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Articles 151 - 180 of 662

Full-Text Articles in Nanotechnology

Evaluation Of The Built Environment Performance In Light Of Sustainable And Universal Design: Criteria And Methods, N.A.Mohamed E. A. Morghany, M. E. Khalil Jul 2024

Evaluation Of The Built Environment Performance In Light Of Sustainable And Universal Design: Criteria And Methods, N.A.Mohamed E. A. Morghany, M. E. Khalil

Journal of Engineering Research

Egypt's Vision 2030 for Sustainable Development Strategy (SDS) emphasizes social inclusion and accessibility. The concept of Universal Design (UD) is crucial in achieving the goals of SDS by facilitating utilization and access to the built environment for all.


Palm Agricultural Residues As A Sustainable Local Construction Material For Siwa House: One Click Life Cycle Assessment Perspective, Nader Mohamed Gharib, Jul 2024

Palm Agricultural Residues As A Sustainable Local Construction Material For Siwa House: One Click Life Cycle Assessment Perspective, Nader Mohamed Gharib,

Journal of Engineering Research

This study focuses on conducting a life cycle assessment (LCA) of using green agricultural waste as a sustainable local building material compared to conventional materials. Agricultural residues present a major waste management issue, however they can be repurposed as renewable construction resources. The aim is to quantify the environmental impacts of an experimental palm midribs roof design versus a traditional reinforced concrete roof. by using One Click LCA software to model the two design scenarios and analyze key sustainability indicators including carbon emissions. By comparing the LCA results, the study benchmarks the global warming potential and identifies opportunities to promote …


The Role Of Interior Architecture In Developing Sustainable Educational Building Spaces And Its Impact On Users In University Institutions, زينب ناجي¹ ريم الحداد Jul 2024

The Role Of Interior Architecture In Developing Sustainable Educational Building Spaces And Its Impact On Users In University Institutions, زينب ناجي¹ ريم الحداد

Journal of Engineering Research

يهدف البحث الى تسليط الضوء على أهمية الاستدامة في التصميم وما تحققه من جوانب ايجابية على الفرد والمجتمع، حيث أن أبنية العمارة المستدامة هي التي يتم تصميمها وإنشاءها بطرق ومواد البناء المحلية والتي لا تؤثر سلبيا على البيئة وصحة المستعملين والقائمين بالبناء وتحافظ على حقوق الأجيال القادمة، وتتناول الأبنية المستدامة العديد من الإعتبارات ومنها إستعمالات الأراضي والتأثير على الموقع والبيئة المحيطة وإستنزاف الطاقة والمياه. و يصبح المبنى الذي يبنى على أساس العمارة المستدامة مفيد لأنه يعتمد على تحسين كفاءة الطاقة المستخدمة وبالتالي توفير المال، والحد من التلوث بزيادة نقاء الهواء الذي يوفر لمستخدمي المبنى بيئة صحية سليمة بالإضافة الى المحافظة …


Opportunities And Challenges For Achieving Sustainable Architectural Education In Egypt, In Light Of Universal Design Approach., مي عيد خليل أحمد م/ هناء شعبان حسن Jul 2024

Opportunities And Challenges For Achieving Sustainable Architectural Education In Egypt, In Light Of Universal Design Approach., مي عيد خليل أحمد م/ هناء شعبان حسن

Journal of Engineering Research

الملخص يعتبر التعليم الجامعي هو المفتاح لتغيير الثقافة المهنية في مجالات التصميم، لذا يقع على عاتق المؤسسات التعليمية مسؤولية التعليم والتثقيف للطلاب الجامعيين، حيث يقدم التعليم المعماري حلولاً مجدية للقضايا الدولية الملحة من خلال تحقيق أهداف التنمية المستدامة والتي صاغتها الأمم المتحدة، يمكن التغلب على هذه القضايا من خلال تطبيق مفهوم التصميم العالمي (الشامل) UD والذي يسعي لتبسيط الحياه علي الجميع وتحقيق الوصول والاستخدام اليسير للجميع بغض النظر عن القدرات البدنية والأعمار.


Challenges Of New And Renewable Energy In The Face Of Climate Change: An Introduction To Evaluating The Egyptian Experience, نهي أحمد عبد المنعم السيد, شاهيناز محمد علي طايع Dr, Nevine Gado Dr. Jul 2024

Challenges Of New And Renewable Energy In The Face Of Climate Change: An Introduction To Evaluating The Egyptian Experience, نهي أحمد عبد المنعم السيد, شاهيناز محمد علي طايع Dr, Nevine Gado Dr.

Journal of Engineering Research

أصبحت التغيرات المناخية وما يترتب عليها من المخاطر البيئية قضية من القضايا الحيوية والتي عقدت لها عدة مؤتمرات دولية مثل مؤتمر المناخ العالمي COP 27 والذي استضافته مصر في عام 2023 لوضع الحلول لتلك الأزمة. ومن أجل ذلك أصبح مردود الطاقة الجديدة والمتجددة احدى اليات وادوات التعامل مع هذه القضية الحيوية كبديل مستدام وصديق للبيئة.


The Impact Of Digital Twin On Real Estate Marketing, نوران عاطف محمد غانم Eng, مروة أحمد قمر الدولة أ.د أحمد عبد الوهاب أحمد رزق Jul 2024

The Impact Of Digital Twin On Real Estate Marketing, نوران عاطف محمد غانم Eng, مروة أحمد قمر الدولة أ.د أحمد عبد الوهاب أحمد رزق

Journal of Engineering Research

يتناول هذا البحث أولا الدراسات النظرية الأكثر حداثة التي تناولت تقنية التوأمة الرقمية وعلاقتها بالعقارات وتسويقها ونشأتها ومفهومها ومكوناتها، ثم انتقلنا الي الدراسات المخصصة لاستخداماتها في قطاع العقارات وأهميتها، ومن بعد تناولنا استخدامتها في التسويق العقاري بصفة خاصة من حيث المشاريع والبرامج. ومن ثم وضحنا أهمية تقنية التوأمة وتأثيرها علي التسويق العقاري من حيث العملاء والشركات والأسواق، وبعد ذلك تناولنا تطبيق للتسويق العقاري باستخدام تقنية التوأمة الرقمية علي التخطيط العمراني وكيفية تأثيره علي تسويق المشروع. ومن خلال القيام بدراسة استبيان لقياس أهمية تأثير تقنية التوأمة الرقمية علي أراء العملاء وتفضيلاتهم في اتخاذ القرارات واختيارهم للشركات حين ذاك، وربط تقنية التوأمة …


Sensory Garden Preferences For Autism Spectrum: Insights From Psychologists And Urban Designers, Maram Adel Ebaid Jul 2024

Sensory Garden Preferences For Autism Spectrum: Insights From Psychologists And Urban Designers, Maram Adel Ebaid

Journal of Engineering Research

Sensory gardens are outdoor environment that stimulate the senses and promote well-being for people with autism spectrum disorder (ASD). In Egypt, there is an absence of gardens, compounded by a limited understanding of the design principles aligned with the needs of people with ASD. The research explores sensory garden features and the specific challenges faced by people with ASD. To bridge this gap, the methodology depends on qualitative approach through interviews with psychology and urban design experts. The results highlight the correlation between prevalent strategies among people with ASD and the elements of sensory gardens, considering both soft and hard …


Incorporation Of Bim Techniques In The Architectural Engineering Curriculum, Ahmed Ahmed M. Saleh, Sherif S. Abdalla Jul 2024

Incorporation Of Bim Techniques In The Architectural Engineering Curriculum, Ahmed Ahmed M. Saleh, Sherif S. Abdalla

Journal of Engineering Research

In this era, the age of the digital revolution, Egyptian engineering universities and academies compete by integrating new technologies such as building information modeling (BIM) inside the educational curriculum. The research aims to examine and integrate BIM techniques within the course specifications in Egyptian universities and academies, majoring in architectural engineering pathing through the four levels of credit hours system so that, teaching the BIM courses is not limited to one or two only. Furthermore, the current situation of BIM maturity levels, dimensions, and tools implementation in some architecture universities and academies curriculum will be determined and monitored. As a …


Operating Efficiency In Accommodation Units And Its Impact On The Design Of Comprehensive Single Patient Rooms In Hospitals, نهال نبيل محمد مصطفي ، احمد هلال محمد محمد ، نادي مصطفي عبد الكريم Jul 2024

Operating Efficiency In Accommodation Units And Its Impact On The Design Of Comprehensive Single Patient Rooms In Hospitals, نهال نبيل محمد مصطفي ، احمد هلال محمد محمد ، نادي مصطفي عبد الكريم

Journal of Engineering Research

هناك الكثير من التحديات التشغيلية والتنظيمية التي تواجهها المجموعات المهنية المختلفة داخل وحدات الإقامة في المستشفيات بسبب عدم كفاية معايير التصميم الموضوعة بالاحتياجات المطلوبة خاصة بغرف المرضي، ومن اهم التحديات التي يواجهها الاطباء وفرق التمريض والفنيين وغيرهم. القدرة السلسة على دخول غرفة المريض والتفاعل مع عناصر الغرفة بشكل واضح دون حدوث تصادمات او احتكاكات، كذلك القدرة علي القيام بالأعمال التحضيرية المتعلقة بالأنشطة التمريضية المطلوبة داخل غرف المرضي وتشمل كافة الأنشطة التي يقوم بها الشخص المهني سواء اكان طبيب ام تمريض ام فني منذ لحظة دخوله غرفة المريض وحتي اداءه المهمة المطلوبة. ويجب ان تتم هذه المهام بشكل مريح وباستجابة سريعة …


Performance And Enhancement Evaluation Of A Solar Still By Using Spraying Technology, Mahmoud Mohamed Dewedar, Yasser A. F. El-Samadony, Alsayed Alsaeed Mohamed, Ahmed Ibrahim Abdo Jul 2024

Performance And Enhancement Evaluation Of A Solar Still By Using Spraying Technology, Mahmoud Mohamed Dewedar, Yasser A. F. El-Samadony, Alsayed Alsaeed Mohamed, Ahmed Ibrahim Abdo

Journal of Engineering Research

The current experimental investigation uses the water spraying approach to increase the productivity and efficiency of pyramid solar still. The design, construction, and testing of a traditional and modified small-scale pyramid solar still were conducted under identical meteorological conditions as in Tanta City, Egypt (30° 47' N, 31°E). One of the modifications is that heated sheet metal will occasionally be sprayed with salted water. We looked into how the modified solar still's (MPSS) performance characteristics were affected by solar radiation, water depth, and sheet metal-specified temperature. Measurements were made of the saline water temperature, glass temperature, spraying flow rate, and …


Securing Body Area Networks With Fingerprint Cryptography And Authentication In Manet, Alaa M. Elbanaa, Roayat Ismail Abdelfatah, Mohamed E. Nasr Jul 2024

Securing Body Area Networks With Fingerprint Cryptography And Authentication In Manet, Alaa M. Elbanaa, Roayat Ismail Abdelfatah, Mohamed E. Nasr

Journal of Engineering Research

Standard MANETs face issues like incorrect transmission and vulnerability to unauthorized node access, posing significant security concerns, especially regarding authentication procedures. To address these challenges, researchers are exploring innovative approaches to enhance authentication mechanisms within MANETs. In this paper, we present a novel solution integrating a Body Area Network (BAN) scheme to capture biomedical data from sensors such as ECG and EEG, facilitating data transmission across MANETs. Furthermore, we employ a hybrid Elgamal algorithm for encrypting biomedical data, bolstered by fingerprint biometrics to fortify the cryptographic process, enhancing network security. Additionally, we conduct comparative analyses, exploring different key sizes and …


A Technical Survey On The Impact Of Exhaust Gas Recirculation And Multifuel Blends On Diesel Engine Performance And Emission Characteristics, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi Prof. Dr. Eng., E. A. El Shenawy Prof. Dr., Mustafa Mohamed Ouda Eng. Jul 2024

A Technical Survey On The Impact Of Exhaust Gas Recirculation And Multifuel Blends On Diesel Engine Performance And Emission Characteristics, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi Prof. Dr. Eng., E. A. El Shenawy Prof. Dr., Mustafa Mohamed Ouda Eng.

Journal of Engineering Research

The increasing demand for fossil fuels poses significant challenges as their reserves gradually deplete over time. Biodiesel is considered one of the most effective alternative fuels to mitigate these issues. Current research focuses on comparing engine performance parameters when blending biodiesel with fossil fuels in Compression Ignition (C.I.) engines. The study demonstrates a comparison of the exhaust emissions produced by biodiesel fuel. In comparison to diesel, biodiesel generally exhibits lower heating value, higher density, increased fuel consumption, and elevated nitrogen oxide levels. To address these challenges, various additives are mixed and blended with biodiesel to meet international fuel standards. These …


Heat And Mass Transfer Characteristics During Vacuum Drying Of Wood, Mohamed Salah Elmetwaly, Lotfy Hassan Rabie Saker, Mohamed Sameh Salem Jul 2024

Heat And Mass Transfer Characteristics During Vacuum Drying Of Wood, Mohamed Salah Elmetwaly, Lotfy Hassan Rabie Saker, Mohamed Sameh Salem

Journal of Engineering Research

The properties affecting the characteristics of heat and mass transfer during vacuum drying of wood are studied in this paper. The experimental work is carried out in 0.0365 m3 test rig vacuum dryer. The drying chamber dimensions are 0.5 m long and 0.305 m diameter carbon steel cylinder. This drying chamber is internally coated with epoxy paint, also this chamber is detachable closing caps at both ends meaning welded at one end and bolted at the other end to facilitate loading and unloading of the specimen. Two stainless steel heat exchanger plates with dimensions 0.3 m length, 0.15 m …


Prediction Of Noise From A Construction Site, Amira Mostafa Ibrahim Miss, Nashwa Mohamed Yossef Prof, Adel Ibrahim Eldosouky Emeritus Professor Jul 2024

Prediction Of Noise From A Construction Site, Amira Mostafa Ibrahim Miss, Nashwa Mohamed Yossef Prof, Adel Ibrahim Eldosouky Emeritus Professor

Journal of Engineering Research

Construction activities significantly contribute to environmental noise pollution, affecting workers' health and the surrounding community, posing significant challenges to human well-being and productivity. This paper presents a prediction method and a modelling technique used to assess construction site noise. Various factors influencing noise generation and propagation, such as equipment types, operational conditions, site characteristics, and environmental factors, are discussed. This paper explores the application of Monte Carlo technique as an effective method for predicting construction site noise and planning noise mitigation strategies.


Numerical Investigation Of Liquefaction Mitigation In-Sandy Soils Under Earthquake Loading Using Vertical Gravel Drains., Marawan M. Shahien M. Shahein, Ahmed Nasr, Baher Mohamed Abd El Fattah Jul 2024

Numerical Investigation Of Liquefaction Mitigation In-Sandy Soils Under Earthquake Loading Using Vertical Gravel Drains., Marawan M. Shahien M. Shahein, Ahmed Nasr, Baher Mohamed Abd El Fattah

Journal of Engineering Research

Liquefaction is one of the most dramatic defects of granular soil. This phenomenon is mostly observed when loose sand is subjected to a dynamic load or earthquake. In this study, the liquefaction that affected the loose soil evaluated, and some recommendations are introduced. (2-D) Numerical analysis using Plaxis (8.2) was conducted to simulate the behavior of the loose soil under dynamic loads. The studied model was carried out on multi-layers soil supported by stone columns subjected to dynamic loads. It was found that stone columns enhanced the soil behavior and reduced the damage that occurred. Liquefaction of the loose soil …


Chemical Kinetic Investigation: Exploring The Impact Of Various Concentrations Of Hho Gas With A 40% Biodiesel/Diesel Blend On Hcci Combustion, Mai H. Aboubakr, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi, Ayman Refat Abd Elbar Jul 2024

Chemical Kinetic Investigation: Exploring The Impact Of Various Concentrations Of Hho Gas With A 40% Biodiesel/Diesel Blend On Hcci Combustion, Mai H. Aboubakr, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi, Ayman Refat Abd Elbar

Journal of Engineering Research

This study uses the Chemkin software program to evaluate the effect of different quantities of oxyhydrogen gas [HHO] added to 40% biodiesel and diesel mix [B40], including B40, B40+5HHO, B40+10HHO, and B40+15HHO, on the HCCI combustion process's efficiency. The information collected includes cylinder pressure, cylinder temperature, accumulated gas phase heat release, heat loss rate, UHC, and mole fractions of O2, CO, CO2, diesel [NC7H16], biodiesel [C5H10O2], and oxyhydrogen [H2O]. The finding is that, when compared to a blend of biodiesel and diesel, using oxyhydrogen in the biodiesel/diesel mix boosts the properties of the HCCI engine.


Exploring The Influence Of Various Factors, Including Initial Temperatures, Equivalence Ratios, And Different Biodiesel/Diesel Blend Ratios, On Homogeneous Charge Compression Ignition (Hcci) Combustion, Mai H. Aboubakr, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi, Ayman Refat Abd Elbar Jul 2024

Exploring The Influence Of Various Factors, Including Initial Temperatures, Equivalence Ratios, And Different Biodiesel/Diesel Blend Ratios, On Homogeneous Charge Compression Ignition (Hcci) Combustion, Mai H. Aboubakr, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi, Ayman Refat Abd Elbar

Journal of Engineering Research

This paper discusses the impact of three study cases that change with different values: the first case is four initial temperature values [313, 323, 333, and 343 K], the second case is three equivalence ratios [0.2, 0.3, and 0.4], and the third case uses various concentrations of biodiesel and diesel mixes [D100, B20, B40, B60, B80, and B100]. The purpose is to use the Chemkin software program to determine the effectiveness of each case in the HCCI combustion process. The results included cylinder pressure, cylinder temperature, accumulated gas phase heat release, heat loss rate, UHC, and mole fractions of O …


Survey And Analysis Of Safety Components And Costs In Construction Projects In Egypt, Emad E. Etman Prof., Haytham Sanad Prof., Asmaa Ibrahim Khater Jul 2024

Survey And Analysis Of Safety Components And Costs In Construction Projects In Egypt, Emad E. Etman Prof., Haytham Sanad Prof., Asmaa Ibrahim Khater

Journal of Engineering Research

The difficulty of determining the factors that achieve safety on Egyptian construction sites as a result of multiple and different criteria and different relative weights of the criteria represents a challenge to achieve safety and a secure environment on construction sites. This issue has been of interest for many decades and continues to be a topic of discussion today because of construction project management is rapidly modernizing. The paper aims to identify the safety standards most commonly used on construction sites, and determine their relative weights as seen by the target audience and also estimate the cost of safety measures …


Enhancing Decision In Information System Through Weighted Preliminary Pretopology Analysis, Mustafa Elsayed, Rifet Agassi Jul 2024

Enhancing Decision In Information System Through Weighted Preliminary Pretopology Analysis, Mustafa Elsayed, Rifet Agassi

Journal of Engineering Research

It is clear from adequate study of the past decades that there has been rapid growth in the information system, which relies mainly on programming systems. This has led to the necessity of dealing with high efficiency with the information system necessary for decision support. Information systems are a mixture of software and hardware to store and process all the data required and are presented in a useful form to extract information by applying topological concepts. In this paper a pretopological space from an information system is to be constructed. The computation of decision accuracy stands as a pivotal stage …


تحسين كفاءه التوازن الحرارى لمستخدمى الفراغات السكنيه, Alamera Kamal Elden Elfeky, Elamira Elfeky, Walaa Ahmed Nour, Lobna Abdallah Agha Jul 2024

تحسين كفاءه التوازن الحرارى لمستخدمى الفراغات السكنيه, Alamera Kamal Elden Elfeky, Elamira Elfeky, Walaa Ahmed Nour, Lobna Abdallah Agha

Journal of Engineering Research

human belonging to nature Considered innate, and known as Biophilie, it has direct and strong relation with human heath and his welfare which affected by quality of internal environment where we Live and work as we spend most of our time in this environment. Biophelic design Aim to improve heath and welfare of human. natural. and reconnect him with his natural environment beside achieving the aesthetic aspect of his place.

in our present time, gap appeared in relation between human and environment as a result of modern design solution, as it has negative effect on human heath and safety, to …


Towards Environmentally Sustainable Preservation Of Heritage Buildings, Rozal Rozal Yousef Hanna1, Ayman Gamal El-Din Abd El- Tawab2, Walaa Abou El- Haggag Mehanna3 Jul 2024

Towards Environmentally Sustainable Preservation Of Heritage Buildings, Rozal Rozal Yousef Hanna1, Ayman Gamal El-Din Abd El- Tawab2, Walaa Abou El- Haggag Mehanna3

Journal of Engineering Research

The construction industry, characterized by its intricate processes and extensive stakeholder networks, stands at the cusp of a digital revolution. The adoption of blockchain-smart contract (BCSC) technology is at the heart of this transformation. This research delves deep into the BCSC within the construction arena to provide comprehensive insight into its probable applications, inherent challenges, and potential future trajectories. Leveraging the PRISMA analysis technique, a curated collection of relevant academic research articles was assembled, shedding light on the existing body of knowledge regarding the application of BCSC technology in construction. The authors developed an innovative user interface tool customized to …


Review: Protection Of Wooden Structures With Nano-Titanium Dioxide Coating, Zienab Zienab A. Ahmed1*, And M. M. Mosallem2 Jul 2024

Review: Protection Of Wooden Structures With Nano-Titanium Dioxide Coating, Zienab Zienab A. Ahmed1*, And M. M. Mosallem2

Journal of Engineering Research

Wood is widely used for various purposes with good performance. Wood works as the main material for furniture, monuments, decorations and constructions. which has the close relationship with human. Durability of wood is important in ensuring an appropriate life for the structure being designed. Wooden construction deteriorates easily due to UV radiation and weather conditions. Many of wood types need a preservative treatment. Several compounds are available for chemical protection, but not all are completely safe for human health. New technologies with low environmental impact and economically feasible are developed, which improves the life cycle of wood. Titanium dioxide is …


Urbanism Strategies For Linking Existing And New Cities, Naglaa J. Q. Mo’Men Abdel-Qader Ebrahim1, Mohsen Bayad2 Jul 2024

Urbanism Strategies For Linking Existing And New Cities, Naglaa J. Q. Mo’Men Abdel-Qader Ebrahim1, Mohsen Bayad2

Journal of Engineering Research

New cities, designed for urban growth outside existing metropolitan regions, face challenges in street infrastructure due to rapid expansion. Efficient control of mobility is crucial as cities grow. Sustainable transportation involves factors like infrastructure, public transit, delivery networks, affordability, efficiency, air quality, health, and reduced emissions. Commuting between established and new urban areas is common, leading to issues like urban sprawl, longer travel times, and congestion in developing countries. The challenge is to improve accessibility while addressing air quality, traffic, congestion, noise, built environment, emissions, and sprawl. This study aims to explore factors influencing mobility choices in Egypt, focusing on …


Manufacturing Of Aligned Electrospun Nanofiber Yarns For Their Enhanced Mechanical And Piezoelectric Properties, Adaugo Mary-Frances Enuka Jun 2024

Manufacturing Of Aligned Electrospun Nanofiber Yarns For Their Enhanced Mechanical And Piezoelectric Properties, Adaugo Mary-Frances Enuka

Theses and Dissertations

Electrospinning is a widely used technique for producing nanofibers with diverse applications. This method uses polymer solutions and strong electric fields to generate nano-sized fibers with unique properties. This study presents a novel manufacturing approach that enables the production of electrospun poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) nanofiber yarns using an automated parallel track system and an adjustable roll-to-roll collector. This research examines the impact of an automated post-drawing system on the polymer chain orientation, crystallinity, tensile strength, morphology, and piezoelectric properties of PVDF-HFP nanofiber yarn. The results reveal that the post-drawing process significantly improves molecular alignment, increases tensile strength, and enhances the …


Understanding Nanoparticle-Liver Interactions In Nanomedicine, Yuxin He, Yifan Wang, Lin Wang, Wen Jiang, Stefan Wilhelm Jun 2024

Understanding Nanoparticle-Liver Interactions In Nanomedicine, Yuxin He, Yifan Wang, Lin Wang, Wen Jiang, Stefan Wilhelm

Faculty, Staff and Student Publications

Introduction: Understanding the interactions between administered nanoparticles and the liver is crucial for developing safe and effective nanomedicines. As the liver can sequester up to 99% of these particles due to its major phagocytic role, understanding these interactions is vital for clinical translation.

Areas covered: This review highlights recent studies on nanoparticle-liver interactions, including the influence of nanoparticle physicochemical properties on delivery, strategies to enhance delivery efficiency by modulating liver Kupffer cells, and their potential for treating certain hepatic diseases. Additionally, we discuss how aging impacts the liver's phagocytic functions.

Expert opinion: While liver accumulation can hinder nanomedicine safety and …


Generation And Characterization Of Lipid Nanoparticles For Dna Plasmid Delivery And Pharmacological Characterization, Sahana John May 2024

Generation And Characterization Of Lipid Nanoparticles For Dna Plasmid Delivery And Pharmacological Characterization, Sahana John

Biotechnology Theses

Lipid nanoparticles (LNPs) have shown promise for delivering nucleic acids like DNA plasmids, but packaging large plasmids remains challenging. The findings and experimental work detailed in this thesis are geared towards providing a proof of concept and providing preliminary confirmation of the guiding principle.

We synthesized LNPs containing cationic lipids (D-Lin-MC3) to encapsulate the large pLVX-ZsGreen and psiCHECK (luciferase) plasmids (~10-14kb) using a microfluidic system. Characterization included size, charge, morphology, plasmid encapsulation efficiency and in vitro/in vivo studies. The LNP-pDNA particles were ~100nm in size with high encapsulation efficiency. The LNPs efficiently transfected 293T cells with low cytotoxicity, enabling strong …


Functionalized Gold Nanoparticles And Halogen Bonding Interactions Involving Fentanyl And Fentanyl Derivatives, Molly M. Sherard, Jamie S. Kaplan, Jeffrey H. Simpson, Kevin W. Kittredge, Michael C. Leopold May 2024

Functionalized Gold Nanoparticles And Halogen Bonding Interactions Involving Fentanyl And Fentanyl Derivatives, Molly M. Sherard, Jamie S. Kaplan, Jeffrey H. Simpson, Kevin W. Kittredge, Michael C. Leopold

Chemistry Faculty Publications

Fentanyl (FTN) and synthetic analogs of FTN continue to ravage populations across the globe, including in the United States where opioids are increasingly being used and abused and are causing a staggering and growing number of overdose deaths each year. This growing pandemic is worsened by the ease with which FTN can be derivatized into numerous derivatives. Understanding the chemical properties/behaviors of the FTN class of compounds is critical for developing effective chemical detection schemes using nanoparticles (NPs) to optimize important chemical interactions. Halogen bonding (XB) is an intermolecular interaction between a polarized halogen atom on a molecule and e−-rich …


Translational Pathways For Ultra Long-Acting Medicines For Chronic Disease: From Hiv To Substance Use Disorders, Suyash Sanjay Deodhar May 2024

Translational Pathways For Ultra Long-Acting Medicines For Chronic Disease: From Hiv To Substance Use Disorders, Suyash Sanjay Deodhar

Theses & Dissertations

Human immunodeficiency virus (HIV) and opioid use disorder (OUD) are among the top global public health challenges, with a significant overlap in the number of cases and higher mortality risks compared to the general population. Treatment and recreational opioid use lead to addictive disorders. Both conditions require repeated dosing of therapy where adherence to a strict lifelong regimen remains a major challenge. Notably, people living with HIV/AIDS (PLWHA) and struggling with opioid use disorders (OUD) show suboptimal adherence to antiretroviral drugs (ARVs). Also, the risk of transmitting HIV and other blood-borne infections through the sharing of needles and other injection …


Development Of Long-Acting Antiviral And Antimicrobial Prodrug Nanoformulations, Srijanee Das May 2024

Development Of Long-Acting Antiviral And Antimicrobial Prodrug Nanoformulations, Srijanee Das

Theses & Dissertations

Over the past decade, the global burden of infectious diseases has increased substantively, underscoring the need for more effective treatment strategies. However, the discovery and development of new drugs with desirable safety, pharmacokinetics, and efficacy is a time consuming and costly process with great uncertainty around success rate. As an alternative to new drug development, prodrugs and novel drug delivery systems have increasingly been explored. Both serve to overcome the drug development challenges. Such drug formulations that permit extended dosing intervals of potent native drugs serve multiple purposes by promoting patient adherence to in improving treatment outcomes. This is especially …


Electrochemical Modulation Of Surface Plasmon Wave To Investigate Dna-Based Sensing Platforms And Detection Of Sars-Cov2., Anil Sharma May 2024

Electrochemical Modulation Of Surface Plasmon Wave To Investigate Dna-Based Sensing Platforms And Detection Of Sars-Cov2., Anil Sharma

Electronic Theses and Dissertations

This study offers a thorough comparative analysis of optical and electrical signaling strategies for assessing the electrochemical properties of different redox-labeled DNA-based biosensing platforms. In addition, it illustrates the development of an optical interrogation technique with electrochemical modulation of surface plasmon waves (ECM-SPW) as a route for analyzing and implementing DNA-based hybridization sensors. For those quantitative analyses, we chose a model sensing platform composed of a methylene blue (MB)-modified single-stranded DNA (ssDNA) signaling probe and an unlabeled capture ssDNA probe that complements the signaling probe. Two types of signaling probes were employed in this work: one with MB attached to …