapies and surgical removal of diseased tissue. The multifunctional material was developed in this study with the aim to improve this therapeutic approach by: (a) enabling locally delivered and sustained release of antibiotics at a tunable rate, so as to eliminate the need for repetitive administration of systemically distributed antibiotics; and (b) controllably dissolving itself, so as to promote natural remineralization of the portion of bone lost to disease. We report hereby on the effect of the previously synthesized calcium phosphates (CAPs) with tunable solubilities and drug release time …
Calcium Phosphate Nanoparticles: A Future Therapeutic Platform For The Treatment Of Osteomyelitis?, Tejal A. Dasai, Vuk Uskoković
Calcium Phosphate Nanoparticles: A Future Therapeutic Platform For The Treatment Of Osteomyelitis?, Tejal A. Dasai, Vuk Uskoković
Pharmacy Faculty Articles and Research
No abstract provided.
Attenuation Of Corneal Myofibroblast Development Through Nanoparticle-Mediated Soluble Transforming Growth Factor-Β Type Ii Receptor (Stgfβrii) Gene Transfer, Ajay Sharma, Jason T. Rodier, Ashish Tandon, Alexander M. Klibanov, Rajiv R. Mohan
Attenuation Of Corneal Myofibroblast Development Through Nanoparticle-Mediated Soluble Transforming Growth Factor-Β Type Ii Receptor (Stgfβrii) Gene Transfer, Ajay Sharma, Jason T. Rodier, Ashish Tandon, Alexander M. Klibanov, Rajiv R. Mohan
Pharmacy Faculty Articles and Research
Purpose: To explore (i) the potential of polyethylenimine (PEI)-DNA nanoparticles as a vector for delivering genes into human corneal fibroblasts, and (ii) whether the nanoparticle-mediated soluble extracellular domain of the transforming growth factor–β type II receptor (sTGFβRII) gene therapy could be used to reduce myofibroblasts and fibrosis in the cornea using an in vitro model.
Methods: PEI-DNA nanoparticles were prepared at a nitrogen-to-phosphate ratio of 30 by mixing linear PEI and a plasmid encoding sTGFβRII conjugated to the fragment crystallizable (Fc) portion of human immunoglobulin. The PEI-DNA polyplex formation was confirmed through gel retardation assay. Human corneal fibroblasts (HCFs) were …